{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:05:15Z","timestamp":1791882315346,"version":"4.3.4"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Antibiotic resistance poses a serious threat to public health, raising the number of diseases in the community. Recent research has shown that plant-derived phenolic compounds have strong antimicrobial, antifungal, and cytotoxic properties against a variety of microorganisms and work as great antioxidants in such treatments. The goal of the current work is to evaluate the anticancerous, antibacterial, antifungal, antioxidant, and cytotoxicity activities in the extracts of the different plant parts (leaves, stems, and roots) of<jats:italic>S. carvifolia<\/jats:italic>(L.) L. This is a medicinally important plant and has been used for different kinds of diseases and ailments such as hysteria and seizures. The phenolic compounds from the different plant parts were analyzed using HPLC and the following were found to be present: chlorogenic acid, gallic acid, rutin, syringic acid, vanillic acid, cinnamic acid, caffeic acid, and protocatechuic acid. Gallic acid was found to have the highest concentration (13.93 mg\/g), while chlorogenic acid (0.25 mg\/g) had the lowest. The maximum TPC value, which ranged from 33.79 to 57.95 mg GAE\/g dry extract weight, was found in the stem. Root extract with 9.4 mg RE\/g had the greatest TFC level. In the leaf and stem extracts, the RSC ranged from 0.747 mg\/mL to 0.734 mg\/1 mL GE\/g dry extract weight, respectively. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to measure<jats:italic>in vitro<\/jats:italic>antioxidant activity. In a concentration-dependent way, promising antioxidant activity was reported. Moreover, 3,5-dinitrosalicylic acid (DNSA) and the Folin\u2013Ciocalteu phenol reagent technique were used to determine reducing sugar content and total phenolic content, respectively. Antibacterial activity against eight strains (MIC: 250\u20131,000\u2009\u03bcg\/mL) was analyzed, and the stem extract exhibited maximum activity. Antifungal activity was also assessed, and potent activity was reported especially in the extract obtained from the stem. Cytotoxicity was evaluated using an MTT assay in the A549 cell line, where different doses (0.0625, 0.125, 0.25, 0.5, and 1\u2009mg\/mL) of leaf, root, and stem extracts were used. Treatment with these extracts reduced the cell viability, indicating that<jats:italic>S. carvifolia<\/jats:italic>may possess anticancer potential, which can be of great therapeutic value.<\/jats:p>","DOI":"10.3389\/fnut.2023.1180225","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T02:08:41Z","timestamp":1689300521000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Major phenolic compounds, antioxidant, antimicrobial, and cytotoxic activities of Selinum carvifolia (L.) collected from different altitudes in India"],"prefix":"10.3389","volume":"10","author":[{"given":"Ravi Prakash","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lav","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Madhukar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaraman","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Prasad","family":"Devkota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen C.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatrughan","family":"Shiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumira","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh","family":"Rustagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ejmech.2012.02.035","article-title":"Thieno [2,3-d] pyrimidinedione derivatives as antibacterial agents","volume":"51","author":"Dewal","year":"2012","journal-title":"Eur J Med Chem"},{"key":"ref2","first-page":"97","author":"Nkomo","year":"2010"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"192ra85","DOI":"10.1126\/scitranslmed.3006055","article-title":"Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells","volume":"5","author":"Kalghatgi","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3923\/jm.2011.124.131","article-title":"Antibacterial activity of Psoralea corylifolia L. seed and aerial parts with various extraction methods","volume":"6","author":"Chanda","year":"2011","journal-title":"Res J Microbiol"},{"key":"ref5","first-page":"649","article-title":"Phytochemical and antimicrobial studies of the ethyl acetate extract of Alchornea cordifolia leaf found in Abuja, Nigeria","volume":"4","author":"Adeshina","year":"2010","journal-title":"J Med Plant Res"},{"key":"ref6","volume-title":"Essential oils and their products as antimicrobial agents: Progress and prospects. Chapter 13, 26p","author":"Rojas","year":"2015"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12906-016-1536-8","article-title":"Iridoids from Canthium subcordatum iso-butanol fraction with potent biological activities","volume":"17","author":"Joubouhi","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12906-018-2229-2","article-title":"Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola","volume":"18","author":"Nzogong","year":"2018","journal-title":"BMC Complement Altern Med"},{"key":"ref9","first-page":"1","article-title":"Food antimicrobials\u2014an introduction","volume-title":"Antimicrobial in food","author":"Davidson","year":"2005"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000454680","article-title":"Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis","volume":"26","author":"Sieniawska","year":"2017","journal-title":"Med Princ Pract"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13065-018-0466-6","article-title":"Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes","volume":"12","author":"Tagousop","year":"2018","journal-title":"Chem Cent J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.micres.2006.06.010","article-title":"In vitro efficacy of bioactive extracts of 15 medicinal plants against ES\u03b2L-producing multidrug-resistant enteric bacteria","volume":"162","author":"Ahmad","year":"2007","journal-title":"Microbiol Res"},{"key":"ref13","first-page":"76","article-title":"A study on the nutraceuticals from the genus Rumex","volume":"3","author":"Rao","year":"2011","journal-title":"Hygeia J D Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1111\/jphp.13156","article-title":"Review on antibacterial activity of Himalayan medicinal plants traditionally used to treat pneumonia and tuberculosis","volume":"71","author":"Adnan","year":"2019","journal-title":"J Pharm Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fagro.2022.1010309","article-title":"Nutritional evaluation, phytochemical makeup, antibacterial and antioxidant properties of wild plants utilized as food by the Gaddis-a tribal tribe in the Western Himalayas","volume":"4","author":"Thakur","year":"2022","journal-title":"Front Agron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4314\/thrb.v10i1.14339","article-title":"An antifungal property of crude plant extracts from Anogeissus leiocarpus and Terminalia avicennioides","volume":"10","author":"Mann","year":"2008","journal-title":"Tanzan J Health Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-981-19-0928-3_18","article-title":"Use of wild edible plants can meet the needs of future generation","volume-title":"Agro-biodiversity and Agri-ecosystem Management","author":"Singh","year":"2022"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3923\/jas.2019.235.240","article-title":"Antifungal Activity of Parkia biglobosa Extract on Pathogenic Strain of Candida albicans","volume":"19","author":"Yahaya","year":"2019","journal-title":"J Appl Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jep.2007.09.014","article-title":"Antifungal activity of medicinal plant extracts; preliminary screening studies","volume":"115","author":"Webster","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4103\/0973-8258.150921","article-title":"Shanmugapriya K Antimicrobial activity of methanolic extracts of indigenous traditional Indian folk Medicinal Plant, Gnaphalium polycaulon","volume":"9","author":"Thangavelu","year":"2015","journal-title":"Int J Green Pharm"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1590\/s151783822006000400030","article-title":"Antibacterial, antifungal and cytotoxic activities of eight Asteraceae and two Rubiaceae plants from Colombian biodiversity","volume":"37","author":"Ni\u00f1o","year":"2006","journal-title":"Braz J Microbiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"103243","DOI":"10.1016\/j.arabjc.2021.103243","article-title":"Antioxidant and antimicrobial study of Schefflera vinosa leaves crude extracts against rice pathogens","volume":"14","author":"Singh","year":"2021","journal-title":"Arab J Chem"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1073327","DOI":"10.3389\/fphar.2023.1073327","article-title":"Assessment of the dual role of Lyonia ovalifolia (Wall.) Drude in inhibiting AGEs and enhancing GLUT4 translocation through LC-ESI-QTOF-MS\/MS determination and in silico studies","volume":"14","author":"Sahu","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1046\/j.1472-765x.1998.00277.x","article-title":"Antimicrobial effects of aqueous plant extracts on the fungi Microsporum canis and Trichophyton rubrum and on three bacterial species","volume":"26","author":"Maoz","year":"1998","journal-title":"Lett Appl Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1088\/978-0-7503-4921-5ch1","article-title":"Understanding environmental associated abiotic stress response in plants under changing climate","volume-title":"Molecular Response and Genetic Engineering for Stress in Plants","author":"Sharma","year":"2022"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1201\/9781003331629-16","article-title":"Bioagents and Volatile Organic Compounds: An Emerging Control Measures for Rice Bacterial Diseases","author":"Singh","year":"2023","journal-title":"Bacterial Diseases of Rice and Their Management"},{"key":"ref27","first-page":"98","article-title":"Evaluation of antioxidant potential and qualitative analysis of major polyphenols by RP\u2013HPLC in Nymphaea nouchali Burm flowers","volume":"2","author":"Nagavani","year":"2010","journal-title":"Int J Pharm"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1603\/EC09375","article-title":"Resistance of cabbage (Brassica oleracea capitata group) crops to Mamestra brassicae","volume":"103","author":"Cartea","year":"2010","journal-title":"J Econ Entomol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0308-8146(00)00226-0","article-title":"Antioxidant activity of some roasted foods","volume":"72","author":"Krings","year":"2001","journal-title":"Food Chem"},{"key":"ref30","first-page":"764","article-title":"Evaluation of phenol, flavonoid contents and antioxidant activity of Polyalthia longifolia","volume":"3","author":"Mundhe","year":"2011","journal-title":"J Chem Pharm Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fphar.2023.1099523","article-title":"The industrially important genus Kaempferia: An ethnopharmacological review","volume":"14","author":"Singh","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref32","first-page":"120","article-title":"Non enzymatic and enzymatic antioxidant activities in aqueous extract of different Ficus deltoidea accessions","volume":"3","author":"Hakiman","year":"2009","journal-title":"J Med Plant Res"},{"key":"ref33","first-page":"40","article-title":"Screening of antioxidant activity and phenolic content of some selected food items cited in the holy Quran","volume":"2","author":"Qusti","year":"2010","journal-title":"EJBS"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S0308-8146(03)00151-1","article-title":"Antioxidant activity and total phenolic content of Iranian Ocimum accessions","volume":"83","author":"Javanmardi","year":"2003","journal-title":"Food Chem"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.jep.2009.07.029","article-title":"Antifungal activity of the benzo [c] phenanthridine alkaloids from Chelidonium majus Linn. against resistant clinical yeast isolates","volume":"125","author":"Meng","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1056474","DOI":"10.3389\/fpls.2022.1056474","article-title":"Sequence and structural similarities of ACCase protein of Phalaris minor and wheat: An insight to explain herbicide selectivity","volume":"13","author":"Rajak","year":"2022","journal-title":"Front Plant Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3390\/pr8010113","article-title":"The potential antibacterial and antifungal activities of wood treated with Withania somnifera fruit extract and the phenolic, caffeine and flavonoid composition of the extract according to HPLC","volume":"8","author":"EL-Hefny","year":"2020","journal-title":"PRO"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/10826076.2020.1848861","article-title":"HPTLC fingerprinting, photopigments and nutrient analysis of Selinum tenuifolium along the altitudinal gradient","volume":"44","author":"Srivastava","year":"2021","journal-title":"J Liq Chromatogr Relat Technol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s10600-012-0418-7","article-title":"Volatile composition of underground parts of Selinum vaginatum and possible uses","volume":"48","author":"Chauhan","year":"2012","journal-title":"Chem Nat Compd"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.flora.2018.08.017","article-title":"Comparative morphological and anatomical studies of leaves, stem, and roots of Selinum vaginatum C.B. Clarke and Selinum tenuifolium Wall","volume":"248","author":"Srivastava","year":"","journal-title":"Flora"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3126\/jnhm.v24i1.2237","article-title":"Non-Medicinal uses of selected wild plants by the people of Mustang district","volume":"24","author":"Bhattarai","year":"2009","journal-title":"Nepal J Nat Hist Mus"},{"key":"ref42","volume-title":"Aspects of traditional medicine in Nepal","author":"Gewali","year":"2008"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1007\/s10265-016-0850-z","article-title":"Impacts of simulated drought stress and artificial damage on concentrations of flavonoids in Jatropha curcas (L.), a biofuel shrub","volume":"129","author":"Lama","year":"2016","journal-title":"J Plant Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.2174\/1389201020666181227150829","article-title":"Status of Selinum Spp. L. a Himalayan Medicinal Plant in India: A Review of Its Pharmacology, Phytochemistry and Traditional Uses","volume":"19","author":"Srivastava","year":"","journal-title":"Curr Pharma Bio"},{"key":"ref45","first-page":"1077","article-title":"Variation in the volatile constituents of different plant parts of Ligusticopsis wallichiana from western Himalaya, India","volume":"7","author":"Padalia","year":"2012","journal-title":"Nat Prod Commun"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/14786419.2017.1356831","article-title":"Terpenoid composition of essential oil from a new chemotype of Selinum wallichianum Raizada & Saxena","volume":"32","author":"Joshi","year":"2018","journal-title":"Nat Prod Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/hlca.201100480","article-title":"Chemical composition of the volatile oil from the roots of Selinum tenuifolium Wall","volume":"95","author":"Chauhan","year":"2012","journal-title":"Helv Chim Acta"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1021\/np50035a035","article-title":"The volatile constituents of roots of Selinum tenuifolium","volume":"47","author":"Dev","year":"1984","journal-title":"J Nat Prod"},{"key":"ref49","first-page":"127","article-title":"Essential oil of Selinum tenuifolium","volume":"22","author":"Sood","year":"1978","journal-title":"Indian Perfurmer"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1080\/14786419.2015.1118635","article-title":"Two new diacetylene glycosides: bhutkesoside A and B from the roots of Ligusticopsis wallichiana","volume":"30","author":"Adhikari","year":"2016","journal-title":"Nat Prod Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/jpbs.JPBS_175_19","article-title":"(2020). Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes","volume":"12","author":"Abubakar","year":"2020","journal-title":"J Pharm Bioallied Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s10298-014-0850-x","article-title":"Phytochemical screening and in vitro antioxidant activity of various Punica granatum l. Peel extracts from Algeria: A comparative study","volume":"12","author":"Belkacem","year":"2014","journal-title":"Phytoth\u00e9rapie"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S2221-1691(13)60020-9","article-title":"(2013). Phytochemical screening and free radical scavenging activity of Citrullus colocynthis seeds extracts","volume":"3","author":"Benariba","year":"2013","journal-title":"Asian Pac J Trop Biomed"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"87","DOI":"10.18006\/2021.9(1).87.99","article-title":"Evaluation of antioxidant and antimicrobial potential of Thespesia lampas root extracts","volume":"9","author":"Kumar","year":"2021","journal-title":"J Exp Biol Agric Sci"},{"key":"ref55","first-page":"2482","article-title":"Phytochemical screening, quantitative analysis and antioxidant activity of Asteriscus imbricatus and Pulicariam auritanica organic extracts","volume":"24","author":"Senhaji","year":"2017","journal-title":"Int Food Res J"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.foodchem.2005.11.032","article-title":"Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants","volume":"100","author":"Maisuthisakul","year":"2007","journal-title":"Food Chem"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ejbt.2014.09.005","article-title":"Determination of fructan exohydrolase activity in the crude extracts of plants","volume":"17","author":"Krivorotova","year":"2014","journal-title":"Electron J Biotechnol"},{"key":"ref58","volume-title":"CLSI Document M07-A9. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically: Approved Standard","year":"2012"},{"key":"ref59","first-page":"1","volume-title":"Methods for Dilution Antimicrobial Susceptibility Test for Bacteria That Grow Aerobically. Approved Standard","year":"2009"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid Colorimetric Assay for Cellular Growth and Survival, Application to Proliferation and Cytotoxicity Assays","volume":"65","author":"Mosman","year":"1983","journal-title":"J Immunol Methods"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e 8871","DOI":"10.5812\/ircmj.8871","article-title":"Cytotoxic properties of some medicinal plant extracts from mazandaran, iran","volume":"15","author":"Nemati","year":"2013","journal-title":"Iran Red Crescent Med J"},{"key":"ref62","first-page":"37","article-title":"Pharmacognostical standardization of Commiphora berryi (Arn) Engl and phytochemical studies on its crude extracts","volume":"3","author":"Selvamani","year":"2009","journal-title":"Afr J Pharm Pharmacol"},{"key":"ref63","first-page":"525","article-title":"Standardization of Feronia limonia L. leaves by HPLC, HPTLC, physicochemical and histological parameters","volume":"10","author":"Jain","year":"2011","journal-title":"Bol Latinoam Caribe Plantas Med Aromat"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1186\/s13104-015-1618-6","article-title":"In vitro antioxidant and free radical scavenging activity of different parts of Tabebuia pallida growing in Bangladesh","volume":"8","author":"Rahman","year":"2015","journal-title":"BMC Res Notes"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1021\/jf001018w","article-title":"Composition and antimicrobial activity of the essential oils of five taxa of Sideritis from Greece","volume":"49","author":"Aligiannis","year":"2001","journal-title":"J Agric Food Chem"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s13104-015-1388-1","article-title":"Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum","volume":"8","author":"Iloki-Assanga","year":"2015","journal-title":"BMC Res Notes"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/plants8070205","article-title":"Comparison of sugar profile between leaves and fruits of blueberry and strawberry cultivars grown inorganic and integrated production system","volume":"8","author":"Ak\u0161i\u0107","year":"2019","journal-title":"Plan Theory"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1744-7348.2010.00443.x","article-title":"Sugars in crop plants","volume":"158","author":"Halford","year":"2011","journal-title":"Ann Appl Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-030-42022-2_9","article-title":"Regulatory framework and policy decisions for genome-edited crops","author":"Kumar","year":"2020","journal-title":"CRISPR\/Cas Genome Editing: Concept and Strategies in Plant Sciences"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1794650","DOI":"10.1155\/2018\/1794650","article-title":"Nonvolatile chemical constituents from the leaves of Ligusticopsis wallichiana (DC.) Pimenov & Kljuykov and their free radical-scavenging activity","author":"Devkota","year":"2018","journal-title":"J Anal Methods Chem"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.athoracsur.2017.03.018","article-title":"Preoperative staphylococcus aureus screening and targeted decolonization in cardiac surgery","volume":"104","author":"Saraswat","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3923\/rjmp.2020.43.52","article-title":"Influence of altitude on Secondary Metabolites and antioxidant activity of Coleus forskohlii root extracts","volume":"14","author":"Rana","year":"2020","journal-title":"Res J Med Plant"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"8293","DOI":"10.1038\/s41598-020-65160-4","article-title":"Influence of climate variations on phenolic composition and antioxidant capacity of Medicago minima populations","author":"Souhir","year":"2020","journal-title":"Sci Rep"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12906-020-02982-9","article-title":"Altitude impact on the chemical profile and biological activities of Satureja thymbra L. essential oil","volume":"20","author":"Khalil","year":"2020","journal-title":"BMC Complement Med Ther"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1180225\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T02:06:19Z","timestamp":1702778779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1180225\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":74,"alternative-id":["10.3389\/fnut.2023.1180225"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2023.1180225","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]},"article-number":"1180225"}}