{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:18:48Z","timestamp":1779333528448,"version":"3.51.4"},"reference-count":61,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"DOI":"10.3389\/fnut.2015.00032","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T21:19:59Z","timestamp":1445289599000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Interaction of Isoflavones and Endophyte-Infected Tall Fescue Seed Extract on Vasoactivity of Bovine Mesenteric Vasculature"],"prefix":"10.3389","volume":"2","author":[{"given":"Yang","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Harmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Flythe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1128\/AEM.34.5.576-581.1977","article-title":"Epichlo\u00eb typhina from toxic tall fescue grasses","volume":"34","author":"Bacon","year":"1977","journal-title":"Appl Environ Microbiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1021\/jf60223a045","article-title":"Ergosine, ergosinine, and chanoclavine I from Epichlo\u00eb typhina","volume":"27","author":"Porter","year":"1979","journal-title":"J Agric Food Chem"},{"key":"B3","doi-asserted-by":"publisher","first-page":"941","DOI":"10.2135\/cropsci1982.0011183X002200050010x","article-title":"Association of N-acetyl loline and N-formyl loline with Epichlo\u00eb-typhina in tall fescue","volume":"22","author":"Bush","year":"1982","journal-title":"Crop Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3852\/13-251","article-title":"Nomenclatural realignment of Neotyphodium species with genus Epichlo\u00eb","volume":"106","author":"Leuchtmann","year":"2014","journal-title":"Mycologia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1126\/science.3008328","article-title":"Occurrence of peptide and clavine ergot alkaloids in tall fescue grass","volume":"232","author":"Lyons","year":"1986","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1021\/jf00080a023","article-title":"Analysis of ergopeptine alkaloids in endophyte-infected tall fescue","volume":"36","author":"Yates","year":"1988","journal-title":"J Agric Food Chem"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1094\/FG-2009-1104-01-RS","article-title":"Ergot alkaloid induced blood vessel dysfunction contributes to fescue toxicosis","volume":"7","author":"Strickland","year":"2009","journal-title":"Forage Grazinglands"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.2527\/jas.2010-3478","article-title":"Board-invited review: St. Anthony\u2019s Fire in livestock: causes, mechanisms, and potential solutions","volume":"89","author":"Strickland","year":"2011","journal-title":"J Anim Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.2527\/jas.2006-821","article-title":"Hemodynamic responses of the caudal artery to toxic tall fescue in beef heifers","volume":"85","author":"Aiken","year":"2007","journal-title":"J Anim Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.2527\/jas.2008-1562","article-title":"Hemodynamics are altered in the caudal artery of beef heifers fed different ergot alkaloid concentrations","volume":"87","author":"Aiken","year":"2009","journal-title":"J Anim Sci"},{"key":"B11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2460\/ajvr.1989.50.02.235","article-title":"Reactivity of dorsal pedal vein of cattle to selected alkaloids associated with Acremonium coenophialum-infected fescue grass","volume":"50","author":"Solomons","year":"1989","journal-title":"Am J Vet Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.2527\/jas.2006-038","article-title":"Assessment of vasoconstrictive potential of d-lysergic acid using an isolated bovine lateral saphenous vein bioassay","volume":"84","author":"Klotz","year":"2006","journal-title":"J Anim Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.2527\/jas.2010-3626","article-title":"Effect of ergot alkaloids on contractility of bovine right ruminal artery and vein","volume":"89","author":"Foote","year":"2011","journal-title":"J Anim Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"L223","DOI":"10.1016\/0024-3205(93)90555-H","article-title":"Evidence that ergovaline acts on serotonin receptors","volume":"53","author":"Dyer","year":"1993","journal-title":"Life Sci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.2527\/jas.2013-7141","article-title":"Dietary exposure to ergot alkaloids decreases contractility of bovine mesenteric vasculature","volume":"92","author":"Egert","year":"2014","journal-title":"J Anim Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"682","DOI":"10.2527\/jas.2011-4323","article-title":"Alterations in serotonin receptor-induced contractility of bovine lateral saphenous vein in cattle grazing endophyte-infected tall fescue","volume":"90","author":"Klotz","year":"2012","journal-title":"J Anim Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4492","DOI":"10.2527\/jas.2012-5896","article-title":"Antagonism of lateral saphenous vein serotonin receptors from steers grazing endophyte-free, wild-type, or novel endophyte-infected tall fescue","volume":"91","author":"Klotz","year":"2013","journal-title":"J Anim Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/02652038509373531","article-title":"Naturally occurring oestrogens in foods\u2009\u2013\u2009a review","volume":"2","author":"Price","year":"1985","journal-title":"Food Addit Contam"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1021\/Jf00045a015","article-title":"Quantitation of phytoestrogens in legumes by HPLC","volume":"42","author":"Franke","year":"1994","journal-title":"J Agric Food Chem"},{"key":"B20","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1097\/00017285-199711000-00003","article-title":"Phytoestrogens and human function","volume":"32","author":"Anderson","year":"1997","journal-title":"Nutr Today"},{"key":"B21","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev.nutr.17.1.353","article-title":"Dietary phytoestrogens","volume":"17","author":"Kurzer","year":"1997","journal-title":"Annu Rev Nutr"},{"key":"B22","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.arplant.55.031903.141729","article-title":"Phytoestrogens","volume":"55","author":"Dixon","year":"2004","journal-title":"Annu Rev Plant Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.jsbmb.2004.12.038","article-title":"Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?","volume":"94","author":"Beck","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1161\/01.CIR.103.2.258","article-title":"The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol","volume":"103","author":"Walker","year":"2001","journal-title":"Circulation"},{"key":"B25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2004.03.025","article-title":"The isoflavone metabolite dehydroequol produces vasodilatation in human resistance arteries via a nitric oxide-dependent mechanism","volume":"176","author":"Chin-Dusting","year":"2004","journal-title":"Atherosclerosis"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/00004872-199715110-00015","article-title":"Renal and vascular actions of equol in the rat","volume":"15","author":"Gimenez","year":"1997","journal-title":"J Hypertens"},{"key":"B27","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/sj.bjp.0704088","article-title":"The vascular activity of some isoflavone metabolites: implications for a cardioprotective role","volume":"133","author":"Chin-Dusting","year":"2001","journal-title":"Br J Pharmacol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.brainres.2007.01.007","article-title":"Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries","volume":"1141","author":"Jackman","year":"2007","journal-title":"Brain Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jnutbio.2009.03.010","article-title":"Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways","volume":"21","author":"Wu","year":"2010","journal-title":"J Nutr Biochem"},{"key":"B30","first-page":"3","article-title":"Ergot compounds: a synopsis","volume":"23","author":"Berde","year":"1980","journal-title":"Adv Biochem Psychopharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"L95","DOI":"10.1016\/S0024-3205(98)00300-2","article-title":"Plant derived estrogens relax rat mesenteric artery in vitro","volume":"63","author":"Nevala","year":"1998","journal-title":"Life Sci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e52020","DOI":"10.3791\/52020","article-title":"Isolating and using sections of bovine mesenteric artery and vein as a bioassay to test for vasoactivity in the small intestine","volume":"92","author":"Klotz","year":"2014","journal-title":"J Vis Exp"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.2527\/jas.2011-4513","article-title":"Constriction of bovine vasculature caused by endophyte-infected tall fescue seed extract is similar to pure ergovaline","volume":"90","author":"Foote","year":"2012","journal-title":"J Anim Sci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fchem.2015.00008","article-title":"Cases of ergotism in livestock and associated ergot alkaloid concentrations in feed","volume":"3","author":"Craig","year":"2015","journal-title":"Front Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1476-5381.1991.tb12545.x","article-title":"Endothelium-independent relaxation of rabbit coronary artery by 17\u03b2-oestradiol in vitro","volume":"104","author":"Jiang","year":"1991","journal-title":"Br J Pharmacol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1124\/jpet.108.138529","article-title":"Isoflavone attenuates vascular contraction through inhibition of the RhoA\/Rho-kinase signaling pathway","volume":"326","author":"Seok","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/aps.2011.51","article-title":"Vasorelaxant and antihypertensive effects of formononetin through endothelium-dependent and -independent mechanisms","volume":"32","author":"Sun","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"B38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1080\/10286020.2011.628939","article-title":"Vasorelaxant effect of formononetin in the rat thoracic aorta and its mechanisms","volume":"14","author":"Zhao","year":"2012","journal-title":"J Asian Nat Prod Res"},{"key":"B39","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nm0496-381","article-title":"Tamoxifen: teaching an old drug new tricks?","volume":"2","author":"Grainger","year":"1996","journal-title":"Nat Med"},{"key":"B40","first-page":"87","article-title":"Estradiol inhibits mitogen-induced proliferation and migration of human aortic smooth-muscle cells-implications for cardiovascular-disease in women","volume-title":"Circulation","author":"Rosselli","year":"1994"},{"key":"B41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/01.HYP.33.1.177","article-title":"Phytoestrogens inhibit growth and MAP kinase activity in human aortic smooth muscle cells","volume":"33","author":"Dubey","year":"1999","journal-title":"Hypertension"},{"key":"B42","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2460\/ajvr.1975.36.09.1353","article-title":"Induction of fescue foot syndrome in cattle by fractionated extracts of toxic fescue hay","volume":"36","author":"Williams","year":"1975","journal-title":"Am J Vet Res"},{"key":"B43","first-page":"45","article-title":"Fescue foot in cattle","volume-title":"Mycotoxic Fungi, Mycotoxins, Mycotoxicoses: An Encyclopedic Handbook","author":"Garner","year":"1978"},{"key":"B44","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.2527\/1996.7471664x","article-title":"Assessment of the mitogenic potential of the alkaloids produced by endophyte (Acremonium coenophialum)-infected tall fescue (Festuca arundinacea) on bovine vascular smooth muscle in vitro","volume":"74","author":"Strickland","year":"1996","journal-title":"J Anim Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.2527\/jas.2006-803","article-title":"Ergovaline-induced vasoconstriction in an isolated bovine lateral saphenous vein bioassay","volume":"85","author":"Klotz","year":"2007","journal-title":"J Anim Sci"},{"key":"B46","first-page":"25","article-title":"The molecular architecture of ergopeptines: a basis for biological interaction","volume":"23","author":"Weber","year":"1980","journal-title":"Adv Biochem Psychopharmacol"},{"key":"B47","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.2527\/1994.72112905x","article-title":"D2 dopamine receptor response to endophyte-infected tall fescue and an antagonist in the rat","volume":"72","author":"Larson","year":"1994","journal-title":"J Anim Sci"},{"key":"B48","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2527\/1995.7351396x","article-title":"Ergovaline binding and activation of D2 dopamine receptors in GH4ZR7 cells","volume":"73","author":"Larson","year":"1995","journal-title":"J Anim Sci"},{"key":"B49","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.2527\/1993.71102708x","article-title":"Vasoconstriction in bovine vasculature induced by the tall fescue alkaloid lysergamide","volume":"71","author":"Oliver","year":"1993","journal-title":"J Anim Sci"},{"key":"B50","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.2527\/2001.7982202x","article-title":"Complex interaction of ergovaline with 5-HT2A, 5-HT1B\/1D, and alpha1 receptors in isolated arteries of rat and guinea pig","volume":"79","author":"Schoning","year":"2001","journal-title":"J Anim Sci"},{"key":"B51","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.2527\/1998.76112853x","article-title":"Endophytic fungal toxin effect on adrenergic receptors in lateral saphenous veins (cranial branch) of cattle grazing tall fescue","volume":"76","author":"Oliver","year":"1998","journal-title":"J Anim Sci"},{"key":"B52","first-page":"411","article-title":"Ergot alkaloids and their derivatives as ligands for serotoninergic, dopaminergic, and adrenergic receptors","volume-title":"Ergot: The Genus Claviceps","author":"Pertz","year":"1999"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.2527\/jas.2013-7142","article-title":"Bovine lateral saphenous veins exposed to ergopeptine alkaloids do not relax","volume":"92","author":"Pesqueira","year":"2014","journal-title":"J Anim Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.2527\/jas.2008-1692","article-title":"Bioaccumulation of ergovaline in bovine lateral saphenous veins in vitro","volume":"87","author":"Klotz","year":"2009","journal-title":"J Anim Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1046\/j.1468-2982.1981.0104223.x","article-title":"Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery","volume":"1","author":"Ostergaard","year":"1981","journal-title":"Cephalalgia"},{"key":"B56","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1161\/01.CIR.98.1.25","article-title":"Coronary side-effect potential of current and prospective antimigraine drugs","volume":"98","author":"Vandenbrink","year":"1998","journal-title":"Circulation"},{"key":"B57","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1124\/jpet.113.207670","article-title":"Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration","volume":"347","author":"Unett","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"B58","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ejphar.2012.10.031","article-title":"Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT2A\/1B receptors and alpha1-adrenoceptors in spontaneously rat arteries","volume":"699","author":"Sun","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"B59","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2527\/jas1988.6681969x","article-title":"In vitro metabolism of formononetin and biochanin A in bovine rumen fluid","volume":"66","author":"Dickinson","year":"1988","journal-title":"J Anim Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1071\/Ar9740509","article-title":"Urinary sediments in sheep feeding on estrogenic clover. 3. Identification of 4\u2019-O-methyl-equol as a major component of some sediments","volume":"25","author":"Nottle","year":"1974","journal-title":"Aust J Agric Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"7735","DOI":"10.3168\/jds.2014-8208","article-title":"Gastrointestinal metabolism of phytoestrogens in lactating dairy cows fed silages with different botanical composition","volume":"97","author":"Njastad","year":"2014","journal-title":"J Dairy Sci"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T02:24:42Z","timestamp":1748658282000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fnut.2015.00032\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":61,"URL":"https:\/\/doi.org\/10.3389\/fnut.2015.00032","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}