{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:27:13Z","timestamp":1778704033097,"version":"3.51.4"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D has been known to be associated with asthma. However, the association between vitamin D status and asthma, lung function as well as hospitalization among adults remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the role of serum vitamin D in asthma prevalence, lung function, and asthma control in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multivariable logistic regression was applied to assess the relationship between serum vitamin D and asthma prevalence, lung function (FEV1, FVC, and FEV1\/FVC), current wheeze, and asthma-linked hospitalizations in a cross-sectional study of 435,040 adults aged 37\u201373 years old from the UK Biobank.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to vitamin D deficiency, the odds of asthma were decreased by 6.4% [adjusted odds ratio (<jats:italic>aOR<\/jats:italic>) = 0.936; 95% <jats:italic>CI<\/jats:italic>: 0.911\u20130.962; <jats:italic>p<\/jats:italic> &amp;lt; 0.001] and 9.8% (<jats:italic>aOR<\/jats:italic> = 0. 0.902; 95% <jats:italic>CI<\/jats:italic>: 0.877\u20130. 0.927; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) in individuals with insufficient and optimal vitamin D concentration, respectively, in the fully adjusted model. In total asthmatic patients, serum vitamin D was obviously and positively related with FEV1 (\u03b2 = 1.328 ml, 95% <jats:italic>CI<\/jats:italic> = 0.575\u20132.080), FVC (\u03b2 = 2.018 ml, 95% <jats:italic>CI<\/jats:italic> = 1.127\u20132.908), and FEV1\/FVC (\u03b2 = 0.006%, 95% <jats:italic>CI<\/jats:italic> = 0.002\u20130.010). Asthmatic patients whose vitamin D level was in the deficient category had 9.3\u201319.9% higher odds of current wheeze than insufficient categories (<jats:italic>aOR<\/jats:italic> = 0.907; 95% <jats:italic>CI<\/jats:italic>: 0.861\u20130.957; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and optimal categories (<jats:italic>aOR<\/jats:italic> = 0.801; 95% <jats:italic>CI<\/jats:italic>: 0.759\u20130.845; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), but the relationship between vitamin D and asthma hospitalization was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin D deficiency was related to higher odds of asthma and current wheeze, and lower lung function in a large sample size study of British adults. Our results indicate a potential positive impact of serum vitamin D on asthma occurrence and disease control in adults.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.954768","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T07:15:03Z","timestamp":1660115703000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Vitamin D status and asthma, lung function, and hospitalization among British 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