{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:40:01Z","timestamp":1790023201681,"version":"4.0.1"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Based on existing systematic reviews and meta-analyse we conducted this comprehensive review to evaluate the quality, effectiveness, and bias of evidence regarding the relationship between probiotic intake and improved constipation outcomes in children. A total of nine meta-analyses and systematic reviews were extracted from 628 articles, summarizing seven effectiveness indicators and the incidence of adverse reactions in the treatment of constipation. According to the results, our study revealed that the intake of probiotics in children with FC significantly improved treatment success rate and defecation frequency, while decreased the recurrence rate of constipation. However, no significant association was detected between probiotics intake and frequency of abdominal pain, stool consistency, frequency of defecation pain, frequency of fecal incontinence of children with FC. The intake of probiotics did not increase the incidence of adverse reactions and demonstrated good safety.<\/jats:p>","DOI":"10.3389\/fnut.2023.1218909","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T06:55:25Z","timestamp":1693551325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of probiotics intake on constipation in children: an umbrella review"],"prefix":"10.3389","volume":"10","author":[{"given":"Mingyang","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrgastro.2011.130","article-title":"Constipation in childhood","volume":"8","author":"Mugie","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e180","DOI":"10.3928\/19382359-20180426-02","article-title":"Constipation Management in Pediatric Primary Care","volume":"47","author":"Khan","year":"2018","journal-title":"Pediatr Ann"},{"key":"ref3","first-page":"0303","article-title":"Constipation in children: fibre and probiotics","volume":"2015","author":"Tabbers","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"937212","DOI":"10.1155\/2014\/937212","article-title":"The effect of probiotics on childhood constipation: a randomized controlled double blind clinical trial","volume":"2014","author":"Sadeghzadeh","year":"2014","journal-title":"Int J Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1097\/MPG.0000000000003593","article-title":"Providing a constipation action plan to families of children with constipation decreases health care utilization","volume":"75","author":"Hawa","year":"2022","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/5584_2018_321","article-title":"Probiotics in functional gastrointestinal disorders","volume":"1125","author":"Hojsak","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"15030643","DOI":"10.3390\/nu15030643","article-title":"Pathogen-specific benefits of probiotic and Synbiotic use in childhood acute gastroenteritis: an updated review of the literature","volume":"15","author":"Sasaran","year":"2023","journal-title":"Nutrients"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. 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