{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:15:36Z","timestamp":1789064136289,"version":"build-2803163510"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Post-stroke dysphagia may cause aspiration pneumonia, malnutrition, dehydration, and other complications. However, data on the effects of nutritional supplementation and its value after stroke are insufficient. We aimed to evaluate the effect of an individualized 1-week nutrition intervention program on swallowing function and nutritional status in stroke patients with oropharyngeal dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study comprised the control group receiving oral nutritional support and continuous nasogastric tube feeding according to the results of the water swallow test (WST). The intervention group additionally underwent a volume-viscosity swallowing test (V-VST) and intermittent oroesophageal tube feeding based on WST. The outcomes were measured after 7 days of intervention, including the improvement of swallowing function assessment by WST, biochemical parameters, such as total serum protein, serum albumin, hemoglobin levels and body composition. This trial was registered with the Chinese Clinical Trial Registry, identifier ChiCTR 2100054054.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 173 participants completed the study between September 1, 2020, and April 30, 2021. Patients receiving individualized nutritional support showed a more significant improvement in the total effective rate of swallowing function (95.3% vs. 85.1%, <jats:italic>P<\/jats:italic> &amp;lt; 0.05). After the intervention, the total serum protein level (0.97 \u00b1 0.41 vs. \u22120.83 \u00b1 0.47 g\/L; <jats:italic>P<\/jats:italic> &amp;lt; 0.05), serum albumin level (0.33 \u00b1 0.28 vs. \u22121.39 \u00b1 0.36 g\/L; <jats:italic>P<\/jats:italic> &amp;lt; 0.001) and lean tissue mass (0.13 \u00b1 0.35 vs. \u22121.00 \u00b1 0.40 g\/L; <jats:italic>P<\/jats:italic> &amp;lt; 0.05) increased in the intervention group. The decrease of hemoglobin levels in the control group was more evident (\u22126.17 \u00b1 1.63 vs. \u22120.64 \u00b1 1.40 g\/L; 95%CI, \u22129.78 to \u22121.28; <jats:italic>P<\/jats:italic> = 0.001). The difference of phase angle between the two groups was statistically significant (5.93 \u00b1 0.88\u00b0 vs. 5.77 \u00b1 0.78\u00b0; <jats:italic>P<\/jats:italic> = 0.035), but not in body fat mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In stroke patients with oropharyngeal dysphagia, the use of individualized nutritional support based on V-VST and intermittent oroesophageal tube feeding during the first week of hospitalization improved swallowing function and maintained nutritional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link>https:\/\/clinicaltrials.gov\/<\/jats:ext-link>, identifier: ChiCTR 2100054054.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.843945","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:52:46Z","timestamp":1649832766000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Individualized Nutritional Support for Hospitalized Patients With Oropharyngeal Dysphagia After Stroke: A Randomized Controlled Trial"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiu-Li","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ni","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","author":"GBD","year":"2021","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1161\/STR.0000000000000098","article-title":"Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"47","author":"Winstein","year":"2016","journal-title":"Stroke."},{"key":"B3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1177\/1747493016639057","article-title":"Post-stroke dysphagia:a review and design considerations for future trials","volume":"11","author":"Cohen","year":"2016","journal-title":"Int J Stroke."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.clnu.2016.07.009","article-title":"Nutritional status of older patients with oropharyngeal dysphagia in a chronic versus an acute clinical situation","volume":"36","author":"Carri\u00f3n","year":"2017","journal-title":"Clin Nutr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/jnnp-2016-313356","article-title":"The association between delays in screening for and assessing dysphagia after acute stroke, and the risk of stroke-associated pneumonia","volume":"88","author":"Bray","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1161\/STROKEAHA.117.018157","article-title":"Early dysphagia screening by trained nurses reduces pneumonia rate in stroke patients: a clinical intervention study","volume":"48","author":"Palli","year":"2017","journal-title":"Stroke."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1111\/jan.13013","article-title":"Systematic review and meta-analysis of the diagnostic accuracy of the water swallow test for screening aspiration in stroke patients","volume":"72","author":"Chen","year":"2016","journal-title":"J Adv Nurs."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.3390\/foods10081900","article-title":"A systematic and a scoping review on the psychometrics and clinical utility of the volume-viscosity swallow test (V-VST) in the clinical screening and assessment of oropharyngeal dysphagia","volume":"10","author":"Riera","year":"2021","journal-title":"Foods."},{"key":"B9","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/s41430-019-0389-x","article-title":"Design and implementation of modified-texture diet in older adults with oropharyngeal dysphagia: a randomized controlled trial","volume":"73","author":"Reyes-Torres","year":"2019","journal-title":"Eur J Clin Nutr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.jocn.2015.03.028","article-title":"Impact of early enteral nutrition on short term prognosis after acute stroke","volume":"22","author":"Zheng","year":"2015","journal-title":"J Clin Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/S0140-6736(18)32776-4","article-title":"Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial","volume":"393","author":"Schuetz","year":"2019","journal-title":"Lancet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke."},{"key":"B13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fneur.2020.00168","article-title":"Positive influence of stroke health manager on risk factors control and medication adherence after ischemic stroke","volume":"11","author":"Yan","year":"2020","journal-title":"Front Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1177\/0148607115621863","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN)","volume":"40","author":"McClave","year":"2016","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3233\/BMR-170788","article-title":"The effect of surface neuromuscular electrical stimulation on patients with post-stroke dysphagia","volume":"31","author":"Meng","year":"2018","journal-title":"J Back Musculoskelet Rehabil."},{"key":"B16","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3969\/j.issn.2096-2479.2018.07.107","article-title":"Application and effectiveness of standardized nutritional interventions in patients with post-stroke swallowing disorder","volume":"3","author":"An","year":"2018","journal-title":"J Clin Nurs Pract."},{"key":"B17","doi-asserted-by":"publisher","first-page":"104602","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104602","article-title":"A comparative study of two tube feeding methods in patients with dysphagia after stroke: a randomized controlled trial","volume":"29","author":"Juan","year":"2020","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7406","DOI":"10.21037\/apm-21-736","article-title":"Intermittent tube feeding for stroke patients with dysphagia: a meta-analysis and systematic review","volume":"10","author":"Wu","year":"2021","journal-title":"Ann Palliat Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"794","DOI":"10.5535\/arm.2016.40.5.794","article-title":"Intermittent oroesophageal tube feeding via the airway in patients with dysphagia","volume":"40","author":"Shin","year":"2016","journal-title":"Ann Rehabil Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/jhn.12185","article-title":"Royal College of Physicians Intercollegiate Stroke Working Party evidence-based guidelines for the nutritional support of patients who have had a stroke","volume":"27","author":"Gomes","year":"2014","journal-title":"J Hum Nutr Diet."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1007\/s00405-018-5167-1","article-title":"The effect of \u201cxanthan gum-based fluid thickener\u201d on hydration, swallowing functions and nutritional status in total maxillectomy patients","volume":"275","author":"Sezgin","year":"2018","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3109\/17549507.2013.830776","article-title":"Intake of thickened liquids by hospitalized adults with dysphagia after stroke","volume":"16","author":"Murray","year":"2014","journal-title":"Int J Speech Lang Pathol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.clnu.2017.09.003","article-title":"ESPEN guideline clinical nutrition in neurology","volume":"37","author":"Burgos","year":"2018","journal-title":"Clin Nutr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1111\/j.1365-2036.2006.03118.x","article-title":"The effect of bolus viscosity on swallowing function in neurogenic dysphagia","volume":"24","author":"Clav\u00e9","year":"2006","journal-title":"Aliment Pharmacol Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1177\/0148607112440285","article-title":"Consensus statement: Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition)","volume":"36","author":"White","year":"2012","journal-title":"JPEN J Parenter Enteral Nutr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/ggi.13854","article-title":"Individualized nutritional treatment for acute stroke patients with malnutrition risk improves functional independence measurement: a randomized controlled trial","volume":"20","author":"Otsuki","year":"2020","journal-title":"Geriatr Gerontol Int."},{"key":"B27","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3969\/j.issn.1672-1756.2019.05.005","article-title":"Practice of multidisciplinary team to improve nutritional outcomes of patients with post-stroke dysphagia","volume":"19","author":"Guo","year":"2019","journal-title":"Chin Nurs Manag."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.843945\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:52:51Z","timestamp":1649832771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.843945\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,13]]},"references-count":27,"alternative-id":["10.3389\/fnut.2022.843945"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.843945","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,13]]},"article-number":"843945"}}