{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:05Z","timestamp":1790790905347,"version":"4.1.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701746"],"award-info":[{"award-number":["81701746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770545"],"award-info":[{"award-number":["81770545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020737","name":"Renji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Up to 50% of patients with Crohn's disease (CD) experience secondary loss of response (SLR) to infliximab. Patients with SLR may show clinical signs of iron deficiency as a result of inflammation despite being iron-replete. The magnetic resonance imaging (MRI)-based radiomic index, R2<jats:sup>*<\/jats:sup>, can detect changes in iron metabolism. Therefore, the R2<jats:sup>*<\/jats:sup> parameter has considerable potential for detection of SLR to infliximab. The aims of this study were to explore the correlation between R2<jats:sup>*<\/jats:sup> and inflammation and to develop a non-invasive nomogram based on R2<jats:sup>*<\/jats:sup> to identify SLR to infliximab in patients with CD. Three hundred and twenty-two infliximab-treated patients with CD who underwent magnetic resonance enterography within 2 weeks before or after 54 weeks of infliximab therapy were divided into training and validation datasets at a ratio of 8:2. Point-biserial analysis was conducted to confirm the relationship between R2<jats:sup>*<\/jats:sup> and inflammation. A multivariate logistic regression model was created using R2<jats:sup>*<\/jats:sup>, CRP and hemoglobin (OR, 1.10, 1.04 and 0.98; <jats:italic>P<\/jats:italic> &amp;lt; 0.05). Receiver-operating characteristic curves and the Hosmer-Lemeshow test were used to assess the performance of the model. A correlation between R2<jats:sup>*<\/jats:sup> and inflammation was identified. Different trends in R2<jats:sup>*<\/jats:sup> and iron status indices were observed between patients with responsive and non-responsive CD, which is worthy of further study. The model was converted to a visualized nomogram that had a good ability to discriminate the outcomes of infliximab therapy with an area under the curve of 0.723 (95% CI, 0.661\u20130.785) in the training dataset and 0.715 (95% CI, 0.587\u20130.843) in the validation dataset. We confirmed a correlation between R2<jats:sup>*<\/jats:sup> and inflammation in patients with CD. Based on the MRI-based radiomic signature, a novel nomogram was established and validated to facilitate individualized identification of SLR to infliximab in patients with CD.<\/jats:p>","DOI":"10.3389\/fnut.2021.773040","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T14:06:59Z","timestamp":1641218819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["MRI-Based Radiomic Signature Identifying Secondary Loss of Response to Infliximab in Crohn's 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