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Nutr."],"abstract":"<jats:p>Nano-selenium (nano-Se) has been extensively explored as a biostimulant for improving the quality of grain crops. However, there are few reports about the effect on the medicinal components of Chinese herbal medicine cultured with nano-Se. Here, we sprayed nano-Se during the cultivation of Panax notoginseng (SePN), and measured the changes of medicinal components compared with conventional Panax notoginseng (PN). Furthermore, we identified a more pronounced effect of SePN on reducing obesity in animals compared with PN. By measuring antioxidant capacity, histopathology, gene expression related to glycolipid metabolism, and gut microbiota composition, we propose a potential mechanism for SePN to improve animal health. Compared with the control groups, foliar spraying of nano-Se increased saponins contents (Rb2, Rb3, Rc, F2, Rb2, and Rf) in the roots of Panax notoginseng, the content of Rb2 increased by 3.9 times particularly. Interestingly, animal studies indicated that taking selenium-rich Panax notoginseng (SePN) can further ameliorate liver antioxidation (SOD, MDA, and GSH) and enzyme activities involved in glycolipid metabolism (ATGL and PFK). It also relieved inflammation and regulated the expression of genes (<jats:italic>MCAD, PPAR-<\/jats:italic>\u03b1, and <jats:italic>PCSK9<\/jats:italic>) related to fatty acid oxidation. The abundance ratio of <jats:italic>Firmicutes\/Bacteroides<\/jats:italic> and beneficial bacteria abundance (<jats:italic>Bifidobacterium, Butyricimonas<\/jats:italic>, and <jats:italic>Parasutterella<\/jats:italic>) in gut microbiota were improved relative to the control. In summary, the application of nano-Se on PN may effectively raise the content of Panax notoginseng saponins (PNS) and immensely lower the risk of metabolic disorders of glycolipids.<\/jats:p>","DOI":"10.3389\/fnut.2022.973027","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T11:36:58Z","timestamp":1661341018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Feeding foliar nano-selenium biofortified panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets"],"prefix":"10.3389","volume":"9","author":[{"given":"Qinyong","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunran","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinuo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijuan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.5455\/njppp.2019.9.1238301012019","article-title":"Prevalence of overweight and obesity among school-going children of Satara district, Maharashtra","volume":"9","author":"Dabade","year":"2019","journal-title":"J Physiol Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.3390\/molecules25194369","article-title":"Distinct influence of hypercaloric diets predominant with fat or fat and sucrose on adipose tissue and liver inflammation in mice","volume":"25","author":"Fonseca","year":"2020","journal-title":"Molecules."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1042\/BCJ20200324","article-title":"Impact of pesticide exposure on adipose tissue development and function","volume":"477","author":"Gutgesell","year":"2020","journal-title":"Biochem J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e13917","DOI":"10.1111\/jfbc.13917","article-title":"Black raspberry (Rubus occidentalis) attenuates inflammatory markers and vascular endothelial dysfunction in Wistar rats fed a high-fat diet with fructose solution","volume":"45","author":"Park","year":"2021","journal-title":"J Food Biochem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/mnfr.201500703","article-title":"Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice","volume":"60","author":"Lecomte","year":"2016","journal-title":"Mol Nutr Food Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"601751","DOI":"10.3389\/fphar.2020.601751","article-title":"Effect of panax notoginseng saponins and major anti-obesity components on weight loss","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0007114521003706","article-title":"Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review","volume":"5","author":"Alharazi","year":"2021","journal-title":"Brit J Nutr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"797310","DOI":"10.1155\/2013\/797310","article-title":"Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes","volume":"2013","author":"Chan","year":"2013","journal-title":"Evid-Based Compl Alt."},{"key":"B9","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jep.2016.05.005","article-title":"Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk)","volume":"188","author":"Wang","year":"2016","journal-title":"FH Chen: a review. 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