{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:07:38Z","timestamp":1790824058324,"version":"4.1.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Emerging studies show that certain plant compounds may reduce the severity of most prevalent ocular abnormalities. The aim of this systematic review and meta-analysis was to assess the effect of dietary flavonoids on major eye disorders.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eligible studies were identified by searching PubMed, Web of Science, Scopus, and Cochrane Library databases for all articles published up to April 2021. The literature search yielded 1,134 articles, and a total of 16 studies were included in the systematic review. A meta-analysis of 11 intervention trials involving a total of 724 participants was performed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Using a random-effects model, the pooled results revealed an overall significant effect of flavonoids on common ophthalmic disorders (standard mean difference = \u22120.39; 95% CI: \u22120.56, \u22120.21, <jats:italic>p<\/jats:italic> &amp;lt; 0.01). Of the subclasses of flavonoids, flavan-3-ols (standard mean difference = \u22120.62; 95% CI: \u22121.03, \u22120.22, <jats:italic>p<\/jats:italic> &amp;lt; 0.01), and anthocyanins (standard mean difference = \u22120.42; 95% CI: \u22120.63, \u22120.21, <jats:italic>p<\/jats:italic> &amp;lt; 0.01) were the only effective intervention for improving the outcomes of ocular conditions. For several of the other flavonoid subclasses, evidence on efficacy was insufficient.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our findings indicate that flavonoids may improve the clinical manifestations associated with ocular disorders. However, further well-constructed clinical trials are required to confirm these results and examine the effect of flavonoids on eye disorders other than those identified in this review.<\/jats:p><jats:p><jats:bold>Systematic Review Registration:<\/jats:bold> PROSPERO, identifier CRD42021247332.<\/jats:p>","DOI":"10.3389\/fnut.2021.651441","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T06:15:35Z","timestamp":1621923335000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of Flavonoid Supplementation on Common Eye Disorders: A Systematic Review and Meta-Analysis of Clinical 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