{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:18:03Z","timestamp":1790018283794,"version":"4.0.1"},"reference-count":340,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Polyphenols are one of the largest plant-derived natural product and they play an important role in plants\u2019 defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to possess antineoplastic properties which include cell cycle arrest, and apoptosis via multiple mechanisms. They also have immunomodulatory activities where they enhance T cell activation and suppress regulatory T cells. They carry out these actions through such pathways as PI3K\/Akt\/mTOR and the kynurenine. They can also reverse cancer resistance to chemotherapy agents. In this review, i look at some of the molecular mechanism of action of polyphenols and their potential roles as therapeutic agents in hematological malignancies. Here i discuss their anti-proliferative and anti-neoplastic activities especially their abilities modulate signaling pathways as well as immune response in hematological malignancies. I also looked at clinical studies done mainly in the last 10\u201315 years on various polyphenol combination and how they enhance synergism. I recommend that further preclinical and clinical studies be carried out to ensure safety and efficacy before polyphenol therapies be officially moved to the clinics.<\/jats:p>","DOI":"10.3389\/fnut.2022.1008893","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:58:12Z","timestamp":1666760292000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies"],"prefix":"10.3389","volume":"9","author":[{"given":"Ogochukwu O.","family":"Izuegbuna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 Countries.","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin."},{"key":"B2","article-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues.","author":"Swerdlow","year":"2017","journal-title":"World Health Organization Classification of Tumours."},{"key":"B3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-020-00170-6","article-title":"Leukemia incidence trends at the global, regional, and national level between 1990 and 2017.","volume":"9","author":"Dong","year":"2020","journal-title":"Exp Hematol Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1097\/QAD.0000000000000428","article-title":"Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study.","volume":"28","author":"Gibson","year":"2014","journal-title":"AIDS."},{"key":"B6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1089\/AID.2021.0020","article-title":"Incidence, treatment, and outcome of HIV-associated hematologic malignancies in people living with HIV in Sweden.","volume":"38","author":"Kieri","year":"2022","journal-title":"AIDS Res Hum Retroviruses."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1182\/bloodadvances.2017015461","article-title":"Cost-effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia in older adults without deletion 17p.","volume":"2","author":"Barnes","year":"2018","journal-title":"Blood Adv."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1182\/blood-2015-03-630947","article-title":"A phase 2 study of idelalisib plus rituximab in treatment-na\u00efve older patients with chronic lymphocytic leukemia.","volume":"126","author":"O\u2019Brien","year":"2015","journal-title":"Blood."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1182\/blood.2020009617","article-title":"Acalabrutinib in treatment-naive chronic lymphocytic leukemia.","volume":"137","author":"Byrd","year":"2021","journal-title":"Blood."},{"key":"B10","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1182\/blood-2008-02-140582","article-title":"Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia.","volume":"112","author":"Tam","year":"2008","journal-title":"Blood."},{"key":"B11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials.","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.3390\/nu8090552","article-title":"Anticancer efficacy of polyphenols and their combinations.","volume":"8","author":"Niedzwiecki","year":"2016","journal-title":"Nutrients."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1126\/science.1217411","article-title":"The rise of chemodiversity in plants.","volume":"336","author":"Weng","year":"2012","journal-title":"Science."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/nu8080515","article-title":"Natural polyphenols for prevention and treatment of cancer.","volume":"8","author":"Zhou","year":"2016","journal-title":"Nutrients."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3892\/ijfn.2020.9","article-title":"Polyphenols in cancer prevention: new insights (Review).","volume":"1","author":"Briguglio","year":"2020","journal-title":"Int J Funct Nutr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability.","volume":"79","author":"Manach","year":"2004","journal-title":"Am J Clin Nutr."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/1178638819882739","article-title":"The effects of dietary polyphenols on circulating cardiovascular disease biokers and iron status: a systematic review.","volume":"12","author":"Speer","year":"2019","journal-title":"Nutr Metab Insights."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.2147\/DDDT.S327238","article-title":"Therapeutic effects and safe uses of plant-derived polyphenolic compounds in cardiovascular diseases: a review.","volume":"15","author":"Alotaibi","year":"2021","journal-title":"Drug Des Devel Ther."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080669","article-title":"Interaction of polyphenols as antioxidant and anti-inflammatory compounds in brain\u2013liver\u2013gut axis.","volume":"9","author":"Singh","year":"2020","journal-title":"Antioxidants."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.2174\/0929867324666171006144208","article-title":"Polyphenols in food: cancer prevention and apoptosis induction.","volume":"25","author":"Sharma","year":"2018","journal-title":"Curr Med Chem."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2019.e00370","article-title":"Phenolic acids: natural versatile molecules with promising therapeutic applications.","volume":"24","author":"Kumar","year":"2019","journal-title":"Biotechnol Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.biotechadv.2012.03.001","article-title":"Production of shikimic acid.","volume":"30","author":"Ghosh","year":"2012","journal-title":"Biotechnol Adv."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00145","article-title":"Shikimic acid production in escherichia coli: from classical metabolic engineering strategies to omics applied to improve its production.","volume":"3","author":"Mart\u00ednez","year":"2015","journal-title":"Front Bioeng Biotechnol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-019-1090-4","article-title":"Metabolic engineering of microorganisms for production of aromatic compounds.","volume":"18","author":"Huccetogullari","year":"2019","journal-title":"Microb Cell Fact."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00032","article-title":"Metabolic engineering of the shikimate pathway for production of aromatics and derived compounds-present and future strain construction strategies.","volume":"6","author":"Averesch","year":"2018","journal-title":"Front Bioeng Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1093\/mp\/ssq048","article-title":"Amino acids biosynthesis pathways in plants.","volume":"3","author":"Tzin","year":"2010","journal-title":"Molecular Plant."},{"key":"B27","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: an overview.","volume":"5","author":"Panche","year":"2016","journal-title":"J Nutr Sci."},{"key":"B28","first-page":"12","article-title":"Roles of flavonoids in plants.","volume":"6","author":"Samanta","year":"2011","journal-title":"Int J Pharm Sci Tech."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.ijbiomac.2018.05.149","article-title":"Recent advances in flavonoid-grafted polysaccharides: synthesis, structural characterization, bioactivities and potential applications.","volume":"116","author":"Liu","year":"2018","journal-title":"Int J Biol Macromol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.1021\/acsomega.0c06156","article-title":"Analysis of conformational, structural, magnetic, and electronic properties related to antioxidant activity: revisiting flavan, anthocyanidin, flavanone, flavonol, isoflavone, flavone, and flavan-3-ol.","volume":"6","author":"Farias","year":"2021","journal-title":"ACS Omega."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072126","article-title":"\u201cSweet Flavonoids\u201d: glycosidase-Catalyzed Modifications.","volume":"19","author":"Sl\u00e1mov\u00e1","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1080\/10408398.2015.1032400","article-title":"Dietary flavonoid aglycones and their glycosides: which show better biological significance?","volume":"57","author":"Xiao","year":"2017","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.710304","article-title":"Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways.","volume":"12","author":"Ch\u00e1irez-Ram\u00edrez","year":"2021","journal-title":"Front Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/plants5020027","article-title":"Flavones: from biosynthesis to health benefits.","volume":"5","author":"Jiang","year":"2016","journal-title":"Plants (Basel)."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231611","article-title":"UV radiation increases phenolic compound protection but decreases reproduction in Silene littorea.","volume":"15","author":"Del Valle","year":"2020","journal-title":"PLoS One."},{"key":"B36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1568026615666141209144506","article-title":"Antioxidant capacities of flavones and benefits in oxidative-stress related diseases.","volume":"15","author":"Catarino","year":"2015","journal-title":"Curr Top Med Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/ps.1731","article-title":"New genetic opportunities from legume intercrops for controlling Striga spp. Parasitic weeds.","volume":"65","author":"Hooper","year":"2009","journal-title":"Pest Manag Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1104\/pp.114.253757","article-title":"Tricin, a flavonoid monomer in monocot lignification.","volume":"167","author":"Lan","year":"2015","journal-title":"Plant Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tplants.2011.11.002","article-title":"Phytoalexins in defense against pathogens.","volume":"17","author":"Ahuja","year":"2012","journal-title":"Trends Plant Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3945\/an.116.012948","article-title":"Flavones: food sources, bioavailability, metabolism, and bioactivity.","volume":"8","author":"Hostetler","year":"2017","journal-title":"Adv Nutr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.2174\/18715206113139990303","article-title":"Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines.","volume":"13","author":"Mahbub","year":"2013","journal-title":"Anticancer Agents Med Chem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1158\/1535-7163.MCT-11-0343","article-title":"Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo.","volume":"11","author":"Budhraja","year":"2012","journal-title":"Mol Cancer Ther."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11441-z","article-title":"The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines.","volume":"12","author":"Mahbub","year":"2022","journal-title":"Sci Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"p. 1821","DOI":"10.1007\/978-3-642-22144-6_60","article-title":"Flavones and Flavonols: Phytochemistry and Biochemistry.","author":"Zhang","year":"2013","journal-title":"Natural Products."},{"key":"B45","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4067\/s0716-97602000000200007","article-title":"Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability.","volume":"33","author":"Crozier","year":"2000","journal-title":"Biol Res."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090888","article-title":"Allium flavonols: health benefits, molecular targets, and bioavailability.","volume":"9","author":"Kothari","year":"2020","journal-title":"Antioxidants."},{"key":"B47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s13105-018-0659-4","article-title":"Anti-obesity effects of kaempferol by inhibiting adipogenesis and increasing lipolysis in 3T3-L1 cells.","volume":"75","author":"Torres-Villarreal","year":"2019","journal-title":"J Physiol Biochem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acs.jnatprod.0c00589","article-title":"Investigation of selected flavonoid derivatives as potent FLT3 inhibitors for the potential treatment of acute myeloid leukemia.","volume":"22","author":"Yen","year":"2021","journal-title":"J Nat Prod."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.534171","article-title":"Quercetin induces apoptosis via downregulation of vascular endothelial growth factor\/akt signaling pathway in acute myeloid leukemia cells. Front pharmacol. 2020;11:534171. Erratum.","volume":"11","author":"Shi","year":"2021","journal-title":"Front Pharmacol."},{"key":"B50","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/jcb.26391","article-title":"Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes.","volume":"119","author":"Moradzadeh","year":"2018","journal-title":"J Cell Biochem."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154061","article-title":"O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia.","volume":"100","author":"Yen","year":"2022","journal-title":"Phytomedicine."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxid Redox Signal."},{"key":"B53","article-title":"Flavanols from nature: a phytochemistry and biological activity review.","volume":"27","author":"Luo","year":"2022","journal-title":"Molecules."},{"key":"B54","author":"Haytowitz","year":"2018","journal-title":"USDA Database for the Flavonoid Content of Selected Foods Release 3.3 Prepared by."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0075-3","article-title":"Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RAR\u03b1 oncoprotein degradation.","volume":"7","author":"Zhang","year":"2014","journal-title":"J Hematol Oncol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.26355\/eurrev_201804_14742","article-title":"Epigallocatechin gallate inhibits the proliferation and induces apoptosis of multiple myeloma cells via inactivating EZH2.","volume":"22","author":"Zhou","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88478-z","article-title":"(\u2013)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1.","volume":"11","author":"Della Via","year":"2021","journal-title":"Sci Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1039\/b802662a","article-title":"Dietary phenolics: chemistry, bioavailability and effects on health.","volume":"26","author":"Crozier","year":"2009","journal-title":"Nat Prod Rep."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.779638","article-title":"Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling.","volume":"23","author":"Ramesh","year":"2021","journal-title":"Front Endocrinol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092901","article-title":"Flavonoids as potential anti-inflammatory molecules: a review.","volume":"27","author":"Al-Khayri","year":"2022","journal-title":"Molecules."},{"key":"B61","doi-asserted-by":"publisher","first-page":"363","DOI":"10.7555\/JBR.33.20180126","article-title":"Function of flavonoids on different types of programmed cell death and its mechanism: a review.","volume":"33","author":"Vetrivel","year":"2019","journal-title":"J Biomed Res."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061076","article-title":"Isoflavones.","volume":"24","author":"K\u0159\u00ed\u017eov\u00e1","year":"2019","journal-title":"Molecules."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.3390\/molecules20022770","article-title":"Phytoalexins: current progress and future prospects.","volume":"20","author":"Jeandet","year":"2015","journal-title":"Molecules."},{"key":"B64","doi-asserted-by":"publisher","first-page":"218","DOI":"10.2174\/1385272820666160928120822","article-title":"Isoflavones, their glycosides and glycoconjugates. Synthesis and biological activity.","volume":"21","author":"Szeja","year":"2017","journal-title":"Curr Org Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s11418-008-0271-y","article-title":"Microbial metabolism of soy isoflavones by human intestinal bacterial strains.","volume":"62","author":"Tsuchihashi","year":"2008","journal-title":"J Nat Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"p. 23","DOI":"10.1016\/B978-0-12-802778-3.00002-0","article-title":"Soy Protein: Impacts, Production, and Applications.","author":"Thrane","year":"2017","journal-title":"Sustainable Protein Sources."},{"key":"B67","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/pbi.12118","article-title":"Co-expression of Arabidopsis transcription factor, AtMYB12, and soybean isoflavone synthase, GmIFS1, genes in tobacco leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotective activity.","volume":"12","author":"Pandey","year":"2014","journal-title":"Plant Biotechnol J."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/CIRCULATIONAHA.119.041306","article-title":"Isoflavone intake and the risk of coronary heart disease in US men and women: results from 3 prospective cohort studies.","volume":"141","author":"Ma","year":"2020","journal-title":"Circulation."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01336","article-title":"Molecular mechanisms of action of genistein in cancer: recent advances.","volume":"10","author":"Tuli","year":"2019","journal-title":"Front Pharmacol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5625\/lar.2014.30.4.143","article-title":"Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models.","volume":"30","author":"Kim","year":"2014","journal-title":"Lab Anim Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"556","DOI":"10.21873\/invivo.12737","article-title":"Soy isoflavones and breast cancer risk: a meta-analysis.","volume":"36","author":"Boutas","year":"2022","journal-title":"In Vivo."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-018-0559-2","article-title":"Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K\/AKT signaling in ovarian cancer.","volume":"18","author":"Chan","year":"2018","journal-title":"Cancer Cell Int."},{"key":"B73","doi-asserted-by":"publisher","first-page":"111","DOI":"10.18632\/oncoscience.120","article-title":"Genistein exerts anti-leukemic effects on genetically different acute myeloid leukemia cell lines by inhibiting protein synthesis and cell proliferation while inducing apoptosis \u2013 molecular insights from an iTRAQ\u2122 quantitative proteomics study.","volume":"2","author":"Narasimhan","year":"2015","journal-title":"Oncoscience."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1530\/EC-18-0459","article-title":"Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein.","volume":"7","author":"Yakimchuk","year":"2018","journal-title":"Endocr Connect."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.3892\/mmr.2015.4740","article-title":"Genistein inhibits the proliferation of human multiple myeloma cells through suppression of nuclear factor-kB and upregulation of microRNA-29b.","volume":"13","author":"Xie","year":"2016","journal-title":"Mol Med Rep."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.3390\/molecules14062202","article-title":"Phenolics: from chemistry to biology.","volume":"14","author":"Pereira","year":"2009","journal-title":"Molecules."},{"key":"B77","doi-asserted-by":"publisher","first-page":"10877","DOI":"10.1021\/jf301807g","article-title":"Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids.","volume":"60","author":"El-Seedi","year":"2012","journal-title":"J Agric Food Chem."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0080-3","article-title":"Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity.","volume":"13","author":"Alam","year":"2016","journal-title":"Nutr Metab."},{"key":"B79","article-title":"Phenolic acids: natural versatile molecules with promising therapeutic applications.","volume":"24","author":"Kumar","year":"2019","journal-title":"Biotechnol Rep (Amst)."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-63","article-title":"Hydroxybenzoic acid isomers and the cardiovascular system.","volume":"13","author":"Juurlink","year":"2014","journal-title":"Nutr J."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111305","article-title":"Anti-oxidation and anti-inflammatory potency evaluation of ferulic acid derivatives obtained through virtual screening.","volume":"22","author":"Shi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B82","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3967\/bes2019.002","article-title":"Antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by solid-state fermentation of aspergillus niger.","volume":"32","author":"Yin","year":"2019","journal-title":"Biomed Environ Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ptr.5528","article-title":"Antidiabetic effects of simple phenolic acids: a comprehensive review.","volume":"30","author":"Vinayagam","year":"2016","journal-title":"Phytother Res."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100069","article-title":"Higher phenolic acid intake independently associates with lower prevalence of insulin resistance and non-alcoholic fatty liver disease.","volume":"28","author":"Salomone","year":"2020","journal-title":"JHEP Rep."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9600.1000468","article-title":"Anticancer properties of phenolic acids in colon cancer \u2013 a review.","volume":"6","author":"Rosa","year":"2016","journal-title":"J Nutr Food Sci."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020221","article-title":"Therapeutic potential of plant phenolic acids in the treatment of cancer.","volume":"10","author":"Abotaleb","year":"2020","journal-title":"Biomolecules."},{"key":"B87","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3906\/sag-1401-127","article-title":"An in vitro and in vivo investigation of the cytotoxic effects of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester and bortezomib in multiple myeloma cells.","volume":"45","author":"Altayli","year":"2015","journal-title":"Turk J Med Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1021\/acs.jnatprod.0c00350","article-title":"Antimyeloma potential of caffeic acid phenethyl ester and its analogues through Sp1 mediated downregulation of IKZF1-IRF4-MYC Axis.","volume":"83","author":"Murugesan","year":"2020","journal-title":"J Nat Prod."},{"key":"B89","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.biopha.2018.05.158","article-title":"Gallic acid targets acute myeloid leukemia via Akt\/mTOR-dependent mitochondrial respiration inhibition.","volume":"105","author":"Gu","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B90","first-page":"525","article-title":"Gallic acid inhibits proliferation and induces apoptosis in lymphoblastic leukemia cell line (C121).","volume":"41","author":"Sourani","year":"2016","journal-title":"Iran J Med Sci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.tem.2021.03.008","article-title":"Non-flavonoid polyphenols in osteoporosis: preclinical evidence.","volume":"32","author":"Bellavia","year":"2021","journal-title":"Trends Endocrinol Metab."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030792","article-title":"Biological activities of stilbenoids.","volume":"19","author":"Akinwumi","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1074\/jbc.RA117.000564","article-title":"Stilbenoid prenyltransferases define key steps in the diversification of peanut phytoalexins.","volume":"293","author":"Yang","year":"2018","journal-title":"J Biol Chem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s11101-018-9578-9","article-title":"A review of dietary stilbenes: sources and bioavailability.","volume":"17","author":"El Khawand","year":"2018","journal-title":"Phytochem Rev."},{"key":"B95","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1021\/acs.jafc.5b05993","article-title":"Comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights.","volume":"64","author":"Seyed","year":"2016","journal-title":"J Agric Food Chem."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1021\/acs.jnatprod.7b00384","article-title":"Natural stilbenoids have anti-inflammatory properties in vivo and down-regulate the production of inflammatory mediators NO, IL6, and MCP1 possibly in a PI3K\/Akt-dependent manner.","volume":"81","author":"Er\u00e4salo","year":"2018","journal-title":"J Nat Prod."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9060336","article-title":"Stilbenoids: a natural arsenal against bacterial pathogens.","volume":"9","author":"Mattio","year":"2020","journal-title":"Antibiotics."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3128951","article-title":"Role of natural stilbenes in the prevention of cancer.","volume":"2016","author":"Sirerol","year":"2016","journal-title":"Oxid Med Cell Longev."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121947","article-title":"Stilbenoid isorhapontigenin as a potential anti-cancer agent against breast cancer through inhibiting sphingosine kinases\/tubulin stabilization.","volume":"11","author":"Subedi","year":"2019","journal-title":"Cancers (Basel)."},{"key":"B100","doi-asserted-by":"publisher","first-page":"4280","DOI":"10.1074\/jbc.M110.200774","article-title":"The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo.","volume":"286","author":"Kirabo","year":"2011","journal-title":"J Biol Chem."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.744823","article-title":"Advances in universal CAR-T cell therapy.","volume":"12","author":"Lin","year":"2021","journal-title":"Front Immunol."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-021-00166-5","article-title":"Neurological management and work-up of neurotoxicity associated with CAR T cell therapy.","volume":"4","author":"M\u00f6hn","year":"2022","journal-title":"Neurol Res Pract."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76055-9","article-title":"Description of neurotoxicity in a series of patients treated with CAR T-cell therapy.","volume":"10","author":"Belin","year":"2020","journal-title":"Sci Rep."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020307","article-title":"Enhanced chimeric antigen receptor T cell therapy through co-application of synergistic combination partners.","volume":"10","author":"Stock","year":"2022","journal-title":"Biomedicines."},{"key":"B105","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.1038\/sj.onc.1209939","article-title":"Mutations in the NF-kappaB signaling pathway: implications for human disease.","volume":"25","author":"Courtois","year":"2006","journal-title":"Oncogene."},{"key":"B106","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.blre.2018.11.003","article-title":"The impact of NF-\u03baB signaling on pathogenesis and current treatment strategies in multiple myeloma.","volume":"34","author":"Vr\u00e1bel","year":"2019","journal-title":"Blood Rev."},{"key":"B107","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jpha.2021.07.002","article-title":"Phytochemicals targeting NF-\u03baB signaling: potential anti-cancer interventions.","volume":"12","author":"Chauhan","year":"2022","journal-title":"J Pharm Anal."},{"key":"B108","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbi.2016.03.018","article-title":"Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase.","volume":"251","author":"Takeda","year":"2016","journal-title":"Chem Biol Interact."},{"key":"B109","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.hoc.2012.02.014","article-title":"mTOR signaling pathway and mTOR inhibitors in cancer therapy.","volume":"26","author":"Gomez-Pinillos","year":"2012","journal-title":"Hematol Oncol Clin North Am."},{"key":"B110","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat Rev Cancer."},{"key":"B111","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.bbalip.2014.12.006","article-title":"PI3K signalling in inflammation.","volume":"1851","author":"Hawkins","year":"2015","journal-title":"Biochim Biophys Acta."},{"key":"B112","first-page":"123","article-title":"PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL).","volume":"393","author":"Okkenhaug","year":"2016","journal-title":"Curr Top Microbiol Immunol."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061571","article-title":"PI3K inhibitors for the treatment of chronic lymphocytic leukemia: current status and future perspectives.","volume":"14","author":"Hus","year":"2022","journal-title":"Cancers."},{"key":"B114","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature19834","article-title":"PI3K\u03b3 is a molecular switch that controls immune suppression.","volume":"539","author":"Kaneda","year":"2016","journal-title":"Nature."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001104","article-title":"The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.","volume":"3","author":"Ramadani","year":"2010","journal-title":"Sci Signal."},{"key":"B116","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB.","volume":"22","author":"Sarbassov","year":"2006","journal-title":"Molecular Cell."},{"key":"B117","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3324\/haematol.2013.087171","article-title":"Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies.","volume":"99","author":"Jabbour","year":"2014","journal-title":"Haematologica."},{"key":"B118","first-page":"111","article-title":"PI3K mutations in breast cancer: prognostic and therapeutic implications.","volume":"7","author":"Mukohara","year":"2015","journal-title":"Breast Cancer."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025924","article-title":"Inhibition of the mechanistic target of rapamycin (mTOR)-rapamycin and beyond.","volume":"6","author":"Lamming","year":"2016","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B120","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-nutr-071714-034355","article-title":"The roles of mTOR complexes in lipid metabolism.","volume":"35","author":"Caron","year":"2015","journal-title":"Annu Rev Nutr."},{"key":"B121","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation.","volume":"125","author":"Kim","year":"2015","journal-title":"J Clin Invest."},{"key":"B122","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy."},{"key":"B123","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1038\/leu.2017.80","article-title":"Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN\/Ikaros\/miR-26b mechanism reveals a critical targetable role for PIK3CD.","volume":"31","author":"Yuan","year":"2017","journal-title":"Leukemia."},{"key":"B124","doi-asserted-by":"publisher","first-page":"5724","DOI":"10.1158\/1078-0432.CCR-08-3215","article-title":"Phosphatidylinositol 3\u2032-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma.","volume":"15","author":"Psyrri","year":"2009","journal-title":"Clin Cancer Res."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0954-x","article-title":"Targeting PI3K in cancer: mechanisms and advances in clinical trials.","volume":"18","author":"Yang","year":"2019","journal-title":"Mol Cancer."},{"key":"B126","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/10428194.2020.1839654","article-title":"The role of PI3K inhibitors in the treatment of malignant lymphomas.","volume":"62","author":"Berning","year":"2021","journal-title":"Leuk Lymphoma."},{"key":"B127","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"PI3K\/AKT signaling pathway and cancer: an updated review.","volume":"46","author":"Martini","year":"2014","journal-title":"Ann Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.trecan.2017.04.002","article-title":"Targeting PI3K signaling in combination cancer therapy.","volume":"3","author":"Pons-Tostivint","year":"2017","journal-title":"Trends Cancer."},{"key":"B129","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.molimm.2018.09.011","article-title":"IDO1 impairs NK cell cytotoxicity by decreasing NKG2D\/NKG2DLs via promoting miR-18a.","volume":"103","author":"Zhang","year":"2018","journal-title":"Mol Immunol."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00396-1","article-title":"mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges.","volume":"10","author":"Zou","year":"2020","journal-title":"Cell Biosci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.2147\/PGPM.S305068","article-title":"Clinical development of AKT inhibitors and associated predictive biomarkers to guide patient treatment in cancer medicine.","volume":"14","author":"Coleman","year":"2021","journal-title":"Pharmgenomics Pers Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/01635581.2017.1267775","article-title":"Quercetin attenuates cell survival, inflammation, and angiogenesis via modulation of AKT signaling in murine T-cell lymphoma.","volume":"69","author":"Maurya","year":"2017","journal-title":"Nutr Cancer."},{"key":"B133","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1365-2141.2007.06714.x","article-title":"Inhibition of Akt induces significant downregulation of surviving and cytotoxicity in human multiple myeloma cells.","volume":"138","author":"Hideshima","year":"2007","journal-title":"Brit J Hematol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1182\/blood-2009-06-229443","article-title":"Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.","volume":"115","author":"Kharas","year":"2010","journal-title":"Blood."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00484","article-title":"Curcumin induces apoptotic cell death via inhibition of PI3-Kinase\/AKT pathway in B-precursor acute lymphoblastic leukemia.","volume":"9","author":"Kuttikrishnan","year":"2019","journal-title":"Front Oncol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1158\/1078-0432.CCR-08-1511","article-title":"Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG.","volume":"15","author":"Ghosh","year":"2009","journal-title":"Clin Cancer Res."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00138","article-title":"Autophagy and stem cells: self-eating for self-renewal.","volume":"4","author":"Chang","year":"2020","journal-title":"Front Cell Dev Biol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1080\/15548627.2015.1043076","article-title":"Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy.","volume":"11","author":"Yu","year":"2015","journal-title":"Autophagy."},{"key":"B139","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10010018","article-title":"mTOR Pathways in cancer and autophagy.","volume":"10","author":"Paquette","year":"2018","journal-title":"Cancers."},{"key":"B140","doi-asserted-by":"publisher","first-page":"825","DOI":"10.26402\/jpp.2019.6.02","article-title":"The wine polyphenol resveratrol modulates autophagy and induces apoptosis in MOLT-4 and HL-60 human leukemia cells.","volume":"70","author":"Siedlecka-Kroplewska","year":"2019","journal-title":"J Physiol Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1158\/0008-5472.CAN-09-3537","article-title":"Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62\/SQSTM1 expression and AMPK activation.","volume":"70","author":"Puissant","year":"2010","journal-title":"Cancer Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"64","DOI":"10.36349\/easjpp.2019.v01i03.001","article-title":"Induction of autophagy in human myeloid and lymphoid leukaemia cell line by using polyphenols alone and combined with a stander chemotherapy.","volume":"1","author":"Ali Azzwali","year":"2019","journal-title":"EASJ Pharm Pharmacol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.4103\/0973-1482.172111","article-title":"The autophagy induced by curcumin via MEK\/ERK pathway plays an early anti-leukemia role in human Philadelphia chromosome-positive acute lymphoblastic leukemia SUP-B15 cells.","volume":"14","author":"Guo","year":"2018","journal-title":"J Cancer Res Ther."},{"key":"B144","doi-asserted-by":"publisher","first-page":"21124","DOI":"10.1073\/pnas.1314124110","article-title":"PI3K regulates MEK\/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.","volume":"110","author":"Ebi","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B145","doi-asserted-by":"publisher","first-page":"C1172","DOI":"10.1152\/ajpcell.00504.2010","article-title":"ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.","volume":"300","author":"Winter","year":"2011","journal-title":"Am J Physiol Cell Physiol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1080\/10286020903264077","article-title":"Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells.","volume":"11","author":"Jia","year":"2009","journal-title":"J Asian Nat Prod Res."},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154820","article-title":"Nicotinate-curcumin impedes foam cell formation from THP-1 cells through restoring autophagy flux.","volume":"11","author":"Gu","year":"2016","journal-title":"PLoS One."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.3109\/10428194.2013.855307","article-title":"Targeting the apoptosis pathway in hematologic malignancies.","volume":"55","author":"Zaman","year":"2014","journal-title":"Leuk Lymphoma."},{"key":"B149","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1182\/blood.V91.3.991","article-title":"Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.","volume":"91","author":"Kaufmann","year":"1998","journal-title":"Blood."},{"key":"B150","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.blre.2017.08.004","article-title":"Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances.","volume":"32","author":"Wu","year":"2018","journal-title":"Blood Rev."},{"key":"B151","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4161\/cc.23464","article-title":"The chains of death: a new view on caspase-8 activation at the DISC.","volume":"12","author":"Schleich","year":"2013","journal-title":"Cell Cycle."},{"key":"B152","doi-asserted-by":"publisher","first-page":"6252","DOI":"10.1038\/onc.2008.302","article-title":"IAP-targeted therapies for cancer.","volume":"27","author":"LaCasse","year":"2008","journal-title":"Oncogene."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00197","article-title":"X-linked inhibitor of apoptosis protein \u2013 a critical death resistance regulator and therapeutic target for personalized cancer therapy.","volume":"4","author":"Obexer","year":"2014","journal-title":"Front Oncol."},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-29-34","article-title":"Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo.","volume":"29","author":"Jiang","year":"2010","journal-title":"J Exp Clin Cancer Res"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.2174\/18715206113139990078","article-title":"Targeted regulation of PI3K\/Akt\/mTOR\/NF-\u03baB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy.","volume":"13","author":"Ahmad","year":"2013","journal-title":"Anticancer Agents Med Chem."},{"key":"B156","doi-asserted-by":"publisher","first-page":"10761","DOI":"10.1074\/jbc.275.15.10761","article-title":"Akt\/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.","volume":"275","author":"Pugazhenthi","year":"2000","journal-title":"J Biol Chem."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.18632\/oncotarget.13817","article-title":"The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer.","volume":"8","author":"Dai","year":"2017","journal-title":"Oncotarget."},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6477-4","article-title":"Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer.","volume":"19","author":"Kizilboga","year":"2019","journal-title":"BMC Cancer."},{"key":"B159","first-page":"2319","article-title":"The Akt pathway in oncology therapy and beyond (Review).","volume":"53","author":"Nitulescu","year":"2018","journal-title":"Int J Oncol."},{"key":"B160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/1097-4644(20001201)79:3<355::AID-JCB20>3.0.CO;2-0","article-title":"MEK\/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells.","volume":"79","author":"Boucher","year":"2000","journal-title":"J Cell Biochem."},{"key":"B161","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1111\/febs.14122","article-title":"Control of cell death and mitochondrial fission by ERK1\/2 MAP kinase signalling.","volume":"284","author":"Cook","year":"2017","journal-title":"FEBS J."},{"key":"B162","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4049\/jimmunol.0803853","article-title":"MEK\/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.","volume":"183","author":"O\u2019Reilly","year":"2009","journal-title":"J Immunol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"309","DOI":"10.18632\/oncotarget.1480","article-title":"Apoptosis inducers in chronic lymphocytic leukemia.","volume":"5","author":"Billard","year":"2014","journal-title":"Oncotarget."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.2174\/1381612043384880","article-title":"Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy.","volume":"10","author":"Pellecchia","year":"2004","journal-title":"Curr Pharm Des."},{"key":"B165","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1182\/blood-2004-07-2761","article-title":"Apoptosis-based therapies for hematologic malignancies.","volume":"106","author":"Reed","year":"2005","journal-title":"Blood."},{"key":"B166","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.3109\/10428194.2013.775437","article-title":"Natural Bcl-2 inhibitor (\u2013)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma.","volume":"54","author":"Ni","year":"2013","journal-title":"Leuk Lymphoma."},{"key":"B167","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1182\/blood-2008-02-138560","article-title":"AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.","volume":"113","author":"Balakrishnan","year":"2009","journal-title":"Blood."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1182\/blood-2018-02-791350","article-title":"The rise of apoptosis: targeting apoptosis in hematologic malignancies.","volume":"132","author":"Valentin","year":"2018","journal-title":"Blood."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.biocel.2010.05.007","article-title":"Piceatannol induces Fas and FasL up-regulation in human leukemia U937 cells via Ca2+\/p38alpha MAPK-mediated activation of c-Jun and ATF-2 pathways.","volume":"42","author":"Liu","year":"2010","journal-title":"Int J Biochem Cell Biol."},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00334","article-title":"Resveratrol sensitizes carfilzomib-induced apoptosis via promoting oxidative stress in multiple myeloma cells.","volume":"9","author":"Li","year":"2018","journal-title":"Front Pharmacol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/aps.2014.132","article-title":"Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation.","volume":"36","author":"Wu","year":"2015","journal-title":"Acta Pharmacol Sin."},{"key":"B172","doi-asserted-by":"publisher","first-page":"839","DOI":"10.7150\/jca.17657","article-title":"Gambogenic acid synergistically potentiates bortezomib-induced apoptosis in multiple myeloma.","volume":"8","author":"Chen","year":"2017","journal-title":"J Cancer."},{"key":"B173","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.tiv.2017.12.001","article-title":"Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-\u03baB pathways.","volume":"47","author":"Allegra","year":"2018","journal-title":"Toxicol In Vitro."},{"key":"B174","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/ccr3.2735","article-title":"Use of curcumin in multiple myeloma patients intolerant of steroid therapy.","volume":"8","author":"Ramakrishna","year":"2020","journal-title":"Clin Case Rep."},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218148","article-title":"Long-term stabilisation of myeloma with curcumin.","volume":"2017","author":"Zaidi","year":"2017","journal-title":"BMJ Case Rep."},{"key":"B176","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3892\/or.2016.4778","article-title":"Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells.","volume":"36","author":"Han","year":"2016","journal-title":"Oncol Rep."},{"key":"B177","doi-asserted-by":"publisher","first-page":"9679","DOI":"10.2147\/OTT.S268899","article-title":"Lights and shade of next-generation PI3K inhibitors in chronic lymphocytic leukemia.","volume":"13","author":"Visentin","year":"2020","journal-title":"Onco Targets Ther."},{"key":"B178","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/030098589803500601","article-title":"The cell cycle: a review.","volume":"35","author":"Schafer","year":"1998","journal-title":"Vet Pathol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1385\/1-59259-788-2:051","article-title":"Analyzing the G2\/M checkpoint.","volume":"280","author":"Stark","year":"2004","journal-title":"Methods Mol Biol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1177\/1947601913479022","article-title":"Cyclins and cell cycle control in cancer and disease.","volume":"3","author":"Casimiro","year":"2012","journal-title":"Genes Cancer."},{"key":"B181","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.3748\/wjg.v22.i7.2159","article-title":"Pharmacological cyclin dependent kinase inhibitors: implications for colorectal cancer.","volume":"22","author":"Balakrishnan","year":"2016","journal-title":"World J Gastroenterol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"18195","DOI":"10.1074\/jbc.270.31.18195","article-title":"Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.","volume":"270","author":"Aprelikova","year":"1995","journal-title":"J Biol Chem."},{"key":"B183","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/cdd.2015.112","article-title":"An essential role for Ink4 and Cip\/Kip cell-cycle inhibitors in preventing replicative stress.","volume":"23","author":"Quereda","year":"2016","journal-title":"Cell Death Differ."},{"key":"B184","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1128\/MCB.01163-13","article-title":"Genetic characterization of the role of the Cip\/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.","volume":"34","author":"Cerqueira","year":"2014","journal-title":"Mol Cell Biol."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003236","article-title":"Oncogenes and tumor suppressor genes.","volume":"2","author":"Lee","year":"2010","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.610820","article-title":"TP53 mutations in acute myeloid leukemia: still a daunting challenge?","volume":"10","author":"Molica","year":"2021","journal-title":"Front Oncol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/gcc.22936","article-title":"Clinical and genomic characterization of patients diagnosed with the provisional entity acute myeloid leukemia with BCR-ABL1, a Swedish population-based study.","volume":"60","author":"Orsmark-Pietras","year":"2021","journal-title":"Genes Chromosomes Cancer."},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1186\/1747-1028-7-10","article-title":"The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle.","volume":"7","author":"Henley","year":"2012","journal-title":"Cell Div."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026104","article-title":"The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression.","volume":"6","author":"Chen","year":"2016","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-020-00089-x","article-title":"Exploring the multiple roles of guardian of the genome: P53.","volume":"21","author":"Feroz","year":"2020","journal-title":"Egypt J Med Hum Genet."},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-021-00385-3","article-title":"MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail.","volume":"22","author":"Sanford","year":"2021","journal-title":"BMC Mol Cell Biol."},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00124","article-title":"The p53 tumor suppressor in the control of metabolism and ferroptosis.","volume":"9","author":"Gnanapradeepan","year":"2018","journal-title":"Front Endocrinol."},{"key":"B193","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-021-02396-8","article-title":"p53 signaling in cancer progression and therapy.","volume":"21","author":"Marei","year":"2021","journal-title":"Cancer Cell Int."},{"key":"B194","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1177\/1947601911408889","article-title":"Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis.","volume":"2","author":"Rivlin","year":"2011","journal-title":"Genes Cancer."},{"key":"B195","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/humu.10190","article-title":"TP53 in hematological cancer: low incidence of mutations with significant clinical relevance.","volume":"21","author":"Peller","year":"2003","journal-title":"Hum Mutat."},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12030724","article-title":"TP53 Expression and Mutational Analysis in Hematological Malignancy in Jeddah, Saudi Arabia.","volume":"12","author":"Alkhatabi","year":"2022","journal-title":"Diagnostics."},{"key":"B197","doi-asserted-by":"publisher","first-page":"451","DOI":"10.4161\/cbt.19589","article-title":"Cyclin dependent kinases in cancer: potential for therapeutic intervention.","volume":"13","author":"Canavese","year":"2012","journal-title":"Cancer Biol Ther."},{"key":"B198","doi-asserted-by":"publisher","first-page":"953","DOI":"10.4161\/cc.27818","article-title":"Invading cancer cells are predominantly in G0\/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging.","volume":"13","author":"Yano","year":"2014","journal-title":"Cell Cycle."},{"key":"B199","first-page":"5170","article-title":"Cyclin E: a potential treatment target to reverse cancer chemoresistance by regulating the cell cycle.","volume":"12","author":"Pang","year":"2020","journal-title":"Am J Transl Res."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.5197.5197","article-title":"Cyclin D1 promotes survival and chemoresistance by maintaining ATR and CHEK1 signaling in TP53-deficient mantle cell lymphoma cell lines.","volume":"124","author":"Mohanty","year":"2014","journal-title":"Blood."},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-145972","article-title":"Palbociclib and ponatinib suppress acute myeloid leukemia in patient-derived xenograft.","author":"Busa","year":"2021","journal-title":"Blood."},{"key":"B202","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1182\/blood-2015-11-683581","article-title":"Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.","volume":"127","author":"Uras","year":"2016","journal-title":"Blood."},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1608.1608","article-title":"CDK4\/6 Inhibitor palbociclib for treatment of KMT2A-rearranged acute myeloid leukemia: interim analysis of the AMLSG 23-14 Trial.","volume":"128","author":"Fr\u00f6hling","year":"2016","journal-title":"Blood."},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0632-z","article-title":"Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death.","volume":"36","author":"Granato","year":"2017","journal-title":"J Exp Clin Cancer Res."},{"key":"B205","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1080\/01635581.2021.1969417","article-title":"GC-MS profiling and antineoplastic activity of pelargonium inquinans ait leaves on acute leukaemia cell lines U937 and Jurkat.","volume":"74","author":"Izuegbuna","year":"2022","journal-title":"Nutr Cancer."},{"key":"B206","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.jfda.2016.10.015","article-title":"The stimulating effects of polyphenol and protein fractions from jelly fig (Ficus awkeotsang Makino) achenes against proliferation of leukemia cells.","volume":"25","author":"Shih","year":"2017","journal-title":"J Food Drug Anal."},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/371730","article-title":"Polyphenols as key players for the antileukaemic effects of propolis.","volume":"2014","author":"Abubakar","year":"2014","journal-title":"Evid Based Complement Alternat Med."},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030699","article-title":"Molecular basis of resveratrol-induced resensitization of acquired drug-resistant cancer cells.","volume":"14","author":"Choi","year":"2022","journal-title":"Nutrients."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.2174\/1871520611313080003","article-title":"Pomegranate extracts and cancer prevention: molecular and cellular activities.","volume":"13","author":"Syed","year":"2013","journal-title":"Anticancer Agents Med Chem."},{"key":"B210","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1080\/01635581.2012.630155","article-title":"Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia.","volume":"64","author":"Dahlawi","year":"2012","journal-title":"Nutr Cancer."},{"key":"B211","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1136\/jcp.2008.056697","article-title":"Spontaneous remission of T lymphoblastic lymphoma.","volume":"61","author":"Ceesay","year":"2008","journal-title":"J Clin Pathol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.3892\/ol.2018.8112","article-title":"Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells.","volume":"15","author":"Mart\u00ednez-Castillo","year":"2018","journal-title":"Oncol Lett."},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.3892\/or.2021.7962","article-title":"Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT.","volume":"45","author":"Zhou","year":"2021","journal-title":"Oncol Rep."},{"key":"B214","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/nutrit\/nuu064","article-title":"Curcumin and cancer: barriers to obtaining a health claim.","volume":"73","author":"Devassy","year":"2015","journal-title":"Nutr Rev."},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2015.43","article-title":"Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines.","volume":"1","author":"Mahbub","year":"2015","journal-title":"Cell Death Discov."},{"key":"B216","doi-asserted-by":"publisher","first-page":"104877","DOI":"10.18632\/oncotarget.20501","article-title":"Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines.","volume":"8","author":"Mahbub","year":"2017","journal-title":"Oncotarget."},{"key":"B217","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3892\/ijo.2017.4026","article-title":"Butein inhibits NF-\u03baB, AP-1 and Akt activation in adult T-cell leukemia\/lymphoma.","volume":"51","author":"Ishikawa","year":"2017","journal-title":"Int J Oncol."},{"key":"B218","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41380-019-0414-4","article-title":"The kynurenine pathway: a finger in every pie.","volume":"25","author":"Savitz","year":"2020","journal-title":"Mol Psychiatry."},{"key":"B219","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1586\/14737175.2015.1049999","article-title":"What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?.","volume":"15","author":"Davis","year":"2015","journal-title":"Expert Rev Neurother."},{"key":"B220","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2147\/OTT.S119362","article-title":"Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors.","volume":"10","author":"Zulfiqar","year":"2017","journal-title":"Onco Targets Ther."},{"key":"B221","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/icb.2013.43","article-title":"Aryl hydrocarbon receptor signaling regulates NF-\u03baB RelB activation during dendritic-cell differentiation.","volume":"91","author":"Vogel","year":"2013","journal-title":"Immunol Cell Biol."},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00497","article-title":"AhR-mediated, non-genomic modulation of IDO1 function.","volume":"5","author":"Pallotta","year":"2014","journal-title":"Front Immunol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nature14222","article-title":"Chromatin architecture reorganization during stem cell differentiation.","volume":"518","author":"Dixon","year":"2015","journal-title":"Nature."},{"key":"B224","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1128\/IAI.72.5.2723-2730.2004","article-title":"Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis: inhibition and degradation of human indoleamine 2,3-dioxygenase.","volume":"72","author":"Hucke","year":"2004","journal-title":"Infect Immun."},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01051","article-title":"Expression of indoleamine 2,3-dioxygenase induced by IFN-\u03b3 and TNF-\u03b1 as potential biomarker of prostate cancer progression.","volume":"9","author":"Banzola","year":"2018","journal-title":"Front Immunol."},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04366-7","article-title":"Single cell analysis of kynurenine and System L amino acid transport in T cells.","volume":"9","author":"Sinclair","year":"2018","journal-title":"Nat Commun."},{"key":"B227","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells.","volume":"185","author":"Mezrich","year":"2010","journal-title":"J Immunol."},{"key":"B228","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1167\/iovs.10-5793","article-title":"3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival.","volume":"52","author":"Zaher","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B229","doi-asserted-by":"publisher","first-page":"18619","DOI":"10.1073\/pnas.0709261104","article-title":"3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.","volume":"104","author":"Hayashi","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B230","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1039\/c6fo00187d","article-title":"Inhibition of LPS-induced inflammatory mediators by 3-hydroxyanthranilic acid in macrophages through suppression of PI3K\/NF-\u03baB signaling pathways.","volume":"7","author":"Lee","year":"2016","journal-title":"Food Funct."},{"key":"B231","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1158\/0008-5472.CAN-12-3831","article-title":"The endogenous tryptophan metabolite and nad+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.","volume":"73","author":"Sahm","year":"2013","journal-title":"Cancer Res."},{"key":"B232","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1189\/jlb.3A0315-135R","article-title":"The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation.","volume":"99","author":"Prodinger","year":"2016","journal-title":"J Leukoc Biol."},{"key":"B233","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/hep.28282","article-title":"Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.","volume":"63","author":"Yoshio","year":"2016","journal-title":"Hepatology."},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00400","article-title":"A First Plasmodium vivax Natural Infection Induces Increased Activity of the Interferon Gamma-Driven Tryptophan Catabolism Pathway.","volume":"11","author":"Dos Santos","year":"2020","journal-title":"Front Microbiol."},{"key":"B235","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41380-019-0414-4","article-title":"The kynurenine pathway: a finger in every pie.","volume":"25","author":"Savitz","year":"2020","journal-title":"Mol Psychiatry."},{"key":"B236","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1093\/eurheartj\/ehs175","article-title":"The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice.","volume":"33","author":"Zhang","year":"2012","journal-title":"Eur Heart J."},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00151","article-title":"The role of indoleamine-2,3-dioxygenase in cancer development, diagnostics, and therapy.","volume":"9","author":"Horny\u00e1k","year":"2018","journal-title":"Front Immunol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s00262-014-1549-4","article-title":"Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer.","volume":"63","author":"Prendergast","year":"2014","journal-title":"Cancer Immunol Immunother."},{"key":"B239","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00262-008-0513-6","article-title":"IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism.","volume":"58","author":"L\u00f6b","year":"2009","journal-title":"Cancer Immunol Immunother."},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106132","article-title":"IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10.","volume":"177","author":"Fang","year":"2022","journal-title":"Pharmacol Res."},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101573","article-title":"Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process.","volume":"75","author":"Salminen","year":"2022","journal-title":"Ageing Res Rev."},{"key":"B242","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.celrep.2015.08.077","article-title":"Tumor-expressed IDO recruits and activates MDSCs in a treg-dependent manner.","volume":"13","author":"Holmgaard","year":"2015","journal-title":"Cell Rep."},{"key":"B243","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/sj.leu.2404485","article-title":"Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase.","volume":"21","author":"Curti","year":"2007","journal-title":"Leukemia."},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.651687","article-title":"Investigating the role of indoleamine 2,3-dioxygenase in acute myeloid leukemia: a systematic review.","volume":"12","author":"Wells","year":"2021","journal-title":"Front Immunol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1182\/bloodadvances.2021004878","article-title":"An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia.","volume":"6","author":"Ragaini","year":"2022","journal-title":"Blood Adv."},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1186\/2051-1426-1-S1-P172","article-title":"Indoleamine 2,3-dioxygenase-1 (IDO1) expression by childhood acute myeloid leukemias inhibits T-cell production of IFN-\u03b3 and confers an unfavorable prognosis.","author":"Rutella","year":"2013","journal-title":"J Immunother Cancer."},{"key":"B247","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.18632\/oncotarget.1504","article-title":"Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia.","volume":"5","author":"Folgiero","year":"2014","journal-title":"Oncotarget."},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.832263","article-title":"Indoleamine 2, 3-dioxygenase 1 mediates survival signals in chronic lymphocytic leukemia via kynurenine\/aryl hydrocarbon receptor-mediated mcl1 modulation.","volume":"13","author":"Atene","year":"2022","journal-title":"Front Immunol."},{"key":"B249","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1089\/jir.2005.25.20","article-title":"The role of IFN-gamma and TNF-alpha-responsive regulatory elements in the synergistic induction of indoleamine dioxygenase.","volume":"25","author":"Robinson","year":"2005","journal-title":"J Interferon Cytokine Res."},{"key":"B250","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.4049\/jimmunol.0803104","article-title":"Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock.","volume":"182","author":"Jung","year":"2009","journal-title":"J Immunol."},{"key":"B251","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/CJI.0b013e31818ac2f7","article-title":"The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells.","volume":"32","author":"Lee","year":"2009","journal-title":"J Immunother."},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V112.11.1623.1623","article-title":"COX-2 inhibition suppresses the interferon-\u03b3-induced expression of indoleamine 2,3-dioxygenase (IDO) in human leukemia cell lines.","volume":"112","author":"Iachininoto","year":"2008","journal-title":"Blood."},{"key":"B253","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1365-2249.2005.02746.x","article-title":"Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro.","volume":"140","author":"Schroecksnadel","year":"2005","journal-title":"Clin Exp Immunol."},{"key":"B254","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1080\/07315724.2014.907756","article-title":"Coffee extracts suppress tryptophan breakdown in mitogen-stimulated peripheral blood mononuclear cells.","volume":"34","author":"Gostner","year":"2015","journal-title":"J Am Coll Nutr."},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111931","article-title":"Phytochemicals as regulators of Th17\/Treg balance in inflammatory bowel diseases.","volume":"141","author":"Chang","year":"2021","journal-title":"Biomed Pharmacother."},{"key":"B256","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nrc2639","article-title":"Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?.","volume":"9","author":"L\u00f6b","year":"2009","journal-title":"Nat Rev Cancer."},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071714","article-title":"Polyphenols as immunomodulatory compounds in the tumor microenvironment: friends or foes?","volume":"20","author":"Focaccetti","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.807271","article-title":"Targeting tryptophan catabolism in cancer immunotherapy era: challenges and perspectives.","volume":"13","author":"Peyraud","year":"2022","journal-title":"Front Immunol."},{"key":"B259","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bbrc.2012.12.093","article-title":"Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.","volume":"431","author":"Noh","year":"2013","journal-title":"Biochem Biophys Res Commun."},{"key":"B260","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1074\/jbc.M807328200","article-title":"Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.","volume":"284","author":"Jeong","year":"2009","journal-title":"J Biol Chem."},{"key":"B261","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.intimp.2010.04.006","article-title":"COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone row-derived dendritic cells.","volume":"10","author":"Jung","year":"2010","journal-title":"Int Immunopharmacol."},{"key":"B262","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3892\/ol.2012.761","article-title":"(\u2013)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells.","volume":"4","author":"Ogawa","year":"2012","journal-title":"Oncol Lett."},{"key":"B263","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bbrc.2012.10.009","article-title":"Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells.","volume":"429","author":"Chen","year":"2012","journal-title":"Biochem Biophys Res Commun."},{"key":"B264","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.bbrc.2007.01.076","article-title":"(\u2013)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.","volume":"354","author":"Jeong","year":"2007","journal-title":"Biochem Biophys Res Commun."},{"key":"B265","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.3109\/10428194.2015.1128541","article-title":"Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia.","volume":"57","author":"Hara","year":"2016","journal-title":"Leuk Lymphoma."},{"key":"B266","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s12032-010-9459-6","article-title":"Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells.","volume":"28","author":"El Kholy","year":"2011","journal-title":"Med Oncol."},{"key":"B267","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V122.21.4408.4408","article-title":"Combination of indoleamine 2,3-dioxygenase inhibitor and cytotoxic agents is a novel therapeutic option for non-hodgkin lymphoma.","volume":"122","author":"Nakamura","year":"2013","journal-title":"Blood."},{"key":"B268","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S1470-2045(19)30274-8","article-title":"Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301\/KEYNOTE-252): a phase 3, randomised, double-blind study.","volume":"20","author":"Long","year":"2019","journal-title":"Lancet Oncol."},{"key":"B269","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S1470-2045(19)30312-2","article-title":"Echoes of a failure: what lessons can we learn?","volume":"20","author":"Sondak","year":"2019","journal-title":"Lancet Oncol."},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117433","article-title":"Indoximod combined with standard induction chemotherapy is well tolerated and induces a high rate of complete remission with MRD-negativity in patients with newly diagnosed AML: results from a phase 1 trial.","author":"Emadi","year":"2018","journal-title":"Blood."},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002057","article-title":"Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma.","volume":"9","author":"Zakharia","year":"2021","journal-title":"J Immunother Cancer."},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-017-0933-2","article-title":"Targeting TDO in cancer immunotherapy.","volume":"34","author":"Yu","year":"2017","journal-title":"Med Oncol."},{"key":"B273","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.","volume":"18","author":"Platten","year":"2019","journal-title":"Nat Rev Drug Discov."},{"key":"B274","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1158\/2326-6066.CIR-16-0400","article-title":"Constitutive IDO1 expression in human tumors is driven by cyclooxygenase-2 and mediates intrinsic immune resistance.","volume":"5","author":"Hennequart","year":"2017","journal-title":"Cancer Immunol Res."},{"key":"B275","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1146\/annurev-cancerbio-030419-033635","article-title":"Is there a clinical future for IDO1 inhibitors after the failure of epacadostat in melanoma?","volume":"4","author":"Van den Eynde","year":"2020","journal-title":"Annu Rev Cancer Biol."},{"key":"B276","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1080\/01635581.2017.1367940","article-title":"The impact of dietary polyphenols on COX-2 expression in colorectal cancer.","volume":"69","author":"Owczarek","year":"2017","journal-title":"Nutr Cancer."},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103179","article-title":"New phenolic cinnamic acid derivatives as selective COX-2 inhibitors. design, synthesis, biological activity and structure-activity relationships.","volume":"91","author":"Ribeiro","year":"2019","journal-title":"Bioorg Chem."},{"key":"B278","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/j.biopha.2016.11.026","article-title":"Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function.","volume":"84","author":"Lu","year":"2016","journal-title":"Biomed Pharmacother."},{"key":"B279","doi-asserted-by":"publisher","first-page":"81555","DOI":"10.18632\/oncotarget.13146","article-title":"Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of \u03b2-catenin and mTORC1\/2.","volume":"7","author":"Riva","year":"2016","journal-title":"Oncotarget."},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1177\/15347354211002647","article-title":"Immunomodulatory effect of green tea treatment in combination with low-dose chemotherapy in elderly acute myeloid leukemia patients with myelodysplasia-related changes.","volume":"20","author":"Calgarotto","year":"2021","journal-title":"Integr Cancer Ther."},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12940-0","article-title":"A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression.","volume":"7","author":"Mangaonkar","year":"2017","journal-title":"Sci Rep."},{"key":"B282","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/bjh.16710","article-title":"IDO in MDS\/AML disease progression and its role in resistance to azacitidine: a potential new drug target?","volume":"190","author":"Leisch","year":"2020","journal-title":"Br J Haematol."},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000423","article-title":"Immune-based therapies for hematological malignancies: an update by the EHA SWG on immunotherapy of hematological malignancies.","volume":"4","author":"Einsele","year":"2020","journal-title":"HemaSphere."},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010087","article-title":"approved drugs for hematological malignancies-the last decade review.","volume":"14","author":"Sochacka-\u0106wik\u0142a","year":"2021","journal-title":"Cancers."},{"key":"B285","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1517\/13543784.2016.1169273","article-title":"Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia.","volume":"25","author":"Wiernik","year":"2016","journal-title":"Expert Opin Investig Drugs."},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0704-8","article-title":"CDK9 inhibitors in acute myeloid leukemia.","volume":"37","author":"Boffo","year":"2018","journal-title":"J Exp Clin Cancer Res."},{"key":"B287","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3324\/haematol.2015.125849","article-title":"Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine\/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia.","volume":"100","author":"Zeidner","year":"2015","journal-title":"Haematologica."},{"key":"B288","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/ajh.25333","article-title":"A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease.","volume":"94","author":"Litzow","year":"2019","journal-title":"Am J Hematol."},{"key":"B289","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jconrel.2021.03.042","article-title":"Development and characterization of a novel flavopiridol formulation for treatment of acute myeloid leukemia.","volume":"333","author":"Chen","year":"2021","journal-title":"J Control Release."},{"key":"B290","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2174\/1871520620666200918113625","article-title":"Anti-cancer activity of curcumin on multiple myeloma.","volume":"21","author":"Mirzaei","year":"2021","journal-title":"Anticancer Agents Med Chem."},{"key":"B291","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s10552-019-01220-z","article-title":"Green tea consumption and risk of hematologic neoplasms: the Japan collaborative cohort study for evaluation of cancer risk (JACC Study).","volume":"30","author":"Takada","year":"2019","journal-title":"Cancer Causes Control."},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-089243","article-title":"Epigallocathechin-3-gallate in AL amyloidosis: a new therapeutic option?","volume":"110","author":"Hunstein","year":"2007","journal-title":"Blood."},{"key":"B293","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00392-010-0142-x","article-title":"Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis.","volume":"99","author":"Mereles","year":"2010","journal-title":"Clin Res Cardiol."},{"key":"B294","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1182\/blood-2016-01-629790","article-title":"What is new in diagnosis and management of light chain amyloidosis?","volume":"128","author":"Palladini","year":"2016","journal-title":"Blood."},{"key":"B295","doi-asserted-by":"publisher","first-page":"3808","DOI":"10.1200\/JCO.2008.21.1284","article-title":"Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia.","volume":"27","author":"Shanafelt","year":"2009","journal-title":"J Clin Oncol."},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.28.15_suppl.6522","article-title":"Phase II trial of daily, oral green tea extract in patients with asymptomatic, Rai stage 0-II chronic lymphocytic leukemia (CLL).","volume":"28","author":"Shanafelt","year":"2010","journal-title":"J Clin Oncol."},{"key":"B297","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/cncr.27719","article-title":"Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia.","volume":"119","author":"Shanafelt","year":"2013","journal-title":"Cancer."},{"key":"B298","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1182\/blood-2020-136346","article-title":"Effects of green tea on various types of indolent low grade b-cell lymphomas.","volume":"136","author":"Willard","year":"2020","journal-title":"Blood."},{"key":"B299","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1182\/bloodadvances.2020004018","article-title":"Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial.","volume":"5","author":"Orgel","year":"2021","journal-title":"Blood Adv."},{"key":"B300","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1159\/000486361","article-title":"quercetin therapy for selected patients with PIM1 Kinase-positive chronic lymphocytic leukemia\/small lymphocytic lymphoma: a pilot study.","volume":"139","author":"Baron","year":"2018","journal-title":"Acta Haematol."},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010074","article-title":"A phase 1B clinical study of combretastatin A1 diphosphate (OXi4503) and cytarabine (ARA-C) in combination (OXA) for patients with relapsed or refractory acute myeloid leukemia.","volume":"12","author":"Uckun","year":"2019","journal-title":"Cancers."},{"key":"B302","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/cas.14770","article-title":"Curcumin analog B14 has high bioavailability and enhances the effect of anti-breast cancer cells in vitro and in vivo.","volume":"112","author":"Shen","year":"2021","journal-title":"Cancer Sci."},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00614","article-title":"Bioactivities of EF24, a novel curcumin analog: a review.","volume":"8","author":"He","year":"2018","journal-title":"Front Oncol."},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112289","article-title":"apoptosis induced by the curcumin analogue ef-24 is neither mediated by oxidative stress-related mechanisms nor affected by expression of main drug transporters ABCB1 and ABCG2 in human leukemia cells.","volume":"18","author":"Skoupa","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B305","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.intimp.2011.12.009","article-title":"Inhibition of the NF-\u03baB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.","volume":"12","author":"Olivera","year":"2012","journal-title":"Int Immunopharmacol."},{"key":"B306","first-page":"3719","article-title":"Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents with enhanced abilities for multiple myeloma.","volume":"31","author":"Kudo","year":"2011","journal-title":"Anticancer Res."},{"key":"B307","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2174\/1389450117666160112113930","article-title":"Natural polyphenols and their synthetic analogs as emerging anticancer agents.","volume":"18","author":"Colomer","year":"2017","journal-title":"Curr Drug Targets."},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00487","article-title":"Nanocurcumin: a promising candidate for therapeutic applications.","volume":"11","author":"Karthikeyan","year":"2020","journal-title":"Front Pharmacol."},{"key":"B309","first-page":"742","article-title":"Progress in nanomedicine: approved and investigational nanodrugs.","volume":"42","author":"Ventola","year":"2017","journal-title":"P T."},{"key":"B310","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/01635581.2017.1285405","article-title":"Curcumin nanotechnologies and its anticancer activity.","volume":"69","author":"Subramani","year":"2017","journal-title":"Nutr Cancer."},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/424239","article-title":"Novel resveratrol and 5-fluorouracil coencapsulated in PEGylated nanoliposomes improve chemotherapeutic efficacy of combination against head and neck squamous cell carcinoma.","volume":"2014","author":"Mohan","year":"2014","journal-title":"Biomed Res Int."},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1038\/srep22390","article-title":"Combination therapy using co-encapsulated resveratrol and paclitaxel in liposomes for drug resistance reversal in breast cancer cells in vivo.","volume":"6","author":"Meng","year":"2016","journal-title":"Sci Rep."},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.649395","article-title":"Resveratrol-based nanoformulations as an emerging therapeutic strategy for cancer.","volume":"8","author":"Sharifi-Rad","year":"2021","journal-title":"Front Mol Biosci."},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109805","article-title":"Folic acid-functionalized tea polyphenol as a tumor-targeting nano-drug delivery system.","volume":"206","author":"Chuan","year":"2021","journal-title":"Mater Design."},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204764","article-title":"Antibody-drug conjugates for cancer therapy.","volume":"25","author":"Hafeez","year":"2020","journal-title":"Molecules."},{"key":"B316","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s41375-022-01576-3","article-title":"Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial.","volume":"36","author":"Pennesi","year":"2022","journal-title":"Leukemia."},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.3390\/nano11112974","article-title":"CD123-targeted nano-curcumin molecule enhances cytotoxic efficacy in leukemic stem cells.","volume":"11","author":"Nirachonkul","year":"2021","journal-title":"Nanomaterials."},{"key":"B318","doi-asserted-by":"publisher","first-page":"E569","DOI":"10.1002\/ijc.26479","article-title":"Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin.","volume":"131","author":"Langone","year":"2012","journal-title":"Int J Cancer."},{"key":"B319","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phymed.2017.10.020","article-title":"Introduction: novel hybrid combinations containing synthetic or antibiotic drugs with plant-derived phenolic or terpenoid compounds.","volume":"37","author":"Wagner","year":"2017","journal-title":"Phytomedicine."},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-021-00301-9","article-title":"Yousefi B The role of polyphenols in overcoming cancer drug resistance: a comprehensive review.","volume":"27","author":"Dana","year":"2022","journal-title":"Cell Mol Biol Lett."},{"key":"B321","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.2174\/1381612825666190110162529","article-title":"Anticancer hybrid combinations: mechanisms of action, implications and future perspectives.","volume":"24","author":"Dom\u00ednguez-Mart\u00edn","year":"2018","journal-title":"Curr Pharm Des."},{"key":"B322","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.2147\/IJN.S115037","article-title":"Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo.","volume":"11","author":"Zhou","year":"2016","journal-title":"Int J Nanomed."},{"key":"B323","doi-asserted-by":"publisher","first-page":"20839","DOI":"10.3390\/molecules191220839","article-title":"Hybrid curcumin compounds: a new strategy for cancer treatment.","volume":"19","author":"Teiten","year":"2014","journal-title":"Molecules."},{"key":"B324","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.18632\/oncotarget.27068","article-title":"Polyphenols enhance the activity of alkylating agents in leukaemia cell lines.","volume":"10","author":"Mahbub","year":"2019","journal-title":"Oncotarget."},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/383142","article-title":"Integrative oncology: best of both worlds-theoretical, practical, and research issues.","volume":"2013","author":"Cramer","year":"2013","journal-title":"Evid Based Complement Alternat Med."},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188381","article-title":"Gambogic acid: a shining natural compound to nanomedicine for cancer therapeutics.","volume":"1874","author":"Hatami","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer."},{"key":"B327","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.toxlet.2013.11.021","article-title":"The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo.","volume":"224","author":"Liu","year":"2014","journal-title":"Toxicol Lett."},{"key":"B328","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.2147\/IJN.S80795","article-title":"Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in RPMI-8226 cells.","volume":"10","author":"Zhang","year":"2015","journal-title":"Int J Nanomed."},{"key":"B329","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3760\/cma.j.issn.0366-6999.20122582","article-title":"An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors.","volume":"126","author":"Chi","year":"2013","journal-title":"Chin Med J."},{"key":"B330","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.canlet.2017.12.014","article-title":"Therapeutic potential of gambogic acid, a caged xanthone, to target cancer.","volume":"416","author":"Banik","year":"2018","journal-title":"Cancer Lett."},{"key":"B331","doi-asserted-by":"publisher","first-page":"10385","DOI":"10.2147\/IJN.S277645","article-title":"Gambogic acid as a candidate for cancer therapy: a review.","volume":"15","author":"Liu","year":"2020","journal-title":"Int J Nanomedicine."},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092937","article-title":"Research progress in the field of gambogic acid and its derivatives as antineoplastic drugs.","volume":"27","author":"Li","year":"2022","journal-title":"Molecules."},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.711787","article-title":"Effect of gambogic acid-loaded porous-lipid\/PLGA microbubbles in combination with ultrasound-triggered microbubble destruction on human glioma.","volume":"9","author":"Wang","year":"2021","journal-title":"Front Bioeng Biotechnol."},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108428","article-title":"The immunoregulatory function of polyphenols: implications in cancer immunity.","volume":"85","author":"de Carvalho","year":"2020","journal-title":"J Nutr Biochem."},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00729","article-title":"Polyphenols: immunomodulatory and Therapeutic Implication in Colorectal Cancer.","volume":"10","author":"Mileo","year":"2019","journal-title":"Front Immunol."},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0929-6","article-title":"Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.","volume":"37","author":"Xu","year":"2018","journal-title":"J Exp Clin Cancer Res."},{"key":"B337","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.canlet.2021.05.019","article-title":"Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer.","volume":"515","author":"Jiang","year":"2021","journal-title":"Cancer Lett."},{"key":"B338","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.2147\/OTT.S130653","article-title":"Bisdemethoxycurcumin in combination with \u03b1-PD-L1 antibody boosts immune response against bladder cancer.","volume":"10","author":"Shao","year":"2017","journal-title":"Onco Targets Ther."},{"key":"B339","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1871520611313020015","article-title":"Combinations of plant polyphenols & anti-cancer molecules: a novel treatment strategy for cancer chemotherapy.","volume":"13","author":"Mohan","year":"2013","journal-title":"Anticancer Agents Med Chem."},{"key":"B340","first-page":"22","article-title":"Maintenance therapy for B-chronic lymphocytic leukemia.","volume":"9","author":"O\u2019Brien","year":"2011","journal-title":"Clin Adv Hematol Oncol."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.1008893\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T11:12:51Z","timestamp":1728213171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.1008893\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":340,"alternative-id":["10.3389\/fnut.2022.1008893"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.1008893","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"article-number":"1008893"}}