{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:04:16Z","timestamp":1791925456301,"version":"4.3.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2016BZ05"],"award-info":[{"award-number":["2016BZ05"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0504000"],"award-info":[{"award-number":["2017YFA0504000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["Y202028"],"award-info":[{"award-number":["Y202028"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    <jats:italic>Lycium barbarum<\/jats:italic>\n                    berry (Ningxia Gouqi,\n                    <jats:italic>Fructus lycii<\/jats:italic>\n                    , goji berry, or wolfberry), as a traditional Chinese herb, was recorded beneficial for longevity in traditional Chinese medical scriptures and currently is a natural dietary supplement worldwide. However, under modern experimental conditions, the longevity effect of\n                    <jats:italic>L. barbarum<\/jats:italic>\n                    berry and the underlying mechanisms have been less studied. Here, we reported that total water extracts of\n                    <jats:italic>L. barbarum<\/jats:italic>\n                    berry (LBE), which contains 22% polysaccharides and other components, such as anthocyanins, extended the lifespan of\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    without side effects on worm fertility and pharyngeal pumping. Interestingly, we found that the lifespan extension effect was more prominent in worms with shorter mean lifespan as compared to those with longer mean lifespan. Furthermore, we showed that the lifespan extension effect of LBE depended on deacetylase\n                    <jats:italic>sir-2.1<\/jats:italic>\n                    . Remarkably, LBE rescued heat shock transcription factor-1 (\n                    <jats:italic>hsf-1<\/jats:italic>\n                    ) deficiency in wild-type worms with different mean lifespans, and this effect also depended on\n                    <jats:italic>sir-2.1<\/jats:italic>\n                    . In addition, we found that LBE extended lifespan and alleviated toxic protein aggregation in neurodegenerative worms with\n                    <jats:italic>hsf-1<\/jats:italic>\n                    deficiency. Our study suggested that LBE may be a potential antiaging natural dietary supplement especially to individuals with malnutrition or chronic diseases and a potential therapeutic agent for neurodegenerative diseases characterized by\n                    <jats:italic>hsf-1<\/jats:italic>\n                    deficiency.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2021.815947","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T13:30:40Z","timestamp":1641994240000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Lycium barbarum Extracts Extend Lifespan and Alleviate Proteotoxicity in Caenorhabditis elegans"],"prefix":"10.3389","volume":"8","author":[{"given":"Haitao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi'e","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jep.2017.10.010","article-title":"The genus Lycium as food and medicine: A botanical, ethnobotanical and historical review","volume":"212","author":"Yao","year":"2018","journal-title":"J Ethnopharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/DDDT.S72892","article-title":"An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides","volume":"9","author":"Cheng","year":"2015","journal-title":"Drug Des Devel Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejphar.2018.01.005","article-title":"Regulation of HSF1 protein stabilization: An updated review","volume":"822","author":"Huang","year":"2018","journal-title":"Eur J Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1126\/science.1253168","article-title":"HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span","volume":"346","author":"Baird","year":"2014","journal-title":"Science."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1111\/acel.12140","article-title":"Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin\/IGF-1 signaling pathways in C. elegans. 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