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Nutr."],"abstract":"<jats:sec><jats:title>Scope and aim<\/jats:title><jats:p>Sweet potato is widely consumed as a healthy and nutritive vegetable containing bioactive constituents for health promotion. This study investigated the beneficial impact of white-fleshed sweet potato extract (SPE) on high fat diet (HFD)-induced obese mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>First, SPE, in which resin glycoside was found as the dominant constituent, was suggested as a potential anti-obesity agent, because 20\u201370% pancreatic lipase (PL) inhibition was measured with SPE by <jats:italic>in vitro<\/jats:italic> turbidity assay and pNPP assay. Hence, next, the effect of SPE on obese mice was detected by oral administration of HFD supplemented with 6% SPE on C57BL\/6J mice for 9 weeks. Surprisingly, being the opposite of what was typically observed from a lipase inhibitor such as orlistat, the fecal fat content in SPE-fed obese mice was decreased (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Meanwhile, 6% SPE supplement indeed significantly ameliorated HFD-induced obesity in mice, including body weight gain, fat accumulation, adipocyte enlargement, insulin resistance, and hepatic steatosis (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The improved liver steatosis was found associated with a down-regulating action of SPE on nuclear factor kappa B activation in HFD-fed mice. The anti-obesity influence of SPE was also confirmed on the HepG2 cell model for non-alcoholic fatty liver disease (NAFLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that SPE, as a dietary supplement, has the great potential for weight control and treating hepatic steatosis, possibly through a different action mechanism from that of orlistat.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.1016020","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T06:56:51Z","timestamp":1669273011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Sweet potato extract alleviates high-fat-diet-induced obesity in C57BL\/6J mice, but not by inhibiting pancreatic 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