{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:25:38Z","timestamp":1762496738405,"version":"build-2065373602"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nucl. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Brown tumours (BTs), also known as osteitis fibrosa cystica, are benign osteolytic lesions associated with hyperparathyroidism (HPT). BTs are cured by correcting the hypercalcaemia and HPT, which often requires surgical resection of the parathyroid adenoma.\n                      <jats:sup>1<\/jats:sup>\n                      \u2078F-fluorocholine (FCH) PET\/CT is becoming an effective tool for detecting parathyroid adenomas in cases of hyperparathyroidism. This study aims to evaluate the role of FCH PET\/CT in detecting brown tumours in patients with hyperparathyroidism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical cases<\/jats:title>\n                    <jats:p>Three cases are presented to demonstrate the effectiveness of FCH PET\/CT in detecting BTs in patients presenting with clinical and biochemical signs of HPT with suspicion of BTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature review<\/jats:title>\n                    <jats:p>A literature review aimed to summarize the bibliographic evidence on the use of this technique in this setting, which is relatively innovative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FCH PET\/CT appears to be a useful tool for detecting BTs, and further prospective studies are needed to confirm this.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnume.2025.1693642","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:22:46Z","timestamp":1762496566000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: 18F-Fluorocholine PET\/CT for detecting brown tumours in patients with hyperparathyroidism: a short case series and literature review"],"prefix":"10.3389","volume":"5","author":[{"given":"J.","family":"Zhang-Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Panagiotidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"Fraser","year":"2009","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0140-6736(17)31430-7","article-title":"Hyperparathyroidism","volume":"391","author":"Bilezikian","year":"2018","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1002\/jbmr.5650061419","article-title":"Characterization and evaluation of asymptomatic primary 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first presentation of primary hyperparathyroidism caused by ectopic parathyroid adenomas: report of two cases and review of literature","volume":"7","author":"Wang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B8","first-page":"209","article-title":"Brown tumors due to secondary hyperparathyroidism detected by 11C-choline PET\/CT","volume":"35","author":"Garc\u00eda","year":"2016","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1097\/RLU.0000000000002814","article-title":"18F-fluorocholine PET\/CT imaging of brown tumors in a patient with severe primary hyperparathyroidism","volume":"44","author":"Zhang-Yin","year":"2019","journal-title":"Clin Nucl Med"},{"key":"B10","first-page":"43","article-title":"The utility of 18F-fluorocholine PET\/CT in the imaging of parathyroid adenomas","volume":"73","author":"Mazurek","year":"2022","journal-title":"Endokrynol Pol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s12149-023-01832-1","article-title":"Brown tumors in nuclear medicine: a systematic review","volume":"37","author":"Jacquet-Francillon","year":"2023","journal-title":"Ann Nucl Med"}],"container-title":["Frontiers in Nuclear Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnume.2025.1693642\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:22:47Z","timestamp":1762496567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnume.2025.1693642\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":11,"alternative-id":["10.3389\/fnume.2025.1693642"],"URL":"https:\/\/doi.org\/10.3389\/fnume.2025.1693642","relation":{},"ISSN":["2673-8880"],"issn-type":[{"value":"2673-8880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]},"article-number":"1693642"}}