{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:34:09Z","timestamp":1791578049536,"version":"4.3.4"},"reference-count":173,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"DOI":"10.3389\/fnut.2020.00029","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T05:24:03Z","timestamp":1584422643000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity"],"prefix":"10.3389","volume":"7","author":[{"given":"Katharina A.","family":"Scherf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Catassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Chirdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Ciclitira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conleth","family":"Feighery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gianfrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. A.","family":"Lundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Schuppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus J. M.","family":"Smulders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tranquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Troncone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"B2","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm0698-713","article-title":"Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease","volume":"4","author":"Molberg","year":"1998","journal-title":"Nat Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1073\/pnas.95.17.10050","article-title":"Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin","volume":"95","author":"Van de Wal","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1056\/NEJMe030050","article-title":"Celiac disease \u2013 how to handle a clinical chameleon","volume":"348","author":"Fasano","year":"2003","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1001\/archinte.163.3.286","article-title":"Prevalence of celiac cisease in at-risk and not-at-risk groups in the United States: A large multicenter study","volume":"163","author":"Fasano","year":"2003","journal-title":"Arch Intern. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.autrev.2018.05.013","article-title":"Celiac disease and endocrine autoimmunity \u2013 the genetic link","volume":"17","author":"Kahaly","year":"2018","journal-title":"Autoimmun Rev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/MOG.0000000000000041","article-title":"Advances in coeliac disease","volume":"30","author":"Lundin","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1053\/j.gastro.2009.09.008","article-title":"Celiac disease: from pathogenesis to novel therapies","volume":"137","author":"Schuppan","year":"2009","journal-title":"Gastroenterology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/00365520310007783","article-title":"Effect of an oats-containing gluten-free diet on symptoms and quality of life in coeliac disease","volume":"39","author":"Per\u00e4aho","year":"2004","journal-title":"A randomized study Scand J Gastroenterol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1136\/bmj.313.7068.1300","article-title":"Absence of oats toxicity in adult coeliac disease","volume":"313","author":"Srinivasan","year":"1996","journal-title":"BMJ"},{"key":"B12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1365-2249.2006.03052.x","article-title":"Immunohistochemical analysis of coeliac mucosa following ingestion of oats","volume":"144","author":"Srinivasan","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/ajcn\/85.1.160","article-title":"A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease","volume":"85","author":"Catassi","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3945\/ajcn.112.040485","article-title":"Immunogenicity of monococcum wheat in celiac patients","volume":"96","author":"Gianfrani","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1002\/mnfr.201500126","article-title":"Extensive in vitro gastrointestinal digestion markedly reduces the immune-toxicity of Triticum monococcum wheat: implication for celiac disease","volume":"59","author":"Gianfrani","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e89068","DOI":"10.1371\/journal.pone.0089068","article-title":"Role of CXCR3\/CXCL10 axis in immune cell recruitment into the small intestine in celiac disease","volume":"9","author":"Bondar","year":"2014","journal-title":"PLoS ONE."},{"key":"B17","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/00042737-200505000-00010","article-title":"Development of a general procedure for complete extraction of gliadins for heat processed and unheated foods","volume":"17","author":"Garc\u00eda","year":"2005","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1094\/CFW-59-4-0605","article-title":"AACCI approved methods technical committee report: collaborative study on the immunochemical quantitation of intact gluten in rice flour and rice-based products using G12 sandwich ELISA","volume":"59","author":"Don","year":"2014","journal-title":"Cereal Foods World"},{"key":"B19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1094\/CFW-58-1-0036","article-title":"AACCI approved methods technical committee report: collaborative study on the immunochemical determination of intact gluten using an R5 sandwich ELISA","volume":"58","author":"Koehler","year":"2013","journal-title":"Cereal Foods World"},{"key":"B20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1094\/CFW-58-3-0402","article-title":"AACCI approved methods technical committee report: collaborative study on the immunochemical determination of partially hydrolyzed gluten using an R5 competitive ELISA","volume":"58","author":"Koehler","year":"2013","journal-title":"Cereal Foods World"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.5740\/jaoacint.19-0094","article-title":"Quantification of wheat, rye, and barley gluten in oat and oats products by ELISA RIDASCREEN\u00ae Total Gluten: Collaborative study, First Action 2018.15","volume":"102","author":"Lacorn","year":"2019","journal-title":"J. AOAC Int"},{"key":"B22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jcs.2005.12.009","article-title":"Towards a new gliadin reference material - isolation and characterisation","volume":"43","author":"Van Eckert","year":"2006","journal-title":"J Cereal Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","article-title":"Integration of genetic and immunological insights into a model of celiac disease pathogenesis","volume":"29","author":"Abadie","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gtc.2018.09.004","article-title":"Epidemiology of celiac disease","volume":"48","author":"Ludvigsson","year":"2019","journal-title":"Gastroenterol Clin North Am"},{"key":"B25","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cgh.2019.06.013","article-title":"Increased prevalence of celiac disease in school-age children in Italy","volume":"18","author":"Gatti","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e687","DOI":"10.1542\/peds.2012-1015","article-title":"Prevalence of childhood celiac disease and changes in infant feeding","volume":"131","author":"Ivarsson","year":"2013","journal-title":"Pediatrics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/ajg.2015.39","article-title":"Prevalence of adult celiac disease in India: regional variations and associations","volume":"111","author":"Ramakrishna","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jpeds.2016.12.077","article-title":"At-risk screened children with celiac disease are comparable in disease severity and dietary adherence to those found because of clinical suspicion: a large cohort study","volume":"183","author":"Kivel\u00e4","year":"2017","journal-title":"J Peds"},{"key":"B30","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/MPG.0b013e3182a45676","article-title":"Case finding for celiac disease is ok, but is it enough?","volume":"57","author":"Catassi","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/apt.14625","article-title":"Natural history and clinical detection of undiagnosed coeliac disease in a North American community","volume":"47","author":"Hujoel","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1053\/j.gastro.2009.03.059","article-title":"Increased prevalence and mortality in undiagnosed celiac disease","volume":"137","author":"Rubio-Tapia","year":"2009","journal-title":"Gastroenterology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3109\/07853890.2010.514285","article-title":"Natural history of celiac disease autoimmunity in a USA cohort followed since 1974","volume":"42","author":"Catassi","year":"2010","journal-title":"Ann Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/MEG.0000000000000992","article-title":"Prevalence, incidence, and autoimmune comorbidities of celiac disease: a nation-wide, population-based study in Denmark from 1977 to 2016","volume":"30","author":"Grode","year":"2018","journal-title":"Eur J Gastroeneterol Hepatol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1056\/NEJMoa1400697","article-title":"Introduction of gluten, HLA status, and the risk of celiac disease in children","volume":"371","author":"Lionetti","year":"2014","journal-title":"N Engl J Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1056\/NEJMoa1404172","article-title":"Randomized feeding intervention in infants at high risk for celiac disease","volume":"371","author":"Vriezinga","year":"2014","journal-title":"N Engl J Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1542\/peds.2014-1787","article-title":"Age at gluten introduction and risk of celiac disease","volume":"135","author":"Aronsson","year":"2015","journal-title":"Pediatrics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1202","DOI":"10.1542\/peds.2013-1752","article-title":"Early feeding and risk of celiac disease in a prospective birth cohort","volume":"132","author":"St\u00f8rdal","year":"2013","journal-title":"Pediatrics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1001\/jama.2019.10329","article-title":"Association of gluten intake duuring the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk","volume":"322","author":"Aronsson","year":"2019","journal-title":"JAMA."},{"key":"B40","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3945\/ajcn.116.144352","article-title":"The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study","volume":"105","author":"Crespo-Escobar","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"B41","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1001\/jama.2019.9678","article-title":"Gluten and celiac disease risk: Is it just a matter of quantity?","volume":"322","author":"Leonard","year":"2019","journal-title":"JAMA"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.14309\/ajg.0000000000000331","article-title":"Gluten intake in early childhood and risk of celiac disease in childhood: a nationwide cohort study","volume":"114","author":"Lund-Blix","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2147\/CLEP.S152168","article-title":"Mode of delivery is not associated with celiac disease","volume":"10","author":"Dydensborg Sander","year":"2018","journal-title":"Clin Epidemiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1053\/j.gastro.2019.02.039","article-title":"Association between antibiotics in the first year of life and celiac disease","volume":"156","author":"Dydensborg Sander","year":"2019","journal-title":"Gastroenterology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1136\/archdischild-2019-317174","article-title":"Association between early life (prenatal and postnatal) antibiotic administration and coeliac disease: a systematic review","volume":"104","author":"Ko\u0142odziej","year":"2019","journal-title":"Arch Dis Child"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1001\/jamapediatrics.2017.2905","article-title":"Association between early-life antibiotic use and the risk of islet or celiac disease autoimmunity","volume":"171","author":"Kemppainen","year":"2017","journal-title":"JAMA Pediatr"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1111\/j.1572-0241.2006.00741.x","article-title":"Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study","volume":"101","author":"Stene","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.cgh.2016.10.033","article-title":"Factors that increase risk of celiac disease autoimmunity after a gastrointestinal infection in early life","volume":"15","author":"Kemppainen","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.chom.2018.10.004","article-title":"Murine norovirus infection induces TH1 inflammatory responses to dietary antigens","volume":"24","author":"Bouziat","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B50","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.aah5298","article-title":"Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease","volume":"356","author":"Bouziat","year":"2017","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","first-page":"l231","DOI":"10.1136\/bmj.l231","article-title":"Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort","volume":"364","author":"Kahrs","year":"2019","journal-title":"BMJ"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e20164102","DOI":"10.1542\/peds.2016-4102","article-title":"Respiratory infections and the risk of celiac disease","volume":"140","author":"Auricchio","year":"2017","journal-title":"Pediatrics"},{"key":"B53","doi-asserted-by":"publisher","first-page":"654143","DOI":"10.1155\/2012\/654143","article-title":"Immune development and intestinal microbiota in celiac disease","volume":"2012","author":"Pozo-Rubio","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5472","DOI":"10.1128\/AEM.00869-13","article-title":"Duodenal-mucosal bacteria associated with celiac disease in children","volume":"79","author":"S\u00e1nchez","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40168-018-0415-6","article-title":"Gut microbiota trajectory in early life may predict development of celiac disease","volume":"6","author":"Olivares","year":"2018","journal-title":"Microbiome"},{"key":"B56","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1080\/00365521.2018.1444788","article-title":"Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity","volume":"53","author":"Rintala","year":"2018","journal-title":"Scand J Gastroenterol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1053\/j.gastro.2016.06.041","article-title":"Duodenal bacteria from patients with celiac disease and healthy subjects distinctly affect gluten breakdown and immunogenicity","volume":"151","author":"Caminero","year":"2016","journal-title":"Gastroenterology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/s41467-019-09037-9","article-title":"Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2","volume":"10","author":"Caminero","year":"2019","journal-title":"Nat Commun"},{"key":"B59","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1053\/j.gastro.2008.11.040","article-title":"Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study","volume":"136","author":"Kurppa","year":"2009","journal-title":"Gastroenterology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1056\/NEJMoa021687","article-title":"Prevalence of celiac disease among children in Finland","volume":"348","author":"M\u00e4ki","year":"2003","journal-title":"N Engl J Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3109\/00365521.2014.974204","article-title":"Celiac disease evolving into dermatitis herpetiformis in patients adhering to normal or gluten-free diet","volume":"50","author":"Salmi","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1053\/j.gastro.2019.04.004","article-title":"Progression of celiac disease in children with antibodies against tissue transglutaminase and normal duodenal architecture","volume":"157","author":"Auricchio","year":"2019","journal-title":"Gastroenterology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1084\/jem.169.1.345","article-title":"Evidence for a primary association of celiac disease to a particular HLA-DQ alpha\/beta heterodimer","volume":"169","author":"Sollid","year":"1989","journal-title":"J Exp Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1084\/jem.178.1.187","article-title":"Gliadin-specific, HLA-DQ(alpha 1*0501, beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients","volume":"178","author":"Lundin","year":"1993","journal-title":"J Exp Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0198-8859(94)90047-7","article-title":"T cells from the small intestinal mucosa of a DR4, DQ7\/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8","volume":"41","author":"Lundin","year":"1994","journal-title":"Hum Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1053\/j.gastro.2011.11.021","article-title":"T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease","volume":"142","author":"Bodd","year":"2012","journal-title":"Gastroenterology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"12390","DOI":"10.1073\/pnas.2135229100","article-title":"The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses","volume":"100","author":"Vader","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"B68","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jaut.2016.03.016","article-title":"HLA-DQ2.5 genes associated with celiac disease risk are preferentially expressed with respect to non-predisposing HLA genes: Implication for anti-gluten T cell response","volume":"70","author":"Pisapia","year":"2016","journal-title":"J Autoimmun"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2017.12.016","article-title":"Expression level of risk genes of MHC class II is a susceptibility factor for autoimmunity: new insights","volume":"89","author":"Gianfrani","year":"2018","journal-title":"J Autoimmun"},{"key":"B70","doi-asserted-by":"publisher","first-page":"E751","DOI":"10.3390\/cells8070751","article-title":"HLA-DQA1 and HLA-DQB1 alleles, conferring susceptibility to celiac disease and type 1 diabetes, are more expressed than non-predisposing alleles and are coordinately regulated","volume":"8","author":"Farina","year":"2019","journal-title":"Cells"},{"key":"B71","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1053\/gast.2002.35381","article-title":"Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues","volume":"123","author":"Arentz-Hansen","year":"2002","journal-title":"Gastroenterology"},{"key":"B72","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"Van de Wal","year":"1998","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nsmb.2817","article-title":"T-cell receptor recognition of HLA-DQ2\u2013gliadin complexes associated with celiac disease","volume":"21","author":"Petersen","year":"2014","journal-title":"Nat Struct Mol Biol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.str.2016.07.010","article-title":"Diverse T cell receptor gene usage in HLA-DQ8-associated celiac disease converges into a consensus binding solution","volume":"24","author":"Petersen","year":"2016","journal-title":"Structure"},{"key":"B75","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00251-012-0599-z","article-title":"Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules","volume":"64","author":"Sollid","year":"2012","journal-title":"Immunogenetics"},{"key":"B76","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.4049\/jimmunol.167.9.4861","article-title":"Staining of celiac disease-relevant T cells by peptide-DQ2 multimers","volume":"167","author":"Quarsten","year":"2001","journal-title":"J Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/73200","article-title":"In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope","volume":"6","author":"Anderson","year":"2000","journal-title":"Nat Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1136\/gut.2004.059998","article-title":"T cells in peripheral blood after gluten challenge in coeliac disease","volume":"54","author":"Anderson","year":"2005","journal-title":"Gut"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1073\/pnas.0608610104","article-title":"Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients","volume":"104","author":"Raki","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/ajg.2011.23","article-title":"Assessing possible celiac disease by an HLA-DQ2-gliadin tetramer test","volume":"106","author":"Brottveit","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1053\/j.gastro.2017.11.006","article-title":"HLA-DQ-Gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption","volume":"154","author":"Sarna","year":"2018","journal-title":"Gastroenterology"},{"key":"B82","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1177\/2050640614540154","article-title":"Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge","volume":"2","author":"Christophersen","year":"","journal-title":"U Eur Gastroenterol J. ("},{"key":"B83","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1136\/gutjnl-2017-314461","article-title":"HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge","volume":"67","author":"Sarna","year":"2018","journal-title":"Gut"},{"key":"B84","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41591-019-0403-9","article-title":"Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions","volume":"25","author":"Christophersen","year":"2019","journal-title":"Nat Med"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1177\/2050640619874183","article-title":"CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease","volume":"7","author":"Z\u00fchlke","year":"2019","journal-title":"U Eur Gastroent J"},{"key":"B86","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Al-Toma","year":"2019","journal-title":"United Eur Gastroenterol J"},{"key":"B87","doi-asserted-by":"publisher","first-page":"eaaw7756","DOI":"10.1126\/sciadv.aaw7756","article-title":"Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease","volume":"5","author":"Goel","year":"2019","journal-title":"Sci Adv"},{"key":"B88","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1177\/2050640619874173","article-title":"Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity","volume":"8","author":"Tye-Din","year":"2019","journal-title":"United Eur. Gastroenterol. J"},{"key":"B89","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.3390\/nu5114553","article-title":"Gluten-free diet in children: an approach to a nutritionally adequate and balanced diet","volume":"5","author":"Penagini","year":"2013","journal-title":"Nutrients"},{"key":"B90","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.cgh.2008.12.032","article-title":"A simple validated gluten-free diet adherence survey for adults with celiac disease","volume":"7","author":"Leffler","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/00005176-199507000-00012","article-title":"Endomysial antibodies as unreliable markers for slight dietary transgressions in adolescents with celiac disease","volume":"21","author":"Troncone","year":"1995","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/ajg.2016.439","article-title":"Fecal gluten peptides reveal limitations of serological tests and food questionnaires for monitoring gluten-free diet in celiac disease patients","volume":"111","author":"Comino","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"B93","unstructured":"Disulphide bonds in wheat gluten: cystine peptides derived from gluten proteins following peptic and thermolytic digestion4329 KeckB K\u00f6hlerP WieserH 10.1007\/BF011932537668061Z Lebensm Unters Forsch2001995"},{"key":"B94","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.fm.2006.07.004","article-title":"Chemistry of gluten proteins","volume":"24","author":"Wieser","year":"2007","journal-title":"Food Microbiol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1126\/science.1074129","article-title":"Structural basis for gluten intolerance in celiac sprue","volume":"297","author":"Shan","year":"2002","journal-title":"Science"},{"key":"B96","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1084\/jem.20071204","article-title":"Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease","volume":"205","author":"Matysiak-Budnik","year":"2008","journal-title":"J Exp Med"},{"key":"B97","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.imlet.2005.02.017","article-title":"Adaptive and innate immune responses in coeliac disease","volume":"99","author":"Gianfrani","year":"2005","journal-title":"Immunol Lett"},{"key":"B98","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00251-019-01141-w","article-title":"Update 2020: nomenclature and listing of celiac disease\u2013relevant gluten epitopes recognized by CD4+ T cells","volume":"72","author":"Sollid","year":"2020","journal-title":"Immunogenetics."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1084\/jem.20102660","article-title":"Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4","volume":"209","author":"Junker","year":"2012","journal-title":"J Exp Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1111\/1541-4337.12475","article-title":"Adverse reactions to wheat or wheat components","volume":"18","author":"Brouns","year":"2019","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1111\/1541-4337.12493","article-title":"Wheat seed proteins: factors influencing their content, composition, and technological properties, and strategies to reduce adverse reactions","volume":"18","author":"Rustgi","year":"2019","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"B102","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/mi.2008.74","article-title":"Diagnosis and treatment of celiac disease","volume":"2","author":"Sollid","year":"2009","journal-title":"Mucosal Immunology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3389\/fped.2018.00350","article-title":"Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies","volume":"6","author":"Tye-Din","year":"2018","journal-title":"Front Pediatr"},{"key":"B104","doi-asserted-by":"publisher","first-page":"13147","DOI":"10.1038\/s41598-019-48299-7","article-title":"E40, a novel microbial protease efficiently detoxifying gluten proteins, for the dietary management of gluten intolerance","volume":"9","author":"Cavaletti","year":"2019","journal-title":"Sci Rep"},{"key":"B105","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1053\/j.gastro.2007.05.028","article-title":"Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue","volume":"133","author":"Gass","year":"2007","journal-title":"Gastroenterology"},{"key":"B106","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/gut.2006.111609","article-title":"Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: Implications for coeliac disease","volume":"57","author":"Mitea","year":"2008","journal-title":"Gut"},{"key":"B107","doi-asserted-by":"publisher","first-page":"13106","DOI":"10.1021\/jacs.5b08325","article-title":"Engineering of Kuma030: A gliadin peptidase that rapidly degrades immunogenic gliadin peptides in gastric conditions","volume":"137","author":"Wolf","year":"2015","journal-title":"J Am Chem Soc"},{"key":"B108","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/B978-0-12-416039-2.00013-6","article-title":"Oral enzyme therapy for celiac sprue","volume":"502","author":"Bethune","year":"2012","journal-title":"Methods Enzymol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"13100","DOI":"10.1038\/s41598-017-13587-7","article-title":"Randomized clinical trial: effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting","volume":"7","author":"K\u00f6nig","year":"2017","journal-title":"Sci Rep"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00217-015-2617-5","article-title":"Production of gluten-free beer by peptidase treatment","volume":"242","author":"Knorr","year":"2016","journal-title":"Eur Food Res Technol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10142-018-0632-x","article-title":"Development of wheat genotypes expressing a glutamine-specific endoprotease from barley and a prolyl endopeptidase from Flavobacterium meningosepticum or Pyrococcus furiosus as a potential remedy to celiac disease","volume":"19","author":"Osorio","year":"2019","journal-title":"Funct Integr Genomics"},{"key":"B112","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fnut.2020.00011","article-title":"Directed-mutagenesis of Flavobacterium meningosepticum prolyl-oligopeptidase and a glutamine-specific endopeptidase from barley","volume":"7","author":"Osorio","year":"2020","journal-title":"Front Nutr"},{"key":"B113","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.gtc.2018.09.002","article-title":"Nutritional considerations of the gluten-free diet","volume":"48","author":"Dennis","year":"2019","journal-title":"Gastroenterol Clin North Am"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/s10620-017-4879-1","article-title":"Skepticism regarding vaccine and gluten-free food safety among patients with celiac disease and non-celiac gluten sensitivity","volume":"63","author":"Rabinowitz","year":"2018","journal-title":"Dig Dis Sci"},{"key":"B115","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/j.1365-2796.2011.02376.x","article-title":"Novel therapies for coeliac disease","volume":"269","author":"Sollid","year":"2011","journal-title":"J Intern Med"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1517\/13543784.2014.916274","article-title":"Current status of drugs in development for celiac disease","volume":"23","author":"Kurppa","year":"2014","journal-title":"Expert Opin Invest Drugs"},{"key":"B117","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41572-018-0054-z","article-title":"Coeliac disease","volume":"5","author":"Lindfors","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"B118","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.gtc.2018.09.011","article-title":"Nondietary therapies for celiac disease","volume":"48","author":"Serena","year":"2019","journal-title":"Gastroenterol Clin North Am"},{"key":"B119","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.molmed.2019.05.009","article-title":"Therapeutic and diagnostic implications of T cell sarring in celiac disease and beyond","volume":"25","author":"Christophersen","year":"2019","journal-title":"Trends Mol Med"},{"key":"B120","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/mi.2014.102","article-title":"Lessons from rodent models in celiac disease","volume":"8","author":"Korneychuk","year":"2015","journal-title":"Mucosal Immunol."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.045","article-title":"Gliadin nanoparticles induce immune tolerance to gliadin in mouse models of celiac disease","author":"Freitag","year":"2020","journal-title":"Gastroenterology."},{"key":"B122","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41586-020-2003-8","article-title":"IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease","volume":"578","author":"Abadie","year":"2020","journal-title":"Nature"},{"key":"B123","doi-asserted-by":"publisher","first-page":"eaar7191","DOI":"10.1126\/science.aar7191","article-title":"Shifting the limits in wheat research and breeding using a fully annotated reference genome","volume":"361","author":"Appels","year":"2018","journal-title":"Science"},{"key":"B124","doi-asserted-by":"publisher","first-page":"eaar8602","DOI":"10.1126\/sciadv.aar8602","article-title":"Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat","volume":"4","author":"Juhasz","year":"2018","journal-title":"Sci Adv"},{"key":"B125","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/07853890701678689","article-title":"Lower economic status and inferior hygienic environment may protect against celiac disease","volume":"40","author":"Kondrashova","year":"2008","journal-title":"Ann Med"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1053\/j.gastro.2017.02.012","article-title":"Lower prevalence of celiac disease and gluten-related disorders in persons living in Southern vs Northern latitudes of the United States","volume":"152","author":"Unalp-Arida","year":"2017","journal-title":"Gastroenterology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1021\/jf305122s","article-title":"Can an increase in celiac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding?","volume":"61","author":"Kasarda","year":"2013","journal-title":"J Agric Food Chem"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s00122-010-1408-4","article-title":"Presence of celiac disease epitopes in modern and old hexaploid wheat varieties. Wheat breeding may have contributed to increased prevalence of celiac disease","volume":"121","author":"Van den Broeck","year":"2010","journal-title":"Theor Appl Genet"},{"key":"B129","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1053\/j.gastro.2004.11.003","article-title":"Mapping of gluten T-cell epitopes in bread wheat ancestors: Implications for celiac disease","volume":"128","author":"Molberg","year":"2005","journal-title":"Gastroenterology"},{"key":"B130","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1053\/j.gastro.2005.06.017","article-title":"Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients","volume":"129","author":"Spaenij-Dekking","year":"2005","journal-title":"Gastroenterology"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1039\/c0mb00046a","article-title":"In search of tetraploid wheat accessions reduced in celiac disease-related gluten epitopes","volume":"6","author":"Van den Broeck","year":"2010","journal-title":"Mol Biosyst"},{"key":"B132","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jcs.2018.08.012","article-title":"Gluten protein composition and aggregation properties as predictors for bread volume of common wheat, spelt, durum wheat, emmer and einkorn","volume":"83","author":"Geisslitz","year":"2018","journal-title":"J Cereal Sci"},{"key":"B133","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/foods8090409","article-title":"Comparative study on gluten protein composition of ancient (einkorn, emmer and spelt) and modern wheat species (durum and common wheat)","volume":"8","author":"Geisslitz","year":"2019","journal-title":"Foods"},{"key":"B134","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11032-018-0779-0","article-title":"Characterization of gluten proteins and celiac disease-related immunogenic epitopes in the Triticeae: cereal domestication and breeding contributed to decrease the content of gliadins and gluten","volume":"38","author":"Ozuna","year":"2018","journal-title":"Mol Breed"},{"key":"B135","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.1021\/acs.jafc.7b02041","article-title":"Understanding the effects of genotype, growing year, and breeding on Tunisian durum wheat allergenicity. 2. The celiac disease case","volume":"65","author":"Boukid","year":"2017","journal-title":"J Agric Food Chem"},{"key":"B136","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.foodchem.2018.04.131","article-title":"Detection and quantitation of immunogenic epitopes related to celiac disease in historical and modern hard red spring wheat cultivars","volume":"264","author":"Malalgoda","year":"2018","journal-title":"Food Chem"},{"key":"B137","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.foodchem.2016.06.043","article-title":"New insights into wheat toxicity: breeding did not seem to contribute to a prevalence of potential celiac disease's immunostimulatory epitopes","volume":"213","author":"Ribeiro","year":"2016","journal-title":"Food Chem"},{"key":"B138","doi-asserted-by":"publisher","first-page":"45092","DOI":"10.1038\/srep45092","article-title":"Quantitation of the immunodominant 33-mer peptide from \u03b1-gliadin in wheat flours by liquid chromatography tandem mass spectrometry","volume":"7","author":"Schalk","year":"2017","journal-title":"Sci Rep"},{"key":"B139","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.foodchem.2016.06.014","article-title":"Protective effects of ID331 Triticum monococcum gliadin on in vitro models of the intestinal epithelium","volume":"212","author":"Iacomino","year":"2016","journal-title":"Food Chem."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/pbi.12482","article-title":"Creation of the first ultra-low gluten barley (Hordeum vulgare L.) for coeliac and gluten-intolerant populations","volume":"14","author":"Tanner","year":"2016","journal-title":"Plant Biotechnol J"},{"key":"B141","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.foodres.2017.04.025","article-title":"Food processing and breeding strategies for coeliac-safe and healthy wheat products","volume":"110","author":"Jouanin","year":"2018","journal-title":"Food Res Int"},{"key":"B142","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jcs.2015.06.005","article-title":"Improving wheat to remove coeliac epitopes but retain functionality","volume":"67","author":"Shewry","year":"2016","journal-title":"J Cereal Sci"},{"key":"B143","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3390\/nu11030487","article-title":"Gluten free wheat: are we there?","volume":"11","author":"Garc\u00eda-Molina","year":"2019","journal-title":"Nutrients"},{"key":"B144","first-page":"23","article-title":"Protein composition and techno-functional properties of transgenic wheat with reduced alpha-gliadin content obtained by RNA interference","volume":"85","author":"Becker","year":"2012","journal-title":"J Appl Bot Food Qual"},{"key":"B145","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jcs.2008.03.005","article-title":"Silencing of \u03b3-gliadins by RNA interference (RNAi) in bread wheat","volume":"48","author":"Gil-Humanes","year":"2008","journal-title":"J Cereal Sci"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12870-014-0393-1","article-title":"Silencing of omega-5 gliadins in transgenic wheat eliminates a major source of environmental variability and improves dough mixing properties of flour","volume":"14","author":"Altenbach","year":"2014","journal-title":"BMC Plant Biol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3389\/fpls.2019.00580","article-title":"Elimination of omega-1,2 gliadins from bread wheat (Triticum aestivum) flour: effects on immunogenic potential and end-use quality","volume":"10","author":"Altenbach","year":"2019","journal-title":"Front Plant Sci"},{"key":"B148","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/pbi.12455","article-title":"Targeting of prolamins by RNAi in bread wheat: effectiveness of seven silencing-fragment combinations for obtaining lines devoid of coeliac disease epitopes from highly immunogenic gliadins","volume":"14","author":"Barro","year":"2016","journal-title":"Plant Biotechnol J"},{"key":"B149","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1111\/pbi.12837","article-title":"Low-gluten, non-transgenic wheat engineered with CRISPR\/Cas9","volume":"16","author":"S\u00e1nchez-Le\u00f3n","year":"2018","journal-title":"Plant Biotechnol J"},{"key":"B150","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1186\/s12870-019-1889-5","article-title":"Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of \u03b1- and \u03b3-gliadin gene families","volume":"19","author":"Jouanin","year":"2019","journal-title":"BMC Plant Biol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.3389\/fpls.2018.01523","article-title":"Development of wheat with hypoimmunogenic gluten obstructed by the gene editing policy in Europe","volume":"9","author":"Jouanin","year":"2018","journal-title":"Front Plant Sci"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1021\/jf00098a029","article-title":"Monoclonal antibody sandwich enzyme immunoassays for determination of gluten in foods","volume":"38","author":"Skerritt","year":"1990","journal-title":"J Agric Food Chem"},{"key":"B153","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/01.meg.0000059119.41030.df","article-title":"Innovative approach to low-level gluten determination in foods using a novel sandwich enzyme-linked immunosorbent assay protocol","volume":"15","author":"Vald\u00e9s","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"e2294","DOI":"10.1371\/journal.pone.0002294","article-title":"Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide","volume":"3","author":"Mor\u00f3n","year":"2008","journal-title":"PLoS ONE"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1093\/ajcn\/88.4.1057","article-title":"Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteom","volume":"88","author":"Mitea","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"B156","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3920\/QAS2012.0174","article-title":"Comparative study of commercially available gluten ELISA kits using an incurred reference material","volume":"5","author":"Bugyi","year":"2013","journal-title":"Qual Assur Saf Crops Foods"},{"key":"B157","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.foodchem.2017.04.092","article-title":"The feasibility of harmonizing gluten ELISA measurements","volume":"234","author":"Rzychon","year":"2017","journal-title":"Food Chem"},{"key":"B158","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s12161-016-0573-8","article-title":"Gluten analysis of wheat starches with seven commercial ELISA test kits - up to six different values","volume":"10","author":"Scherf","year":"2017","journal-title":"Food Anal Methods"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.5740\/jaoacint.SMPR2017.021","article-title":"Standard method performance requirements (SMPRs\u00ae) 2017.021: quantitation of wheat, rye, and barley gluten in oats","volume":"101","author":"Boison","year":"2018","journal-title":"J AOAC Int"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5740\/jaoacint.19-0081","article-title":"Preparation of validation materials for estimating gluten recovery by ELISA according to SMPR 2017.021","volume":"103","author":"Wehling","year":"2019","journal-title":"J AOAC Int"},{"key":"B161","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1093\/jaoac\/93.2.442","article-title":"Validation procedures for quantitative food allergen ELISA methods: community guidance and best practices. J","volume":"93","author":"Abbott","year":"2010","journal-title":"AOAC Int"},{"key":"B162","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1021\/jf3046736","article-title":"Accuracy of ELISA detection methods for gluten and reference materials: a realistic assessment","volume":"61","author":"Diaz-Amigo","year":"2013","journal-title":"J Agric Food Chem"},{"key":"B163","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jcs.2015.08.006","article-title":"Recent developments in analytical methods for tracing gluten","volume":"67","author":"Scherf","year":"2016","journal-title":"J Cereal Sci"},{"key":"B164","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.foodchem.2017.05.121","article-title":"Fundamental study on reactivities of gluten protein types from wheat, rye and barley with five sandwich ELISA test kits","volume":"237","author":"Lexhaller","year":"2017","journal-title":"Food Chem"},{"key":"B165","doi-asserted-by":"publisher","first-page":"e0172819","DOI":"10.1371\/journal.pone.0172819","article-title":"Isolation and characterization of gluten protein types from wheat, rye, barley and oats for use as reference materials","volume":"12","author":"Schalk","year":"2017","journal-title":"PLoS ONE"},{"key":"B166","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.foodchem.2017.05.005","article-title":"Variation in protein composition among wheat (Triticum aestivum L.) cultivars to identify cultivars suitable as reference material for wheat gluten analysis","volume":"267","author":"Hajas","year":"2018","journal-title":"Food Chem"},{"key":"B167","doi-asserted-by":"publisher","first-page":"126049","DOI":"10.1016\/j.foodchem.2019.126049","article-title":"Characterisation and comparison of selected wheat (Triticum aestivum L.) cultivars and their blends to develop a gluten reference material","volume":"313","author":"Schall","year":"2020","journal-title":"Food Chem"},{"key":"B168","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1094\/CCHEM-07-14-0166-R","article-title":"Evaluating the performance of gluten ELISA test kits: the numbers do not tell the tale","volume":"92","author":"Bruins Slot","year":"2015","journal-title":"Cereal Chem"},{"key":"B169","volume-title":"Standard Method Performance Requirements (SMPRs","year":"2006"},{"key":"B170","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.5740\/jaoacint.13-043","article-title":"Validation procedures for quantitative gluten ELISA methods: AOAC allergen community and best practices","volume":"96","author":"Koerner","year":"2013","journal-title":"J AOAC Int"},{"key":"B171","unstructured":"Rockville, MDAOAC InternationalGuidelines for Collaborative Study Procedures to Validate Characteristics of a Method of Analysis, Official Methods of Analysis.2016"},{"key":"B172","unstructured":"Rockville, MDAOAC InternationalGuidelines for Standard Method Performance Requirements, Official Methods of Analysis2016"},{"key":"B173","first-page":"137","article-title":"Considerations concerning methods for gluten quantitation in foods (R5\/G12 ELISA)","volume-title":"Proceedings of the 30th Meeting, Working Group on Prolamin Analysis and Toxicity.","author":"Koehler","year":"2017"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnut.2020.00029\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T18:33:31Z","timestamp":1695926011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnut.2020.00029\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,17]]},"references-count":173,"alternative-id":["10.3389\/fnut.2020.00029"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2020.00029","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,17]]},"article-number":"29"}}