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Nutr."],"abstract":"<jats:p>The aging thyroid is associated with a plethora of morphological and functional changes. Limited studies have addressed the gene expression signature in the aging thyroid, except for sporadic reports using data from postmortem samples in the Genotype-Tissue Expression (GTEx) project. In this investigation, we analyzed the RNA sequencing data of 58 samples of normal-appearing counterpart thyroid tissues from The Cancer Genome Atlas. Aging-correlated genes were identified by determining the Spearman rank-order correlation between patient age and gene expression level. Additionally, we performed gene set enrichment analysis and conducted a weighted correlation network analysis. The results were compared with those analyzed using the GTEx data. The over-represented protein class of aging-correlated genes is mainly metabolite interconversion enzymes. Our analyses identified alterations in immune and inflammatory responses, mitochondrial functions, cytoskeletal proteins, as well as amino acid and cytochrome P450 metabolism. There was no significant association between thyroid differentiation and age. Our findings may shed molecular light on thyroid disorders in the geriatric population.<\/jats:p>","DOI":"10.3389\/fnut.2022.859702","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T06:59:01Z","timestamp":1653461941000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcriptomic Characteristics Associated With Aging in the Thyroid Gland"],"prefix":"10.3389","volume":"9","author":[{"given":"Chien-Liang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Nan","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chiung","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1210\/er.2018-00170","article-title":"The aging thyroid: a reappraisal within the geroscience integrated perspective","volume":"40","author":"Franceschi","year":"2019","journal-title":"Endocr Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S2213-8587(18)30026-3","article-title":"The physiology of endocrine systems with ageing","volume":"6","author":"van den Beld","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.21873\/invivo.11657","article-title":"Increasing age hinders the decline in B-type natriuretic peptide following parathyroidectomy in dialysis patients","volume":"33","author":"Chu","year":"2019","journal-title":"In Vivo."},{"key":"B4","doi-asserted-by":"publisher","first-page":"15145","DOI":"10.1038\/srep15145","article-title":"Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases","volume":"5","author":"Yang","year":"2015","journal-title":"Sci Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1089\/thy.2017.0359","article-title":"Transcriptome network analysis reveals aging-related mitochondrial and proteasomal dysfunction and immune activation in human thyroid","volume":"28","author":"Cho","year":"2018","journal-title":"Thyroid."},{"key":"B6","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/s41467-017-02772-x","article-title":"The effects of death and post-mortem cold ischemia on human tissue transcriptomes","volume":"9","author":"Ferreira","year":"2018","journal-title":"Nat Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.surg.2016.12.039","article-title":"Recurrence-associated genes in papillary thyroid cancer: an analysis of data from The Cancer Genome Atlas","volume":"161","author":"Chien","year":"2017","journal-title":"Surgery."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/jso.25670","article-title":"Is papillary thyroid microcarcinoma a biologically different disease? 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