{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:49:27Z","timestamp":1792000167648,"version":"4.4.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    is a bacterial strain that is used as a probiotic with health-promoting effects. Our study investigated the hepatoprotective effect of\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    HFY09 (LP-HFY09) in mice with ethanol-induced liver injury. The protection afforded by LP-HFY09 was evaluated by observing the morphology of hepatic tissue and measuring liver lipid indexes and function indexes, levels of anti-oxidative enzymes, and anti-inebriation enzymes, as well as oxidative metabolism-related gene expression. Gavage administration of LP-HFY09 [1 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    CFU\/kg body weight (bw)] limited the loss of bw, alcohol damage to the liver, and maintained the normal hepatic tissue morphology.\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    HFY09 intervention in ethanol-induced mice led to decreases in serum triglyceride (TG), total cholesterol (TC), aspartic transaminase, alanine transaminase, hyaluronidase (HAase), and precollagen III (PC III), and increases in liver alcohol dehydrogenase (ADH), and acetaldehyde dehydrogenase (ALDH).\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    HFY09 assisted with alleviating inflammation by elevating the level of interleukin 10 (IL-10) and decreasing the levels of pro-inflammatory factors [IL-6, IL-1\u03b2, and tumor necrosis factor-\u03b1 (TNF)-\u03b1].\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    HFY09 significantly elevated hepatic levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased liver malondialdehyde (MDA) from 3.45 to 1.64 nmol\/mg protein.\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    HFY09 exhibited an overall strong regulatory effect on liver protection when compared to that of commercial\n                    <jats:italic>Lactobacillus delbrueckii<\/jats:italic>\n                    subsp.\n                    <jats:italic>bulgaricus<\/jats:italic>\n                    . The hepatoprotective effect of LP-HFY09 was reflected by the upregulated expression of peroxisome proliferator activated-receptors \u03b1, SOD1, SOD2, glutathione peroxidase (GSH-Px), nicotinamide adenine dinucleotide phosphate (NADPH), and catalase (CAT), and the downregulated expression of cyclooxygenase-1 (COX1), c-Jun N-terminal kinase (JNK), and extracellular regulated protein kinases (ERK). Administration of LP-HFY09 at a concentration of 1.0 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    CFU\/kg bw could be a potential intervention, for people who frequently consume alcohol.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2021.684588","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T01:32:19Z","timestamp":1624498339000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice"],"prefix":"10.3389","volume":"8","author":[{"given":"Yi","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyao","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1002\/ijc.27553","article-title":"Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach","volume":"131","author":"Lachenmeier","year":"2012","journal-title":"Int J Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.jhep.2016.04.029","article-title":"Treatment of alcohol use disorders in patients with alcoholic liver disease","volume":"65","author":"Addolorato","year":"2016","journal-title":"J Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/jgh.12030","article-title":"Alcoholic liver disease: pathogenesis, management, and novel targets for therapy","volume":"28","author":"Orman","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/alcalc\/agu088","article-title":"Genetic variability in CYP2E1 and catalase gene among currently and formerly alcohol-dependent male subjects","volume":"50","author":"Plemenitas","year":"2014","journal-title":"Alcohol Alcohol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1111\/j.1440-1746.2011.06756.x","article-title":"Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances","volume":"26","author":"Seth","year":"","journal-title":"J Gastroenterol Hepatol. 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