{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:18:22Z","timestamp":1790723902165,"version":"4.1.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>This study aimed to investigate the immunomodulatory activation of low-molecular-weight peptides from monkfish (<jats:italic>Lophius litulon<\/jats:italic>) roe (named MRP) on cyclophosphamide (CTX)-induced immunosuppressed mice. Our results indicated that MRP (100 mg\/kg\/d BW) could significantly increase the body weight and immune organ index, and improve the morphological changes in the spleen and thymus of mice. These effects subsequently enhance the serum levels of interleukin (IL)-6, IL-1\u03b2, tumor necrosis factor (TNF)-\u03b1, and immunoglobulin (Ig) A, IgM, and IgG. Furthermore, MRP could also improve CTX-induced oxidative stress, and activate the NF-\u03baB and MAPK pathways in the spleen tissues. The findings reported herein indicate that MRP has a good immunomodulatory activation toward immunosuppressed mice, hence can potentially be developed as an immune adjuvant or functional food.<\/jats:p>","DOI":"10.3389\/fnut.2022.929105","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T06:44:09Z","timestamp":1663742649000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of low molecular weight peptides from monkfish (Lophius litulon) roe on immune response in immunosuppressed mice"],"prefix":"10.3389","volume":"9","author":[{"given":"Zhexin","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1556\/1886.2019.00016","article-title":"Immunomodulatory and antimicrobial effects of vitamin C","volume":"9","author":"Mousavi","year":"2019","journal-title":"Eur J Microbiol Immu."},{"key":"B2","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.foodchem.2008.07.086","article-title":"Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice","volume":"113","author":"Yang","year":"2009","journal-title":"Food Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/obr.12991","article-title":"Obesity and ageing: two sides of the same coin","volume":"21","author":"Tam","year":"2020","journal-title":"Obes Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e62420","DOI":"10.7554\/eLife.62420","article-title":"The effects of age and systemic metabolism on anti-tumor T cell responses","volume":"9","author":"Drijvers","year":"2020","journal-title":"Elife."},{"key":"B5","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3389\/fimmu.2020.00690","article-title":"Immunomodulatory roles of polysaccharide capsules in the intestine","volume":"11","author":"Hsieh","year":"2020","journal-title":"Front Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev-nutr-120919-094440","article-title":"Nutrition regulates innate immunity in health and disease","volume":"40","author":"Nobs","year":"2020","journal-title":"Annu Rev Nutr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.3389\/fimmu.2020.02143","article-title":"Glucocorticoids regulate circadian rhythm of innate and adaptive immunity","volume":"11","author":"Shimba","year":"2020","journal-title":"Front Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1089\/vim.2021.0042","article-title":"Levamisole therapy in COVID-19","volume":"34","author":"Al-Kuraishy","year":"2021","journal-title":"Viral Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/TP.0000000000003350","article-title":"Thirty years of tacrolimus in clinical practice","volume":"105","author":"Ong","year":"2021","journal-title":"Transplantation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.foodchem.2017.10.087","article-title":"Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: a review","volume":"245","author":"Chalamaiah","year":"2018","journal-title":"Food Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/md18030153","article-title":"Antioxidant peptides from the protein hydrolysate of monkfish (Lophius litulon) muscle: purification, identification, and cytoprotective function on HepG2 cells damage by H2O2","volume":"18","author":"Hu","year":"2020","journal-title":"Mar Drugs."},{"key":"B12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/md20050312","article-title":"Monkfish peptides mitigate high fat diet-induced hepatic steatosis in mice","volume":"20","author":"Ye","year":"2022","journal-title":"Mar Drugs."},{"key":"B13","doi-asserted-by":"publisher","first-page":"129970","DOI":"10.1016\/j.foodchem.2021.129970","article-title":"Structure identification of soybean peptides and their immunomodulatory activity","volume":"359","author":"Wen","year":"2021","journal-title":"Food Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"112111","DOI":"10.1016\/j.fct.2021.112111","article-title":"Isolation, purification and identification of immunologically active peptides from Hericium erinaceus","volume":"151","author":"Yu","year":"2021","journal-title":"Food Chem Toxicol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"103408","DOI":"10.1016\/j.jff.2019.06.010","article-title":"Immunoenhancement effects of pentadecapeptide derived from Cyclina sinensis on immune-deficient mice induced by Cyclophosphamide","volume":"60","author":"Yu","year":"2019","journal-title":"J Funct Foods."},{"key":"B16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/md17010030","article-title":"Purification and characterization of a novel pentadecapeptide from protein hydrolysates of Cyclina sinensis and its immunomodulatory effects on RAW2647","volume":"17","author":"Li","year":"2019","journal-title":"Cells Mar Drugs."},{"key":"B17","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3390\/md18090468","article-title":"Optimization of extraction of bioactive peptides from monkfish (Lophius litulon) and characterization of their role in H2O2-induced lesion","volume":"18","author":"Tian","year":"2020","journal-title":"Mar Drugs."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1039\/D0FO03471A","article-title":"DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet","volume":"12","author":"Zhou","year":"2021","journal-title":"Food Funct."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6643","DOI":"10.1039\/D0FO00971G","article-title":"Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors","volume":"11","author":"Yu","year":"2020","journal-title":"Food Funct."},{"key":"B20","doi-asserted-by":"publisher","first-page":"104085","DOI":"10.1016\/j.jff.2020.104085","article-title":"Ameliorative effect of low molecular weight peptides from the head of red shrimp (Solenocera crassicornis) against cyclophosphamide-induced hepatotoxicity in mice","volume":"72","author":"Jiang","year":"2020","journal-title":"J Funct Foods."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.3390\/molecules24224201","article-title":"Marine collagen peptides promote cell proliferation of NIH-3T3 fibroblasts via NF-\u03baB signaling pathway","volume":"24","author":"Yang","year":"2019","journal-title":"Molecules."},{"key":"B22","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3390\/md16070222","article-title":"Physicochemical properties and biocompatibility evaluation of collagen from the skin of giant croaker (Nibea japonica)","volume":"16","author":"Tang","year":"2018","journal-title":"Mar Drugs."},{"key":"B23","doi-asserted-by":"publisher","first-page":"103888","DOI":"10.1016\/j.jff.2020.103888","article-title":"Immunomodulatory activity of low molecular-weight peptides from Nibea japonica skin in cyclophosphamide-induced immunosuppressed mice","volume":"68","author":"Yu","year":"2020","journal-title":"J Funct Foods."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1002\/jsfa.11602","article-title":"Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury possibly by regulating Nrf2\/HO-1 and TLR4\/NF-kappa B signaling pathways","volume":"102","author":"Tian","year":"2022","journal-title":"J Sci Food Agr."},{"key":"B25","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.procbio.2020.08.011","article-title":"Preparation and purification of an immunoregulatory peptide from Stolephorus chinensis of the east sea of china","volume":"98","author":"Xu","year":"2020","journal-title":"Process Biochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e12572","DOI":"10.1111\/jfbc.12572","article-title":"Molecular interactions, bioavailability, and cellular mechanisms of angiotensin-converting enzyme inhibitory peptides","volume":"43","author":"Fan","year":"2019","journal-title":"J Funct Foods."},{"key":"B27","doi-asserted-by":"publisher","first-page":"103680","DOI":"10.1016\/j.jff.2019.103680","article-title":"Considering food matrix and gastrointestinal effects in enhancing bioactive peptide absorption and bioavailability","volume":"64","author":"Sun","year":"2020","journal-title":"J Funct Foods."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.1039\/C9FO00577C","article-title":"Immunomodulatory effects of pseudostellaria heterophylla peptide on spleen lymphocytes via a Ca2+\/CaN\/NFATc1\/IFN-gamma pathway","volume":"10","author":"Yang","year":"2019","journal-title":"Food Funct."},{"key":"B29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1139\/o01-213","article-title":"Towards a structure-function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides","volume":"80","author":"Vogel","year":"2002","journal-title":"Biochem Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1002\/jsfa.10819","article-title":"The immunomodulatory effects of carapax trionycisultrafine powder on cyclophosphamide-induced immunosuppression in Balb\/c mice","volume":"101","author":"Chen","year":"2021","journal-title":"J Sci Food Agr."},{"key":"B31","doi-asserted-by":"publisher","first-page":"110393","DOI":"10.1016\/j.foodres.2021.110393","article-title":"Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice","volume":"145","author":"Huang","year":"2021","journal-title":"Food Res Int."},{"key":"B32","doi-asserted-by":"publisher","first-page":"130487","DOI":"10.1016\/j.foodchem.2021.130487","article-title":"Effects of co-fermented collagen peptide-jackfruit juice on the immune response and gut microbiota in immunosuppressed mice","volume":"365","author":"Ma","year":"2021","journal-title":"Food Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.procbio.2020.11.016","article-title":"Immune enhancement and antioxidant effects of low molecular-weight peptides derived from Nibea japonica muscles on immune-deficient mice induced by cyclophosphamide","volume":"102","author":"Zeng","year":"2021","journal-title":"Process Biochem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"110756","DOI":"10.1016\/j.foodres.2021.110756","article-title":"Sulfated modification enhances the immunomodulatory effect of Cyclocarya paliurus polysaccharide on cyclophosphamide-induced immunosuppressed mice through MyD88-dependent MAPK\/NF-\u03baB and PI3K-Akt signaling pathways","volume":"150","author":"Yu","year":"2021","journal-title":"Food Res Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"103420","DOI":"10.1016\/j.jff.2019.103420","article-title":"Immunomodulatory effects of collagen hydrolysates from yak (Bos grunniens) bone on cyclophosphamide-induced immunosuppression in BALB\/c mice","volume":"60","author":"Gao","year":"2019","journal-title":"J Funct Foods."},{"key":"B36","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ijbiomac.2020.02.318","article-title":"Mesona chinensis benth polysaccharides protect against oxidative stress and immunosuppression in cyclophosphamide-treated mice via MAPKs signal transduction pathways","volume":"152","author":"Huang","year":"2020","journal-title":"Int J Biol Macromol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1039\/C8FO00269J","article-title":"The immunomodulatory activity and mechanism of docosahexenoic acid (DHA) on immunosuppressive mice models","volume":"9","author":"Han","year":"2018","journal-title":"Food Funct."},{"key":"B38","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3390\/antiox9080745","article-title":"Protective effect of low molecular weight peptides from Solenocera crassicornis head against cyclophosphamide- induced nephrotoxicity in miceviathe Keap1\/Nrf2 Pathway","volume":"9","author":"Jiang","year":"2020","journal-title":"Antioxidants."},{"key":"B39","doi-asserted-by":"publisher","first-page":"117901","DOI":"10.1016\/j.lfs.2020.117901","article-title":"Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway","volume":"256","author":"Lin","year":"2020","journal-title":"Life Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/1753425919838322","article-title":"Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling","volume":"26","author":"Gruber","year":"2020","journal-title":"Innate Immun."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like receptors and the control of immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell."},{"key":"B42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/mc.23271","article-title":"Toll-like receptor-4 deficiency inhibits ultraviolet radiation-induced tumor development by modulation of immune and inflammatory responses","volume":"60","author":"Ahmad","year":"2021","journal-title":"Mol Carcinogen."},{"key":"B43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/imm.12957","article-title":"Toll-like receptor 4 signalling regulates antibody response to adenoviral vector-based vaccines by imprinting germinal centre quality","volume":"155","author":"Li","year":"2018","journal-title":"Immunology."},{"key":"B44","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1039\/D0FO02674C","article-title":"Purification and characterization of immunomodulatory peptides from enzymatic hydrolysates of duck egg ovalbumin","volume":"12","author":"He","year":"2021","journal-title":"Food Funct."},{"key":"B45","doi-asserted-by":"publisher","first-page":"12259","DOI":"10.1021\/acs.jafc.0c04353","article-title":"Isolation, identification, and immunomodulatory effect of a peptide from Pseudostellaria heterophylla protein hydrolysate","volume":"68","author":"Yang","year":"2020","journal-title":"J Agr Food Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"104562","DOI":"10.1016\/j.jff.2021.104562","article-title":"Macrophage immunomodulatory effects of low molecular weight peptides from Mytilus coruscus via NF-\u03baB\/MAPK signaling pathways","volume":"83","author":"He","year":"2021","journal-title":"J Funct Foods."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.929105\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T06:44:11Z","timestamp":1663742651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2022.929105\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":46,"alternative-id":["10.3389\/fnut.2022.929105"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2022.929105","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,21]]},"article-number":"929105"}}