{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:31:12Z","timestamp":1790346672172,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>As an immune-modulator, vitamin D is known to regulate immune response and is implicated in disease pathogenesis. Celiac disease (CD) is a systemic autoimmune disease and susceptibility conferred by vitamin D metabolism is under investigation. Studies on the association of vitamin D metabolism and genetic polymorphisms are expected to explain CD pathogenesis. We performed a systematic review\u2013based meta-analysis to investigate the 25(OH)D serum levels and susceptibility conferred by the genetic variants of VDR in CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic review was conducted through a web-based literature search following stringent study inclusion\u2013exclusion criteria. The Newcastle\u2013Ottawa Scale and GRADE tools were used to assess the quality of evidence in studies and the study outcome. Cohen's \u03ba value was estimated to access the reviewer's agreement. RevMan 5.4.1 was used to perform the meta-analyses. Weighted mean difference and Meta <jats:italic>p<\/jats:italic>-value was assessed for 25(OH)D serum levels. Meta-odds ratio and <jats:italic>Z<\/jats:italic>-test <jats:italic>p<\/jats:italic>-value were evaluated to estimate the allelic susceptibility of <jats:italic>VDR<\/jats:italic> variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8 out of 12 studies were evaluated for \u201c25(OH)D\u201d serum level, while four studies were found eligible for SNPs (<jats:italic>Bsm1, Apa1, Fok1<\/jats:italic>, and <jats:italic>Taq1<\/jats:italic>) of <jats:italic>VDR<\/jats:italic>. Significantly higher levels [WMD = 5.49, <jats:italic>p<\/jats:italic> &amp;lt; 0.00001] of 25(OH)D were observed in healthy controls than in patients with CD. rs2228570-T (<jats:italic>Fok1<\/jats:italic>) [Meta-OR = 1.52, <jats:italic>p<\/jats:italic> = 0.02] was confirmed to be predisposing allele for CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced serum level of 25(OH)D and association of <jats:italic>Fok1<\/jats:italic> T-allele of <jats:italic>VDR<\/jats:italic> confirmed in this study plays a critical role in immunomodulation and maintaining barrier integrity, which is majorly implicated in CD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2022.996450","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T08:36:06Z","timestamp":1674117366000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["A meta-analysis suggests the association of reduced serum level of vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin D receptor gene with celiac disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Tanya","family":"Shree","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabyasachi","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-018-0054-z","article-title":"Coeliac disease","volume":"5","author":"Lindfors","year":"2019","journal-title":"Nat. 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