{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:01Z","timestamp":1787026921003,"version":"build-2736575974"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hyperglycemia preconception deranges the establishment of a functional placenta; however, the risk of developing preeclampsia (PE) in prediabetic patients remains obscure. The aim was to assess abnormal placental changes as a risk factor for the development of PE in high-fat, high-carbohydrate (HFHC) diet-induced prediabetic (PD) rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HFHC diet-induced female prediabetic Sprague\u2013Dawley rats were mated, and blood glucose concentrations, mean arterial pressure (MAP), and body weights were monitored on gestational days (GNDs) 0, 9, and 18. On GND 18, animals were euthanized. Blood and placentas were collected for biochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prediabetic rats showed significantly increased blood glucose concentration, proinflammatory cytokines, MAP, placental weight, and fetoplacental ratio compared with non-prediabetic (NPD) rats. Prediabetic rats showed significantly decreased placental vascular endothelial growth factor receptor 1 (VEGFR1) and placental growth factor (PLGF) and plasma nitric oxide (NO) compared with NPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Prediabetes may have promoted endothelial dysfunction in the placenta and hypoxia, thus reducing PLGF and VEGFR1, which may have promoted proinflammation, endothelial dysfunction associated with NO decline, and hypertension, which is also observed in preeclamptic patients. Prediabetes may have promoted lipogenesis in placentas and fetuses that may have induced macrosomia and IUGR, also observed in preeclamptic patients. The findings from this study highlight the need for screening and monitoring of prediabetes during pregnancy to reduce the risk of developing preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2023.1241785","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:33:16Z","timestamp":1698046396000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["High-fat, high-carbohydrate diet-induced prediabetes preconception in Sprague\u2013Dawley rats as a risk factor for the development of preeclampsia: assessing changes in placental metabolic insults"],"prefix":"10.3389","volume":"10","author":[{"given":"Asiphaphola","family":"Ludidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelisiwe","family":"Siboto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayanda","family":"Nkosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nombuso Duduzile","family":"Xulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andile","family":"Khathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ntethelelo Hopewell","family":"Sibiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phikelelani Siphosethu","family":"Ngubane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11892-015-0579-4","article-title":"Preeclampsia and diabetes","volume":"15","author":"Weissgerber","year":"2015","journal-title":"Curr Diab Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1080\/10641955.2020.1758939","article-title":"Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis","volume":"39","author":"Arafa","year":"2020","journal-title":"Hypert Pregn."},{"key":"B3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bpobgyn.2010.10.004","article-title":"Controversies in gestational diabetes","volume":"25","author":"Nolan","year":"2011","journal-title":"Best Pract Res Clin Obstetr Gynaecol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.preghy.2018.07.004","article-title":"Preterm birth, low birthweight, and small for gestational age among women with preeclampsia: Does maternal age matter?","volume":"13","author":"Li","year":"2018","journal-title":"Pregn Hypert."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/ajpr\/2019\/v2i130099","article-title":"Level of knowledge on prematurity and its complications in women seeking care at referral hospitals in Mexico","volume":"2","author":"Guti\u00e9rrez-Padilla","year":"2019","journal-title":"Asian J Pediatr Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.preghy.2017.01.001","article-title":"Incidence and pregnancy outcomes of superimposed preeclampsia with or without proteinuria among women with chronic hypertension","volume":"7","author":"Nakanishi","year":"2017","journal-title":"Pregn. 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