{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:40:02Z","timestamp":1791225602835,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Studies on the effects of synbiotics on obesity in children are limited. The objective of this randomized double-blind placebo-controlled trial was to test the effects of a multispecies synbiotic during 12 weeks on anthropometric measurements, glucose metabolism and lipid parameters in 61 children with exogenous obesity. All children were treated with a standard diet and increased physical activity and received once daily a synbiotic supplement (probiotic mixture including <jats:italic>Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium longum, Enterococcus faecium<\/jats:italic> and fructo-oligosaccharides) or daily placebo for 12 weeks. At baseline, no statistically significant differences existed in anthropometric measurements, glucose and lipid parameters between both groups. We observed changes for anthropometric measures (% reduction comparing to baseline) in both synbiotic and placebo groups. After 12 weeks; changes (% reduction comparing to baseline) in weight (<jats:italic>p<\/jats:italic> &amp;lt; 0.01), BMI (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), waist circumference (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) and waist circumference to height ratio (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) were significantly higher in the children receiving the synbiotic supplement. There is no difference in glucose metabolism, lipid parameters, presence of non-alcoholic fatty liver disease between both groups after 12 weeks. The daily intake of a multispecies synbiotic in addition to diet and increased physical activity did improve anthropometric measurements: body weight, BMI, waist circumference and waist\/height ratio. The supplementation of this synbiotic is an efficient weight-loss strategy above diet and exercise in pediatric obesity (Trial identifier: NCT05162209).<\/jats:p>","DOI":"10.3389\/fnut.2022.898037","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T08:09:00Z","timestamp":1656662940000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of Multispecies Synbiotic Supplementation on Anthropometric Measurements, Glucose and Lipid Parameters in Children With Exogenous Obesity: A Randomized, Double Blind, Placebo-Controlled Clinical Trial (Probesity-2 Trial)"],"prefix":"10.3389","volume":"9","author":[{"given":"Gonca","family":"Kilic Yildirim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Dinleyici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Vandenplas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ener Cagri","family":"Dinleyici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"B1","unstructured":"Obesity and Overweight"},{"key":"B2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The epidemiology of obesity: a big picture","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s12098-017-2531-x","article-title":"Obesity in children: definition, etiology and approach","volume":"85","author":"Aggarwal","year":"2018","journal-title":"Indian J Pediatr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"657020","DOI":"10.3389\/fped.2021.657020","article-title":"Gut microbiota and obesity in adults and children: the state of the art","volume":"9","author":"Petraroli","year":"2021","journal-title":"Front Pediatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.pcl.2018.08.004","article-title":"Childhood obesity and the metabolic syndrome","volume":"66","author":"Nehus","year":"2019","journal-title":"Pediatr Clin North Am."},{"key":"B6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/nu13103627","article-title":"Effects of probiotics and synbiotics on weight loss in subjects with overweight or obesity: a systematic review","volume":"2021","author":"\u00c1lvarez-Arra\u00f1o","year":"3627","journal-title":"Nutrients."},{"key":"B7","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3390\/nu13020666","article-title":"Is probiotic supplementation useful for the management of body weight and other anthropometric measures in adults affected by overweight and obesity with metabolic related diseases? 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