{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:51:47Z","timestamp":1791823907152,"version":"4.3.4"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    <jats:italic>Hericium erinaceus<\/jats:italic>\n                    polysaccharides (HEPs) have attracted widespread attention in regulating gut microbiota (GM). To investigate digestibility and fermentation of HEPs and their effects on GM composition, three polysaccharide fractions, namely, HEP-30, HEP-50, and HEP-70, were fractionally precipitated with 30%, 50%, and 70% ethanol concentrations (v\/v) from hot water-soluble extracts of\n                    <jats:italic>Hericium erinaceus<\/jats:italic>\n                    , respectively. Three kinds of prepared HEPs were structurally characterized and simulated gastrointestinal digestion, and their effects on human fecal microbiota fermentations of male and female and short-chain fatty acid (SCFA) production\n                    <jats:italic>in vitro<\/jats:italic>\n                    were clarified. Under digestive conditions simulating saliva, stomach, and small intestine, HEPs were not significantly influenced and safely reached the distal intestine. After 24 h of\n                    <jats:italic>in vitro<\/jats:italic>\n                    fermentation, the content of SCFAs was significantly enhanced (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05), and the retention rates of total and reducing sugars and pH value were significantly decreased (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05). Thus, HEPs could be utilized by GM, especially HEP-50, and enhanced the relative abundance of SCFA-producing bacteria, e.g.,\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>Butyricicoccus<\/jats:italic>\n                    , and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    . Furthermore, HEPs reduced the relative abundances of opportunistic pathogenic bacteria, e.g.,\n                    <jats:italic>Escherichia-Shigella<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    , and\n                    <jats:italic>Enterobacter<\/jats:italic>\n                    . This study suggests that gradual ethanol precipitation is available for the preparation of polysaccharides from\n                    <jats:italic>Hericium erinaceus<\/jats:italic>\n                    , and the extracted polysaccharide could be developed as functional foods with great development value.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2022.858585","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T05:01:42Z","timestamp":1648702902000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":64,"title":["Digestive Characteristics of Hericium erinaceus Polysaccharides and Their Positive Effects on Fecal Microbiota of Male and Female Volunteers During in vitro Fermentation"],"prefix":"10.3389","volume":"9","author":[{"given":"Baoming","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianguo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongliang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xionge","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangshui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature24460","article-title":"Quantitative 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