{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:08:46Z","timestamp":1753891726922,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nucl. Med."],"abstract":"<jats:p>Peripheral neuropathy is a prevalent complication in plasma cell disorders, posing significant diagnostic and therapeutic challenges. This study presents three cases initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP). Despite initial symptom regression post-immunomodulatory treatment, the patients exhibited progressive neurological deficits. Advanced laboratory evaluation confirmed monoclonal protein presence, yet traditional diagnostic methods, including bone marrow biopsy and flow cytometry, yielded normal results. Utilizing <jats:sup>18<\/jats:sup>F-FDG PET\/CT, we identified multiple hypermetabolic vertebral lesions, which upon biopsy, confirmed the diagnosis of plasmacytoma. Our findings underscore the utility of PET\/CT as a reliable diagnostic tool for monoclonal gammopathy associated neuropathy, advocating for its consideration in cases with equivocal diagnosis. When the diagnosis is in doubt, biopsy of a lesion may facilitate early and accurate diagnosis, potentially influencing treatment strategies and patient outcomes.<\/jats:p>","DOI":"10.3389\/fnume.2024.1446780","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:03:50Z","timestamp":1723615430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Application of 18F-FDG PET\/CT in identifying plasmacytoma in monoclonal gammopathy associated peripheral neuropathy"],"prefix":"10.3389","volume":"4","author":[{"given":"Jiequn","family":"Weng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1136\/practneurol-2020-002837","article-title":"Paraproteinaemic neuropathy: MGUS and beyond","volume":"21","author":"Carroll","year":"2021","journal-title":"Pract Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"118055","DOI":"10.1016\/j.jns.2021.118055","article-title":"CIDP and hemopathies, an underestimated association","volume":"429","author":"Deschamps","year":"2021","journal-title":"J Neurol Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.mayocp.2017.02.003","article-title":"Monoclonal gammopathy-associated peripheral neuropathy: diagnosis and management","volume":"92","author":"Chaudhry","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s10072-016-2542-9","article-title":"An observational study assessing peripheral neuropathy related to multiple myeloma","volume":"37","author":"Leone","year":"2016","journal-title":"Neurol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/jns.12455","article-title":"European Academy of Neurology\/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force-second revision","volume":"26","author":"Van Den Bergh","year":"2021","journal-title":"J Peripher Nerv Syst"},{"key":"B6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12883-021-02118-7","article-title":"CIDP mimics: a case series","volume":"21","author":"Moshe-Lilie","year":"2021","journal-title":"BMC Neurol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"117335","DOI":"10.1016\/j.jns.2021.117335","article-title":"Polyneuropathy and monoclonal gammopathy of undetermined significance (MGUS); 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