{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:22:51Z","timestamp":1790792571344,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The progression and metastasis of cancers are associated with systematic immune inflammation and nutritional dysfunction. The systemic immune-inflammation index and prognostic nutritional index (PNI) have shown a prognostic impact in several malignancies. Therefore, our study aimed to evaluate immune inflammation and nutritional index prognostic significance in patients with medulloblastoma (MB).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We retrospectively analyzed 111 patients with MB between 2001 and 2021 at our institution. The optimal cutoff values for systemic immune-inflammation index (SII), neutrophil\/lymphocyte ratio (NLR), monocyte\/lymphocyte counts ration (MLR), and PNI were evaluated with receiver operating characteristic (ROC) curve analysis. Clinical characteristics and SII, NLR, MLR, and PNI were tested with the Pearson's chi-squared test. The Kaplan\u2013Meier survival curves and the Cox proportional hazards model were used to evaluate the effects of immune inflammation and nutritional index on overall survival (OS).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Receiver operating characteristic curve analysis determined the optimal SII, NLR, MLR, and PNI cutoff values of 2,278, 14.83, 0.219, and 56.5 that significantly interacts with OS and divided the patients into two groups. Comparative survival analysis exhibited that the high-SII cohort had significantly shorter OS (<jats:italic>p<\/jats:italic> = 0.0048) than the low-SII cohort. For the univariate analysis, the results revealed that preoperative hydrocephalus (<jats:italic>p<\/jats:italic> = 0.01), SII (<jats:italic>p<\/jats:italic> = 0.006), albumin\u2013bilirubin score (ALBI) (<jats:italic>p<\/jats:italic> = 0.04), and coSII\u2013PNI were predictors of OS. In the multivariate analysis, preoperative hydrocephalus (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), ALBI (<jats:italic>p<\/jats:italic> = 0.010), SII (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), and coSII\u2013PNI as independent prognostic factors were significantly correlated with OS.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The preoperative SII, ALBI, and coSII\u2013PNI serve as robust prognostic biomarkers for patients with MB undergoing surgical resection.<\/jats:p>","DOI":"10.3389\/fnut.2021.754958","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:15:06Z","timestamp":1639725306000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Prognostic Value of the Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Patients With Medulloblastoma Undergoing Surgical 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