{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:03:00Z","timestamp":1788256980273,"version":"build-2803163510"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Hypercholesteremia or high cholesterol is one of the important factors leading to atherosclerosis and other cardiovascular diseases. The application of probiotics with cholesterol-lowering characteristics has become increasingly popular over the past decade due to their contribution to human health. This study aimed to evaluate the probiotic effects of <jats:italic>Lactobacillus fermentum<\/jats:italic> ZJUIDS06 and <jats:italic>Lactobacillus plantarum<\/jats:italic> ZY08 on hyperlipidemic golden hamsters. A hyperlipidemic model was established through a high cholesterol diet in golden hamsters, after which lyophilized <jats:italic>Lactobacillus fermentum<\/jats:italic> ZJUIDS06 and <jats:italic>Lactobacillus plantarum<\/jats:italic> ZY08 were orally administered individually for 8 weeks. The physiological characteristics of golden hamsters and short chain fatty acid (SCFA) in the colon were assessed by automatic Biochemical Analyzer and gas choromatograph, respectively. A MiSeq sequencing-based analysis of the bacterial 16S rRNA gene (V3\u2013V4 region) in the cecum content was performed to analyze the cecum microbiota. Correlations between sets of these variables were also investigated using the R package \u201ccorrplot.\u201d Results showed that neither <jats:italic>Lactobacillus fermentum<\/jats:italic> ZJUIDS06 nor <jats:italic>Lactobacillus plantarum<\/jats:italic> ZY08 inhibited body weight increase. However, supplementation with <jats:italic>Lactobacillus fermentum<\/jats:italic> ZJUIDS06 for 8 weeks increased colon SCFA levels (<jats:italic>P<\/jats:italic> &amp;lt; 0.05), decreased serum low-density lipoprotein, total cholesterol, and triglycerides levels, and also induced changes in the cecum microbiota of hyperlipidemic golden hamsters. Remarkably, oral administration of <jats:italic>Lactobacillus fermentum<\/jats:italic> ZJUIDS06 increased the relative abundance of <jats:italic>Parabacteroides<\/jats:italic> in the cecum, which served as a biomarker for colon SCFA production and improvement of serum cholesterol levels. In a word, <jats:italic>Lactobacillus fermentum<\/jats:italic> ZJUIDS06 improved hyperlipidemia in golden hamsters, which correlated with an increase in SCFA levels and relative abundance of <jats:italic>Parabacteroides<\/jats:italic>, indicating its potential importance in functional foods that can help lower cholesterol.<\/jats:p>","DOI":"10.3389\/fnut.2021.705763","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T04:18:47Z","timestamp":1624853927000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Probiotic Effects of Lactobacillus fermentum ZJUIDS06 and Lactobacillus plantarum ZY08 on Hypercholesteremic Golden Hamsters"],"prefix":"10.3389","volume":"8","author":[{"given":"Dongting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Firrman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1136\/heartjnl-2014-306906","article-title":"High-dose atorvastatin is superior to moderate-dose simvastatin in preventing peripheral arterial disease","volume":"101","author":"Stoekenbroek","year":"2015","journal-title":"Heart."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1093\/eurheartj\/ehx362","article-title":"Infections, atherosclerosis, and coronary heart disease","volume":"38","author":"Pothineni","year":"2017","journal-title":"Euro Heart J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0226961","DOI":"10.1371\/journal.pone.0226961","article-title":"Carotid plaques and neurological impairment in patients with acute cerebral infarction","volume":"15","author":"Ni","year":"2020","journal-title":"PLoS ONE."},{"key":"B4","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.hlc.2016.04.025","article-title":"Non-HDL-C is a better predictor for the severity of coronary atherosclerosis compared with LDL-C","volume":"25","author":"Zhang","year":"2016","journal-title":"Heart Lung Circul."},{"key":"B5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00392-017-1106-1","article-title":"HDL cholesterol: reappraisal of its clinical relevance","volume":"106","author":"M\u00e4rz","year":"2017","journal-title":"Clin Res Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/14740338.2018.1394455","article-title":"Statin drug interactions and related adverse reactions: an update","volume":"17","author":"Bellosta","year":"2018","journal-title":"Expert Opinion Drug Safety."},{"key":"B7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.tcm.2019.11.013","article-title":"American Society for Preventive Cardiology. 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