{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:10:56Z","timestamp":1784031056915,"version":"3.55.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The association of vitamin D status with osteoarthritis (OA) has been demonstrated previously. The current study was performed to examine the association of vitamin D status with oxidative stress markers and matrix metalloproteinases (MMPs) in patients with knee OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study was conducted on 124 subjects with mild to moderate knee OA and 65 healthy controls. Demographic data was collected from all participants at baseline. Serum levels of vitamin D as well as markers of oxidative stress including malondialdehyde (MDA), total oxidant status (TOS), superoxide dismutase (SOD), oxidative stress index (OSI), paraoxonase-1 (PON-1), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant capacity (TAC) were evaluated for each participant. Furthermore, serum concentrations of MMP-1, MMP-3, MMP-13, and cartilage oligomeric matrix protein (COMP) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of the present study indicated that individuals with vitamin D insufficiency had higher levels of MDA, TOS, SOD, and OSI as well as lower levels of PON-1 and TAC. Based on the linear regression analysis, serum vitamin D levels were inversely correlated with MDA, TOS, SOD, OSI, MMP-1, and MMP-13 and positively associated with TAC levels (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.0001). Patients with sufficient vitamin D levels had lower MMP-1 and MMP-13 levels compared to patients with vitamin D insufficiency (<jats:italic>p<\/jats:italic> &amp;lt;\u20090.001 and p\u2009&amp;lt;\u20090.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings from this study showed a strong association between vitamin D deficiency and increased oxidative stress and MMPs activity in patients with knee OA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2023.1101516","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T05:53:54Z","timestamp":1675835634000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis"],"prefix":"10.3389","volume":"10","author":[{"given":"Farshad","family":"Amirkhizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mojtaba","family":"Ghoreishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudabeh","family":"Hamedi-Shahraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayyeh","family":"Asghari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1756-185X.2011.01615.x","article-title":"Osteoarthritis of the knees in the COPCORD world","volume":"14","author":"Haq","year":"2011","journal-title":"Int J Rheum Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3109\/00365513.2012.687116","article-title":"Paraoxonase-1 activity and oxidative status in patients with knee osteoarthritis and their relationship with radiological and clinical parameters","volume":"72","author":"Ert\u00fcrk","year":"2012","journal-title":"Scand J Clin Lab Invest"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.semarthrit.2009.06.001","article-title":"Commentary: Is it useful to subset primary osteoarthritis? A critique based on evidence regarding the etiopathogenesis of osteoarthritis","volume":"39","author":"Brandt","year":"2009","journal-title":"Sem Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/art.40515","article-title":"Emerging treatment models in rheumatology: challenges for osteoarthritis trials","volume":"70","author":"Felson","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1093\/rheumatology\/kei049","article-title":"The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of individuals living with this condition","volume":"44","author":"Gupta","year":"2005","journal-title":"Rheumatology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/ard.60.2.91","article-title":"Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care","volume":"60","author":"Peat","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1002\/oby.20835","article-title":"Body mass index and knee osteoarthritis risk: a dose-response meta-analysis","volume":"22","author":"Zhou","year":"2014","journal-title":"Obesity"},{"key":"ref9","first-page":"2271","article-title":"Prevalence of knee osteoarthritis in the United States: arthritis data from the third National Health and nutrition examination survey 1991\u20131994","volume":"33","author":"Dillon","year":"2006","journal-title":"J Rheumatol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.bbadis.2016.01.003","article-title":"ROS\/oxidative stress signaling in osteoarthritis","volume":"1862","author":"Lepetsos","year":"2016","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref13","first-page":"44","article-title":"The role of aging in the development of osteoarthritis","volume":"128","author":"Loeser","year":"2017","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00296-006-0247-8","article-title":"Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis","volume":"27","author":"Altindag","year":"2007","journal-title":"Rheumatol Int"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.cotox.2018.01.002","article-title":"On the history of oxidative stress: concept and some aspects of current development","volume":"7","author":"Sies","year":"2018","journal-title":"Curr Opini Toxicol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.joca.2017.07.020","article-title":"Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes","volume":"26","author":"Ansari","year":"2018","journal-title":"Osteoarthr Cartil"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","article-title":"Reactive oxygen species and superoxide dismutases: role in joint diseases","volume":"74","author":"Afonso","year":"2007","journal-title":"Joint Bone Spine"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.jnutbio.2012.04.001","article-title":"Dietary polyphenols and mechanisms of osteoarthritis","volume":"23","author":"Shen","year":"2012","journal-title":"J Nutr Biochem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1002\/art.21387","article-title":"Extracellular superoxide dismutase and oxidant damage in osteoarthritis","volume":"52","author":"Regan","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1093\/jn\/135.9.2096","article-title":"Punica granatum L. extract inhibits IL-1\u03b2\u2013induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-\u03baB in human chondrocytes in vitro","volume":"135","author":"Ahmed","year":"2005","journal-title":"J Nutr"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1038\/jid.2008.116","article-title":"Infrared radiation-induced matrix metalloproteinase in human skin: implications for protection","volume":"128","author":"Schroeder","year":"2008","journal-title":"J Investig Dermatol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1161\/STROKEAHA.107.488189","article-title":"Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the biomarker evaluation for antioxidant therapies in stroke (BEAT-stroke) study","volume":"39","author":"Kelly","year":"2008","journal-title":"Stroke"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.resp.2010.08.019","article-title":"Redox-control of matrix metalloproteinase-1: a critical link between free radicals, matrix remodeling and degenerative disease","volume":"174","author":"Kar","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1046\/j.1359-4117.2002.01032.x","article-title":"Inhibitory effect of vitamin D3 on 3\u2032 methyl-4-dimethyl-amino-azobenzene-induced rat hepatocarcinogenesis: a study on antioxidant Defense enzymes","volume":"2","author":"Karmakar","year":"2002","journal-title":"J Exp Ther Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0271-5317(99)00141-4","article-title":"Vitamin D3 as a modulator of cellular antioxidant defence in murine lymphoma","volume":"20","author":"Mukhopadhyay","year":"2000","journal-title":"Nutr Res"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s00403-014-1494-2","article-title":"Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers","volume":"306","author":"L\u00f3pez-L\u00f3pez","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/art.24486","article-title":"Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort study","volume":"60","author":"Ding","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1093\/rheumatology\/ket132","article-title":"Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review","volume":"52","author":"Cao","year":"2013","journal-title":"Rheumatology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.redox.2014.01.024","article-title":"Vitamin D deficiency associates with \u03b3-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis","volume":"2","author":"Barker","year":"2014","journal-title":"Redox Biol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3233\/BMR-160589","article-title":"Do vitamin D levels affect the clinical prognoses of patients with knee osteoarthritis?","volume":"30","author":"Alkan","year":"2017","journal-title":"J Back Musculoskelet Rehabil"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.3945\/jn.114.193227","article-title":"Vitamin D deficiency is associated with progression of knee osteoarthritis","volume":"144","author":"Zhang","year":"2014","journal-title":"J Nutr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.apme.2017.01.011","article-title":"Association of vitamin D and knee osteoarthritis\u2013a review","volume":"14","author":"Vaishya","year":"2017","journal-title":"Apollo Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s12640-015-9584-2","article-title":"Evaluation of delta-aminolevulinic dehydratase activity, oxidative stress biomarkers, and vitamin D levels in patients with multiple sclerosis","volume":"29","author":"Polachini","year":"2016","journal-title":"Neurotox Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s12020-014-0336-5","article-title":"Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A Randomized clinical trial","volume":"47","author":"Sharifi","year":"2014","journal-title":"Endocrine"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.jpeds.2012.04.046","article-title":"Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children","volume":"161","author":"Codo\u00f1er-Franch","year":"2012","journal-title":"J Pediatr"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.clnesp.2021.07.032","article-title":"Vitamin D status and systemic redox biomarkers in adults with obesity","volume":"45","author":"Asghari","year":"2021","journal-title":"Clin Nutr ESPEN"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1080\/19390211.2019.1577935","article-title":"When and how to diagnose and treat vitamin D deficiency in adults: a practical and clinical update","volume":"17","author":"Aoun","year":"2020","journal-title":"J Diet Suppl"},{"key":"ref41","first-page":"494","article-title":"Radiological assessment of osteoarthritis of the hip joint and acetabular dysplasia in osteoarthritis","volume":"16","author":"Smith","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.5829\/idosi.wasj.2012.18.08.754","article-title":"The Iranian version of international physical activity questionnaire (IPAQ) in Iran: content and construct validity, factor structure, internal consistency and stability","volume":"18","author":"Moghaddam","year":"2012","journal-title":"World Appl Sci J"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0076-6879(99)99005-5","article-title":"[2] ferric reducing\/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration","volume":"299","author":"Benzie","year":"1999","journal-title":"Methods Enzymol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1017\/S1751731113000396","article-title":"Oxidative stress index (OSi) as a new tool to assess redox status in dairy cattle during the transition period","volume":"7","author":"Abuelo","year":"2013","journal-title":"Animal"},{"key":"ref47","volume-title":"National Institutes of Health, Office of Dietary Supplements: Vitamin D fact sheet for consumers","year":"2021"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3390\/nu2070693","article-title":"Vitamin D and bone health: potential mechanisms","volume":"2","author":"Laird","year":"2010","journal-title":"Nutrients"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jcot.2018.05.012","article-title":"Does vitamin D deficiency influence the incidence and progression of knee osteoarthritis?\u2013a literature review","volume":"10","author":"Vaishya","year":"2019","journal-title":"J Clin Orthop Trauma"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1080\/10408398.2018.1546671","article-title":"Vitamin D status, oxidative stress, and inflammation in children and adolescents: a systematic review","volume":"60","author":"Filgueiras","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1155\/MI.2005.210","article-title":"Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in vitro","volume":"2005","author":"Kobayashi","year":"2005","journal-title":"Mediat Inflamm"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"418","DOI":"10.5312\/wjo.v11.i10.418","article-title":"Association of vitamin D and knee osteoarthritis in younger individuals","volume":"11","author":"Tripathy","year":"2020","journal-title":"World J Orthop"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1055\/a-1098-8815","article-title":"Association between vitamin D and knee osteoarthritis: a PRISMA-compliant meta-analysis","volume":"159","author":"Yu","year":"2020","journal-title":"Z Orthop Unfall"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.nut.2014.02.024","article-title":"Vitamin D status and its association with adiposity and oxidative stress in schoolchildren","volume":"30","author":"Zhang","year":"2014","journal-title":"Nutrition"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.nut.2015.09.016","article-title":"Profile of oxidative stress markers is dependent on vitamin D levels in patients with chronic hepatitis C","volume":"32","author":"de Almeida","year":"2016","journal-title":"Nutrition"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.atherosclerosis.2012.12.013","article-title":"Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes","volume":"227","author":"Yiu","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1365-2567.2008.03024.x","article-title":"1\u03b1, 25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by mycobacterium tuberculosis infection","volume":"127","author":"Coussens","year":"2009","journal-title":"Immunology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4046\/trd.2014.77.2.73","article-title":"Vitamin D inhibits expression and activity of matrix metalloproteinase in human lung fibroblasts (HFL-1) cells","volume":"77","author":"Kim","year":"2014","journal-title":"Tuberc Respir Dis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.kjms.2015.02.001","article-title":"Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis","volume":"31","author":"Wang","year":"2015","journal-title":"Kaohsiung J Med Sci"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2325967117711376","DOI":"10.1177\/2325967117711376","article-title":"Vitamin D and its effects on articular cartilage and osteoarthritis","volume":"5","author":"Garfinkel","year":"2017","journal-title":"Orthop J Sports Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/ajh\/hpt160","article-title":"Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic rats","volume":"27","author":"Nakai","year":"2014","journal-title":"Am J Hypertens"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/icb\/icq034","article-title":"Nrf2, a guardian of healthspan and gatekeeper of species longevity","volume":"50","author":"Lewis","year":"2010","journal-title":"Integr Comp Biol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.1210\/en.2013-1242","article-title":"Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells","volume":"154","author":"Holmes","year":"2013","journal-title":"Endocrinology"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2013.05.002","article-title":"SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage","volume":"63","author":"Tseng","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"C135","DOI":"10.1152\/ajpcell.00188.2017","article-title":"Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia)","volume":"314","author":"Berridge","year":"2018","journal-title":"Am J Phys Cell Phys"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1101516\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T05:53:59Z","timestamp":1675835639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1101516\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":66,"alternative-id":["10.3389\/fnut.2023.1101516"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2023.1101516","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,8]]},"article-number":"1101516"}}