{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:50:24Z","timestamp":1785934224886,"version":"3.56.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014392","name":"Avid Radiopharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To test the hypothesis that high glycemic diet is related to 1-year change in brain amyloid based on our prior cross-sectional evidence that high glycemic diet is associated with brain amyloid.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This longitudinal, observational study assessed the relationship between reported habitual consumption of a high glycemic diet (HGDiet) pattern and 1-year brain amyloid change measured by Florbetapir F18 PET scans in 102 cognitively normal older adults with elevated or sub-threshold amyloid status that participated in a 1-year randomized, controlled exercise trial at the University of Kansas Medical Center in Kansas City.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among all participants (<jats:italic>n<\/jats:italic> = 102), higher daily intake of the HGDiet pattern (\u03b2 = 0.06, <jats:italic>p<\/jats:italic> = 0.04), sugar (\u03b2 = 0.07, <jats:italic>p<\/jats:italic> = 0.01), and total carbohydrate (\u03b2 = 0.06, <jats:italic>p<\/jats:italic> = 0.04) were related to more precuneal amyloid accumulation. These relationships in the precuneus were accentuated in participants with elevated amyloid at enrollment (<jats:italic>n<\/jats:italic> = 70) where higher intake of the HGDiet pattern, sugar, and carbohydrate were related to more precuneal amyloid accumulation (\u03b2 = 0.11, <jats:italic>p<\/jats:italic> = 0.01 for all measures). In individuals with elevated amyloid, higher intake of the HGDiet pattern was also related to more amyloid accumulation in the lateral temporal lobe (\u03b2 = 0.09, <jats:italic>p<\/jats:italic> &amp;lt; 0.05) and posterior cingulate gyrus (\u03b2 = 0.09, <jats:italic>p<\/jats:italic> &amp;lt; 0.05) and higher sugar and carbohydrate intake were also related to more amyloid accumulation in the posterior cingulate gyrus (\u03b2 = 0.10, <jats:italic>p<\/jats:italic> &amp;lt; 0.05 for both measures).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This longitudinal observational analysis suggests that a high glycemic diet relates to higher brain amyloid accumulation over 1 year in regions of the temporoparietal cortex in cognitively normal adults, particularly in those with elevated amyloid status. Further studies are required to assess whether there is causal link between a high glycemic diet and brain amyloid.<\/jats:p><jats:p><jats:bold>Clinical Trial Registration:<\/jats:bold><jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>, Identifier (NCT02000583).<\/jats:p>","DOI":"10.3389\/fnut.2021.741534","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T05:57:04Z","timestamp":1632722224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Matthew K.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra K.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill 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