{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:04:16Z","timestamp":1791201856179,"version":"4.2.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    Inflammatory bowel disease (IBD) is a chronic disease with multiple complications during its development, and it is difficult to cure. The aim of this study was to evaluate the alleviating effect of different concentrations of the bioactive peptide IQW (Ile-Gln-Trp) on dextran sodium sulfate (DSS)-induced colitis in mice. For this study, we randomly divided 56 ICR mice into seven groups: the (I) control (CON), (II) dextran sodium sulfate treatment (2.5% DSS), (III) IQW-DSS (20 \u03bcg\/ml) treatment, (IV) IQW-DSS (40 \u03bcg\/ml) treatment, (V) IQW-DSS (60 \u03bcg\/ml) treatment, (VI) IQW-DSS (80 \u03bcg\/ml) treatment, and (VII) IQW-DSS (100 \u03bcg\/ml) groups. The results showed that IQW at 60 \u03bcg\/ml alleviated body weight loss, improved the liver index (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05), and improved histomorphological and pathological changes in the colon compared to the DSS-treated group. IQW at 60 \u03bcg\/ml and IQW at 80 \u03bcg\/ml modified intestinal microbial disorders. In addition, IQW at 60 \u03bcg\/ml significantly increased butyric acid levels and decreased valeric acid levels, while IQW at 80 \u03bcg\/ml significantly increased isobutyric acid and isovaleric acid levels. Hence, IQW at a concentration of 60 \u03bcg\/ml alleviates DSS-induced colitis by enhancing the body's anti-inflammatory ability and regulating intestinal flora and metabolic changes. In the above context, IQW at 60 \u03bcg\/ml could be a potential candidate for IBD prevention and treatment.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2022.927363","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:34:25Z","timestamp":1662078865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The mitigative effect of ovotransferrin-derived peptide IQW on DSS-induced colitis via alleviating intestinal injury and reprogramming intestinal microbes"],"prefix":"10.3389","volume":"9","author":[{"given":"Yajuan","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangnan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1136\/gutjnl-2019-320065","article-title":"Big Data in Ibd: Big Progress for Clinical Practice","volume":"69","author":"Seyed Tabib","year":"2020","journal-title":"Gut."},{"key":"B2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11894-019-0705-6","article-title":"Evolving epidemiology of Ibd","volume":"21","author":"Windsor","year":"2019","journal-title":"Curr Gastroenterol Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn's disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell."},{"key":"B7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jaci.2019.11.003","article-title":"The microbiome and inflammatory bowel disease","volume":"145","author":"Glassner","year":"2020","journal-title":"J Allergy Clin Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1080\/1040841X.2021.1876631","article-title":"Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium","volume":"47","author":"Ahlawat","year":"2021","journal-title":"Crit Rev Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00281-014-0454-4","article-title":"The gut microbiota and inflammatory bowel disease","volume":"37","author":"Matsuoka","year":"2015","journal-title":"Semin Immunopathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/biology11010108","article-title":"Association between fecal short-chain fatty acid levels, diet, and body mass index in patients with inflammatory bowel disease","volume":"11","author":"Dabek-Drobny","year":"2022","journal-title":"Biology (Basel)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5582245","DOI":"10.1155\/2021\/5582245","article-title":"Roles of dietary bioactive peptides in redox balance and metabolic disorders","volume":"2021","author":"Qiao","year":"2021","journal-title":"Oxid Med Cell Longev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.2174\/1381612824666180829103945","article-title":"Effects of bioactive peptide on inflammatory bowel disease, focus on signal transduction and intestinal microbiota","volume":"24","author":"Ma","year":"2018","journal-title":"Curr Pharm Des."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6504518","DOI":"10.1155\/2017\/6504518","article-title":"The utility of ovotransferrin and ovotransferrin-derived peptides as possible candidates in the clinical treatment of cardiovascular diseases","volume":"2017","author":"Chen","year":"2017","journal-title":"Oxid Med Cell Longev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1021\/jf3046076","article-title":"Structure and activity study of egg protein ovotransferrin derived peptides (Irw and Iqw) on endothelial inflammatory response and oxidative stress","volume":"61","author":"Majumder","year":"2013","journal-title":"J Agric Food Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"6429845","DOI":"10.1155\/2019\/6429845","article-title":"Irw and Iqw reduce colitis-associated cancer risk by alleviating dss-induced colonic inflammation","volume":"2019","author":"Ma","year":"2019","journal-title":"Biomed Res Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1159\/000495240","article-title":"Effects of Irw and Iqw on oxidative stress and gut microbiota in dextran sodium sulfate-induced colitis","volume":"51","author":"Liu","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1021\/jf505248n","article-title":"Oral administration of hen egg white ovotransferrin attenuates the development of colitis induced by dextran sodium sulfate in mice","volume":"63","author":"Kobayashi","year":"2015","journal-title":"J Agric Food Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1007\/s11427-020-1835-4","article-title":"Potential role of lactobacillus plantarum in colitis induced by dextran sulfate sodium through altering gut microbiota and host metabolism in murine model","volume":"64","author":"Ding","year":"2021","journal-title":"Sci China Life Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3791\/3678","article-title":"Investigating intestinal inflammation in Dss-induced model of Ibd","volume":"11","author":"Kim","year":"2012","journal-title":"J Vis Exp."},{"key":"B22","doi-asserted-by":"publisher","first-page":"727664","DOI":"10.3389\/fimmu.2021.727664","article-title":"Characterization and analysis of the temporal and spatial dynamic of several enteritis modeling methodologies","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/foods9060735","article-title":"Chicken egg proteins and derived peptides with antioxidant properties","volume":"9","author":"Benede","year":"2020","journal-title":"Foods"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e2000461","DOI":"10.1002\/mnfr.202000461","article-title":"An insight into the roles of dietary tryptophan and its metabolites in intestinal inflammation and inflammatory bowel disease","volume":"65","author":"Li","year":"2021","journal-title":"Mol Nutr Food Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/nu10030288","article-title":"L-Glutamine Attenuates Dss-Induced Colitis Via Induction of Mapk Phosphatase-1","volume":"10","author":"Jeong","year":"2018","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","first-page":"270","DOI":"10.17305\/bjbms.2020.5016","article-title":"Dysbiosis of gut microbiota in inflammatory bowel disease: current therapies and potential for microbiota-modulating therapeutic approaches","volume":"21","author":"Alshehri","year":"2021","journal-title":"Bosn J Basic Med Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J Gastroenterol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1097\/MIB.0000000000000382","article-title":"Recent advances in characterizing the gastrointestinal microbiome in Crohn's disease: a systematic review","volume":"21","author":"Wright","year":"2015","journal-title":"Inflamm Bowel Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2752265","DOI":"10.1155\/2021\/2752265","article-title":"Effects of Iqw and Irw on inflammation and gut microbiota in etec-induced diarrhea","volume":"2021","author":"Liu","year":"2021","journal-title":"Mediators Inflamm."},{"key":"B31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3389\/fmicb.2019.00643","article-title":"Egg protein transferrin-derived peptides irw and iqw regulate citrobacter rodentium-induced, inflammation-related microbial and metabolomic profiles","volume":"10","author":"Ma","year":"2019","journal-title":"Front Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/j.1574-6941.2011.01085.x","article-title":"Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species","volume":"76","author":"Munoz-Tamayo","year":"2011","journal-title":"FEMS Microbiol Ecol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.4014\/jmb.2002.02044","article-title":"Fecal microbiota transplantation (Fmt) alleviates experimental colitis in mice by gut microbiota regulation","volume":"30","author":"Zhang","year":"2020","journal-title":"J Microbiol Biotechnol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.resmic.2015.09.006","article-title":"Diet drives quick changes in the metabolic activity and composition of human gut microbiota in a validated in vitro gut model","volume":"167","author":"Aguirre","year":"2016","journal-title":"Res Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s10620-018-5417-5","article-title":"Branched short-chain fatty acid isovaleric acid causes colonic smooth muscle relaxation via camp\/Pka pathway","volume":"64","author":"Blakeney","year":"2018","journal-title":"Dig Dis Sci."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.927363\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:34:28Z","timestamp":1662078868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.927363\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":35,"alternative-id":["10.3389\/fnut.2022.927363"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.927363","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"article-number":"927363"}}