{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:41:28Z","timestamp":1788234088792,"version":"build-2803163510"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is a leading cause of cirrhosis and hepatocellular carcinoma. Due to its complex pathophysiology, there is currently no approved therapy. Polysaccharide, a kind of natural product, possesses a wide range of pharmacological activities. Numerous preclinical studies have confirmed that polysaccharides could interfere with the occurrence and development of NAFLD at multiple interrelated levels, such as improvement of glucose and lipid metabolism, antioxidation, anti-inflammation, and regulation of gut-liver axis, thus showing great potential as novel anti-NAFLD drugs. In this paper, we reviewed the polysaccharides with anti-NAFLD effect in recent years, and also systematically analyzed their possible pharmacological mechanisms.<\/jats:p>","DOI":"10.3389\/fnut.2023.1107551","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T23:42:00Z","timestamp":1678405320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"Yu-long","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/s2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/14728214.2016.1220533","article-title":"Promising therapies for treatment of nonalcoholic steatohepatitis","volume":"21","author":"Noureddin","year":"2016","journal-title":"Expert Opin Emerg Drugs"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1016\/j.apsb.2022.05.001","article-title":"Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: a promising drug Potentilla discolor Bunge","volume":"12","author":"Ji","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","article-title":"Current and future pharmacological therapies for NAFLD\/NASH","volume":"53","author":"Sumida","year":"2018","journal-title":"J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.4254\/wjh.v14.i9.1718","article-title":"Therapies for non-alcoholic fatty liver disease: a 2022 update","volume":"14","author":"Shen","year":"2022","journal-title":"World J Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"879111","DOI":"10.3389\/fnut.2022.879111","article-title":"Therapeutic prospects of polysaccharides for ovarian cancer","volume":"9","author":"Wang","year":"2022","journal-title":"Front Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"868657","DOI":"10.3389\/fnut.2022.868657","article-title":"Anti-inflammatory effect of a novel pectin polysaccharide from Rubus chingii Hu on colitis mice","volume":"9","author":"Kong","year":"2022","journal-title":"Front Nutr"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ijbiomac.2020.02.315","article-title":"An insight into anti-inflammatory effects of natural polysaccharides","volume":"153","author":"Hou","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"120953","DOI":"10.1016\/j.lfs.2022.120953","article-title":"Natural polysaccharides as potential anti-fibrotic agents: a review of their progress","volume":"308","author":"Wang","year":"2022","journal-title":"Life Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.numecd.2008.12.015","article-title":"Hepatic lipid metabolism and non-alcoholic fatty liver disease","volume":"19","author":"Tessari","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41392-022-01073-0","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"105195","DOI":"10.1016\/j.jff.2022.105195","article-title":"Protective effects of polysaccharide from Artocarpus heterophyllus lam. 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