{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:08:35Z","timestamp":1773198515281,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nucl. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prostate specific membrane antigen (PSMA) is a type II transmembrane protein overexpressed in the neovasculature of some pancreatic ductal adenocarcinoma (PDAC). PET\/CT can detect this expression and has now become an essential tool in this context. However, this antigen can also be expressed by other neoplasms. While this may create diagnostic uncertainty, it could also open therapeutic opportunities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical case<\/jats:title>\n                    <jats:p>Here we describe a case in which a PET\/CT performed to restage a patient with prostate adenocarcinoma experiencing biochemical recurrence revealed the coexistence of a PDAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature review<\/jats:title>\n                    <jats:p>A literature review aimed to summarize the bibliographic evidence on the use of this technique in this setting, which is relatively uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prostate-specific membrane antigen can be overexpressed in PDACs. This finding may offer potential for theranostic applications<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnume.2026.1767321","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:43:49Z","timestamp":1773125029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidental detection of PDAC via 18F-PSMA PET\/CT in a patient with recurrent prostate cancer. A case report"],"prefix":"10.3389","volume":"6","author":[{"given":"Giordano","family":"Savelli","sequence":"first","affiliation":[{"name":"Nuclear Medicine \u201cAlessandra Bono\u201d, Fondazione Poliambulanza Istituto Ospedaliero","place":["Brescia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Bonacina","sequence":"additional","affiliation":[{"name":"Nuclear Medicine \u201cAlessandra Bono\u201d, Fondazione Poliambulanza Istituto Ospedaliero","place":["Brescia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Soffientini","sequence":"additional","affiliation":[{"name":"Nuclear Medicine \u201cAlessandra Bono\u201d, Fondazione Poliambulanza Istituto Ospedaliero","place":["Brescia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Archiati","sequence":"additional","affiliation":[{"name":"Radiology, Fondazione Poliambulanza Istituto Ospedaliero","place":["Brescia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Bn\u00e0","sequence":"additional","affiliation":[{"name":"Radiology, Fondazione Poliambulanza Istituto Ospedaliero","place":["Brescia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Zaniboni","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Poliambulanza Istituto Ospedaliero","place":["Brescia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s12032-014-0857-z","article-title":"Prostate-specific membrane antigen as a marker of pancreatic cancer cells","volume":"31","author":"Ren","year":"2014","journal-title":"Med Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2847303","DOI":"10.1155\/2017\/2847303","article-title":"Neovascular prostate-specific membrane antigen expression is associated with improved overall survival under palliative chemotherapy in patients with pancreatic ductal adenocarcinoma","volume":"2017","author":"Stock","year":"2017","journal-title":"Biomed Res Int"},{"key":"B3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/RLU.0000000000001423","article-title":"Serous cystadenoma of the pancreas showing uptake on 68Ga PSMA PET\/CT","volume":"42","author":"Chan","year":"2017","journal-title":"Clin Nucl Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1097\/RLU.0000000000001767","article-title":"Pancreatic ductal adenocarcinoma with high radiotracer uptake in 68Ga-prostate-specific membrane antigen PET\/CT","volume":"42","author":"Sahbai","year":"2017","journal-title":"Clin Nucl Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3390\/diagnostics11010129","article-title":"Incidental finding of a PSMA-positive pancreatic cancer in a patient suffering from a metastasized PSMA-positive prostate cancer","volume":"11","author":"Sirtl","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-025-00822-y","article-title":"18F-prostate-specific membrane antigen PET\/CT imaging for potentially resectable pancreatic cancer (PANSCAN-2): a phase I\/II study","volume":"25","author":"Puik","year":"2025","journal-title":"Cancer Imaging"},{"key":"B7","doi-asserted-by":"publisher","first-page":"826273","DOI":"10.1155\/2010\/826273","article-title":"Pancreatic metastasis from prostate cancer","volume":"2010","author":"Jacob","year":"2010","journal-title":"Case Rep Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"S693","DOI":"10.14309\/00000434-201710001-01274","article-title":"Pancreatic metastasis from prostate cancer: a rare occurrence","volume":"112","author":"Omer","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.3390\/cancers14153638","article-title":"The role of PSMA PET\/CT in the primary diagnosis and follow-up of prostate cancer - a practical clinical review","volume":"14","author":"Lisney","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/JU","article-title":"Detection rate of prostate specific membrane antigen tracers for positron emission tomography\/computerized tomography in prostate cancer biochemical recurrence: a systematic review and network meta-analysis","volume":"205","author":"Crocerossa","year":"2021","journal-title":"J Urol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.euo.2022.03","article-title":"[68ga]ga-PSMA versus [18F]PSMA positron emission tomography\/computed tomography in the staging of primary and recurrent prostate cancer. 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