{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:53:24Z","timestamp":1792324404252,"version":"4.4.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Phytochemicals present in <jats:italic>Moringa oleifera<\/jats:italic> (<jats:italic>M. oleifera<\/jats:italic>) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phytochemical and antioxidant potential of <jats:italic>M. oleifera<\/jats:italic> leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussions<\/jats:title><jats:p>The toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with <jats:italic>M. oleifera<\/jats:italic> ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the <jats:italic>M. oleifera<\/jats:italic> treated group in comparison to positive control (hepatotoxic rats). <jats:italic>M. oleifera<\/jats:italic> leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. <jats:italic>M. oleifera<\/jats:italic> leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.1078896","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T04:49:51Z","timestamp":1671079791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic 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