{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:00:49Z","timestamp":1775217649798,"version":"3.50.1"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Parenteral nutrition (PN) is widely used in palliative care (PC), but there is limited evidence to support its use at the end of life (EOL). This aim of this was to investigate the relationship between routine laboratory parameters and survival in patients receiving PN, and to develop a decision tree model to support clinicians decide whether to start or forgo PN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The laboratory parameters of 113 patients with advanced diseases who were admitted to a specialized palliative care unit (PCU) were analyzed at two points in time: T0 = before PN, T1 = two weeks after initiation of PN. Univariate Mann-Whitney U-tests and multivariate linear regression models, as well as a decision tree analysis were computed; all in relation to survival time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final regression model was significant with <jats:italic>p<\/jats:italic> = 0.001 (adjusted R2 = 0.15) and included two predictors for survival time after PN initiation: the CRP\/albumin ratio and urea at T1 (ps = 0.019). Decision tree analysis revealed three important predictors for classification of survival time after PN initiation: CRP, urea, and LDH (all at T0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The decision tree model may help to identify patients likely to benefit from PN, thus supporting the clinical decision whether or not to start PN.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2023.1173106","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T08:52:05Z","timestamp":1699001525000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Routine laboratory parameters to support decision on parenteral nutrition in palliative care"],"prefix":"10.3389","volume":"10","author":[{"given":"Lea","family":"Kum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth L.","family":"Zeilinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Vohla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Brunevskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feroniki","family":"Adamidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva K.","family":"Masel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Mayr-Pirker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa L.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e4rbel","family":"Sturtzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"Kreye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Unseld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s40487-022-00189-1","article-title":"Parenteral nutrition in advanced Cancer: the healthcare providers\u2019 perspective","volume":"10","author":"Balstad","year":"2022","journal-title":"Oncol Ther"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"100092","DOI":"10.1016\/j.esmoop.2021.100092","article-title":"Cancer cachexia in adult patients: ESMO clinical practice guidelines\u2606","volume":"6","author":"Arends","year":"2021","journal-title":"ESMO Open"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e843","DOI":"10.1634\/theoncologist.2019-0856","article-title":"Impact on health-related quality of life of parenteral nutrition for patients with advanced Cancer Cachexia: results from a randomized controlled trial","volume":"25","author":"Bouleuc","year":"2020","journal-title":"Oncologist"},{"key":"ref4","article-title":"End-of-life care","volume-title":"StatPearls [internet]","author":"Huffman","year":"2023"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00520-012-1564-y","article-title":"Concepts and definitions for \u201csupportive care,\u201d \u201cbest supportive care,\u201d \u201cpalliative care,\u201d and \u201chospice care\u201d in the published literature, dictionaries, and textbooks","volume":"21","author":"Hui","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.clnu.2016.02.006","article-title":"ESPEN guideline on ethical aspects of artificial nutrition and hydration","volume":"35","author":"Druml","year":"2016","journal-title":"Clin Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/annonc\/mdt549","article-title":"The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a multi-Centre observational study with prospective follow-up of 414 patients","volume":"25","author":"Bozzetti","year":"2014","journal-title":"Ann Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1093\/annonc\/mdq620","article-title":"Artificial nutrition and hydration in the last week of life in cancer patients. 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