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Nutr."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The first objective of this study was to probe the effects of genkwanin (GKA) on osteoclast. The second goal of this study was to study whether GKA can protect lipopolysaccharide (LPS) and ovariectomized (OVX) induced bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Various concentrations of GKA (1 and 10 mg\/kg) were injected into mice. Different concentrations of GKA (1 and 5 \u03bcM) were used to detect the effects of GKA on osteoclast and osteoblast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Findings<\/jats:title><jats:p>GKA attenuated the osteoclast differentiation promoted by RANKL and expression of marker genes containing <jats:italic>c-fos, ctsk<\/jats:italic> as well as bone resorption related gene <jats:italic>Trap<\/jats:italic> and to the suppression of MAPK signaling pathway. In addition, GKA induced BMMs cell apoptosis <jats:italic>in vitro<\/jats:italic>. Moreover, GKA prevented LPS-induced and ovariectomized-induced bone loss in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our research revealed that GKA had a potential to be an effective therapeutic agent for osteoclast-mediated osteoporosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.921037","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T08:55:12Z","timestamp":1655974512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Genkwanin Prevents Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss"],"prefix":"10.3389","volume":"9","author":[{"given":"Xin","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanning","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling.","volume":"285","author":"Raggatt","year":"2010","journal-title":"J Biol Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"421746","DOI":"10.1155\/2015\/421746","article-title":"Biology of bone tissue: structure, function, and factors that influence bone cells.","volume":"2015","author":"Florencio-Silva","year":"2015","journal-title":"Biomed Res Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.clinbiochem.2012.03.021","article-title":"An overview of the regulation of bone remodelling at the cellular level.","volume":"45","author":"Kular","year":"2012","journal-title":"Clin Biochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases.","volume":"289","author":"Rodan","year":"2000","journal-title":"Science."},{"key":"B5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts.","volume":"6","author":"Han","year":"2018","journal-title":"Bone Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00113-015-0085-9","article-title":"[Regulation of bone metabolism in osteoporosis : novel drugs for osteoporosis in development].","volume":"118","author":"Jakob","year":"2015","journal-title":"Unfallchirurg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/BF01622200","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. 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