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The non-linear dose-response relationship between selenium status and health effects is U-shaped; individuals with low baseline selenium levels may benefit from supplementation, whereas those with acceptable or high selenium levels may face possible health hazards. Selenium supplementation is beneficial in various populations and conditions; however, given its small safety window, the safety of selenium supplementation is still a subject of debate. This review summarizes the current understanding of the health-promoting effects of selenium on the human body, the dietary reference intake, and evidence of the association between selenium deficiency and disease.<\/jats:p>","DOI":"10.3389\/fnut.2023.1136458","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:42:54Z","timestamp":1678927374000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":110,"title":["Review on the health-promoting effect of adequate selenium status"],"prefix":"10.3389","volume":"10","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhineng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"B1","first-page":"199","article-title":"Letter from Mr. Berzelius to Mr. Berthollet on two new metals.","volume":"7","author":"Berzelius","year":"2021","journal-title":"Ann Chim Phys."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102258","article-title":"Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics.","volume":"29","author":"Toubhans","year":"2020","journal-title":"Nanomedicine."},{"key":"B3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12951-017-0276-3","article-title":"Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation.","volume":"15","author":"Sonkusre","year":"2017","journal-title":"J Nanobiotechnol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00204-009-0505-0","article-title":"In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review.","volume":"84","author":"Valdiglesias","year":"2010","journal-title":"Arch Toxicol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/S0167-5699(98)01294-8","article-title":"Selenium: an essential element for immune function.","volume":"19","author":"McKenzie","year":"1998","journal-title":"Immunol Today."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease.","volume":"14","author":"Fairweather-Tait","year":"2011","journal-title":"Antioxid Redox Signal."},{"key":"B7","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2015.00136","article-title":"Biofortification and phytoremediation of selenium in China.","volume":"6","author":"Wu","year":"2015","journal-title":"Front Plant Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/10590501.2013.844757","article-title":"Friend or foe? 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