{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:06Z","timestamp":1788306726665,"version":"build-2803163510"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Serum uric acid can act as a risk factor for cardiovascular disease (CVD) and as antioxidant defense. Vitamin D deficiency can activate the parathyroid to induce the release of parathyroid hormone, which was thought to increase serum uric acid level, and low vitamin D status may also be associated with risk of CVD. No known studies have explored the association between serum 25(OH) D, vitamin D intake, and HU for the American population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We extracted 15,723 US adults aged 20\u201385 years from the National Health and Nutrition Examination Survey (NHANES) in 2007\u20132014. All dietary intakes were evaluated through 24-h dietary recalls. Multivariable logistic regression analysis was performed to examine the associations after adjustment for confounders.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q4 of serum 25(OH) D levels were 0.78 (95% CI, 0.65\u20130.93), 0.97 (0.81\u20131.16), and 0.72 (0.60\u20130.88); ORs in Q2\u2013Q5 of total vitamin D intake were 0.83 (0.69\u20130.98), 0.69 (0.58\u20130.83), 0.66 (0.55\u20130.79), and 0.59 (0.48\u20130.71), respectively. In females, OR was 0.80 (0.66\u20130.97) of serum 25(OH) D for Q3, and ORs in Q5 of total vitamin D intake were 0.80 (0.65\u20130.98).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our findings indicated that the serum 25(OH) D intakes of dietary vitamin D, supplemental vitamin D, and total vitamin D were inversely associated with HU in males. In females, a lower risk of HU with higher serum 25(OH) D, dietary vitamin D, and total vitamin D intake was found, but with no association between supplemental vitamin D intake and the risk of HU.<\/jats:p>","DOI":"10.3389\/fnut.2020.592777","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T05:50:51Z","timestamp":1605851451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Association Between Vitamin D and Hyperuricemia Among Adults in the United States"],"prefix":"10.3389","volume":"7","author":[{"given":"Yi-Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Wei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/BOR.0000000000000028","article-title":"Definition of hyperuricemia and gouty conditions","volume":"26","author":"Bardin","year":"2014","journal-title":"Curr Opin Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1056\/NEJMcp030733","article-title":"Clinical practice. 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