{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:57:34Z","timestamp":1792634254546,"version":"4.5.0"},"reference-count":177,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Selenium is an essential trace metalloid element that is associated with fundamental importance to human health. Our umbrella review aimed to evaluate the quality of evidence, validity, and biases in the relationship between selenium intake and health-related outcomes according to published systematic reviews with pooled data and meta-analyses. Selenium intake is associated with a decreased risk of digestive system cancers, all-cause mortality, depression, and Keshan disease, when in children reduce the risk of Kashin-Beck disease. Additionally, selenium supplementation can improve sperm quality, polycystic ovary syndrome, autoimmune thyroid disease, cardiovascular disease, and infective outcomes. Selenium supplementation also has relationship with a decreased concentration of serum lipids including total cholesterol and very low-density lipoprotein cholesterol. However, no evidence has shown that selenium is associated with better outcomes among patients in intensive care units. Furthermore, selenium intake may be related with a higher risk of type 2 diabetes and non-melanoma skin cancers. Moreover, most of included studies are evaluated as low quality according to our evidence assessment. Based on our study findings and the limited advantages of selenium intake, it is not recommended to receive extra supplementary selenium for general populations, and selenium supplementation should not be continued in patients whose selenium-deficient status has been corrected.<\/jats:p>","DOI":"10.3389\/fnut.2023.1263853","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:48:01Z","timestamp":1694627281000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":69,"title":["Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses"],"prefix":"10.3389","volume":"10","author":[{"given":"Puze","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3390\/molecules24071298","article-title":"Selenium\u2013fascinating microelement, properties and sources in food","volume":"24","author":"Kieliszek","year":"2019","journal-title":"Molecules"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1021\/acschembio.6b00031","article-title":"Why nature chose selenium","volume":"11","author":"Reich","year":"2016","journal-title":"ACS Chem Biol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1021\/ja01569a087","article-title":"Selenium as an integral part of factor 3 against dietary necrosis liver degeneration","volume":"79","author":"Schwarz","year":"1957","journal-title":"J Am Chem Soc"},{"key":"ref4","article-title":"Selenium deficiency","volume-title":"StatPearls [Internet]","author":"Shreenath","year":"2022"},{"key":"ref5","article-title":"Selenium","volume-title":"StatPearls [Internet]","author":"Nessel","year":"2022"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/07388550902728261","article-title":"Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality of selenium, dedicated to the memory of Klaus Schwarz (1914\u20131978) on the occasion of the thirtieth anniversary of his death","volume":"29","author":"Schrauzer","year":"2009","journal-title":"Crit Rev Biotechnol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.3390\/ijms24032633","article-title":"Biological activity of selenium and its impact on human health","volume":"24","author":"Genchi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"129697","DOI":"10.1016\/j.foodchem.2021.129697","article-title":"Red and processed meat consumption and cancer outcomes: umbrella review","volume":"356","author":"Huang","year":"2021","journal-title":"Food Chem"},{"key":"ref9","unstructured":"2020"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"128396","DOI":"10.1016\/j.foodchem.2020.128396","article-title":"Tomato and lycopene and multiple health outcomes: umbrella review","volume":"343","author":"Li","year":"2021","journal-title":"Food Chem"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e071609","DOI":"10.1136\/bmj-2022-071609","article-title":"Dietary sugar consumption and health: umbrella review","volume":"381","author":"Huang","year":"2023","journal-title":"BMJ"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/advances\/nmy040","article-title":"Dietary antioxidants, circulating antioxidant concentrations, total antioxidant capacity, and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective observational studies","volume":"9","author":"Jayedi","year":"2018","journal-title":"Adv Nutr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis","volume":"297","author":"Bjelakovic","year":"2007","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1080\/01635581.2011.607544","article-title":"Effects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials","volume":"63","author":"Lee","year":"2011","journal-title":"Nutr Cancer"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1080\/10408398.2018.1548427","article-title":"Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies","volume":"60","author":"Kuria","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/S0140-6736(04)17138-9","article-title":"Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis","volume":"364","author":"Bjelakovic","year":"2004","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"CD005195","DOI":"10.1002\/14651858.CD005195.pub4","article-title":"Selenium for preventing cancer","volume":"1","author":"Vinceti","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e00395","DOI":"10.1042\/BSR20160345","article-title":"Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies","volume":"36","author":"Wang","year":"2016","journal-title":"Biosci Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1080\/09637486.2016.1197892","article-title":"Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis","volume":"67","author":"Chen","year":"2016","journal-title":"Int J Food Sci Nutr"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.22034\/APJCP.2018.19.6.1431","article-title":"The association between selenium and prostate cancer: a systematic review and meta-analysis","volume":"19","author":"Sayehmiri","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e00356","DOI":"10.1042\/BSR20160131","article-title":"Association between selenium levels and oesophageal adenocarcinoma risk: evidence from a meta-analysis","volume":"36","author":"Hong","year":"2016","journal-title":"Biosci Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"810494","DOI":"10.3389\/fnut.2021.810494","article-title":"Associations of the dietary iron, copper, and selenium level with metabolic syndrome: a meta-analysis of observational studies","volume":"8","author":"Ding","year":"2022","journal-title":"Front Nutr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4398","DOI":"10.21037\/apm-21-449","article-title":"The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis","volume":"10","author":"Zuo","year":"2021","journal-title":"Ann Palliat Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1089\/thy.2016.0256","article-title":"Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and Meta-analysis","volume":"26","author":"Wichman","year":"2016","journal-title":"Thyroid"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1089\/thy.2009.0351","article-title":"Selenium supplementation in the treatment of Hashimoto\u2019s thyroiditis: a systematic review and a meta-analysis","volume":"20","author":"Toulis","year":"2010","journal-title":"Thyroid"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3763565","DOI":"10.1155\/2018\/3763565","article-title":"Effects of selenium supplementation on graves\u2019 disease: a systematic review and meta-analysis","volume":"2018","author":"Zheng","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s40200-019-00419-w","article-title":"Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials","volume":"18","author":"Mahdavi Gorabi","year":"2019","journal-title":"J Diabetes Metab Disord"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.3390\/nu14224933","article-title":"Potential benefits of selenium supplementation in reducing insulin resistance in patients with cardiometabolic diseases: a systematic review and meta-analysis","volume":"14","author":"Ouyang","year":"2022","journal-title":"Nutrients"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"111210","DOI":"10.1016\/j.envres.2021.111210","article-title":"A systematic review and dose-response meta-analysis of exposure to environmental selenium and the risk of type 2 diabetes in nonexperimental studies","volume":"197","author":"Vinceti","year":"2021","journal-title":"Environ Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s10654-018-0422-8","article-title":"Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis","volume":"33","author":"Vinceti","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s40200-019-00419-w","article-title":"Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials","volume":"18","author":"Mahdavi Gorabi","year":"2019","journal-title":"J Diabetes Metab Disord"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/advances\/nmy057","article-title":"The effect of nutrients and dietary supplements on sperm quality parameters: a systematic review and meta-analysis of randomized clinical trials","volume":"9","author":"Salas-Huetos","year":"2018","journal-title":"Adv Nutr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.urology.2021.10.041","article-title":"Systematic review and meta-analysis on effect of carnitine, coenzyme Q10 and selenium on pregnancy and semen parameters in couples with idiopathic male infertility","volume":"161","author":"Sharma","year":"2022","journal-title":"Urology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12902-023-01286-6","article-title":"Effects of selenium supplementation on polycystic ovarian syndrome: a systematic review and meta-analysis on randomized clinical trials","volume":"23","author":"Zhao","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1080\/09513590.2022.2118709","article-title":"Selenium supplementation for polycystic ovary syndrome: a meta-analysis of randomized controlled trials","volume":"38","author":"Wu","year":"2022","journal-title":"Gynecol Endocrinol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nrendo.2014.156","article-title":"Reproductive endocrinology: revisiting ovulation induction in PCOS","volume":"10","author":"Fauser","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13148-018-0442-y","article-title":"Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis","volume":"10","author":"Pan","year":"2018","journal-title":"Clin Epigenetics"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"127046","DOI":"10.1016\/j.jtemb.2022.127046","article-title":"The effects of selenium supplementation on blood lipids and blood pressure in adults: a systematic review and dose-response meta-analysis of randomized control trials","volume":"74","author":"Kelishadi","year":"2022","journal-title":"J Trace Elem Med Biol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s12011-018-1302-5","article-title":"Prevention of Keshan disease by selenium supplementation: a systematic review and meta-analysis","volume":"186","author":"Zhou","year":"2018","journal-title":"Biol Trace Elem Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.joca.2008.06.011","article-title":"Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis","volume":"17","author":"Zou","year":"2009","journal-title":"Osteoarthr Cartil"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1007\/s10067-019-04704-0","article-title":"The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis","volume":"38","author":"Zou","year":"2019","journal-title":"Clin Rheumatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.clnesp.2020.11.026","article-title":"Daily parenteral selenium therapy in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials","volume":"41","author":"Mousavi","year":"2021","journal-title":"Clin Nutr ESPEN"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s13054-016-1529-5","article-title":"High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis","volume":"20","author":"Manzanares","year":"2016","journal-title":"Crit Care"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e14733","DOI":"10.1097\/MD.0000000000014733","article-title":"A meta-analysis of randomized controlled trials: efficacy of selenium treatment for sepsis","volume":"98","author":"Li","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"ms77e1837","DOI":"10.54905\/disssi\/v26i121\/ms77e1837","article-title":"Role of zinc, selenium, vitamin D and vitamin C in boosting respiratory system: a meta-analysis approach","volume":"26","author":"Nazari","year":"2022","journal-title":"Med Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s40200-021-00821-3","article-title":"The effects of dietary selenium supplementation on inflammatory markers among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Djalalinia","year":"2021","journal-title":"J Diabetes Metab Disord"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12011-015-0545-7","article-title":"Selenium and preeclampsia: a systematic review and meta-analysis","volume":"171","author":"Xu","year":"2016","journal-title":"Biol Trace Elem Res"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ajcnut.2022.11.007","article-title":"Selenium and immune function: a systematic review and meta-analysis of experimental human studies","volume":"117","author":"Filippini","year":"2023","journal-title":"Am J Clin Nutr"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/psc.654","article-title":"Isosteric replacement of sulfur with other chalcogens in peptides and proteins","volume":"11","author":"Moroder","year":"2005","journal-title":"J Pept Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.3390\/ijms24032633","article-title":"Biological activity of selenium and its impact on human health","volume":"24","author":"Genchi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.5713\/ajas.2007.1135","article-title":"Selenium in food chain and animal nutrition: lessons from nature","volume":"20","author":"Lyons","year":"2007","journal-title":"Asian Australas J Anim Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jtemb.2015.07.005","article-title":"Revised reference values for selenium intake","volume":"32","author":"Kipp","year":"2015","journal-title":"J Trace Elem Med Bio"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10565-011-9203-9","article-title":"Selenium interactions and toxicity: a review. Selenium interactions and toxicity","volume":"28","author":"Zwolak","year":"2012","journal-title":"Cell Biol Toxicol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3390\/nu7042209","article-title":"Biomarkers of selenium status","volume":"7","author":"Combs","year":"2015","journal-title":"Nutrients"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.3390\/nu7031494","article-title":"A review of dietary selenium intake and selenium status in Europe and the Middle East","volume":"7","author":"Stoffaneller","year":"2015","journal-title":"Nutrients"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"20953","DOI":"10.1038\/srep20953","article-title":"Distribution of soil selenium in China is potentially controlled by deposition and volatilization?","volume":"6","author":"Sun","year":"2016","journal-title":"Sci Rep"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1753-4887.2006.tb00198.x","article-title":"Bioavailability of selenium from foods","volume":"64","author":"Finley","year":"2006","journal-title":"Nutr Rev"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.nut.2012.11.012","article-title":"Selenium: significance, and outlook for supplementation","volume":"29","author":"Kieliszek","year":"2013","journal-title":"Nutrition"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3390\/molecules21050609","article-title":"Current knowledge on the importance of selenium in food for living organisms: a review","volume":"21","author":"Kieliszek","year":"2016","journal-title":"Molecules"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jfca.2017.01.001","article-title":"Selenium content of Brazilian foods: a review of the literature values","volume":"58","author":"dos Santos","year":"2017","journal-title":"J Food Compos Anal"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"145","DOI":"10.5601\/jelem.2013.18.1.13","article-title":"Selenium in medicine and treatment","volume":"18","author":"Fr\u0105czek","year":"2013","journal-title":"J Elem"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1024\/0300-9831.77.3.205","article-title":"Effect of genotype on micronutrient absorption and metabolism: a review of iron, copper, iodine and selenium, and folates","volume":"77","author":"Mithen","year":"2007","journal-title":"Int J Vitam Nutr Res"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12011-019-01771-x","article-title":"From selenium absorption to selenoprotein degradation","volume":"192","author":"Ha","year":"2019","journal-title":"Biol Trace Elem Res"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1093\/genetics\/145.3.627","article-title":"Molecular characterization of two high affinity sulfate transporters in Saccharomyces cerevisiae","volume":"145","author":"Cherest","year":"1997","journal-title":"Genetics"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1093\/jn\/130.7.1653","article-title":"Selenomethionine: a review of its nutritional significance, metabolism and toxicity","volume":"130","author":"Schrauzer","year":"2000","journal-title":"J Nutr"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1079\/BJN19920032","article-title":"Supplementation with wheat selenium induces a dose-dependent response in serum and urine of a Se-replete population","volume":"67","author":"Meltzer","year":"1992","journal-title":"Br J Nutr"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"621687","DOI":"10.3389\/fendo.2021.621687","article-title":"Selenium kinetics in humans change following 2 years of supplementation with selenomethionine","volume":"12","author":"Patterson","year":"2021","journal-title":"Front Endocrinol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.3390\/ijms24032633","article-title":"Biological activity of selenium and its impact on human health","volume":"24","author":"Genchi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3390\/nu12030725","article-title":"Selenium, zinc, and manganese status in pregnant women and its relation to maternal and child complications","volume":"12","author":"Iqbal","year":"2020","journal-title":"Nutrients"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.freeradbiomed.2014.07.005","article-title":"Plasma selenium levels and oxidative stress biomarkers: a gene-environment interaction population-based study","volume":"74","author":"Galan-Chilet","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1740-8709.2010.00262.x","article-title":"The nutritional requirements of infants. Towards EU alignment of reference values: the EURRECA network","volume":"6","author":"Hermoso","year":"2010","journal-title":"Matern Child Nutr"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1177\/0884533612446706","article-title":"A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products","volume":"27","author":"Vanek","year":"2012","journal-title":"Nutr Clin Pract"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"e07704","DOI":"10.2903\/j.efsa.2023.7704","article-title":"Scientific opinion on the tolerable upper intake level for selenium","volume":"21","author":"Turck","year":"2023","journal-title":"EFSA J"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"127235","DOI":"10.1016\/j.jtemb.2023.127235","article-title":"Toxicity of repeated oral intake of organic selenium, inorganic selenium, and selenium nanoparticles: a review","volume":"79","author":"Hadrup","year":"2023","journal-title":"J Trace Elem Med Biol"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3390\/nu10091203","article-title":"Selenium, selenoproteins, and immunity","volume":"10","author":"Avery","year":"2018","journal-title":"Nutrients"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.3390\/molecules28073198","article-title":"Selenium in peptide chemistry","volume":"28","author":"Pehlivan","year":"2023","journal-title":"Molecules"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1007\/s00018-009-0032-4","article-title":"The human selenoproteome: recent insights into functions and regulation","volume":"66","author":"Reeves","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol Rev"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1007\/PL00000667","article-title":"The deiodinase family: selenoenzymes regulating thyroid hormone availability and action","volume":"57","author":"K\u00f6hrle","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s002040050176","article-title":"Chemical form of selenium-containing metabolite in small intestine and liver of mice following orally administered selenocystine","volume":"69","author":"Hasegawa","year":"1995","journal-title":"Arch Toxicol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"G854","DOI":"10.1152\/ajpgi.1992.262.5.G854","article-title":"Evidence for intestinal release of absorbed selenium in a form with high hepatic extraction","volume":"262","author":"Kato","year":"1992","journal-title":"Am J Phys"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"40414","DOI":"10.1074\/jbc.M112.421404","article-title":"Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis","volume":"287","author":"Hill","year":"2012","journal-title":"J Biol Chem"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1146\/annurev-nutr-071714-034250","article-title":"Regulation of selenium metabolism and transport","volume":"35","author":"Burk","year":"2015","journal-title":"Annu Rev Nutr"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.bbagen.2009.03.026","article-title":"Selenoprotein P-expression, functions, and roles in mammals","volume":"1790","author":"Burk","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"126801","DOI":"10.1016\/j.jtemb.2021.126801","article-title":"Absorption, distribution, metabolism and excretion (ADME) of oral selenium from organic and inorganic sources: a review","volume":"67","author":"Hadrup","year":"2021","journal-title":"J Trace Elem Med Biol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00204-014-1380-x","article-title":"Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenate dependent on trimethylselenium ion (TMSe) status","volume":"90","author":"J\u00e4ger","year":"2016","journal-title":"Arch Toxicol"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"126519","DOI":"10.1016\/j.jtemb.2020.126519","article-title":"Determination of eleven small selenium species in human urine by chromatographic-coupled ICP-MS methods","volume":"61","author":"Hildebrand","year":"2020","journal-title":"J Trace Elem Med Biol"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"15932","DOI":"10.1073\/pnas.252610699","article-title":"Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range","volume":"99","author":"Kobayashi","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1515\/BC.2000.107","article-title":"Selenium in biology: facts and medical perspectives","volume":"381","author":"K\u00f6hrl","year":"2000","journal-title":"Biol Chem"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"S168","DOI":"10.1134\/S0006297922140139","article-title":"Selenium metabolism and biosynthesis of selenoproteins in the human body","volume":"87","author":"Minich","year":"2022","journal-title":"Biochemistry"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1089\/ars.2015.6391","article-title":"Update on selenoprotein biosynthesis","volume":"23","author":"Bulteau","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3945\/an.110.000265","article-title":"Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis","volume":"2","author":"Turanov","year":"2011","journal-title":"Adv Nutr"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0968-0004(91)90180-4","article-title":"Selenoprotein synthesis: an expansion of the genetic code","volume":"16","author":"B\u00f6ck","year":"1991","journal-title":"Trends Biochem Sci"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1016\/j.bbagen.2018.05.006","article-title":"Selenium metabolism in plants","volume":"1862","author":"White","year":"2018","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.3390\/molecules28073198","article-title":"Selenium in peptide chemistry","volume":"28","author":"Pehlivan","year":"2023","journal-title":"Molecules"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"337","DOI":"10.2174\/138920312801619448","article-title":"Post-transcriptional control of selenoprotein biosynthesis","volume":"13","author":"Seeher","year":"2012","journal-title":"Curr Protein Pept Sci"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"Holmstr\u00f6m","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1042\/BST20190049","article-title":"Hydrogen peroxide reactivity and specificity in thiol-based cell signalling","volume":"48","author":"Winterbourn","year":"2020","journal-title":"Biochem Soc Trans"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"5853238","DOI":"10.1155\/2017\/5853238","article-title":"Oxidative stress and inflammation in cardiovascular disease","volume":"2017","author":"Garc\u00eda","year":"2017","journal-title":"Oxidative Med Cell Longev"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/jcrt.JCRT_862_16","article-title":"Oxidative stress and its role in cancer","volume":"17","author":"Jelic","year":"2021","journal-title":"J Cancer Res Ther"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","article-title":"Oxidative stress in Alzheimer\u2019s disease","volume":"30","author":"Chen","year":"2014","journal-title":"Neurosci Bull"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nature03688","article-title":"Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability","volume":"436","author":"Radisky","year":"2005","journal-title":"Nature"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ccr.2011.09.012","article-title":"Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands","volume":"20","author":"O\u2019Hagan","year":"2011","journal-title":"Cancer Cell"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.abb.2016.08.003","article-title":"Selenium and redox signaling","volume":"617","author":"Brigelius-Floh\u00e9","year":"2017","journal-title":"Arch Biochem Biophys"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1147414","DOI":"10.3389\/fphar.2023.1147414","article-title":"Research progress of glutathione peroxidase family (GPX) in redoxidation","volume":"14","author":"Pei","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"e2249948","DOI":"10.1002\/eji.202249948","article-title":"The thioredoxin system: balancing redox responses in immune cells and tumors","volume":"53","author":"Muri","year":"2023","journal-title":"Eur J Immunol"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"e05386","DOI":"10.2903\/j.efsa.2018.5387","article-title":"Assessment of the application for renewal of authorisation of selenomethionine produced by Saccharomyces cerevisiae CNCM I-3060 (selenised yeast inactivated) for all animal species","volume":"16","author":"Bampidis","year":"2018","journal-title":"EFSA J"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol Asp Med"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s13205-018-1415-8","article-title":"Equilibrium modeling of selenium binding from aqueous solutions by Candida utilis ATCC 9950 yeasts","volume":"8","author":"Kieliszek","year":"2018","journal-title":"3 Biotech"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.freeradbiomed.2015.09.023","article-title":"Glutathione--linking cell proliferation to oxidative stress","volume":"89","author":"Diaz-Vivancos","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-pharmtox-052220-102509","article-title":"Thioredoxin reductase inhibition for cancer therapy","volume":"62","author":"Gencheva","year":"2022","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.3390\/biomedicines10071757","article-title":"The thioredoxin system of mammalian cells and its modulators","volume":"10","author":"Hasan","year":"2022","journal-title":"Biomedicine"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1039\/C3MT00185G","article-title":"Selenium biochemistry and its role for human health","volume":"6","author":"Roman","year":"2014","journal-title":"Metallomics"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1110\/ps.8.8.1605","article-title":"The disulfide-coupled folding pathway of apamin as derived from diselenide-quenched analogs and intermediates","volume":"8","author":"Pegoraro","year":"1999","journal-title":"Protein Sci"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1006\/jmbi.1998.2189","article-title":"Isomorphous replacement of cystine with selenocystine in endothelin: oxidative refolding, biological and conformational properties of [Sec3,Sec11,Nle7]-endothelin-1","volume":"284","author":"Pegoraro","year":"1998","journal-title":"J Mol Biol"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.redox.2016.12.025","article-title":"Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P","volume":"11","author":"Hybsier","year":"2017","journal-title":"Redox Biol"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1080\/15548627.2020.1714209","article-title":"Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein","volume":"16","author":"Dai","year":"2020","journal-title":"Autophagy"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cac2.12250","article-title":"Ferroptosis in cancer and cancer immunotherapy","volume":"42","author":"Zhao","year":"2022","journal-title":"Cancer Commun"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol Dis"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4143\/crt.2016.572","article-title":"Ferroptosis: a novel anti-tumor action for cisplatin","volume":"50","author":"Guo","year":"2018","journal-title":"Cancer Res Treat"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"e2307","DOI":"10.1038\/cddis.2016.208","article-title":"Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells","volume":"7","author":"Ma","year":"2016","journal-title":"Cell Death Dis"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3892\/ijo.2018.4259","article-title":"Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis","volume":"52","author":"Yamaguchi","year":"2018","journal-title":"Int J Oncol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cells"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1530\/eje.0.1380482","article-title":"Hormonal control of programmed cell death\/apoptosis","volume":"138","author":"Kiess","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3390\/molecules14031263","article-title":"Selenium as an essential micronutrient: roles in cell cycle and apoptosis","volume":"14","author":"Zeng","year":"2009","journal-title":"Molecules"},{"key":"ref132","first-page":"6805","article-title":"Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate","volume":"61","author":"Miki","year":"2001","journal-title":"Cancer Res"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/biof.5520310302","article-title":"Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells","volume":"31","author":"Zeng","year":"2007","journal-title":"Biofactors"},{"key":"ref134","first-page":"6707","article-title":"Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism?","volume":"63","author":"Irmak","year":"2003","journal-title":"Cancer Res"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2023.01.024","article-title":"Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K\/AKT-mediated apoptosis and cell proliferation signaling in testis of mice","volume":"197","author":"Xu","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3945\/jn.117.252544","article-title":"Dietary selenium deficiency or excess reduces sperm quality and testicular mRNA abundance of nuclear glutathione peroxidase 4 in rats","volume":"147","author":"Zhou","year":"2017","journal-title":"J Nutr"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1007\/s12011-021-02910-z","article-title":"Selenium deficiency induces apoptosis and necroptosis through ROS\/MAPK signal in human uterine smooth muscle cells","volume":"200","author":"Wang","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.3390\/jcm10163755","article-title":"Effects of Selenium supplementation on sperm parameters and DNA-fragmentation rate in patients with chronic autoimmune thyroiditis","volume":"10","author":"Cannarella","year":"2021","journal-title":"J Clin Med"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-023-03638-8","article-title":"The effect of selenium therapy on semen parameters, antioxidant capacity, and sperm DNA fragmentation in men with idiopathic oligoasthenoteratospermia","author":"Alahmar","year":"2023","journal-title":"Biol Trace Elem Res"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1128\/MCB.19.3.1950","article-title":"Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity","volume":"19","author":"Bonizzi","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1089\/ars.2011.4145","article-title":"The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities","volume":"16","author":"Huang","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1128\/iai.41.1.185-189.1983","article-title":"Selenium and immune functions in humans","volume":"41","author":"Arvilommi","year":"1983","journal-title":"Infect Immun"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.clnu.2015.12.003","article-title":"Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults","volume":"36","author":"Ivory","year":"2017","journal-title":"Clin Nutr"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1089\/jmf.2015.0145","article-title":"Impact of selenium supplementation in neutropenia and immunoglobulin production in childhood Cancer patients","volume":"19","author":"Rocha","year":"2016","journal-title":"J Med Food"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fnut.2020.00164","article-title":"Selenium and RNA virus interactions: potential implications for SARS-Cov-2 infection (COVID-19)","volume":"7","author":"Hiffler","year":"2020","journal-title":"Front Nutr"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF02778988","article-title":"Inhibitory effect of selenite and other antioxidants on complement-mediated tissue injury in patients with epidemic hemorrhagic fever","volume":"56","author":"Hou","year":"1997","journal-title":"Biol Trace Elem Res"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0029665122002646","article-title":"The relevance of selenium to viral disease with special reference to SARS-CoV-2 and COVID-19","volume":"82","author":"Rayman","year":"2023","journal-title":"Proc Nutr Soc"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"9733","DOI":"10.1128\/JVI.00694-10","article-title":"Viral mutation rates","volume":"84","author":"Sanjuan","year":"2010","journal-title":"J Virol"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/ilar\/ilx026","article-title":"Are RNA viruses candidate agents for the next global pandemic?","volume":"58","author":"Carrasco-Hernandez","year":"2017","journal-title":"A Review ILAR journal"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202006.0069.v1","article-title":"RNA viruses vs. DNA synthesis: a general viral strategy that may contribute to the protective antiviral effects of selenium","author":"Taylor","year":"2020","journal-title":"Preprints"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3390\/antiox12030559","article-title":"SARS-CoV-2 Main protease targets host selenoproteins and glutathione biosynthesis for knockdown via proteolysis, potentially disrupting the thioredoxin and glutaredoxin redox cycles","volume":"12","author":"Gallardo","year":"2023","journal-title":"Antioxidants"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1089\/ars.2011.4145","article-title":"The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities","volume":"16","author":"Huang","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"110984","DOI":"10.1016\/j.envres.2021.110984","article-title":"Selenium (Se) plays a key role in the biological effects of some viruses: implications for COVID-19","volume":"196","author":"Liu","year":"2021","journal-title":"Environ Res"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"391","DOI":"10.5604\/17331331.1227664","article-title":"Viral infection of the heart: pathogenesis and diagnosis","volume":"65","author":"Kuffner","year":"2017","journal-title":"Pol J Microbiol"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.4314\/ahs.v13i4.34","article-title":"Enteroviruses as a possible cause of hypertension, dilated cardiomyopathy (DCM) and hypertensive heart failure (HHF) in South western Nigeria","volume":"13","author":"Okonko","year":"2013","journal-title":"Afr Health Sci"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"576916","DOI":"10.3389\/fped.2021.576916","article-title":"Keshan disease: a potentially fatal endemic cardiomyopathy in Remote Mountains of China","volume":"9","author":"Shi","year":"2021","journal-title":"Front Pediatr"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3390\/ijms23010280","article-title":"Role of selenium in viral infections with a major focus on SARS-CoV-2","volume":"23","author":"Martinez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"15774","DOI":"10.1073\/pnas.1007909107","article-title":"12\/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases","volume":"107","author":"Conrad","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3945\/jn.109.120725","article-title":"Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols","volume":"140","author":"Hoffmann","year":"2010","journal-title":"J Nutr"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.4049\/jimmunol.179.5.3258","article-title":"A role for dietary selenium and selenoproteins in allergic airway inflammation","volume":"179","author":"Hoffmann","year":"2007","journal-title":"J Immunol"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0009-8981(03)00223-7","article-title":"Selenium regulates transcription factor NF-kappaB activation during the acute phase reaction","volume":"334","author":"Maehira","year":"2003","journal-title":"Clin Chim Acta"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1089\/jmf.2015.0145","article-title":"Impact of selenium supplementation in neutropenia and immunoglobulin production in childhood cancer patients","volume":"19","author":"Rocha","year":"2016","journal-title":"J Med Food"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"10054","DOI":"10.18632\/oncotarget.24300","article-title":"Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma","volume":"9","author":"Rohr-Udilova","year":"2018","journal-title":"Oncotarget"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/ijc.33902","article-title":"Selenium and cancer risk: wide-angled Mendelian randomization analysis","volume":"150","author":"Yuan","year":"2022","journal-title":"Int J Cancer"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0946-672X(02)80002-5","article-title":"Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over","volume":"16","author":"Bates","year":"2002","journal-title":"J Trace Elem Med Biol"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1182\/blood-2004-07-2599","article-title":"The origins of age-related proinflammatory state","volume":"105","author":"Ferrucci","year":"2005","journal-title":"Blood"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"6601","DOI":"10.1038\/s41598-018-24826-w","article-title":"Integrated analysis of microRNA and mRNA expression profiles in rats with selenium deficiency and identification of associated miRNA-mRNA network","volume":"8","author":"Feng","year":"2018","journal-title":"Sci Rep"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/ejhf.1644","article-title":"Selenium and outcome in heart failure","volume":"22","author":"Bomer","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"e2100644","DOI":"10.1002\/mnfr.202100644","article-title":"Selenium deficiency induces pathological cardiac lipid metabolic remodeling and inflammation","volume":"66","author":"Tang","year":"2022","journal-title":"Mol Nutr Food Res"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1055\/s-0042-110491","article-title":"Effect of selenium supplementation on recurrent hyperthyroidism caused by graves\u2019 disease: a prospective pilot study","volume":"48","author":"Wang","year":"2016","journal-title":"Horm Metab Res"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1056\/NEJMoa1012985","article-title":"Selenium and the course of mild Graves\u2019 orbitopathy","volume":"364","author":"Weissel","year":"2011","journal-title":"N Engl J Med"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"102236","DOI":"10.1016\/j.redox.2022.102236","article-title":"The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities","volume":"50","author":"Steinbrenner","year":"2022","journal-title":"Redox Biol"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.envint.2014.04.019","article-title":"Arsenic and selenium toxicity and their interactive effects in humans","volume":"69","author":"Sun","year":"2014","journal-title":"Environ Int"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease","volume":"14","author":"Fairweather-Tait","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3390\/nu5030700","article-title":"Daily dietary selenium intake in a high selenium area of Enshi, China","volume":"5","author":"Huang","year":"2013","journal-title":"Nutrients"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"126435","DOI":"10.1016\/j.jtemb.2019.126435","article-title":"Acute human toxicity and mortality after selenium ingestion: a review","volume":"58","author":"Hadrup","year":"2020","journal-title":"J Trace Elem Med Biol"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jtemb.2018.01.012","article-title":"Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease","volume":"50","author":"Ning","year":"2018","journal-title":"J Trace Elem Med Biol"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1263853\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:48:08Z","timestamp":1694627288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1263853\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":177,"alternative-id":["10.3389\/fnut.2023.1263853"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2023.1263853","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"article-number":"1263853"}}