{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:28:02Z","timestamp":1778671682731,"version":"3.51.4"},"reference-count":40,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"DOI":"10.3389\/fnut.2017.00009","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T03:32:55Z","timestamp":1492486375000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessing Volumetric Absorptive Microsampling Coupled with Stable Isotope Dilution Assay and Liquid Chromatography\u2013Tandem Mass Spectrometry as Potential Diagnostic Tool for Whole Blood 5-Methyltetrahydrofolic Acid"],"prefix":"10.3389","volume":"4","author":[{"given":"Markus","family":"Kopp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rychlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.3945\/jn.109.113670","article-title":"One-carbon metabolism\u2013genome interactions in folate-associated pathologies12","volume":"139","author":"Stover","year":"2009","journal-title":"J Nutr"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1151S","DOI":"10.1093\/ajcn\/76.5.1151S","article-title":"S-Adenosyl-l-methionine (SAMe): from the bench to the bedside \u2013 molecular basis of a pleiotrophic molecule","volume":"76","author":"Bottiglieri","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/nrn1986","article-title":"Neural tube defects and folate: case far from closed","volume":"7","author":"Blom","year":"2006","journal-title":"Nature rev Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.reprotox.2015.07.073","article-title":"Preventable neural tube defects in Germany","volume":"56","author":"Obeid","year":"2015","journal-title":"Reprod Toxicol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/71.4.993","article-title":"Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study","volume":"71","author":"Snowdon","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00702-012-0822-y","article-title":"Folate and Alzheimer: when time matters","volume":"120","author":"Hinterberger","year":"2013","journal-title":"J Neural Transm"},{"key":"B7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jn\/130.2.129","article-title":"Folate and carcinogenesis: an integrated scheme","volume":"130","author":"Choi","year":"2000","journal-title":"J Nutr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2621.2004.tb17887.x","article-title":"The role of folate in reducing chronic and developmental disease risk: an overview","volume":"69","author":"Caudill","year":"2004","journal-title":"J Food Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1373\/clinchem.2007.096545","article-title":"Influence of 5,10-methylenetetrahydrofolate reductase polymorphism on whole-blood folate concentrations measured by LC-MS\/MS, microbiologic assay, and bio-rad radioassay","volume":"54","author":"Fazili","year":"2008","journal-title":"Clin Chem"},{"key":"B11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00216-012-6180-7","article-title":"Assay of whole blood (6S)-5-CH3-H4folate using ultra performance liquid chromatography tandem mass spectrometry","volume":"404","author":"Kirsch","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"B12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1079\/BJN2001338","article-title":"A critical evaluation of the application of biomarkers in epidemiological studies on diet and health","volume":"86","author":"Wild","year":"2001","journal-title":"Br J Nutr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/jcp.56.12.924","article-title":"Red cell or serum folate? Results from the national pathology alliance benchmarking review","volume":"56","author":"Galloway","year":"2003","journal-title":"J Clin Pathol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3945\/ajcn.111.013367","article-title":"Folate status assessment history: implications for measurement of biomarkers in NHANES","volume":"94","author":"Shane","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ab.2009.11.007","article-title":"Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays","volume":"398","author":"M\u00f6nch","year":"2010","journal-title":"Anal Biochem"},{"key":"B16","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1093\/ajcn\/66.6.1398","article-title":"Field-study screening of blood folate concentrations: specimen stability and finger-stick sampling","volume":"66","author":"O\u2019Broin","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"B17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/ajcn\/70.3.359","article-title":"Screening of folate status with use of dried blood spots on filter paper","volume":"70","author":"O\u2019Broin","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0143639","article-title":"Quantitation of 5-methyltetrahydrofolic acid in dried blood spots and dried plasma spots by stable isotope dilution assays","volume":"10","author":"Kopp","year":"2015","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1079\/BJN20041211","article-title":"Plasma folate as marker of folate status in epidemiological studies: the European Investigation into Cancer and Nutrition (EPIC)-Potsdam study","volume":"92","author":"Drogan","year":"2004","journal-title":"Br J Nutr"},{"key":"B20","volume-title":"Guideline: Optimal Serum and Red Blood Cell Folate Concentrations in Women of Reproductive Age for Prevention of Neural Tube Defects","author":"WHO","year":"2015"},{"key":"B21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1542\/peds.32.3.338","article-title":"A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants","volume":"32","author":"Guthrie","year":"1963","journal-title":"Pediatrics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"653","DOI":"10.4155\/bio.14.310","article-title":"A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit","volume":"7","author":"Spooner","year":"2015","journal-title":"Bioanalysis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/201918","article-title":"Potential of dried blood self-sampling for cyclosporine c(2) monitoring in transplant outpatients","volume":"2010","author":"Leichtle","year":"2010","journal-title":"J Transplant"},{"key":"B24","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/clinchem\/39.6.1354","article-title":"Influence of hematocrit on quantitative analysis of \u201cblood spots\u201d on filter paper","volume":"39","author":"O\u2019Broin","year":"1993","journal-title":"Clin Chem"},{"key":"B25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/clinchem\/46.1.126","article-title":"Recoveries of phenylalanine from two sets of dried-blood-spot reference materials: prediction from hematocrit, spot volume, and paper matrix","volume":"46","author":"Adam","year":"2000","journal-title":"Clin Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cca.2006.04.013","article-title":"Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry","volume":"373","author":"Holub","year":"2006","journal-title":"Clin Chim Acta"},{"key":"B27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/bmc.1367","article-title":"Dried blood spot sampling in combination with LC-MS\/MS for quantitative analysis of small molecules","volume":"24","author":"Li","year":"2010","journal-title":"Biomed Chromatogr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jchromb.2012.05.040","article-title":"Distribution of 25-hydroxyvitamin D3 in dried blood spots and implications for its quantitation by tandem mass spectrometry","volume":"901","author":"Kvaskoff","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"B29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/jn\/132.2.318","article-title":"Rapid and simple measurement of retinol in human dried whole blood spots","volume":"132","author":"Erhardt","year":"2002","journal-title":"J Nutr"},{"key":"B30","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s007690050234","article-title":"Limits of detection, identification and determination: a statistical approach for practitioners","volume":"3","author":"Vogelgesang","year":"1998","journal-title":"Accredit Qual Assur"},{"key":"B31","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/ejcn.2014.45","article-title":"Revised D-A-CH intake recommendations for folate: how much is needed?","volume":"68","author":"Krawinkel","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"B32","first-page":"718","article-title":"Chapter 151: hemoglobin and hematocrit","volume-title":"Clinical Methods: The History, Physical, and Laboratory Examinations","author":"Billett","year":"1990","edition":"3rd ed"},{"key":"B33","doi-asserted-by":"publisher","first-page":"8489","DOI":"10.1021\/ac5022562","article-title":"Volumetric absorptive microsampling: a dried sample collection technique for quantitative bioanalysis","volume":"86","author":"Denniff","year":"2014","journal-title":"Anal Chem"},{"key":"B34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.aca.2015.04.056","article-title":"Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study","volume":"881","author":"De Kesel","year":"2015","journal-title":"Anal Chim Acta"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.4155\/bio.15.111","article-title":"Hematocrit-independent recovery is a key for bioanalysis using volumetric absorptive microsampling devices, Mitra","volume":"7","author":"Mano","year":"2015","journal-title":"Bioanalysis"},{"key":"B36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev.nutr.21.1.255","article-title":"New perspectives on folate catabolism","volume":"21","author":"Suh","year":"2001","journal-title":"Annu Rev Nutr"},{"key":"B37","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/clinchem\/48.7.1128","article-title":"Dried-serum spot assay for folate","volume":"48","author":"O\u2019Broin","year":"2002","journal-title":"Clin Chem"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1515\/cclm-2013-0228","article-title":"Current and future use of \u201cdried blood spot\u201d analyses in clinical chemistry","volume":"51","author":"Lehmann","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1007\/s13361-015-1152-8","article-title":"Native liquid extraction surface analysis mass spectrometry: analysis of noncovalent protein complexes directly from dried substrates","volume":"26","author":"Martin","year":"2015","journal-title":"J Am Soc Mass Spectrom"},{"key":"B40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4137\/117739010700200010","article-title":"A practical approach to red blood cell folate analysis","volume":"2","author":"Piyathilake","year":"2007","journal-title":"Anal Chem Insights"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnut.2017.00009\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T15:21:22Z","timestamp":1658935282000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnut.2017.00009\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":40,"URL":"https:\/\/doi.org\/10.3389\/fnut.2017.00009","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]}}}