{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:13:23Z","timestamp":1791839603381,"version":"4.3.4"},"reference-count":196,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD). However, various therapeutics and possible drug-drug interactions may also increase the risk of MS by altering lipid and glucose metabolism and promoting weight gain. In addition, the medications cause side effects such as nausea, flatulence, bloating, insomnia, restlessness, asthenia, palpitations, cardiac arrhythmias, dizziness, and blurred vision. Therefore, is important to identify and develop new safe and effective agents based on a multi-target approach to treat and manage MS. Natural products, such as curcumin, have multi-modalities to simultaneously target several factors involved in the development of MS. This review discusses the recent preclinical and clinical findings, and up-to-date meta-analysis from Randomized Controlled Trials regarding the effects of curcumin on MS, as well as the metabonomics and a pharma-metabolomics outlook considering curcumin metabolites, the gut microbiome, and environment for a complementary personalized prevention and treatment for MS management.<\/jats:p>","DOI":"10.3389\/fnut.2022.891339","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T06:42:55Z","timestamp":1654756975000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management"],"prefix":"10.3389","volume":"9","author":[{"given":"Agustina Dwi Retno","family":"Nurcahyanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fonny","family":"Cokro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha P.","family":"Wulanjati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona F.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Sobeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2458-10-529","article-title":"Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model","author":"Scholze","year":"2010","journal-title":"BMC Public Health."},{"key":"B2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/1753944717711379","article-title":"Metabolic syndrome: pathophysiology, management, and modulation by natural compounds","volume":"11","author":"Rochlani","year":"2017","journal-title":"Ther Adv Cardiovasc Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1210\/ER.2008-0024","article-title":"The metabolic syndrome","volume":"29","author":"Cornier","year":"2008","journal-title":"Endocr Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4103\/JRPP.JRPP_17_2","article-title":"Severity of gastrointestinal side effects of metformin tablet compared to metformin capsule in Type 2 Diabetes Mellitus patients","volume":"6","author":"Siavash","year":"2017","journal-title":"J Res Pharm Pract."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1592\/PHCO.21.17.1422.34430","article-title":"Metformin as a cause of late-onset chronic diarrhea","volume":"21","author":"Foss","year":"2001","journal-title":"Pharmacotherapy."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/IJO.2012.144","article-title":"Pharmacotherapy for childhood obesity: present and future prospects","volume":"37","author":"Sherafat-Kazemzadeh","year":"2013","journal-title":"Int J Obes (Lond)."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/FENDO.2017.00006","article-title":"Clinical review of antidiabetic drugs: Implications for Type 2 Diabetes Mellitus management","volume":"8","author":"Chaudhury","year":"2017","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.2337\/DC12-2462\/-\/DC1","article-title":"Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: A 24-week, randomized, placebo-controlled study (GetGoal-Duo 1)","volume":"36","author":"Riddle","year":"2013","journal-title":"Diabetes Care."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40200-015-0184-8","article-title":"Targeting metabolic disorders by natural products","volume":"14","author":"Tabatabaei-Malazy","year":"2015","journal-title":"J Diabetes Metab Disord."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.3109\/13880209.2011.621959","article-title":"Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo","volume":"49","author":"Karou","year":"2011","journal-title":"Pharm Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jep.2019.02.024","article-title":"Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: a review","volume":"235","author":"Chukwuma","year":"2019","journal-title":"J Ethnopharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"T1","DOI":"10.1530\/JOE-13-0327","article-title":"Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models to disease mechanisms","volume":"220","author":"Guo","year":"2014","journal-title":"J Endocrinol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"174079","DOI":"10.1016\/J.EJPHAR.2021.174079","article-title":"Signaling pathway in metabolic disorders: an emerging therapeutic target","volume":"901","author":"Garg","year":"2021","journal-title":"Eur J Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.3390\/NU5051544","article-title":"Non-Alcoholic Fatty Liver Disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease","volume":"5","author":"Gaggini","year":"2013","journal-title":"Nutrients."},{"key":"B15","doi-asserted-by":"publisher","first-page":"422","DOI":"10.5114\/AOMS.2017.68717","article-title":"Natural approaches in metabolic syndrome management","volume":"14","author":"Patti","year":"2018","journal-title":"Arch Med Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3389\/FPHAR.2020.01021","article-title":"Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications","volume":"11","author":"Sharifi-Rad","year":"2020","journal-title":"Front Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.3390\/MOLECULES26134036","article-title":"Curcumin as a natural remedy for atherosclerosis: a pharmacological review","volume":"26","author":"Singh","year":"2021","journal-title":"Molecules."},{"key":"B18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/MEDICINES2030251","article-title":"Modes of action of herbal medicines and plant secondary metabolites","volume":"2","author":"Wink","year":"2015","journal-title":"Medicines."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6.1","DOI":"10.1146\/annurev-food-052720-100326","article-title":"Current understanding of mode of action of multicomponent bioactive phytochemicals: potential for nutraceuticals and antimicrobials","volume":"13","author":"Wink","year":"2022","journal-title":"Annu Rev Food Sci Technol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/ADVANCES\/NMX011","article-title":"The problem of curcumin and its bioavailability: Could its gastrointestinal influence contribute to its overall health-enhancing effects?","volume":"9","author":"Lopresti","year":"2018","journal-title":"Adv Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.3390\/NU11092147","article-title":"Dietary Curcumin: Correlation between bioavailability and health potential","volume":"11","author":"Cas","year":"2019","journal-title":"Nutrients."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4143\/CRT.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res Treat."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2891-13-11","article-title":"Comparative absorption of curcumin formulations","volume":"13","author":"J\u00e4ger","year":"2014","journal-title":"Nutr J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/MNFR.201300724","article-title":"The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes","volume":"58","author":"Schiborr","year":"2014","journal-title":"Mol Nutr Food Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3389\/FPHAR.2016.00485","article-title":"Improvement of oral bioavailability of curcumin upon microencapsulation with methacrylic copolymers","author":"Paolino","year":"2016","journal-title":"Front Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/BPH.13621","article-title":"Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br J Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.2174\/1381612824666180828162053","article-title":"The effects of curcumin on glycemic control and lipid profiles among patients with metabolic syndrome and related disorders: a Systematic Review and Metaanalysis of Randomized Controlled Trials","volume":"24","author":"Tabrizi","year":"2018","journal-title":"Curr Pharm Des."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/PTR.6323","article-title":"Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"33","author":"Azhdari","year":"2019","journal-title":"Phyther Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00580-016-2339-5","article-title":"The effect of curcumin (Curcuma longa L) on circulating levels of adiponectin in patients with metabolic syndrome","volume":"26","author":"Salahshooh","year":"2017","journal-title":"Comp Clin Path."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/NU13020684","article-title":"Effects of curcumin on glycemic control and lipid profile in polycystic ovary syndrome: Systematic review with meta-analysis and trial sequential analysis","volume":"13","author":"Chien","year":"2021","journal-title":"Nutrients."},{"key":"B31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"Targets of curcumin","volume":"12","author":"Zhou","year":"2011","journal-title":"Curr Drug Targets."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.3390\/NU10101553","article-title":"Bioactivity, health benefits, and related molecular mechanisms of curcumin: current progress, challenges, and perspectives","volume":"10","author":"Xu","year":"2018","journal-title":"Nutrients."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/FGENE.2019.00514","article-title":"Curcumin as an alternative epigenetic modulator: mechanism of action and potential effects","volume":"10","author":"Hassan","year":"2019","journal-title":"Front Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/J.JNUTBIO.2010.03.014","article-title":"Epigenetic regulation of high glucose-induced proinflammatory cytokine productionin monocytes by curcumin","volume":"22","author":"Yun","year":"2011","journal-title":"J Nutr Biochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5047","DOI":"10.3390\/IJMS22095047","article-title":"Epigenetics, microRNA and metabolic syndrome: a comprehensive review","volume":"22","author":"Ramzan","year":"2021","journal-title":"Int J Mol Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/MOLECULES20010185","article-title":"Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses","volume":"20","author":"Agarwai","year":"2014","journal-title":"Molecules."},{"key":"B37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/ANNUREV.NUTR.012809.104755","article-title":"Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals","volume":"30","author":"Aggarwal","year":"2010","journal-title":"Annu Rev Nutr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-3-030-64872-5_7","article-title":"Curcumin can bind and interact with CRP: an in silico study","volume":"1308","author":"Shakour","year":"2021","journal-title":"Adv Exp Med Biol."},{"key":"B39","first-page":"141","article-title":"Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research","volume":"14","author":"Jurenka","year":"2009","journal-title":"Altern Med Rev A J Clin Ther."},{"key":"B40","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1002\/PTR.6054","article-title":"Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: review","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phyther Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/BIOF.1074","article-title":"Curcumin and obesity","volume":"39","author":"Bradford","year":"2013","journal-title":"BioFactors."},{"key":"B42","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard","year":"2006","journal-title":"Euro Cytokine Netw."},{"key":"B43","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nat Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/nm.3735","article-title":"Chronic enrichment of hepatic endoplasmic reticulum\u2013mitochondria contact leads to mitochondrial dysfunction in obesity","volume":"20","author":"Arruda","year":"2014","journal-title":"Nat Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/EC-14-0092","article-title":"Mitochondrial dysfunction and insulin resistance: an update","volume":"4","author":"Montgomery","year":"2015","journal-title":"Endocr Connect."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1194\/JLR.M067397","article-title":"Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance","volume":"57","author":"Wang","year":"2016","journal-title":"J Lipid Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/FPHAR.2017.00148","article-title":"Curcumin improves palmitate-induced insulin resistance in human umbilical vein endothelial cells by maintaining proteostasis in endoplasmic reticulum","volume":"8","author":"Ye","year":"2017","journal-title":"Front Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1080\/10408398.2017.1341865","article-title":"The emerging role of curcumin for improving vascular dysfunction: a review","volume":"58","author":"Campbell","year":"2017","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.3892\/MMR.2017.7205","article-title":"Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-\u03baB, ICAM-1, MMP-9 and caspase-3 expression","volume":"16","author":"Li","year":"2017","journal-title":"Mol Med Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/J.PHAREP.2017.07.014","article-title":"Curcumin inhibits cardiac hypertrophy and improves cardiovascular function via enhanced Na +\/Ca 2+ exchanger expression after transverse abdominal aortic constriction in rats","volume":"70","author":"Bai","year":"2018","journal-title":"Pharmacol Reports."},{"key":"B51","first-page":"474","article-title":"Curcumin suppress cardiac fibroblasts activities by regulating proliferation, migration, and the extracellular matrix","volume":"30","author":"Chung","year":"2014","journal-title":"Acta Cardiol Sin."},{"key":"B52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/J.NUT.2016.09.005","article-title":"Tiny molecule, big power: multi-target approach for curcumin in diabetic cardiomyopathy","volume":"34","author":"Karuppagounder","year":"2017","journal-title":"Nutrition."},{"key":"B53","article-title":"New perspectives on how to discover drugs from herbal medicines: CAM'S outstanding contribution to modern therapeutics. Evidence-based complement","volume-title":"Altern Med.","author":"Pan","year":"2013"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1111\/J.1476-5381.2012.01916.X","article-title":"The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients","volume":"166","author":"Polson","year":"2012","journal-title":"Br J Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/J.DRUDIS.2012.03.016","article-title":"Progressing preclinical drug candidates: strategies on preclinical safety studies and the quest for adequate exposure","volume":"17","author":"Higgins","year":"2012","journal-title":"Drug Discov Today."},{"key":"B56","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2014.30","article-title":"You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes","volume-title":"Nutr Diabetes.","author":"Lai","year":"2014"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12986-016-0123-9","article-title":"Animal models of metabolic syndrome: a review","volume":"13","author":"Wong","year":"2016","journal-title":"Nutr Metab (Lond)."},{"key":"B58","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102307","article-title":"Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation","volume-title":"Nutrients.","author":"Wu","year":"2019"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/NU11071542","article-title":"Low-dose curcumin nanoparticles normalise lood pressure in male wistar rats with diet-induced metabolic syndrome","volume":"11","author":"Preez","year":"2019","journal-title":"Nutrients."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-27105-w","article-title":"Dietary intake of curcumin improves eIF2 signaling and reduces lipid levels in the white adipose tissue of obese mice","volume":"8","author":"Kobori","year":"2018","journal-title":"Sci Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/S10787-018-0466-0","article-title":"Curcumin ameliorates palmitate-induced inflammation in skeletal muscle cells by regulating JNK\/NF-kB pathway and ROS production","volume":"26","author":"Sadeghi","year":"2018","journal-title":"Inflammopharmacology."},{"key":"B62","doi-asserted-by":"publisher","first-page":"425","DOI":"10.22074\/CELLJ.2017.4415","article-title":"Anti-inflammatory effects of curcumin on insulin resistance index, levels of interleukin-6, C-Reactive Protein, and liver histology in Polycystic Ovary Syndrome-Induced rats","volume":"19","author":"Mohammadi","year":"2017","journal-title":"Cell J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1139\/CJPP-2016-0152","article-title":"Curcumin improves the metabolic syndrome in high-fructose-diet-fed rats: role of TNF-\u03b1, NF-\u03baB, and oxidative stress","volume":"95","author":"Kelany","year":"2017","journal-title":"Can J Physiol Pharmacol."},{"key":"B64","first-page":"585","article-title":"Protective effect of curcumin in fructose-induced metabolic syndrome and in streptozotocin-induced diabetes in rats","volume":"19","author":"Bulboaca","year":"2016","journal-title":"Iran J Basic Med Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1371\/JOURNAL.PONE.0049976","article-title":"Curcumin as a potent and selective inhibitor of 11\u03b2-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats","author":"Hu","year":"2013","journal-title":"PLoS ONE."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5402\/2012\/957283","article-title":"Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of \u201ccurcumin with piperine and quercetin\u201d","volume":"2012","author":"Kaur","year":"2012","journal-title":"ISRN Pharmacol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1476-511X-9-40","article-title":"Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression","volume":"9","author":"Feng","year":"2010","journal-title":"Lipids Health Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/J.METABOL.2019.154015","article-title":"Curcumin analog CUR5-8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity","author":"Lee","year":"2020","journal-title":"Metabolism."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/NUTRIT\/NUAA114","article-title":"Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials","volume":"79","author":"Ferguson","year":"2021","journal-title":"Nutr Rev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.NUTRES.2018.08.003","article-title":"Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress","volume":"60","author":"Qin","year":"2018","journal-title":"Nutr Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/PTR.6226","article-title":"The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials","volume":"33","author":"Tabrizi","year":"2019","journal-title":"Phytother Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"104280","DOI":"10.1016\/j.phrs.2019.104280","article-title":"Oral turmeric\/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials","volume":"146","author":"White","year":"2019","journal-title":"Pharmacol Res."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/J.CYTO.2021.155541","article-title":"Effect of curcumin on proinflammatory cytokines: a meta-analysis of randomized controlled trials","volume":"143","author":"Gorabi","year":"2021","journal-title":"Cytokine."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1016\/J.DSX.2019.07.045","article-title":"The effect of curcumin supplementation on circulating adiponectin: a systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Clark","year":"2019","journal-title":"Diabetes Metab Syndr Clin Res Rev."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/NU13020404","article-title":"Potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated Type 2 Diabetes-A meta-analysis of Randomized Controlled Trial","volume":"13","author":"Altobelli","year":"2021","journal-title":"Nutrients."},{"key":"B76","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/JHN.12648","article-title":"Efficacy and safety of Rhizoma curcumea longae with respect to improving the glucose metabolism of patients at risk for cardiovascular disease: a meta-analysis of randomised controlled trials","volume":"32","author":"Huang","year":"2019","journal-title":"J Hum Nutr Diet."},{"key":"B77","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/J.PHRS.2017.09.010","article-title":"Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: Systematic review and meta-analysis of randomized controlled trials","volume":"128","author":"de Melo","year":"2018","journal-title":"Pharmacol Res."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHRS.2019.104505","article-title":"The effect of Curcumin\/Turmeric on blood pressure modulation: a systematic review and meta-analysis","volume":"150","author":"Hadi","year":"2019","journal-title":"Pharmacol Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1080\/10408398.2017.1396201","article-title":"Lipid-modifying activity of curcuminoids: a systematic review and meta-analysis of randomized controlled trials","volume":"59","author":"Simental-Mend\u00eda","year":"2019","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B80","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/J.CLNU.2013.09.012","article-title":"A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels","volume":"33","author":"Sahebkar","year":"2014","journal-title":"Clin Nutr."},{"key":"B81","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/S12937-017-0293-Y","article-title":"Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials","author":"Qin","year":"2017","journal-title":"Nutr J."},{"key":"B82","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/10408398.2018.1517724","article-title":"The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials","volume":"60","author":"Mousavi","year":"2020","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B83","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/ADVANCES\/NMZ021","article-title":"A systematic review and meta-analysis of Randomized Controlled Trials on the effects of turmeric and curcuminoids on blood lipids in adults with metabolic diseases","volume":"10","author":"Yuan","year":"2019","journal-title":"Adv Nutr."},{"key":"B84","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3389\/FPHAR.2019.00649","article-title":"The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of Randomized Controlled Trials","volume":"10","author":"Akbari","year":"2019","journal-title":"Front Pharmacol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1515\/hmbci-2013-0053","article-title":"The role of leptin\/adiponectin ratio in metabolic syndrome and diabetes","volume":"18","author":"L\u00f3pez-Jaramillo","year":"2014","journal-title":"Horm Mol Biol Clin Investig."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1186\/S13098-020-00532-4","article-title":"Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome","volume":"12","author":"A","year":"2020","journal-title":"Diabetol Metab Syndr."},{"key":"B87","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1021\/JF802737Z","article-title":"Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells","volume":"57","author":"Lee","year":"2009","journal-title":"J Agric Food Chem."},{"key":"B88","first-page":"4195","article-title":"Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study","volume":"19","author":"Di Pierro","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/POSTGRADMEDJ-2015-133281","article-title":"Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective","volume":"92","author":"Zaccardi","year":"2016","journal-title":"Postgrad Med J."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.2337\/DC12-0116","article-title":"Curcumin extract for prevention of type 2 diabetes","volume":"35","author":"Chuengsamarn","year":"2012","journal-title":"Diabetes Care."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1186\/S13098-019-0437-7","article-title":"The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial","volume":"11","author":"Hodaei","year":"2019","journal-title":"Diabetol Metab Syndr."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/J.PHYMED.2015.10.011","article-title":"Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: the available clinical data","volume":"23","author":"Cicero","year":"2016","journal-title":"Phytomedicine."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ANTIOX10020270","article-title":"Mechanisms of non-alcoholic fatty liver disease in the metabolic syndrome. A narrative review","volume":"10","author":"Rinaldi","year":"2021","journal-title":"Antioxidants."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/J.CTIM.2020.102322","article-title":"Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial","author":"Saberi-Karimian","year":"2020","journal-title":"Complement Ther Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/S00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur J Nutr."},{"key":"B96","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/J.JBMT.2020.02.021","article-title":"Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease","volume":"24","author":"Moradi","year":"2020","journal-title":"J Bodyw Mov Ther."},{"key":"B97","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-3-030-64872-5_3","article-title":"The effect of curcumin phytosome on the treatment of patients with non-alcoholic fatty liver disease: a Double-Blind, Randomized, Placebo-Controlled Trial","volume":"1308","author":"Mirhafez","year":"2021","journal-title":"Adv Exp Med Biol."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/NU10091153","article-title":"Nutraceutical approach to Non-Alcoholic Fatty Liver Disease (NAFLD): the available clinical evidence","volume":"10","author":"Cicero","year":"2018","journal-title":"Nutrients."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1186\/S12876-019-1055-4","article-title":"Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial","volume":"19","author":"Saadati","year":"2019","journal-title":"BMC Gastroenterol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"183","DOI":"10.15403\/JGLD-179","article-title":"Effect of phytosomal curcumin on circulating levels of adiponectin and leptin in patients with Non-Alcoholic Fatty Liver Disease: A randomized, double-blind, placebo-controlled clinical trial","volume":"28","author":"Mirhafez","year":"2019","journal-title":"J Gastrointestin Liver Dis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/S41430-018-0382-9","article-title":"The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease","volume":"73","author":"Saadati","year":"2019","journal-title":"Eur J Clin Nutr."},{"key":"B102","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1055\/S-0043-100019","article-title":"Efficacy and safety of phytosomal curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial","volume":"67","author":"Panahi","year":"2017","journal-title":"Drug Res (Stuttg)."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN-2017-016914","article-title":"Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol","volume":"7","author":"Jazayeri-Tehrani","year":"2017","journal-title":"BMJ Open."},{"key":"B104","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/FJC.0000000000000406","article-title":"Curcumin lowers serum lipids and uric acid in subjects with Nonalcoholic Fatty Liver Disease: a Randomized Controlled Trial","volume":"68","author":"Panahi","year":"2016","journal-title":"J Cardiovasc Pharmacol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5455\/AIM.2017.25.169-174","article-title":"Therapeutic effects of curcumin on ultrasonic morphological characteristics of liver in patients with metabolic syndrome","volume":"25","author":"Selmanovic","year":"2017","journal-title":"Acta Inform Medica."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1038\/S41430-018-0386-5","article-title":"A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial","volume":"73","author":"Chashmniam","year":"2019","journal-title":"Eur J Clin Nutr."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13098-021-00731-7\/TABLES\/4","article-title":"The effect of turmeric on lipid profile, malondialdehyde, liver echogenicity and enzymes among patients with nonalcoholic fatty liver disease: a randomized double blind clinical trial","volume":"13","author":"Jarhahzadeh","year":"2021","journal-title":"Diabetol Metab Syndr."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/PTR.5659","article-title":"Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial","volume":"30","author":"Rahmani","year":"2016","journal-title":"Phytother Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/PTR.6542","article-title":"The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: a systematic review and dose-response meta-analysis of randomized controlled trials","volume":"34","author":"Baziar","year":"2020","journal-title":"Phytother Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1024\/0300-9831\/A000629","article-title":"Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease","volume":"91","author":"Mirhafez","year":"2021","journal-title":"Int J Vitam Nutr Res."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/J.CTIM.2020.102447","article-title":"A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled, clinical trial","volume":"51","author":"Hariri","year":"2020","journal-title":"Complement Ther Med."},{"key":"B112","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/NU13082654","article-title":"Curcumin and biochemical parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)-A Review","author":"R\u00f3za\u0144ski","year":"2021","journal-title":"Nutrients."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/J.CTIM.2019.102283","article-title":"The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials","volume":"48","author":"Jalali","year":"2020","journal-title":"Complement Ther Med."},{"key":"B114","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1017\/S0007114519002484","article-title":"Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease","volume":"123","author":"Cerletti","year":"2020","journal-title":"Br J Nutr."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2019.108938","article-title":"Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease","volume":"115","author":"Gheibi","year":"2019","journal-title":"Biomed Pharmacother."},{"key":"B116","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-3-030-73234-9_2","article-title":"Curcumin and piperine combination for the treatment of patients with Non-Alcoholic Fatty Liver Disease: a double-blind randomized placebo-controlled trial","volume":"1328","author":"Mirhafez","year":"2021","journal-title":"Adv Exp Med Biol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"15989","DOI":"10.1002\/JCB.28877","article-title":"Curcuminoids plus piperine improve nonalcoholic fatty liver disease: a clinical trial","volume":"120","author":"Panahi","year":"2019","journal-title":"J Cell Biochem."},{"key":"B118","first-page":"190","article-title":"Does curcumin have an effect on sleep duration in metabolic syndrome patients?","volume":"11","author":"Saberi-Karimin","year":"2021","journal-title":"Avicenna J Phytomed."},{"key":"B119","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/S12576-017-0571-7","article-title":"Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism","volume":"68","author":"Olechnowicz","year":"2017","journal-title":"J Physiol Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/NU13020548","article-title":"Association of serum levels of zinc, copper, and iron with risk of metabolic syndrome","volume":"13","author":"Lu","year":"2021","journal-title":"Nutrients."},{"key":"B121","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/J.ADDR.2009.02.003","article-title":"Induction of heat shock proteins for protection against oxidative stress","volume":"61","author":"Kalmar","year":"2009","journal-title":"Adv Drug Deliv Rev."},{"key":"B122","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1515\/CCLM.2008.166","article-title":"Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome","volume":"46","author":"Armutcu","year":"2008","journal-title":"Clin Chem Lab Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1080\/19390211.2018.1472711","article-title":"The effect of curcumin on serum copper and zinc and zn\/cu ratio in individuals with metabolic syndrome: a double-blind clinical trial","volume":"16","author":"Safarian","year":"2018"},{"key":"B124","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1080\/19390211.2018.1472710","article-title":"The effects of curcumin on serum heat shock protein 27 antibody titers in patients with metabolic syndrome","volume":"16","author":"Mohammadi","year":"2019","journal-title":"J Diet Suppl."},{"key":"B125","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/J.CLINBIOCHEM.2007.12.008","article-title":"Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease","volume":"41","author":"Alamdari","year":"2008","journal-title":"Clin Biochem."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/PTR.5899","article-title":"The effects of curcumin and curcumin-phospholipid complex on the serum pro-oxidant-antioxidant balance in subjects with metabolic syndrome","volume":"31","author":"Ghazimoradi","year":"2017","journal-title":"Phyther Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/PTR.5779","article-title":"Effects of curcumin on serum vitamin E concentrations in individuals with metabolic syndrome","volume":"31","author":"Mohammadi","year":"2017","journal-title":"Phyther Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"5303","DOI":"10.2147\/IJN.S213831","article-title":"Nanoformulations of natural products for management of metabolic syndrome","volume":"14","author":"Taghipour","year":"2019","journal-title":"Int J Nanomedicine."},{"key":"B129","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1002\/PTR.7109","article-title":"The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial","volume":"35","author":"Bateni","year":"2021","journal-title":"Phyther Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1002\/IJC.24967","article-title":"The dark side of curcumin","volume":"126","author":"Burgos-Mor\u00f3n","year":"2010","journal-title":"Int J Cancer."},{"key":"B131","volume-title":"European Union herbal monograph on Curcuma longa L., rhizoma Final Initial assessment Discussion in Working Party on European Union monographs and European Union list (MLWP).","year":"2018"},{"key":"B132","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/J.CTIM.2014.07.006","article-title":"Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial","volume":"22","author":"Panahi","year":"2014","journal-title":"Complement Ther Med."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.2903\/J.EFSA.2010.1679","article-title":"Scientific opinion on the re-evaluation of curcumin (E 100) as a food additive","volume":"8","year":"2010","journal-title":"EFSA J."},{"key":"B134","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.3390\/molecules16064567","article-title":"Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment","volume":"16","author":"Basnet","year":"2011","journal-title":"Molecules."},{"key":"B135","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.3389\/FPHAR.2021.780330\/BIBTEX","article-title":"Curcuma longa hepatotoxicity: a baseless accusation. Cases assessed for causality using RUCAM method","volume":"12","author":"Stati","year":"2021","journal-title":"Front Pharmacol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2147\/IMCRJ.S333342","article-title":"Turmeric-induced hepatotoxicity: report of 2 cases","volume":"14","author":"Sohal","year":"2021","journal-title":"Int Med Case Rep J."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/6741213","article-title":"Turmeric induced liver injury: a report of two cases","volume":"2019","author":"Luber","year":"2019","journal-title":"Case Reports Hepatol."},{"key":"B138","unstructured":""},{"key":"B139","first-page":"560","article-title":"Personalized medicine: Part 1: evolution and development into theranostics","volume":"35","author":"Vogenberg","year":"2010","journal-title":"Pharm Ther."},{"key":"B140","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/J.JVAL.2013.06.005","article-title":"The faces of personalized medicine: a framework for understanding its meaning and scope","volume":"16","author":"Redekop","year":"2013","journal-title":"Value Health."},{"key":"B141","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/J.CELL.2008.08.026","article-title":"Metabolic phenotyping in health and disease","volume":"134","author":"Holmes","year":"2008","journal-title":"Cell."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/4551054A","article-title":"Systems biology: metabonomics","volume":"455","author":"Nicholson","year":"2008","journal-title":"Nature."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1186\/S13054-016-1222-8","article-title":"Metabonomics and intensive care","volume":"20","author":"Antcliffe","year":"2016","journal-title":"Crit Care."},{"key":"B144","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/J.JDIACOMP.2018.12.002","article-title":"Exploratory metabolomics of nascent metabolic syndrome","volume":"33","author":"Shim","year":"2019","journal-title":"J Diabetes Complications."},{"key":"B145","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4239\/WJD.V10.I1.23","article-title":"Exploratory metabolomics of metabolic syndrome: a status report","volume":"10","author":"Lent-Schochet","year":"2019","journal-title":"World J Diabetes."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-56909-7","article-title":"Metabolomic and lipidomic signatures of metabolic syndrome and its physiological components in adults: a systematic review","volume":"10","author":"Monnerie","year":"2020","journal-title":"Sci Rep."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1021\/ACS.JPROTEOME.7B00116","article-title":"Systems metabolomics for prediction of metabolic syndrome","volume":"16","author":"Pujos-Guillot","year":"2017","journal-title":"J Proteome Res."},{"key":"B148","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3389\/FPHAR.2017.00474\/BIBTEX","article-title":"Metabolomics and integrative omics for the development of Thai traditional medicine","volume":"8","author":"Khoomrung","year":"2017","journal-title":"Front Pharmacol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/FPHAR.2019.00158","article-title":"Emerging applications of metabolomics in traditional chinese medicine treating hypertension: biomarkers, pathways and more","volume":"10","author":"Yang","year":"2019","journal-title":"Front Pharmacol."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1007\/S11306-016-1066-X","article-title":"Pharmacometabolomics informs pharmacogenomics","author":"Neavin","year":"2016","journal-title":"Metabolomics."},{"key":"B151","doi-asserted-by":"publisher","first-page":"e05469","DOI":"10.1016\/J.HELIYON.2020.E05469","article-title":"Reductive metabolites of curcumin and their therapeutic effects","volume":"6","author":"Pandey","year":"2020","journal-title":"Heliyon."},{"key":"B152","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3109\/00498257809069589","article-title":"The metabolism and excretion of curcumin (1,7-Bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat","volume":"8","author":"Holder","year":"2008"},{"key":"B153","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/MP700113R","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol Pharm."},{"key":"B154","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/J.BCP.2007.08.016","article-title":"Curcumin as \u201cCurecumin\u201d: from kitchen to clinic","volume":"75","author":"Goel","year":"2008","journal-title":"Biochem Pharmacol."},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1002\/BMC.4267","article-title":"The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice","volume":"32","author":"Wang","year":"2018","journal-title":"Biomed Chromatogr."},{"key":"B156","article-title":"Biotransformation of curcumin through reduction and glucuronidation in mice","volume":"27","author":"Pan","year":"1999","journal-title":"Drug Metab Dispos."},{"key":"B157","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1016\/S0024-3205(00)00868-7","article-title":"Occurrence of orally administered curcuminoid as glucuronide and glucuronide\/sulfate conjugates in rat plasma","volume":"67","author":"Asai","year":"2000","journal-title":"Life Sci."},{"key":"B158","doi-asserted-by":"publisher","first-page":"6615","DOI":"10.1073\/PNAS.1016217108\/-\/DCSUPPLEMENTAL","article-title":"Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism","volume":"108","author":"Hassaninasab","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B159","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/S12539-011-0090-9","article-title":"Molecular docking studies of curcumin analogs with phospholipase A2","volume":"3","author":"Dileep","year":"2011","journal-title":"Interdiscip Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/J.BIOPHA.2018.04.143","article-title":"Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells","volume":"103","author":"Yu","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1781208","article-title":"Effects of tetrahydrocurcumin on tumor growth and cellular signaling in cervical cancer xenografts in nude mice","author":"Yoysungnoen","year":"2016","journal-title":"Biomed Res Int."},{"key":"B162","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/PNAS.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc Natl Acad Sci."},{"key":"B163","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/NRENDO.2011.126","article-title":"Targeting gut microbiota in obesity: effects of prebiotics and probiotics","volume":"7","author":"Delzenne","year":"2011","journal-title":"Nat Rev Endocrinol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/NRI2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"9418","DOI":"10.1021\/ACSCATAL.1C02017","article-title":"An overview of cytochrome P450 immobilization strategies for drug metabolism studies, biosensing, and biocatalytic applications: challenges and opportunities","volume":"11","author":"Valikhani","year":"2021","journal-title":"ACS Catal."},{"key":"B166","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/J.PHARMTHERA.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol Ther."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.2174\/1389450118666170125144557","article-title":"Cytochrome P450 structure, function and clinical significance: a Review","volume":"19","author":"Manikandan","year":"2018","journal-title":"Curr Drug Targets."},{"key":"B168","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1007\/S00204-020-02936-7","article-title":"Inhibition and induction of CYP enzymes in humans: an update","volume":"94","author":"Hakkola","year":"2020","journal-title":"Arch Toxicol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/tpj.2012.42","article-title":"Pharmacogenomics of phase II metabolizing enzymes and drug transporters: clinical implications","volume":"13","author":"Ch Yiannakopoulou","year":"2012","journal-title":"Pharmacogenomics J."},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.18103\/IMR.V3I11.631","article-title":"Modulation of hepatic drug metabolizing enzymes by the natural polyphenol curcumin","volume":"3","author":"Rosengren","year":"2017","journal-title":"Intern Med Rev."},{"key":"B171","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/S13318-014-0180-2","article-title":"Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects","volume":"40","author":"Al-Jenoobi","year":"2015","journal-title":"Eur J Drug Metab Pharmacokinet."},{"key":"B172","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1124\/DMD.116.073213","article-title":"Curcumin, piperine, and capsaicin: a comparative study of spice-mediated inhibition of human cytochrome P450 isozyme activities","volume":"45","author":"Shamsi","year":"2017","journal-title":"Drug Metab Dispos."},{"key":"B173","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep06587","article-title":"Oral intake of curcumin markedly activated CYP 3A4: in vivo and ex-vivo studies","volume":"4","author":"Hsieh","year":"2014","journal-title":"Sci Rep."},{"key":"B174","first-page":"811","article-title":"Evaluation of liposomal curcumin cytochrome P450 metabolism","volume":"30","author":"Mach","year":"2010","journal-title":"Anticancer Res."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1345\/APH.1M533","article-title":"Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers","volume":"44","author":"Chen","year":"2010","journal-title":"Ann Pharmacother."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1124\/DMD.108.020552","article-title":"Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor","volume":"36","author":"Volak","year":"2008","journal-title":"Drug Metab Dispos."},{"key":"B177","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/0049825031000065197","article-title":"Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues","volume":"33","author":"Vietri","year":"2003","journal-title":"Xenobiotica."},{"key":"B178","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/J.1365-2125.2012.04364.X","article-title":"Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers","volume":"75","author":"Volak","year":"2013","journal-title":"Br J Clin Pharmacol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1177\/0960327114551396","article-title":"Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice","volume":"34","author":"Liu","year":"2015","journal-title":"Hum Exp Toxicol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1016\/J.LFS.2005.09.017","article-title":"Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse","volume":"78","author":"Valentine","year":"2006","journal-title":"Life Sci."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3390\/NU11071613","article-title":"Gut Microbiome: profound implications for diet and disease","volume":"11","author":"Hills","year":"2019","journal-title":"Nutrients."},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2009.08.042","article-title":"High-fat diet determines the composition of the murine gut microbiome independently of obesity","volume":"137","author":"Hildebrandt","year":"2009","journal-title":"Gastroenterology."},{"key":"B183","doi-asserted-by":"publisher","first-page":"11070","DOI":"10.1073\/PNAS.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B184","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/SCIENCE.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science."},{"key":"B185","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/NRGASTRO.2015.47","article-title":"Towards a more comprehensive concept for prebiotics","volume":"12","author":"Bindels","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/J.TIM.2021.01.003","article-title":"Shaping the future of probiotics and prebiotics","volume":"29","author":"Cunningham","year":"2021","journal-title":"Trends Microbiol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/PNAS.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci."},{"key":"B188","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2016","journal-title":"Nat Med."},{"key":"B189","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/J.COPH.2013.09.008","article-title":"Gut microbiota, enteroendocrine functions and metabolism","volume":"13","author":"Cani","year":"2013","journal-title":"Curr Opin Pharmacol."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0108577","article-title":"Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-\/- mice\u2013role of intestinal permeability and macrophage activation","volume":"9","author":"Ghosh","year":"2014","journal-title":"PLoS ONE."},{"key":"B191","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/S13679-015-0172-9","article-title":"Gut microbiota dysbiosis in obesity-linked metabolic diseases and prebiotic potential of polyphenol-rich extracts","volume":"4","author":"Anh\u00ea","year":"2015","journal-title":"Curr Obes Rep."},{"key":"B192","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2515690X18790725","article-title":"Effects of turmeric and curcumin dietary supplementation on human gut microbiota: a double-blind, randomized, placebo-controlled pilot study","volume":"23","author":"Peterson","year":"2018","journal-title":"J Evidence-Based Integr Med."},{"key":"B193","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/S00394-005-0568-5","article-title":"The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites","volume":"45","author":"Silberberg","year":"2006","journal-title":"Eur J Nutr."},{"key":"B194","first-page":"386","article-title":"Role of oxidative stress in pathogenesis of metabolic syndrome","volume":"3","author":"Mahjoub","year":"2012","journal-title":"Casp J Intern Med."},{"key":"B195","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1038\/emm.2013.53","article-title":"Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study","volume":"45","author":"Yubero-Serrano","year":"2013","journal-title":"Exp Mol Med."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J Clin Invest."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.891339\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T06:43:15Z","timestamp":1654756995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.891339\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":196,"alternative-id":["10.3389\/fnut.2022.891339"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.891339","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,9]]},"article-number":"891339"}}