{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T19:45:24Z","timestamp":1773171924908,"version":"3.50.1"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p><jats:bold>Aims:<\/jats:bold> We aimed to assess the association between dietary inflammation index (DII) with parathyroid hormone (PTH) and hyperparathyroidism (HP) in adults with\/without chronic kidney disease (CKD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Data were obtained from the 2003\u20132006 National Health and Nutrition Examination Survey (NHANES). The participants who were &amp;lt;18 years old, pregnant, or missing the data of DII, PTH, and CKD were excluded. DII was calculated based on a 24-h dietary recall interview for each participant. Weighted multivariable regression analysis and subgroup analysis were conducted to estimate the independent relationship between DII with PTH and the HP in the population with CKD\/non-CKD.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 7,679 participants were included with the median DII of \u22120.24 (\u22122.20 to 1.80) and a mean PTH level of 43.42 \u00b1 23.21 pg\/ml. The average PTH was 45.53 \u00b1 26.63 pg\/ml for the participants in the highest tertile group compared with 41.42 \u00b1 19.74 pg\/ml in the lowest tertile group (<jats:italic>P<\/jats:italic> &amp;lt; 0.0001). The rate of HP was 11.15% overall, while the rate in the highest DII tertile was 13.28 and 8.60% in the lowest DII tertile (<jats:italic>P<\/jats:italic> &amp;lt; 0.0001). The participants with CKD tended to have higher PTH levels compared with their counterparts (61.23 \u00b1 45.62 vs. 41.80 \u00b1 19.16 pg\/ml, <jats:italic>P<\/jats:italic> &amp;lt; 0.0001). A positive association between DII scores and PTH was observed (\u03b2 = 0.46, 95% CI: 0.25, 0.66, <jats:italic>P<\/jats:italic> \u2264 0.0001), and higher DII was associated with an increased risk of HP (OR = 1.05, 95% CI: 1.02, 1.08, <jats:italic>P<\/jats:italic> = 0.0023). The results from subgroup analysis indicated that this association was similar in the participants with different renal function, gender, age, BMI, hypertension, and diabetes statuses and could also be appropriate for the population with CKD.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Higher consumption of a pro-inflammatory diet appeared to cause a higher PTH level and an increased risk of HP. Anti-inflammatory dietary management may be beneficial to reduce the risk of HP both in the population with and without CKD.<\/jats:p>","DOI":"10.3389\/fnut.2021.688369","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T04:22:55Z","timestamp":1624594975000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The Association Between Dietary Inflammatory Index and Parathyroid Hormone in Adults With\/Without Chronic Kidney Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Zheng","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoxi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baihai","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12902-017-0221-3","article-title":"Vitamin D, parathyroid hormone and metabolic syndrome \u2013 the PORMETS study","volume":"17","author":"Raposo","year":"2017","journal-title":"BMC Endocr Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"16033","DOI":"10.1038\/nrdp.2016.33","article-title":"Primary hyperparathyroidism","volume":"2","author":"Bilezikian","year":"2016","journal-title":"Nat Rev Dis Primers."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1172\/JCI118224","article-title":"Parathyroid cell proliferation in normal and chronic renal failure rats. 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