{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:46:25Z","timestamp":1779378385389,"version":"3.53.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid \u03b2-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.<\/jats:p>","DOI":"10.3389\/fnut.2022.1019205","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T12:52:50Z","timestamp":1667479970000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats"],"prefix":"10.3389","volume":"9","author":[{"given":"Qin","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanlan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1136\/postgradmedj-2019-137221","article-title":"Acupuncture versus sham acupuncture for simple obesity: a systematic review and meta-analysis.","volume":"96","author":"Zhong","year":"2020","journal-title":"Postgrad Med J."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22727-7","article-title":"Emerging concepts in intestinal immune control of obesity-related metabolic disease.","volume":"12","author":"Khan","year":"2021","journal-title":"Nat Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000375143","article-title":"The global burden of obesity and the challenges of prevention.","volume":"66","author":"Seidell","year":"2015","journal-title":"Ann Nutr Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1002\/fsn3.2394","article-title":"Effects of miao sour soup on hyperlipidemia in high-fat diet-induced obese rats via the Ampk signaling pathway.","volume":"9","author":"Yang","year":"2021","journal-title":"Food Sci Nutr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3969\/j.issn.1005-6521.2019.07.027","article-title":"Analysis and research on main nutrition and functional components of KaiLi red acid soup.","volume":"40","author":"Lu","year":"2019","journal-title":"Food Res Dev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1039\/c9fo00580c","article-title":"Let food be your medicine: nutraceutical properties of lycopene.","volume":"10","author":"Grabowska","year":"2019","journal-title":"Food Funct."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20170286","article-title":"Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications.","volume":"37","author":"Zheng","year":"2017","journal-title":"Biosci Rep."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2020.107628","article-title":"Microbial production of limonene and its derivatives: achievements and perspectives.","volume":"44","author":"Ren","year":"2020","journal-title":"Biotechnol Adv."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/biom9110738","article-title":"Therapeutic potential of alpha- and beta-pinene: a miracle gift of nature.","volume":"9","author":"Salehi","year":"2019","journal-title":"Biomolecules."},{"key":"B10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1152\/physiol.00016.2017","article-title":"Lactic acid: no longer an inert and end-product of glycolysis.","volume":"32","author":"Sun","year":"2017","journal-title":"Physiology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbrc.2010.01.095","article-title":"Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats.","volume":"393","author":"Nagai","year":"2010","journal-title":"Biochem Biophys Res Commun."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094691","article-title":"Effect of long-term supplementation with acetic acid on the skeletal muscle of aging Sprague Dawley rats.","volume":"23","author":"Maruta","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1039\/c5fo00531k","article-title":"Anti-obesity activity of the water extract of Lactobacillus Paracasei Subsp. 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