{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:35:51Z","timestamp":1757540151462,"version":"3.41.2"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p><jats:bold>Background and Aim:<\/jats:bold> Genetic variation in fatty acid desaturases (FADS) has previously been linked to several diet-related diseases. We aimed to determine whether the FADS2 rs174583 variant interacts with the Dietary Approach to Stop Hypertension (DASH) score and Mediterranean dietary score (MDS) to influence cardio-metabolic risk factors among obese adults.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This cross-sectional study was performed among 347 apparently healthy obese adults (aged 20\u201350 years). Dietary quality indicator scores (DASH and MDS) were generated using a validated 147-item Food Frequency Questionnaire (FFQ). The FADS2 rs174583 variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The gene\u2013diet interaction was analyzed by the ANCOVA multivariate interaction model.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A significant interaction was observed between rs174583 and adherence to the DASH score in relation to serum triglyceride (TG) concentration among the female group (<jats:italic>P<\/jats:italic><jats:sub>Interaction<\/jats:sub> = 0.046); CT-genotype carriers who were assigned to the second tertile of DASH compared with those in the first tertile had a lower TG level (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Another significant interaction was revealed between adherence to MDS score and rs174583 polymorphism on serum glucose levels (<jats:italic>P<\/jats:italic><jats:sub><jats:italic>Interaction<\/jats:italic><\/jats:sub> = 0.044); the lowest mean of glucose level was observed in homozygous minor subjects (TT) in the third tertile of MDS, in comparison with other tertiles of this dietary index (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). There was a similar significant interaction between DASH and rs174583 in relation to diastolic blood pressure (<jats:italic>P<\/jats:italic><jats:sub>Interaction<\/jats:sub> = 0.038) among the male group. Additionally, a significant positive association was found between TT genotype and odds of having high TG both in the crude (OR, 3.21; 95% CI, 1.02\u201310.14) and adjusted (OR, 3.58; 95% CI, 1.07\u201311.97) models, taking into account different confounders.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Adherence to the dietary quality indicators (DASH and MDS) modified the relationship between FADS2 rs174583 polymorphism and cardio-metabolic risk factors in obese subjects. Prospective cohort studies are needed to confirm the results of our study.<\/jats:p>","DOI":"10.3389\/fnut.2021.669207","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T04:16:52Z","timestamp":1623039412000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Interaction Between Fatty Acid Desaturase-2 (FADS2) rs174583 Genetic Variant and Dietary Quality Indices (DASH and MDS) Constructs Different Metabolic Phenotypes Among Obese Individuals"],"prefix":"10.3389","volume":"8","author":[{"given":"Mahdieh","family":"Khodarahmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Nikniaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdieh","family":"Abbasalizad 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