{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:33:08Z","timestamp":1781803988612,"version":"3.54.5"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Placental function is vital to the fetal growth of sows, and resveratrol (RES) can protect cells against oxidative stress, which is one of the major factors impairing placental function. This study aimed to investigate the effect of dietary resveratrol (RES) on placental function and reproductive performance during late pregnancy in a sow model from the aspects of oxidative stress, insulin resistance, and gut microbiota. A total of 26 hybrid pregnant sows (Landrace \u00d7 Yorkshire) with similar parity were randomly allocated into two groups (<jats:italic>n<\/jats:italic> = 13) and fed with a basal diet or a diet containing 200 mg\/kg of resveratrol from day 85 of gestation until parturition. The dietary supplementation of RES increased the litter weight at parturition by 12.53% (<jats:italic>p<\/jats:italic> = 0.145), with ameliorated insulin resistance (HOMA-IR), increased triglyceride (TG) levels, and decreased interleukin (IL)-1\u03b2 and IL-6 levels in serum (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Moreover, resveratrol increased the placental vascular density (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) with the enhanced expression of nutrient transporter genes (<jats:italic>SLC2A1<\/jats:italic> and <jats:italic>SLC2A3<\/jats:italic>) and antioxidant genes, such as <jats:italic>superoxide dismutase 2<\/jats:italic> (<jats:italic>SOD2<\/jats:italic>) and <jats:italic>heme oxygenase-1<\/jats:italic> (<jats:italic>HO-1<\/jats:italic>) but declined the expression of inflammatory genes, such as <jats:italic>IL-1<\/jats:italic>\u03b2 and <jats:italic>IL-6<\/jats:italic> (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The characterization of the fecal microbiota revealed that resveratrol decreased the relative abundance of the <jats:italic>Christensensllaceae R-7 group<\/jats:italic> and <jats:italic>Ruminococcaceae UCG-008<\/jats:italic> (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), which had a positive linear correlation with the expression of <jats:italic>IL-1<\/jats:italic>\u03b2 and <jats:italic>IL-6<\/jats:italic> (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), but had a negative linear correlation with the expression of <jats:italic>SOD2, HO-1, SLC2A1<\/jats:italic>, and <jats:italic>SCL2A3<\/jats:italic> genes (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). These data demonstrated that dietary supplementation with resveratrol can improve placental function with ameliorated insulin resistance, oxidative stress, and inflammation potentially by regulating <jats:italic>Ruminococcaceae UCG-008<\/jats:italic> and the <jats:italic>Christensensllaceae R-7 group<\/jats:italic> in sows.<\/jats:p>","DOI":"10.3389\/fnut.2022.1001031","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T15:51:22Z","timestamp":1666972282000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of dietary resveratrol on placental function and reproductive performance of late pregnancy 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