{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:27Z","timestamp":1790009607589,"version":"4.0.1"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Excessive calorie intake and physical inactivity have dramatically increased nutrient overload-associated disease, becoming a global public health issue. <jats:italic>Chimonanthus salicifolius<\/jats:italic> S. Y. Hu (<jats:italic>CHI<\/jats:italic>) is a homology plant of food and medicine in China and shows several health benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This work investigated the antioxidant activity, the alleviating effects, and the mechanism of action on diabetes and hyperlipidemia of <jats:italic>CHI<\/jats:italic> leaves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>Results showed that <jats:italic>CHI<\/jats:italic> leaves infusion displayed <jats:italic>in vitro<\/jats:italic> antioxidant activity measured by ABTS and ferric reducing antioxidant power methods. In wild-type Kunming mice, <jats:italic>CHI<\/jats:italic> leaves infusion consumption activated the hepatic antioxidant enzymes, including glutathione reductase, glutathione <jats:italic>S<\/jats:italic>-transferase, glutathione peroxidase and thioredoxin reductase as well as thioredoxin reductase 1. In alloxan-induced type 1 diabetic mice, <jats:italic>CHI<\/jats:italic> leaves infusion ameliorated diabetic symptoms, including polyuria, polydipsia, polyphagia and hyperglycemia, in a dose-dependent and time-course manners. The mechanism involved <jats:italic>CHI<\/jats:italic> leaves up-regulating renal water reabsorption associated protein \u2013 urine transporter A1\u2013and promoting the trafficking of urine transporter A1 and aquaporin 2 to the apical plasma membrane. Despite this, in high-fat diet-induced hyperlipidemic golden hamsters, <jats:italic>CHI<\/jats:italic> leaves powder did not significantly effect on hyperlipidemia and body weight gain. This might be attributed to <jats:italic>CHI<\/jats:italic> leaves powder increasing the calorie intake. Interestingly, we found that <jats:italic>CHI<\/jats:italic> leaves extract containing a lower dose of total flavonoid than <jats:italic>CHI<\/jats:italic> leaves powder pronouncedly reduced the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in serum in golden hamsters fed a high-fat diet. Furthermore, <jats:italic>CHI<\/jats:italic> leaves extract elevated the diversity of gut microbiota and the abundance of <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Ruminococcaceae_UCG-014.<\/jats:italic> It also decreased the abundance of <jats:italic>Lactobacillus<\/jats:italic> at the genus level in golden hamsters fed a high-fat diet. Overall, <jats:italic>CHI<\/jats:italic> leaves benefit oxidative stress prevention and metabolic syndrome amelioration <jats:italic>in vivo.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2023.1168049","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:50:22Z","timestamp":1682679022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Antioxidant, antihyperglycemic, and antihyperlipidemic properties of Chimonanthus salicifolius S. Y. 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