{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:44:24Z","timestamp":1772563464553,"version":"3.50.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2015-67017-23182"],"award-info":[{"award-number":["2015-67017-23182"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Obesity is considered a primary contributing factor in the development of many diseases, including cancer, diabetes, and cardiovascular illnesses. Phytochemical-rich foods, associated to healthy gastrointestinal microbiota, have been shown to reduce obesity and associated comorbidities. In the present article, we describe the effects of the probiotic <jats:italic>Lactobacillus johnsonii<\/jats:italic> N6.2 and blueberry extracts (BB) on the gut microbiota and lipid profile of rats under a high-fat (HF) or low-calorie (LC) diet. <jats:italic>L. johnsonii<\/jats:italic> was found to increase the levels of long chain fatty acids (LCFA) in the serum of all animals under HF diet, while reduced LCFA concentrations were observed in the adipose tissue of animals under HF diet supplemented with BB extracts. All animals under HF diet also showed lower protein levels of SREBP1 and SCAP when treated with <jats:italic>L. johnsonii<\/jats:italic>. The gut microbiota diversity, \u03b2-diversity was significantly changed by <jats:italic>L. johnsonii<\/jats:italic> in the presence of BB. A significant reduction in \u03b1-diversity was observed in the ileum of animals under HF diet supplemented with <jats:italic>L. johnsonii<\/jats:italic> and BB, while increased \u03b1-diversity was observed in the ilium of animals under LC diet supplemented with <jats:italic>L. johnsonii<\/jats:italic> or BB. In summary, <jats:italic>L. johnsonii<\/jats:italic> and BB supplementation induced significant changes in gut microbiota diversity and lipid metabolism. The phospholipids pool was the lipidome component directly affected by the interventions. The ileum and colon microbiota showed clear differences depending on the diet and the treatments examined.<\/jats:p>","DOI":"10.3389\/fnut.2021.757256","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T05:28:08Z","timestamp":1634189288000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Lactobacillus johnsonii N6.2 and Blueberry Phytophenols Affect Lipidome and Gut Microbiota Composition of Rats Under High-Fat Diet"],"prefix":"10.3389","volume":"8","author":[{"given":"Leandro Dias","family":"Teixeira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica F.","family":"Torrez 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