{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:20:06Z","timestamp":1794000006955,"version":"4.8.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Dietary regimens are crucial in the management of non-alcoholic fatty liver disease (NAFLD). The effects of intermittent fasting (IF) have gained attention in this regard, but further research is warranted. Thus, we aimed to ascertain the overall effects of the 5:2 IF diet (5 days a week of normal food intake and 2 consecutive fasting days) in patients with NAFLD compared to a control group (usual diet).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      A 12-week randomized controlled trial was performed to evaluate the effects of the 5:2 IF diet on anthropometric indices, body composition, liver indices, serum lipids, glucose metabolism, and inflammatory markers in patients with NAFLD. The IF group (\n                      <jats:italic>n<\/jats:italic>\n                      = 21) decreased body weight (86.65 \u00b1 12.57\u201382.94 \u00b1 11.60 kg), body mass index (30.42 \u00b1 2.27\u201329.13 \u00b1 1.95 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), waist circumference (103.52 \u00b1 6.42\u2013100.52 \u00b1 5.64 cm), fat mass (26.64 \u00b1 5.43\u201323.85 \u00b1 5.85 kg), fibrosis (6.97 \u00b1 1.94\u20135.58 \u00b1 1.07 kPa), steatosis scores\/CAP (313.09 \u00b1 25.45\u2013289.95 \u00b1 22.36 dB\/m), alanine aminotransferase (41.42 \u00b1 20.98\u201328.38 \u00b1 15.21 U\/L), aspartate aminotransferase (34.19 \u00b1 10.88\u201325.95 \u00b1 7.26 U\/L), triglycerides (171.23 \u00b1 39.88\u2013128.04 \u00b1 34.88 mg\/dl), high-sensitivity C-reactive protein (2.95 \u00b1 0.62 \u22122.40 \u00b1 0.64 mg\/L), and cytokeratin-18 (1.32 \u00b1 0.06\u20131.19 \u00b1 0.05 ng\/ml) values compared to the baseline and the end of the control group (\n                      <jats:italic>n<\/jats:italic>\n                      = 23)\u2014\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.05 were considered as significant. However, the intervention did not change the levels of high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, HOMA-IR, and total antioxidant capacity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adhering to the 5:2 IF diet can reduce weight loss and related parameters (fat mass and anthropometric indicators of obesity), as well as hepatic steatosis, liver enzymes, triglycerides, and inflammatory biomarkers in patients with NAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2022.948655","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T03:03:05Z","timestamp":1658804585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":74,"title":["Effects of the 5:2 intermittent 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