{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:06:52Z","timestamp":1785683212775,"version":"3.56.0"},"reference-count":142,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neurological disorders have been considered the major contributors to global long-term disability and lower quality of life. Lifestyle factors, such as dietary patterns, are increasingly recognized as important determinants of neurological function. Some dietary behaviors, such as Nordic diet (ND) were likely to have protective effects on brain function. However, an understanding of the effectiveness of the ND pattern to improve neurological function and brain health is not fully understood. We review the current evidence that supports the ND pattern in various aspects of neurological function and addresses both proven and less established mechanisms of action based on its food ingredients and biochemical compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this systematic review, PubMed, Web of Science, and Scopus databases were searched from inception to February 2023. Observational and intervention studies were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 627 screened studies, 5 observational studies (including three cohorts and two cross-sectional studies) and 3 intervention studies investigating the association between ND and neurological function. Observational studies investigated the association of ND with the following neurological functions: cognition, stroke, and neuropsychological function. Intervention studies investigated the effects of ND on cognition and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Despite the limited literature on ND and its association with neurological function, several aspects of ND may lead to some health benefits suggesting neuroprotective effects. The current state of knowledge attributes the possible effects of characteristic components of the ND to its antioxidant, anti-inflammatory, lipid-lowering, gut-brain-axis modulating, and ligand activities in cell signaling pathways. Based on existing evidence, the ND may be considered a recommended dietary approach for the improvement of neurological function and brain health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>[<jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>], identifier [CRD2023451117].<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2023.1215358","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T12:45:41Z","timestamp":1692017141000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Nordic diet and its benefits in neurological function: a systematic review of observational and intervention studies"],"prefix":"10.3389","volume":"10","author":[{"given":"Reyhaneh Sadat","family":"Jafari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahideh","family":"Behrouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3390\/antiox9040346","article-title":"Diet and mental health: review of the recent updates on molecular mechanisms","volume":"9","author":"Godos","year":"2020","journal-title":"Antioxidants"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1001\/jama.2017.3828","article-title":"Depression is the leading cause of disability around the world","volume":"317","author":"Friedrich","year":"2017","journal-title":"JAMA"},{"key":"ref3","first-page":"1789","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume-title":"The Lancet","author":"James","year":"2018"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e2020088","DOI":"10.23750\/abm.v91i3.9443","article-title":"Prevalence of Parkinson disease in Italy: a systematic review and meta-analysis","volume":"91","author":"Ricc\u00f2","year":"2020","journal-title":"Acta Bio Medica"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1001\/jamaneurol.2019.1971","article-title":"Prevalence of biologically vs clinically defined Alzheimer spectrum entities using the National Institute on Aging\u2013Alzheimer\u2019s association research framework","volume":"76","author":"Jack","year":"2019","journal-title":"JAMA Neurol"},{"key":"ref6","first-page":"1","article-title":"An approach on the biological disease of psychiatric and neurological disorders in young patients","volume":"8","author":"Austen","year":"2021","journal-title":"J Mult Scler"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1093\/nutrit\/nuaa113","article-title":"Ketogenic diet and cognition in neurological diseases: a systematic review","volume":"79","author":"Pav\u00f3n","year":"2021","journal-title":"Nutr Rev"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"a006239","DOI":"10.1101\/cshperspect.a006239","article-title":"Epidemiology of Alzheimer disease","volume":"2","author":"Mayeux","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1002\/pmic.201300124","article-title":"Proteomic analysis of the dorsal and ventral hippocampus of rats maintained on a high fat and refined sugar diet","volume":"13","author":"Francis","year":"2013","journal-title":"Proteomics"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","article-title":"Cognitive impairment following high fat diet consumption is associated with brain inflammation","volume":"219","author":"Pistell","year":"2010","journal-title":"J Neuroimmunol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3349\/ymj.2005.46.5.585","article-title":"Molecular targets of dietary polyphenols with anti-inflammatory properties","volume":"46","author":"Yoon","year":"2005","journal-title":"Yonsei Med J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1017\/S0029665110001539","article-title":"Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study","volume":"69","author":"Estruch","year":"2010","journal-title":"Proc Nutr Soc"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.3390\/nu13114080","article-title":"Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia","volume":"13","author":"Dominguez","year":"2021","journal-title":"Nutrients"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s12603-018-1019-3","article-title":"Mediterranean diet, food consumption and risk of late-life depression: the Mugello study","volume":"22","author":"Pagliai","year":"2018","journal-title":"J Nutr Health Aging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.30476\/IJNS.2019.82686.1025","article-title":"Nordic diet and cardio-metabolic diseases: a review","volume":"4","author":"Nouripour","year":"2019","journal-title":"Int J Nutr Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s00394-018-1804-0","article-title":"The effect of healthy Nordic diet on cardio-metabolic markers: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"58","author":"Ramezani-Jolfaie","year":"2019","journal-title":"Eur J Nutr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1365-2796.2010.02290.x","article-title":"Effects of a healthy Nordic diet on cardiovascular risk factors in hypercholesterolaemic subjects: a randomized controlled trial (NORDIET)","volume":"269","author":"Adamsson","year":"2011","journal-title":"J Intern Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3945\/jn.110.131375","article-title":"Healthy aspects of the Nordic diet are related to lower total mortality","volume":"141","author":"Olsen","year":"2011","journal-title":"J Nutr"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1017\/S0007114512001262","article-title":"Adherence to the Baltic Sea diet consumed in the Nordic countries is associated with lower abdominal obesity","volume":"109","author":"Kanerva","year":"2013","journal-title":"Br J Nutr"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3109\/07853890.2013.870020","article-title":"Associations of the Baltic Sea diet with obesity-related markers of inflammation","volume":"46","author":"Kanerva","year":"2014","journal-title":"Ann Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/ejcn.2017.1","article-title":"Adherence to a healthy Nordic food index and risk of myocardial infarction in middle-aged Danes: the diet, cancer and health cohort study","volume":"71","author":"Gunge","year":"2017","journal-title":"Eur J Clin Nutr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1161\/STROKEAHA.116.015019","article-title":"Adherence to a healthy Nordic diet and risk of stroke: a Danish cohort study","volume":"48","author":"Hansen","year":"2017","journal-title":"Stroke"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1017\/S0007114515001890","article-title":"The Nordic diet and cognition\u2013the DR's EXTRA study","volume":"114","author":"M\u00e4nnikk\u00f6","year":"2015","journal-title":"Br J Nutr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e042431","DOI":"10.1002\/alz.042431","article-title":"Effect of berries and fruits on cognitive change during a 2-year multi-domain lifestyle intervention: the Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER) prevention (nonpharmacological)\/nutrition","volume":"16","author":"Eskelinen","year":"2020","journal-title":"Alzheimers Dement"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1017\/S136898001100351X","article-title":"Guidelines for the new Nordic diet","volume":"15","author":"Mithril","year":"2012","journal-title":"Public Health Nutr"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/sj.ejcn.1602435","article-title":"Cereal grains and legumes in the prevention of coronary heart disease and stroke: a review of the literature","volume":"60","author":"Flight","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1017\/S1368980013002395","article-title":"The Baltic Sea diet score: a tool for assessing healthy eating in Nordic countries","volume":"17","author":"Kanerva","year":"2014","journal-title":"Public Health Nutr"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4000\/aof.8723","article-title":"Nordic Cuisine but National Identities. \u201cNew Nordic Cuisine\u201d and the gastronationalist projects of Denmark and Sweden","volume":"13","author":"Neuman","year":"2018","journal-title":"Anthropol Food"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1017\/S1368980012004521","article-title":"Dietary composition and nutrient content of the new Nordic diet","volume":"16","author":"Mithril","year":"2013","journal-title":"Public Health Nutr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1017\/S0007114515005309","article-title":"A healthy Nordic diet and physical performance in old age: findings from the longitudinal Helsinki birth cohort study","volume":"115","author":"Per\u00e4l\u00e4","year":"2016","journal-title":"Br J Nutr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"22790","DOI":"10.3402\/fnr.v57i0.22790","article-title":"Health effects associated with foods characteristic of the Nordic diet: a systematic literature review","volume":"57","author":"\u00c5kesson","year":"2013","journal-title":"Food Nutr Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1017\/S1368980008001985","article-title":"Towards health-promoting and environmentally friendly regional diets\u2013a Nordic example","volume":"12","author":"Bere","year":"2009","journal-title":"Public Health Nutr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/fnut.2021.683678","article-title":"The Mediterranean and Nordic diet: a review of differences and similarities of two sustainable, health-promoting dietary patterns","author":"Krznari\u0107","year":"2021","journal-title":"Front Nutr"},{"key":"ref35","first-page":"544","article-title":"Perspective: food-based dietary guidelines in Europe\u2014scientific concepts, current status, and perspectives","volume-title":"Advances in nutrition","author":"Bechthold","year":"2018"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/MED.0000000000000361","article-title":"Dietary guidelines in type 2 diabetes: the Nordic diet or the ketogenic diet?","volume":"24","author":"Magnusdottir","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref37","first-page":"627","volume-title":"Nordic Nutrition Recommendations 2012: Integrating nutrition and physical activity","year":"2014"},{"key":"ref38","first-page":"22903","volume-title":"New Nordic nutrition recommendations are here","author":"Fogelholm","year":"2013"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"S275","DOI":"10.1093\/advances\/nmy117","article-title":"Plant-based diets for personal, population, and planetary health","volume":"10","author":"Hemler","year":"2019","journal-title":"Adv Nutr"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jalz.2018.10.001","article-title":"Dietary changes and cognition over 2 years within a multidomain intervention trial\u2014the Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER)","volume":"15","author":"Lehtisalo","year":"2019","journal-title":"Alzheimers Dement"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JAD-200423","article-title":"White matter changes on diffusion tensor imaging in the FINGER randomized controlled trial","volume":"78","author":"Stephen","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e22646","DOI":"10.1371\/journal.pone.0022646","article-title":"Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study","volume":"6","author":"Lankinen","year":"2011","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/ejcn.2013.192","article-title":"Effects of an isocaloric healthy Nordic diet on ambulatory blood pressure in metabolic syndrome: a randomized SYSDIET sub-study","volume":"68","author":"Brader","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"18189","DOI":"10.3402\/fnr.v56i0.18189","article-title":"What is a healthy Nordic diet? Foods and nutrients in the NORDIET study","volume":"56","author":"Adamsson","year":"2012","journal-title":"Food Nutr Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/joim.12044","article-title":"Effects of an isocaloric healthy N ordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome\u2013a randomized study (SYSDIET)","volume":"274","author":"Uusitupa","year":"2013","journal-title":"J Intern Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"8633","DOI":"10.3390\/nu7105418","article-title":"Adherence to a healthy Nordic food index is associated with a lower risk of type-2 diabetes\u2014the Danish diet, cancer and health cohort study","volume":"7","author":"Lacoppidan","year":"2015","journal-title":"Nutrients"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s10654-015-0021-x","article-title":"Adherence to the healthy Nordic food index and total and cause-specific mortality among Swedish women","volume":"30","author":"Roswall","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1017\/S0007114512002085","article-title":"Adherence to a healthy Nordic food index is associated with a lower incidence of colorectal cancer in women: the diet, Cancer and health cohort study","volume":"109","author":"Kyr\u00f8","year":"2013","journal-title":"Br J Nutr"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1016\/j.diabres.2014.08.016","article-title":"The healthy Nordic diet and incidence of type 2 diabetes\u201410-year follow-up","volume":"106","author":"Kanerva","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3945\/ajcn.114.092783","article-title":"Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome","volume":"101","author":"Kolehmainen","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1017\/S0007114515001634","article-title":"Associations of diet quality with cognition in children\u2013the physical activity and nutrition in children study","volume":"114","author":"Haapala","year":"2015","journal-title":"Br J Nutr"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1017\/S0007114515003323","article-title":"Diet-induced changes in iron and n-3 fatty acid status and associations with cognitive performance in 8\u201311-year-old Danish children: secondary analyses of the optimal well-being, development and health for Danish children through a healthy new Nordic diet school meal study","volume":"114","author":"S\u00f8rensen","year":"2015","journal-title":"Br J Nutr"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1017\/S0007114515000033","article-title":"The effects of Nordic school meals on concentration and school performance in 8-to 11-year-old children in the OPUS school meal study: a cluster-randomised, controlled, cross-over trial","volume":"113","author":"S\u00f8rensen","year":"2015","journal-title":"Br J Nutr"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/nu13030902","article-title":"Feasibility and acceptability of a healthy Nordic diet intervention for the treatment of depression: a randomized controlled pilot trial","volume":"13","author":"Sabet","year":"2021","journal-title":"Nutrients"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1177\/0260106020964981","article-title":"Impact of a Nordic diet on psychological function in young students","volume":"27","author":"Abbaszadeh","year":"2021","journal-title":"Nutr Health"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/nu10020229","article-title":"The Nordic prudent diet reduces risk of cognitive decline in the Swedish older adults: a population-based cohort study","volume":"10","author":"Shakersain","year":"2018","journal-title":"Nutrients"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"6701","DOI":"10.2174\/1381612823666161123094235","article-title":"Functional foods for health: the interrelated antioxidant and anti-inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans","volume":"22","author":"Serafini","year":"2016","journal-title":"Curr Pharm Des"},{"key":"ref59","first-page":"377","article-title":"Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients","volume":"10","author":"Bourre","year":"2006","journal-title":"J Nutr Health Aging"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3390\/nu12010228","article-title":"Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence","volume":"12","author":"Tardy","year":"2020","journal-title":"Nutrients"},{"key":"ref61","first-page":"145","article-title":"Vegetables, fruits and phytoestrogens in the prevention of diseases","volume":"50","author":"Heber","year":"2004","journal-title":"J Postgrad Med"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"384S","DOI":"10.3945\/an.112.003517","article-title":"Health-promoting components of fruits and vegetables in the diet","volume":"4","author":"Liu","year":"2013","journal-title":"Adv Nutr"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1080\/10408398.2012.755149","article-title":"The health potential of fruits and vegetables phytochemicals: notable examples","volume":"56","author":"Rodriguez-Casado","year":"2016","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3945\/an.115.009233","article-title":"Anthocyanins","volume":"6","author":"Wallace","year":"2015","journal-title":"Adv Nutr"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1080\/10408398.2015.1030064","article-title":"Health benefits of anthocyanins and molecular mechanisms: update from recent decade","volume":"57","author":"Li","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"22395","DOI":"10.3390\/molecules201219785","article-title":"Retinoprotective effects of bilberry anthocyanins via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms in a visible light-induced retinal degeneration model in pigmented rabbits","volume":"20","author":"Wang","year":"2015","journal-title":"Molecules"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/nu11051075","article-title":"Role of berry anthocyanins and phenolic acids on cell migration and angiogenesis: an updated overview","volume":"11","author":"Tsakiroglou","year":"2019","journal-title":"Nutrients"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"8653","DOI":"10.3390\/ijms21228653","article-title":"The anti-neuroinflammatory role of anthocyanins and their metabolites for the prevention and treatment of brain disorders","volume":"21","author":"Henriques","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1179\/1743132812Y.0000000137","article-title":"Differential nuclear factor-kappa B phosphorylation induced by lipopolysaccharide in the hippocampus of P2X7 receptor knockout mouse","volume":"35","author":"Kim","year":"2013","journal-title":"Neurol Res"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"196","DOI":"10.5455\/bcp.20160520092044","article-title":"The neuroinflammation perspective of depression: reuniting the outstanding mechanisms of the pathophysiology","volume":"26","author":"Sahin","year":"2016","journal-title":"Klinik Psikofarmakoloji B\u00fclteni"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s12640-019-00047-5","article-title":"Endothelial PPAR\u03b3 is crucial for averting age-related vascular dysfunction by stalling oxidative stress and ROCK","volume":"36","author":"Uddin","year":"2019","journal-title":"Neurotox Res"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cotox.2017.10.009","article-title":"DNA repair after oxidative stress: current challenges","volume":"7","author":"Van Houten","year":"2018","journal-title":"Curr Opin Toxicol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin Interv Aging"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"914273","DOI":"10.1155\/2012\/914273","article-title":"Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxidative Med Cell Longev"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.brainresbull.2011.11.014","article-title":"Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease","volume":"87","author":"Choi","year":"2012","journal-title":"Brain Res Bull"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1021\/jf203989k","article-title":"Anthocyanin-rich a\u00e7ai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells","volume":"60","author":"Poulose","year":"2012","journal-title":"J Agric Food Chem"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.3390\/ijms14011502","article-title":"Anthocyanins downregulate lipopolysaccharide-induced inflammatory responses in BV2 microglial cells by suppressing the NF-\u03baB and Akt\/MAPKs signaling pathways","volume":"14","author":"Jeong","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"6297080","DOI":"10.1155\/2017\/6297080","article-title":"Comparison of the neuroprotective and anti-inflammatory effects of the anthocyanin metabolites, protocatechuic acid and 4-hydroxybenzoic acid","volume":"2017","author":"Winter","year":"2017","journal-title":"Oxidative Med Cell Longev"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1007\/s11064-015-1646-6","article-title":"Protocatechuic acid inhibits inflammatory responses in LPS-stimulated BV2 microglia via NF-\u03baB and MAPKs signaling pathways","volume":"40","author":"Wang","year":"2015","journal-title":"Neurochem Res"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-018-1082-y","article-title":"Nordic diet, Mediterranean diet, and the risk of chronic diseases: the EPIC-Potsdam study","volume":"16","author":"Galbete","year":"2018","journal-title":"BMC Med"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jff.2011.08.004","article-title":"Crucial facts about health benefits of popular cruciferous vegetables","volume":"4","author":"Manchali","year":"2012","journal-title":"J Funct Foods"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.3389\/fphar.2021.767975","article-title":"Glucosinolates from cruciferous vegetables and their potential role in chronic disease: investigating the preclinical and clinical evidence","volume":"12","author":"Connolly","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11101-008-9109-1","article-title":"The \u2018mustard oil bomb\u2019: not so easy to assemble?! Localization, expression and distribution of the components of the myrosinase enzyme system","volume":"8","author":"Kissen","year":"2009","journal-title":"Phytochem Rev"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1002\/mnfr.201300377","article-title":"The metabolism of methylsulfinylalkyl-and methylthioalkyl-glucosinolates by a selection of human gut bacteria","volume":"58","author":"Luang-In","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbr.2015.12.030","article-title":"Sulforaphane produces antidepressant-and anxiolytic-like effects in adult mice","volume":"301","author":"Wu","year":"2016","journal-title":"Behav Brain Res"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/MCO.0000000000000511","article-title":"Crucifers and related vegetables and supplements for neurologic disorders: what is the evidence?","volume":"21","author":"Panjwani","year":"2018","journal-title":"Curr Opin Clin Nutr Metabolic Care"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1002\/mnfr.201400550","article-title":"Suppression of LPS-induced transcription and cytokine secretion by the dietary isothiocyanate sulforaphane","volume":"58","author":"Folkard","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1600194","DOI":"10.1002\/mnfr.201600194","article-title":"Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways","volume":"61","author":"Kim","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.3390\/ijms22062929","article-title":"Pre-clinical neuroprotective evidences and plausible mechanisms of sulforaphane in Alzheimer\u2019s disease","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000487639","article-title":"Sulforaphane augments glutathione and influences brain metabolites in human subjects: a clinical pilot study","volume":"3","author":"Sedlak","year":"2017","journal-title":"Complex Psychiatry"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/pcn.13276","article-title":"Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: a randomized, double-blind, placebo-controlled clinical trial","volume":"75","author":"Ghazizadeh-Hashemi","year":"2021","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jnutbio.2016.10.004","article-title":"Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation","volume":"39","author":"Zhang","year":"2017","journal-title":"J Nutr Biochem"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3109\/13506129.2012.751367","article-title":"Amelioration of Alzheimer\u2019s disease by neuroprotective effect of sulforaphane in animal model","volume":"20","author":"Kim","year":"2013","journal-title":"Amyloid"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jnutbio.2017.09.016","article-title":"Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice","volume":"51","author":"Sunkaria","year":"2018","journal-title":"J Nutr Biochem"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/antiox5030030","article-title":"Protandim protects oligodendrocytes against an oxidative insult","volume":"5","author":"Lim","year":"2016","journal-title":"Antioxidants"},{"key":"ref97","first-page":"1934578X0900400504","article-title":"Apple-products phytochemicals and processing: a review","volume":"4","author":"Soler","year":"2009","journal-title":"Nat Prod Commun"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","article-title":"Health effects of quercetin: from antioxidant to nutraceutical","volume":"585","author":"Boots","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3389\/fphar.2018.01383","article-title":"Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain","volume":"9","author":"Khan","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-24618-2","article-title":"Quercetin attenuates AZT-induced neuroinflammation in the CNS","volume":"8","author":"Yang","year":"2018","journal-title":"Sci Rep"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"2986796","DOI":"10.1155\/2016\/2986796","article-title":"Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more","volume":"2016","author":"Costa","year":"2016","journal-title":"Oxidative Med Cell Longev"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.bbadis.2013.12.011","article-title":"Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases","volume":"1842","author":"Gan","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"8388","DOI":"10.1080\/10408398.2021.1928596","article-title":"Whole grain cereals: the potential roles of functional components in human health","volume":"62","author":"Guo","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1079\/NRR200374","article-title":"Whole grains and human health","volume":"17","author":"Slavin","year":"2004","journal-title":"Nutr Res Rev"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41575-020-00375-4","article-title":"Dietary fibre in gastrointestinal health and disease","volume":"18","author":"Gill","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref106","first-page":"108","article-title":"Effect of fertilization and variety on the beta-glucan content in the grain of oats","volume":"17","author":"Dvoncova","year":"2010","journal-title":"\u017bywno\u015b\u0107 Nauka Technologia Jako\u015b\u0107"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"965","DOI":"10.2135\/cropsci1995.0011183X003500040005x","article-title":"\u03b2-Glucan content and its relationship to agronomic characteristics in elite oat germplasm","volume":"35","author":"Peterson","year":"1995","journal-title":"Crop Sci"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut\u2013brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/gerona\/glaa090","article-title":"Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling older adults: a randomized, double-blind, placebo-controlled, multicenter trial","volume":"76","author":"Kim","year":"2021","journal-title":"J Gerontol"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.nut.2018.03.009","article-title":"Exploration of the association between dietary fiber intake and depressive symptoms in adults","volume":"54","author":"Xu","year":"2018","journal-title":"Nutrition"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1017\/S0007114516004311","article-title":"Association between carbohydrate nutrition and prevalence of depressive symptoms in older adults","volume":"116","author":"Gopinath","year":"2016","journal-title":"Br J Nutr"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.3390\/nu12092813","article-title":"Sources of dietary fiber are differently associated with prevalence of depression","volume":"12","author":"Kim","year":"2020","journal-title":"Nutrients"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.bbi.2010.01.015","article-title":"Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization","volume":"24","author":"Sherry","year":"2010","journal-title":"Brain Behav Immun"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"O\u2019Mahony","year":"2015","journal-title":"Behav Brain Res"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.biopsych.2006.06.036","article-title":"Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse","volume":"62","author":"Schroeder","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00018-015-2120-y","article-title":"The impact of low-protein high-carbohydrate diets on aging and lifespan","volume":"73","author":"Le Couteur","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1016\/j.celrep.2018.10.070","article-title":"Comparing the effects of low-protein and high-carbohydrate diets and caloric restriction on brain aging in mice","volume":"25","author":"Wahl","year":"2018","journal-title":"Cell Rep"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.3390\/molecules26102954","article-title":"The potential effects of phytoestrogens: the role in neuroprotection","volume":"26","author":"Gorzkiewicz","year":"2021","journal-title":"Molecules"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/B978-0-12-411462-3.00039-4","article-title":"Neuroprotection by dietary isoflavones and their role in cerebral ischemia","volume-title":"Bioactive nutraceuticals and dietary supplements in neurological and brain disease","author":"Schreihofer","year":"2015"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jnutbio.2005.06.010","article-title":"Soy isoflavones and cognitive function","volume":"16","author":"Lee","year":"2005","journal-title":"J Nutr Biochem"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.neuint.2012.03.011","article-title":"Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-\u03baB activation in a cerebral ischemia mouse model","volume":"60","author":"Qian","year":"2012","journal-title":"Neurochem Int"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.intimp.2013.07.013","article-title":"Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia","volume":"17","author":"Jantaratnotai","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/00001756-200502280-00013","article-title":"Genistein protects dopaminergic neurons by inhibiting microglial activation","volume":"16","author":"Wang","year":"2005","journal-title":"Neuroreport"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.plefa.2008.01.003","article-title":"Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women","volume":"78","author":"Astorg","year":"2008","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"e623","DOI":"10.1542\/peds.2009-3277","article-title":"Fish and n-3 polyunsaturated fatty acid intake and depressive symptoms: Ryukyus child health study","volume":"126","author":"Murakami","year":"2010","journal-title":"Pediatrics"},{"key":"ref126","first-page":"71","article-title":"The role of omega-3 polyunsaturated fatty acids in the etiopathogenesis and treatment of psychiatric disorders","volume":"26","author":"Pawe\u0142czyk","year":"2010","journal-title":"Farmakoterapia w Psychiatrii i Neurologii"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/ncpneuro1044","article-title":"Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association","volume":"5","author":"Fotuhi","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1017\/S0954422416000184","article-title":"Dietary DHA and health: cognitive function ageing","volume":"29","author":"Cardoso","year":"2016","journal-title":"Nutr Res Rev"},{"key":"ref129","first-page":"15","article-title":"Influence of selected dietary components on the functioning of the human nervous system","volume":"69","author":"Wendolowicz","year":"2018","journal-title":"Rocz Panstw Zakl Hig"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1007\/s12035-016-0004-2","article-title":"The role of the microbial metabolites including tryptophan catabolites and short chain fatty acids in the pathophysiology of immune-inflammatory and neuroimmune disease","volume":"54","author":"Morris","year":"2017","journal-title":"Mol Neurobiol"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/nu8020068","article-title":"B vitamins and the brain: mechanisms, dose and efficacy\u2014a review","volume":"8","author":"Kennedy","year":"2016","journal-title":"Nutrients"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/0019-5545.42391","article-title":"Understanding nutrition, depression and mental illnesses","volume":"50","author":"Rao","year":"2008","journal-title":"Indian J Psychiatry"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1212\/01.wnl.0000183148.34197.2e","article-title":"Benefits of fatty fish on dementia risk are stronger for those without APOE \u03b54","volume":"65","author":"Huang","year":"2005","journal-title":"Neurology"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/nure.12033","article-title":"Evidence of health benefits of canola oil","volume":"71","author":"Lin","year":"2013","journal-title":"Nutr Rev"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.bbamem.2017.05.003","article-title":"The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma","volume":"1859","author":"Gal\u00e1n-Arriero","year":"2017","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"e2023784119","DOI":"10.1073\/pnas.2023784119","article-title":"Oleic acid is an endogenous ligand of TLX\/NR2E1 that triggers hippocampal neurogenesis","volume":"119","author":"Kandel","year":"2022","journal-title":"Proc Natl Acad Sci"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"10732","DOI":"10.1038\/s41598-019-47057-z","article-title":"Neuroprotective effects of oleic acid in rodent models of cerebral ischaemia","volume":"9","author":"Song","year":"2019","journal-title":"Sci Rep"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.numecd.2009.12.007","article-title":"Olive oil and health: summary of the II international conference on olive oil and health consensus report, Ja\u00e9n and C\u00f3rdoba (Spain) 2008","volume":"20","author":"L\u00f3pez-Miranda","year":"2010","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/nu13020284","article-title":"Consumption of oleic acid on the preservation of cognitive functions in Japanese elderly individuals","volume":"13","author":"Sakurai","year":"2021","journal-title":"Nutrients"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.mad.2014.01.002","article-title":"Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet","volume":"136","author":"Willcox","year":"2014","journal-title":"Mech Ageing Dev"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.3390\/ijms20112797","article-title":"Mediterranean and MIND diets containing olive biophenols reduces the prevalence of Alzheimer\u2019s disease","volume":"20","author":"Omar","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1079\/PHN2004561","article-title":"Mediterranean diet and cognitive decline","volume":"7","author":"Panza","year":"2004","journal-title":"Public Health Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1215358\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T12:46:04Z","timestamp":1692017164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1215358\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":142,"alternative-id":["10.3389\/fnut.2023.1215358"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2023.1215358","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]},"article-number":"1215358"}}