{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:58:39Z","timestamp":1791557919912,"version":"4.3.4"},"reference-count":248,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>In the past two decades, the rapid increase in the incidence of metabolic diseases, including obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and hyperuricemia, has been attributed to high-fat diets (HFD) and decreased physical activity levels. Although the phenotypes and pathologies of these metabolic diseases vary, patients with these diseases exhibit disease-specific alterations in the composition and function of their gut microbiota. Studies in germ-free mice have shown that both HFD and gut microbiota can promote the development of metabolic diseases, and HFD can disrupt the balance of gut microbiota. Therefore, investigating the interaction between gut microbiota and HFD in the pathogenesis of metabolic diseases is crucial for identifying novel therapeutic strategies for these diseases. This review takes HFD as the starting point, providing a detailed analysis of the pivotal role of HFD in the development of metabolic disorders. It comprehensively elucidates the impact of HFD on the balance of intestinal microbiota, analyzes the mechanisms underlying gut microbiota dysbiosis leading to metabolic disruptions, and explores the associated genetic factors. Finally, the potential of targeting the gut microbiota as a means to address metabolic disturbances induced by HFD is discussed. In summary, this review offers theoretical support and proposes new research avenues for investigating the role of nutrition-related factors in the pathogenesis of metabolic disorders in the organism.<\/jats:p>","DOI":"10.3389\/fnut.2023.1291853","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T05:57:45Z","timestamp":1702619865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiaokang","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101091","DOI":"10.1016\/j.redox.2018.101091","article-title":"The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome","volume":"21","author":"Traber","year":"2019","journal-title":"Redox Biol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1167317","DOI":"10.3389\/fendo.2023.1167317","article-title":"Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006","volume":"14","author":"Pei","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0140-6736(16)30054-X","article-title":"Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19\u00b72 million participants","volume":"387","year":"2016","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","article-title":"Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1161\/CIRCULATIONAHA.107.716159","article-title":"Dietary intake and the development of the metabolic syndrome: the atherosclerosis risk in communities study","volume":"117","author":"Lutsey","year":"2008","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e2000982","DOI":"10.1002\/mnfr.202000982","article-title":"Effects of the Mediterranean diet or nut consumption on gut microbiota composition and fecal metabolites and their relationship with Cardiometabolic risk factors","volume":"65","author":"Gali\u00e9","year":"2021","journal-title":"Mol Nutr Food Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.chom.2019.06.013","article-title":"Meta-analysis reveals reproducible gut microbiome alterations in response to a high-fat diet","volume":"26","author":"Bisanz","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/19490976.2016.1270811","article-title":"Western diets, gut dysbiosis, and metabolic diseases: are they linked?","volume":"8","author":"Martinez","year":"2017","journal-title":"Gut Microbes"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.chom.2022.03.030","article-title":"High-fat diet disrupts REG3\u03b3 and gut microbial rhythms promoting metabolic dysfunction","volume":"30","author":"Frazier","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyad092","article-title":"Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts","author":"Begum","year":"2023","journal-title":"Int J Epidemiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/ajcn\/nqz259","article-title":"Association between sustainable dietary patterns and body weight, overweight, and obesity risk in the NutriNet-Sant\u00e9 prospective cohort","volume":"112","author":"Seconda","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1002\/oby.23783","article-title":"The cross-sectional association between a sustainable diet index and obesity among US adults","volume":"31","author":"Jung","year":"2023","journal-title":"Obesity (Silver Spring)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1093\/ajcn.81.2.341","article-title":"Origins and evolution of the Western diet: health implications for the 21st century","volume":"81","author":"Cordain","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000000529","article-title":"Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association","volume":"136","author":"Sacks","year":"2017","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.3390\/nu14224911","article-title":"Dietary patterns and obesity in Chinese adults: a systematic review and Meta-analysis","volume":"14","author":"Jiang","year":"2022","journal-title":"Nutrients"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e072003","DOI":"10.1136\/bmj-2022-072003","article-title":"Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis","volume":"380","author":"Karam","year":"2023","journal-title":"BMJ"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"m696","DOI":"10.1136\/bmj.m696","article-title":"Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials","volume":"369","author":"Ge","year":"2020","journal-title":"BMJ"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.clnu.2023.03.011","article-title":"The sulfur microbial diet and increased risk of obesity: findings from a population-based prospective cohort study","volume":"42","author":"Liu","year":"2023","journal-title":"Clin Nutr"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1128\/mSystems.00219-19","article-title":"Distinct gut microbiota induced by different fat-to-sugar-ratio high-energy diets share similar pro-obesity genetic and metabolite profiles in Prediabetic mice","volume":"4","author":"Shan","year":"2019","journal-title":"mSystems"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.clnu.2019.01.019","article-title":"Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities","volume":"39","author":"Tang","year":"2020","journal-title":"Clin Nutr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.cmet.2019.08.010","article-title":"Microglial UCP2 mediates inflammation and obesity induced by high-fat feeding","volume":"30","author":"Kim","year":"2019","journal-title":"Cell Metab"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.neuron.2020.03.022","article-title":"PNOC(ARC) neurons promote Hyperphagia and obesity upon high-fat-diet feeding","volume":"106","author":"Jais","year":"2020","journal-title":"Neuron"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/ajcn\/nqac058","article-title":"Associations of lower-carbohydrate and lower-fat diets with mortality among people with prediabetes","volume":"116","author":"Li","year":"2022","journal-title":"Am J Clin Nutr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e1003347","DOI":"10.1371\/journal.pmed.1003347","article-title":"Intake of dietary fats and fatty acids and the incidence of type 2 diabetes: a systematic review and dose-response meta-analysis of prospective observational studies","volume":"17","author":"Neuenschwander","year":"2020","journal-title":"PLoS Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ajcnut.2023.05.026","article-title":"A randomized clinical trial comparing low-fat with precision nutrition-based diets for weight loss: impact on glycemic variability and HbA1c","volume":"118","author":"Kharmats","year":"2023","journal-title":"Am J Clin Nutr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"14032","DOI":"10.1038\/s41598-021-93409-z","article-title":"Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats","volume":"11","author":"Glavas","year":"2021","journal-title":"Sci Rep"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1038\/s41598-019-39177-3","article-title":"Early overnutrition reduces Pdx1 expression and induces \u03b2 cell failure in Swiss Webster mice","volume":"9","author":"Glavas","year":"2019","journal-title":"Sci Rep"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.2337\/db21-0310","article-title":"Developmental timing of high-fat diet exposure impacts glucose homeostasis in mice in a sex-specific manner","volume":"70","author":"Glavas","year":"2021","journal-title":"Diabetes"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"32345","DOI":"10.1074\/jbc.M313478200","article-title":"Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease","volume":"279","author":"Samuel","year":"2004","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1158\/0008-5472.CAN-20-1954","article-title":"Fat induces glucose metabolism in nontransformed liver cells and promotes liver tumorigenesis","volume":"81","author":"Broadfield","year":"2021","journal-title":"Cancer Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.cmet.2022.05.007","article-title":"Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance","volume":"34","author":"Wu","year":"2022","journal-title":"Cell Metab"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"109037","DOI":"10.1016\/j.jnutbio.2022.109037","article-title":"A comprehensive review on high -fat diet-induced diabetes mellitus: an epigenetic view","volume":"107","author":"Prasad","year":"2022","journal-title":"J Nutr Biochem"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.cell.2005.09.041","article-title":"Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes","volume":"123","author":"Ohtsubo","year":"2005","journal-title":"Cells"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"30265","DOI":"10.1038\/srep30265","article-title":"High fat diet-induced TGF-\u03b2\/Gbb signaling provokes insulin resistance through the tribbles expression","volume":"6","author":"Hong","year":"2016","journal-title":"Sci Rep"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.3390\/nu14071344","article-title":"Mediterranean dietary treatment in Hyperlipidemic children: should it be an option?","volume":"14","author":"Massini","year":"2022","journal-title":"Nutrients"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1093\/ajcn\/nqy144","article-title":"Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial","volume":"108","author":"Gomez-Marin","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3390\/nu14020235","article-title":"Alleviation of dyslipidemia via a traditional balanced Korean diet represented by a Low glycemic and Low cholesterol diet in obese women in a randomized controlled trial","volume":"14","author":"Kim","year":"2022","journal-title":"Nutrients"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/nutrit\/nuaa044","article-title":"Effects of macronutrient intake in obesity: a meta-analysis of low-carbohydrate and low-fat diets on markers of the metabolic syndrome","volume":"79","author":"Willems","year":"2021","journal-title":"Nutr Rev"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/jcm9020296","article-title":"The effect of the Paleolithic diet vs. healthy diets on glucose and insulin homeostasis: a systematic review and Meta-analysis of randomized controlled trials","volume":"9","author":"Jamka","year":"2020","journal-title":"J Clin Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.121.056805","article-title":"Deep Lipidomics in human plasma: Cardiometabolic disease risk and effect of dietary fat modulation","volume":"146","author":"Eichelmann","year":"2022","journal-title":"Circulation"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"700778","DOI":"10.3389\/fnut.2021.700778","article-title":"Can millet consumption help manage hyperlipidemia and obesity?: a systematic review and meta-analysis","volume":"8","author":"Anitha","year":"2021","journal-title":"Front Nutr"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3945\/ajcn.115.109165","article-title":"Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies","volume":"102","author":"Holl\u00e6nder","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/ajcn\/nqz344","article-title":"Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study","volume":"111","author":"Vasilopoulou","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1080\/10408398.2020.1790496","article-title":"Effects of \u03b1-linolenic acid intake on blood lipid profiles:a systematic review and meta-analysis of randomized controlled trials","volume":"61","author":"Yue","year":"2021","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1590\/2359-3997000000229","article-title":"Orange juice with a high-fat meal prolongs postprandial lipemia in apparently healthy overweight\/obese women","volume":"61","author":"Coelho","year":"2017","journal-title":"Arch Endocrinol Metab"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.mayocp.2020.10.044","article-title":"Impact of a high-shrimp diet on cardiovascular risk: An NHANES analysis","volume":"96","author":"Narasimhan","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"634780","DOI":"10.3389\/fcimb.2021.634780","article-title":"Impact of gut microbiota and microbiota-related metabolites on hyperlipidemia","volume":"11","author":"Jia","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1053\/j.gastro.2018.03.038","article-title":"Improved diet quality associates with reduction in liver fat, particularly in individuals with high genetic risk scores for nonalcoholic fatty liver disease","volume":"155","author":"Ma","year":"2018","journal-title":"Gastroenterology"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1073\/pnas.1713837115","article-title":"High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism","volume":"115","author":"Lanaspa","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3945\/an.116.013151","article-title":"Nonalcoholic fatty liver disease, the gut microbiome, and diet","volume":"8","author":"Mokhtari","year":"2017","journal-title":"Adv Nutr"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41574-019-0256-9","article-title":"The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state","volume":"15","author":"Hodson","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13059-018-1439-8","article-title":"Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption","volume":"19","author":"Sanders","year":"2018","journal-title":"Genome Biol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1007\/s00018-019-03114-4","article-title":"Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease","volume":"76","author":"Kim","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1800930","DOI":"10.1002\/mnfr.201800930","article-title":"Functional interactions between gut microbiota transplantation, quercetin, and high-fat diet determine non-alcoholic fatty liver disease development in germ-free mice","volume":"63","author":"Porras","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12916-023-02793-y","article-title":"Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK biobank participants","volume":"21","author":"Petermann-Rocha","year":"2023","journal-title":"BMC Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1001\/jama.2018.20579","article-title":"Effect of a Low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys: a randomized clinical trial","volume":"321","author":"Schwimmer","year":"2019","journal-title":"JAMA"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1002\/hep.30076","article-title":"Ad libitum Mediterranean and Low-fat diets both significantly reduce hepatic steatosis: a randomized controlled trial","volume":"68","author":"Properzi","year":"2018","journal-title":"Hepatology"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1136\/gutjnl-2020-323106","article-title":"Effect of green-64Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial","volume":"70","author":"Meir","year":"2021","journal-title":"Gut"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1097\/HEP.0000000000000330","article-title":"Intermittent fasting- the future treatment in Nash patients?","volume":"78","author":"Minciun\u0103","year":"","journal-title":"Hepatology"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e233513","DOI":"10.1001\/jamanetworkopen.2023.3513","article-title":"Effects of time-restricted eating on nonalcoholic fatty liver disease: the TREATY-FLD randomized clinical trial","volume":"6","author":"Wei","year":"2023","journal-title":"JAMA Netw Open"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"50996","DOI":"10.1172\/JCI150996","article-title":"Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease","volume":"131","author":"Cohen","year":"2021","journal-title":"J Clin Invest"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1126\/scitranslmed.aay0284","article-title":"Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates","volume":"11","author":"Goedeke","year":"2019","journal-title":"Sci Transl Med"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","article-title":"Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD","volume":"67","author":"Jiao","year":"2018","journal-title":"Gut"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"101635","DOI":"10.1016\/j.redox.2020.101635","article-title":"Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy","volume":"36","author":"Gao","year":"2020","journal-title":"Redox Biol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tips.2019.12.005","article-title":"Targeting FGF21 for the treatment of nonalcoholic steatohepatitis","volume":"41","author":"Zarei","year":"2020","journal-title":"Trends Pharmacol Sci"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13098-022-00823-y","article-title":"Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet","volume":"14","author":"Zhang","year":"2022","journal-title":"Diabetol Metab Syndr"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1093\/cvr\/cvz091","article-title":"The effect of diet on hypertensive pathology: is there a link via gut microbiota-driven immunometabolism?","volume":"115","author":"Jama","year":"2019","journal-title":"Cardiovasc Res"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41569-023-00879-x","article-title":"A high-salt diet promotes atherosclerosis by altering haematopoiesis","volume":"20","author":"Lee","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/HYPERTENSIONAHA.118.12134","article-title":"Male and female intrauterine growth-restricted offspring differ in blood pressure, renal function, and glucose homeostasis responses to a postnatal diet high in fat and sugar","volume":"73","author":"Intapad","year":"2019","journal-title":"Hypertension"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1161\/HYPERTENSIONAHA.122.19608","article-title":"Voluntary exercise eliminates maternal gestational hypertension-induced hypertensive response sensitization to Postweaning high-fat diet in male adult offspring","volume":"79","author":"Xue","year":"2022","journal-title":"Hypertension"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.3390\/nu11091982","article-title":"The interplay between maternal and post-weaning high-fat diet and gut microbiota in the developmental programming of hypertension","volume":"11","author":"Hsu","year":"2019","journal-title":"Nutrients"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.3390\/nu11122908","article-title":"Hypertension programmed by perinatal high-fat diet: effect of maternal gut microbiota-targeted therapy","volume":"11","author":"Hsu","year":"2019","journal-title":"Nutrients"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/nm.2541","article-title":"Under pressure: the search for the essential mechanisms of hypertension","volume":"17","author":"Coffman","year":"2011","journal-title":"Nat Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates T(H)17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1161\/01.HYP.0000248430.26229.0f","article-title":"Low carbohydrate\/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension","volume":"48","author":"Okere","year":"2006","journal-title":"Hypertension"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"111543","DOI":"10.1016\/j.exger.2021.111543","article-title":"High carbohydrate high fat diet causes arterial hypertension and histological changes in the aortic wall in aged rats: the involvement of connective tissue growth factors and fibronectin","volume":"154","author":"Logvinov","year":"2021","journal-title":"Exp Gerontol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/HYPERTENSIONAHA.115.06263","article-title":"Central renin-angiotensin system activation and inflammation induced by high-fat diet sensitize angiotensin II-elicited hypertension","volume":"67","author":"Xue","year":"2016","journal-title":"Hypertension"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1161\/CIRCULATIONAHA.122.059045","article-title":"Effects of cuisine-based Chinese heart-healthy diet in lowering blood pressure among adults in China: multicenter, single-blind, randomized","volume":"146","author":"Wang","year":"2022","journal-title":"Parallel Controlled Feeding Trial Circulation"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"5883","DOI":"10.1007\/s11033-022-07370-9","article-title":"Caloric restriction overcomes pre-diabetes and hypertension induced by a high fat diet and renal artery stenosis","volume":"49","author":"de Souza Nunes Faria","year":"2022","journal-title":"Mol Biol Rep"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"F1327","DOI":"10.1152\/ajprenal.00272.2019","article-title":"Uric acid and inflammation in kidney disease","volume":"318","author":"Jung","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1093\/ajcn\/nqaa160","article-title":"Sugar-sweetened beverage consumption and risk of hyperuricemia: a longitudinal analysis of the health workers cohort study participants in Mexico","volume":"112","author":"Meneses-Le\u00f3n","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.2337\/dc20-1002","article-title":"Effects of Low-fat, Mediterranean, or Low-carbohydrate weight loss diets on serum urate and Cardiometabolic risk factors: a secondary analysis of the dietary intervention randomized controlled trial (DIRECT)","volume":"43","author":"Yokose","year":"2020","journal-title":"Diabetes Care"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.cmet.2020.02.016","article-title":"Sugar-induced obesity and insulin resistance are uncoupled from shortened survival in Drosophila","volume":"31","author":"van Dam","year":"2020","journal-title":"Cell Metab"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1365257","DOI":"10.1155\/2016\/1365257","article-title":"The establishment and characteristics of rat model of atherosclerosis induced by hyperuricemia","volume":"2016","author":"Liu","year":"2016","journal-title":"Stem Cells Int"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.3389\/fmicb.2018.02233","article-title":"Alterations of the gut microbiome associated with the treatment of Hyperuricaemia in male rats","volume":"9","author":"Yu","year":"2018","journal-title":"Front Microbiol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"20602","DOI":"10.1038\/srep20602","article-title":"Intestinal microbiota distinguish gout patients from healthy humans","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/07315724.2019.1571454","article-title":"Antiobesity and uric acid-lowering effect of Lactobacillus plantarum GKM3 in high-fat-diet-induced obese rats","volume":"38","author":"Hsu","year":"2019","journal-title":"J Am Coll Nutr"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41419-020-03122-4","article-title":"High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction","volume":"11","author":"Sun","year":"2020","journal-title":"Cell Death Dis"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fnut.2022.919882","article-title":"Personalized nutrition intervention improves health status in overweight\/obese Chinese adults: a randomized controlled trial","volume":"9","author":"Kan","year":"2022","journal-title":"Front Nutr"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3390\/nu10081087","article-title":"Tetragonia tetragonoides (pall.) Kuntze (New Zealand spinach) prevents obesity and hyperuricemia in high-fat diet-induced obese mice","volume":"10","author":"Lee","year":"2018","journal-title":"Nutrients"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"110353","DOI":"10.1016\/j.intimp.2023.110353","article-title":"Chloroquine inhibits NLRP3 inflammasomes activation and alleviates renal fibrosis in mouse model of hyperuricemic nephropathy with aggravation by a high-fat-diet","volume":"120","author":"Cui","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"110994","DOI":"10.1016\/j.biopha.2020.110994","article-title":"Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats","volume":"133","author":"Adeyanju","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2022.2119934","article-title":"Probiotics, bioactive compounds and dietary patterns for the effective management of hyperuricemia: a review","author":"Sun","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/art.41614","article-title":"Effects of dietary patterns on serum urate: results from a randomized trial of the effects of diet on hypertension","volume":"73","author":"Juraschek","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"112713","DOI":"10.1016\/j.celrep.2023.112713","article-title":"High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic \u03b3\u03b4 T\u2009cell IL-17 production","volume":"42","author":"Sonomoto","year":"2023","journal-title":"Cell Rep"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.nutres.2017.11.008","article-title":"Adverse effect of early-life high-fat\/high-carbohydrate (\"Western\") diet on bacterial community in the distal bowel of mice","volume":"50","author":"Villamil","year":"2018","journal-title":"Nutr Res"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"37278","DOI":"10.1038\/srep37278","article-title":"A high-fat high-sucrose diet rapidly alters muscle integrity, inflammation and gut microbiota in male rats","volume":"6","author":"Collins","year":"2016","journal-title":"Sci Rep"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41467-023-35861-1","article-title":"Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol","volume":"14","author":"Yang","year":"2023","journal-title":"Nat Commun"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"654074","DOI":"10.3389\/fcimb.2021.654074","article-title":"Intestinal microbiota mediates high-fructose and high-fat diets to induce chronic intestinal inflammation","volume":"11","author":"Tan","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.3390\/nu12103197","article-title":"A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference","volume":"12","author":"Wang","year":"2020","journal-title":"Nutrients"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1501023","DOI":"10.1002\/mnfr.201501023","article-title":"Food combination based on a pre-hispanic Mexican diet decreases metabolic and cognitive abnormalities and gut microbiota dysbiosis caused by a sucrose-enriched high-fat diet in rats","volume":"61","author":"Avila-Nava","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2283-4","article-title":"High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species","author":"Zeng","year":"2023","journal-title":"Sci China Life Sci"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"114034","DOI":"10.1016\/j.biopha.2022.114034","article-title":"Polysaccharide-rich fractions from Enteromorpha prolifera improve hepatic steatosis and gut barrier integrity in high-fat diet-induced obese mice linking to modulation of gut microbiota","volume":"157","author":"Zou","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jnutbio.2018.07.005","article-title":"Alterations and structural resilience of the gut microbiota under dietary fat perturbations","volume":"61","author":"Liu","year":"2018","journal-title":"J Nutr Biochem"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1038\/ismej.2012.27","article-title":"Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations","volume":"6","author":"Zhang","year":"2012","journal-title":"ISME J"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11745-017-4253-2","article-title":"Short term high fat diet induces obesity-enhancing changes in mouse gut microbiota that are partially reversed by cessation of the high fat diet","volume":"52","author":"Shang","year":"2017","journal-title":"Lipids"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.bbi.2022.03.001","article-title":"Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation","volume":"102","author":"Vicentini","year":"2022","journal-title":"Brain Behav Immun"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"111461","DOI":"10.1016\/j.celrep.2022.111461","article-title":"Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior","volume":"41","author":"Di Ges\u00f9","year":"2022","journal-title":"Cell Rep"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative effects of a high-fat diet on intestinal permeability: a review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv Nutr"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"e00579-21","DOI":"10.1128\/mBio.00579-21","article-title":"Reframing nutritional microbiota studies to reflect an inherent metabolic flexibility of the human gut: a Narrative Review Focusing on High-Fat Diets","volume":"12","author":"Sholl","year":"2021","journal-title":"mBio"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"B\u00e4ckhed","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.molmet.2016.10.001","article-title":"Dietary fat and gut microbiota interactions determine diet-induced obesity in mice","volume":"5","author":"K\u00fcbeck","year":"2016","journal-title":"Mol Metab"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1186\/s12967-023-04319-9","article-title":"Effects of probiotic administration on overweight or obese children: a meta-analysis and systematic review","volume":"21","author":"Li","year":"2023","journal-title":"J Transl Med"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"922993","DOI":"10.3389\/fnut.2022.922993","article-title":"A multi-strain probiotic blend reshaped obesity-related gut dysbiosis and improved lipid metabolism in obese children","volume":"9","author":"Chen","year":"2022","journal-title":"Front Nutr"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"101051","DOI":"10.1016\/j.xcrm.2023.101051","article-title":"Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure","volume":"4","author":"Yadav","year":"2023","journal-title":"Cell Rep Med"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s40168-021-01110-0","article-title":"Prevotella copri increases fat accumulation in pigs fed with formula diets","volume":"9","author":"Chen","year":"2021","journal-title":"Microbiome"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"43300","DOI":"10.1038\/srep43300","article-title":"Bifidobacterium breve with \u03b1-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat","volume":"7","author":"Patterson","year":"2017","journal-title":"Sci Rep"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"934695","DOI":"10.3389\/fimmu.2022.934695","article-title":"Akkermansia muciniphila and gut immune system: a good friendship that attenuates inflammatory bowel disease, obesity, and diabetes","volume":"13","author":"Rodrigues","year":"2022","journal-title":"Front Immunol"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat Med"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat Med"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/gutjnl-2020-322753","article-title":"Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function","volume":"70","author":"Fabian","year":"2021","journal-title":"Gut"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"8905","DOI":"10.3748\/wjg.v22.i40.8905","article-title":"Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases","volume":"22","author":"Zhang","year":"2016","journal-title":"World J Gastroenterol"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ismej.2012.153","article-title":"An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice","volume":"7","author":"Fei","year":"2013","journal-title":"ISME J"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"6500","DOI":"10.7150\/thno.44113","article-title":"Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus","volume":"10","author":"Lv","year":"2020","journal-title":"Theranostics"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s10020-022-00473-w","article-title":"Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes","volume":"28","author":"Hao","year":"2022","journal-title":"Mol Med"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"746998","DOI":"10.3389\/fimmu.2021.746998","article-title":"Causal relationship between gut microbiota and autoimmune diseases: a two-sample Mendelian randomization study","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1053\/j.gastro.2021.12.272","article-title":"Intestinal cathelicidin antimicrobial peptide shapes a protective neonatal gut microbiota against pancreatic autoimmunity","volume":"162","author":"Liang","year":"2022","journal-title":"Gastroenterology"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1136\/gutjnl-2017-314508","article-title":"Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice","volume":"67","author":"Arno","year":"2018","journal-title":"Gut"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1038\/s41467-022-32015-7","article-title":"Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota","volume":"13","author":"Hosomi","year":"2022","journal-title":"Nat Commun"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"811","DOI":"10.2337\/dc21-2358","article-title":"Gut microbiome composition is predictive of incident type 2 diabetes in a population cohort of 5,572 Finnish adults","volume":"45","author":"Ruuskanen","year":"2022","journal-title":"Diabetes Care"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"e2118811","DOI":"10.1001\/jamanetworkopen.2021.18811","article-title":"Association of Insulin Resistance and Type 2 diabetes with gut microbial diversity: a microbiome-wide analysis from population studies","volume":"4","author":"Chen","year":"2021","journal-title":"JAMA Netw Open"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fcimb.2022.1089991","article-title":"Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: a randomized, controlled, prospective study","volume":"12","author":"Wu","year":"2023","journal-title":"Front Cellular Infect Microbiol"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1186\/s12967-023-04306-0","article-title":"The effects of probiotics supplementation on glycaemic control among adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised clinical trials","volume":"21","author":"Li","year":"2023","journal-title":"J Transl Med"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"e01300","DOI":"10.1128\/msystems.01300-22","article-title":"Adjunctive Probio-X treatment enhances the therapeutic effect of a conventional drug in managing type 2 diabetes mellitus by promoting short-chain fatty acid-producing Bacteria and bile acid pathways","volume":"8","author":"Chen","year":"2023","journal-title":"mSystems"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/j.ajt.2023.06.011","article-title":"Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia","volume":"23","author":"Li","year":"2023","journal-title":"Am J Transplant"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"102590","DOI":"10.1016\/j.ebiom.2019.11.051","article-title":"Role of gut microbiota in type 2 diabetes pathophysiology","volume":"51","author":"Gurung","year":"2020","journal-title":"EBioMedicine"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/pedi.12424","article-title":"Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome","volume":"17","author":"Paun","year":"2016","journal-title":"Pediatr Diabetes"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"100997","DOI":"10.1016\/j.molmet.2020.100997","article-title":"Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity","volume":"37","author":"Molinaro","year":"2020","journal-title":"Molecular Metabolism"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s40168-022-01318-8","article-title":"Vertical transmission of the gut microbiota influences glucose metabolism in offspring of mice with hyperglycaemia in pregnancy","volume":"10","author":"Xue","year":"2022","journal-title":"Microbiome"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","article-title":"Dietary lipids, gut microbiota and lipid metabolism","volume":"20","author":"Schoeler","year":"2019","journal-title":"Rev Endocr Metab Disord"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1007\/s00394-018-1821-z","article-title":"Effects of products designed to modulate the gut microbiota on hyperlipidaemia","volume":"58","author":"Deng","year":"2019","journal-title":"Eur J Nutr"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"106570","DOI":"10.1016\/j.phrs.2022.106570","article-title":"Antibiotic-induced gut microbiota depletion exacerbates host hypercholesterolemia","volume":"187","author":"Kappel","year":"2023","journal-title":"Pharmacol Res"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1007\/s12602-018-9441-8","article-title":"Bifidobacterium bifidum TMC3115 can characteristically influence glucose and lipid profile and intestinal microbiota in the middle-aged and elderly","volume":"11","author":"Wang","year":"2019","journal-title":"Probiotics Antimicrobial Proteins"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"e0251722","DOI":"10.1128\/spectrum.02517-22","article-title":"Bacteroides vulgatus ameliorates lipid metabolic disorders and modulates gut microbial composition in Hyperlipidemic rats","volume":"11","author":"Xu","year":"2023","journal-title":"Microbiol Spectr"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1038\/s41467-019-12896-x","article-title":"Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism","volume":"10","author":"Huang","year":"2019","journal-title":"Nat Commun"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/j.bbadis.2016.06.006","article-title":"Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways","volume":"1862","author":"He","year":"2016","journal-title":"Biochim Biophys Acta (BBA) \u2013 Mol Basis Dis"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"114207","DOI":"10.1016\/j.jep.2021.114207","article-title":"Mechanisms of traditional Chinese medicine in modulating gut microbiota metabolites-mediated lipid metabolism","volume":"278","author":"Li","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nrgastro.2013.183","article-title":"NAFLD, NASH and liver cancer","volume":"10","author":"Michelotti","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/MOG.0000000000000349","article-title":"Intestinal microbiota and nonalcoholic steatohepatitis","volume":"33","author":"Brandl","year":"2017","journal-title":"Curr Opin Gastroenterol"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/gutjnl-2018-316307","article-title":"Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease","volume":"68","author":"Chu","year":"2019","journal-title":"Gut"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s00018-019-03011-w","article-title":"The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)","volume":"76","author":"Safari","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"e634","DOI":"10.1002\/ctm2.634","article-title":"Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease","volume":"11","author":"Yu","year":"2021","journal-title":"Clin Transl Med"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1038\/s41467-018-05767-4","article-title":"The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice","volume":"9","author":"Kindt","year":"2018","journal-title":"Nat Commun"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s40168-021-01125-7","article-title":"Commensal microbe-derived acetate suppresses NAFLD\/NASH development via hepatic FFAR2 signalling in mice","volume":"9","author":"Aoki","year":"2021","journal-title":"Microbiome"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/hep.31755","article-title":"Microbiota-driven activation of intrahepatic B cells aggravates NASH through innate and adaptive signaling","volume":"74","author":"Barrow","year":"2021","journal-title":"Hepatology"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.3389\/fmicb.2018.01602","article-title":"Genetically obese human gut microbiota induces liver steatosis in germ-free mice fed on Normal diet","volume":"9","author":"Wang","year":"2018","journal-title":"Front Microbiol"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1002\/hep.32705","article-title":"Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression","volume":"77","author":"Ju\u00e1rez-Fern\u00e1ndez","year":"2023","journal-title":"Hepatology"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s40168-021-01052-7","article-title":"Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome","volume":"9","author":"Mayneris-Perxachs","year":"2021","journal-title":"Microbiome"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1128\/mBio.03263-19","article-title":"Endotoxin producers overgrowing in human gut microbiota as the causative agents for nonalcoholic fatty liver disease","volume":"11","author":"Fei","year":"2020","journal-title":"MBio"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.chom.2020.07.007","article-title":"Microbiota and fatty liver disease-the known, the unknown, and the future","volume":"28","author":"Lang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1038\/s41591-022-02016-6","article-title":"Microbiome-derived ethanol in nonalcoholic fatty liver disease","volume":"28","author":"Meijnikman","year":"2022","journal-title":"Nat Med"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.cmet.2017.04.001","article-title":"Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease","volume":"25","author":"Loomba","year":"2017","journal-title":"Cell Metab"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1053\/j.gastro.2020.01.049","article-title":"Nonalcoholic fatty liver disease: modulating gut microbiota to improve severity?","volume":"158","author":"Aron-Wisnewsky","year":"2020","journal-title":"Gastroenterology"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity","volume":"3","author":"Tilg","year":"2021","journal-title":"Nat Metab"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrcardio.2017.120","article-title":"Beyond gut feelings: how the gut microbiota regulates blood pressure","volume":"15","author":"Marques","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1161\/CIRCRESAHA.116.310339","article-title":"Hypertension opens the flood gates to the gut microbiota","volume":"120","author":"Taylor","year":"2017","journal-title":"Circ Res"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1161\/CIRCRESAHA.117.310734","article-title":"Gut microbiota: potential for a unifying hypothesis for prevention and treatment of hypertension","volume":"120","author":"Qi","year":"2017","journal-title":"Circ Res"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1161\/CIRCRESAHA.121.318065","article-title":"The gut microbiome in hypertension: recent advances and future perspectives","volume":"128","author":"Avery","year":"2021","journal-title":"Circ Res"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1093\/cvr\/cvac121","article-title":"Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage","volume":"119","author":"Avery","year":"2023","journal-title":"Cardiovasc Res"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1161\/HYPERTENSIONAHA.122.18878","article-title":"Causality of opportunistic pathogen Klebsiella pneumoniae to hypertension development","volume":"79","author":"Li","year":"2022","journal-title":"Hypertension"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"e0195622","DOI":"10.1128\/spectrum.01956-22","article-title":"Characteristics and correlations of the Oral and gut fungal microbiome with hypertension","volume":"11","author":"Chen","year":"2023","journal-title":"Microbiol Spectr"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/HYPERTENSIONAHA.118.11175","article-title":"Attenuation of Microbiotal Dysbiosis and hypertension in a CRISPR\/Cas9 gene ablation rat model of GPER1","volume":"72","author":"Waghulde","year":"2018","journal-title":"Hypertension"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1161\/HYPERTENSIONAHA.116.07910","article-title":"Increased systolic and diastolic blood pressure is associated with altered gut microbiota composition and butyrate production in early pregnancy","volume":"68","author":"Gomez-Arango","year":"2016","journal-title":"Hypertension"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"e12328","DOI":"10.1002\/jev2.12328","article-title":"Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model","volume":"12","author":"Chen","year":"2023","journal-title":"J Extracell Vesicles"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1042\/CS20191253","article-title":"Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia","volume":"134","author":"Chang","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1164\/rccm.202203-0490OC","article-title":"Pulmonary arterial hypertension patients have a Proinflammatory gut microbiome and altered circulating microbial metabolites","volume":"207","author":"Moutsoglou","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1111\/bph.15512","article-title":"Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus","volume":"178","author":"de la Visitaci\u00f3n","year":"2021","journal-title":"Br J Pharmacol"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1161\/CIRCRESAHA.119.316394","article-title":"Intestinal Flora modulates blood pressure by regulating the synthesis of intestinal-derived corticosterone in high salt-induced hypertension","volume":"126","author":"Yan","year":"2020","journal-title":"Circ Res"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1152\/physiolgenomics.00081.2016","article-title":"Alterations in the gut microbiota can elicit hypertension in rats","volume":"49","author":"Adnan","year":"2017","journal-title":"Physiol Genomics"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40168-016-0222-x","article-title":"Gut microbiota dysbiosis contributes to the development of hypertension","volume":"5","author":"Li","year":"2017","journal-title":"Microbiome"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijcard.2018.04.074","article-title":"Gut microbiota and serum metabolite differences in African Americans and white Americans with high blood pressure","volume":"271","author":"Walejko","year":"2018","journal-title":"Int J Cardiol"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1080\/10408398.2021.1874287","article-title":"The gut microbiota as a target to control hyperuricemia pathogenesis: potential mechanisms and therapeutic strategies","volume":"62","author":"Wang","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"e8664","DOI":"10.7717\/peerj.8664","article-title":"The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia","volume":"8","author":"Liu","year":"2020","journal-title":"PeerJ"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41522-021-00235-2","article-title":"Metagenomic analysis revealed the potential role of gut microbiome in gout","volume":"7","author":"Chu","year":"2021","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref194","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/art.42009","article-title":"Association between gut microbiota and elevated serum urate in two independent cohorts","volume":"74","author":"Wei","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1159\/000521273","article-title":"Effects of washed microbiota transplantation on serum uric acid Levels, symptoms, and intestinal barrier function in patients with acute and recurrent gout: a pilot study","volume":"40","author":"Xie","year":"2022","journal-title":"Dig Dis"},{"key":"ref196","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1897211","article-title":"Limosilactobacillus fermentum JL-3 isolated from \"Jiangshui\" ameliorates hyperuricemia by degrading uric acid","volume":"13","author":"Wu","year":"2021","journal-title":"Gut Microbes"},{"key":"ref197","doi-asserted-by":"publisher","first-page":"106350","DOI":"10.1016\/j.phrs.2022.106350","article-title":"Lacticaseibacillus rhamnosus Fmb14 prevents purine induced hyperuricemia and alleviate renal fibrosis through gut-kidney axis","volume":"182","author":"Zhao","year":"2022","journal-title":"Pharmacol Res"},{"key":"ref198","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1080\/15257770.2015.1125000","article-title":"Evaluation of purine utilization by Lactobacillus gasseri strains with potential to decrease the absorption of food-derived purines in the human intestine","volume":"35","author":"Yamada","year":"2016","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"ref199","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s40168-023-01605-y","article-title":"Lactiplantibacillus plantarum enables blood urate control in mice through degradation of nucleosides in gastrointestinal tract","volume":"11","author":"Li","year":"2023","journal-title":"Microbiome"},{"key":"ref200","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.1016\/j.cell.2023.06.010","article-title":"A widely distributed gene cluster compensates for uricase loss in hominids","volume":"186","author":"Liu","year":"2023","journal-title":"Cells"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s40168-022-01264-5","article-title":"Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity","volume":"10","author":"M\u00fcnzker","year":"2022","journal-title":"Microbiome"},{"key":"ref202","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.3390\/nu13082795","article-title":"Effect of diet and dietary components on the composition of the gut microbiota","volume":"13","author":"Beam","year":"2021","journal-title":"Nutrients"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/19490976.2019.1697149","article-title":"Contribution of diet to gut microbiota and related host cardiometabolic health: diet-gut interaction in human health","volume":"11","author":"Wan","year":"2020","journal-title":"Gut Microbes"},{"key":"ref204","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1038\/s41467-018-07146-5","article-title":"Long term but not short term exposure to obesity related microbiota promotes host insulin resistance","volume":"9","author":"Foley","year":"2018","journal-title":"Nat Commun"},{"key":"ref205","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.phrs.2018.04.008","article-title":"Helminth infection in mice improves insulin sensitivity via modulation of gut microbiota and fatty acid metabolism","volume":"132","author":"Pace","year":"2018","journal-title":"Pharmacol Res"},{"key":"ref206","doi-asserted-by":"publisher","first-page":"11302","DOI":"10.7150\/thno.47746","article-title":"Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPK\u03b1\/STAT3 signaling in diet-induced obesity","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1038\/s41467-022-29005-0","article-title":"Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice","volume":"13","author":"Daniel","year":"2022","journal-title":"Nat Commun"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"e0002822","DOI":"10.1128\/spectrum.00028-22","article-title":"Gut microbiota-testis Axis: FMT mitigates high-fat diet-diminished male fertility via improving systemic and testicular metabolome","volume":"10","author":"Hao","year":"2022","journal-title":"Microbiol Spectr"},{"key":"ref209","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/toxsci\/kfy205","article-title":"Insights into a possible mechanism underlying the connection of Carbendazim-induced lipid metabolism disorder and gut microbiota Dysbiosis in mice","volume":"166","author":"Jin","year":"2018","journal-title":"Toxicol Sci"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jcmgh.2021.02.009","article-title":"Intestinal \u03b11-2-Fucosylation contributes to obesity and steatohepatitis in mice","volume":"12","author":"Zhou","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1126\/science.ade0522","article-title":"The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9","volume":"381","author":"Wang","year":"2023","journal-title":"Science"},{"key":"ref212","doi-asserted-by":"publisher","first-page":"103176","DOI":"10.1016\/j.ebiom.2020.103176","article-title":"Bifidobacterium longum counters the effects of obesity: partial successful translation from rodent to human","volume":"63","author":"Schellekens","year":"2021","journal-title":"EBioMedicine"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/j.cmet.2021.07.007","article-title":"Intestinal hypoxia-inducible factor 2\u03b1 regulates lactate levels to shape the gut microbiome and alter thermogenesis","volume":"33","author":"Wu","year":"2021","journal-title":"Cell Metab"},{"key":"ref214","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2337\/db21-0382","article-title":"Gut microbiota regulate pancreatic growth, exocrine function, and gut hormones","volume":"71","author":"Girdhar","year":"2022","journal-title":"Diabetes"},{"key":"ref215","doi-asserted-by":"publisher","first-page":"680241","DOI":"10.3389\/fnut.2021.680241","article-title":"Broccoli florets supplementation improves insulin sensitivity and alters gut microbiome population-a steatosis mice model induced by high-fat diet","volume":"8","author":"Zandani","year":"2021","journal-title":"Front Nutr"},{"key":"ref216","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1038\/s41591-018-0222-4","article-title":"Gut microbiota and intestinal FXR mediate the clinical benefits of metformin","volume":"24","author":"Sun","year":"2018","journal-title":"Nat Med"},{"key":"ref217","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jare.2022.06.003","article-title":"Amelioration of type 2 diabetes by the novel 6, 8-guanidyl luteolin quinone-chromium coordination via biochemical mechanisms and gut microbiota interaction","volume":"46","author":"Ge","year":"2023","journal-title":"J Adv Res"},{"key":"ref218","doi-asserted-by":"publisher","first-page":"110954","DOI":"10.1016\/j.biopha.2020.110954","article-title":"Anemarrhena asphodeloides modulates gut microbiota and restores pancreatic function in diabetic rats","volume":"133","author":"Yan","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"e0165483","DOI":"10.1371\/journal.pone.0165483","article-title":"Daesiho-Tang is an effective herbal formulation in attenuation of obesity in mice through alteration of gene expression and modulation of intestinal microbiota","volume":"11","author":"Hussain","year":"2016","journal-title":"PLoS One"},{"key":"ref220","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.1016\/j.clnu.2021.01.031","article-title":"Fecal g. Streptococcus and g. Eubacterium_coprostanoligenes_group combined with sphingosine to modulate the serum dyslipidemia in high-fat diet mice","volume":"40","author":"Wei","year":"2021","journal-title":"Clin Nutr"},{"key":"ref221","doi-asserted-by":"publisher","first-page":"e1800446","DOI":"10.1002\/mnfr.201800446","article-title":"Sulfated polysaccharide from sea cucumber and its depolymerized derivative prevent obesity in association with modification of gut microbiota in high-fat diet-fed mice","volume":"62","author":"Zhu","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"ref222","doi-asserted-by":"publisher","first-page":"129908","DOI":"10.1016\/j.foodchem.2021.129908","article-title":"A fucoidan from Sargassum fusiforme with novel structure and its regulatory effects on intestinal microbiota in high-fat diet-fed mice","volume":"358","author":"Liu","year":"2021","journal-title":"Food Chem"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"120249","DOI":"10.1016\/j.carbpol.2022.120249","article-title":"Regulatory effects mediated by ulvan oligosaccharide and its zinc complex on lipid metabolism in high-fat diet-fed mice","volume":"300","author":"Chi","year":"2023","journal-title":"Carbohydr Polym"},{"key":"ref224","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.nut.2019.03.001","article-title":"Fucoidan and galactooligosaccharides ameliorate high-fat diet-induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism","volume":"65","author":"Chen","year":"2019","journal-title":"Nutrition"},{"key":"ref225","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.clnu.2022.05.021","article-title":"Interaction of n-3 polyunsaturated fatty acids with host CD36 genetic variant for gut microbiome and blood lipids in human cohorts","volume":"41","author":"Miao","year":"2022","journal-title":"Clin Nutr"},{"key":"ref226","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1038\/s41467-020-16274-w","article-title":"Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels","volume":"11","author":"Johnson","year":"2020","journal-title":"Nat Commun"},{"key":"ref227","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1038\/s41467-022-29968-0","article-title":"A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease","volume":"13","author":"Cheng","year":"2022","journal-title":"Nat Commun"},{"key":"ref228","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1053\/j.gastro.2016.08.057","article-title":"An intestinal microbiota-Farnesoid X receptor Axis modulates metabolic disease","volume":"151","author":"Gonzalez","year":"2016","journal-title":"Gastroenterology"},{"key":"ref229","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2019.08.018","article-title":"Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae","volume":"30","author":"Yuan","year":"2019","journal-title":"Cell Metab"},{"key":"ref230","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1002\/hep.32235","article-title":"A GLP-1\/GLP-2 receptor dual agonist to treat NASH: targeting the gut-liver axis and microbiome","volume":"75","author":"Kim","year":"2022","journal-title":"Hepatology"},{"key":"ref231","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1038\/s41564-023-01418-7","article-title":"Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid","volume":"8","author":"Wei","year":"2023","journal-title":"Nat Microbiol"},{"key":"ref232","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41522-023-00399-z","article-title":"Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism","volume":"9","author":"Liu","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref233","doi-asserted-by":"publisher","first-page":"125662","DOI":"10.1016\/j.ijbiomac.2023.125662","article-title":"The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism","volume":"246","author":"Shu","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"ref234","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.celrep.2018.03.109","article-title":"Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages","volume":"23","author":"Krishnan","year":"2018","journal-title":"Cell Rep"},{"key":"ref235","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1126\/scitranslmed.aaz2841","article-title":"Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome","volume":"12","author":"Rom","year":"2020","journal-title":"Sci Transl Med"},{"key":"ref236","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.jhep.2023.07.005","article-title":"Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma","volume":"79","author":"Song","year":"2023","journal-title":"J Hepatol"},{"key":"ref237","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/apt.14689","article-title":"Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders","volume":"48","author":"Gill","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"ref238","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, metabolites, and \"western-lifestyle\" inflammatory diseases","volume":"40","author":"Thorburn","year":"2014","journal-title":"Immunity"},{"key":"ref239","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1161\/HYPERTENSIONAHA.118.11695","article-title":"Prebiotics, probiotics, and acetate supplementation prevent hypertension in a model of obstructive sleep apnea","volume":"72","author":"Ganesh","year":"2018","journal-title":"Hypertension"},{"key":"ref240","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.1073\/pnas.1215927110","article-title":"Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation","volume":"110","author":"Pluznick","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref241","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4161\/gmic.27492","article-title":"A novel SCFA receptor, the microbiota, and blood pressure regulation","volume":"5","author":"Pluznick","year":"2014","journal-title":"Gut Microbes"},{"key":"ref242","doi-asserted-by":"publisher","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat Commun"},{"key":"ref243","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1152\/physiolgenomics.00089.2016","article-title":"Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41","volume":"48","author":"Natarajan","year":"2016","journal-title":"Physiol Genomics"},{"key":"ref244","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1210\/en.2008-0059","article-title":"Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids","volume":"149","author":"Ge","year":"2008","journal-title":"Endocrinology"},{"key":"ref245","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1111\/bph.15768","article-title":"Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota","volume":"179","author":"Li","year":"2022","journal-title":"Br J Pharmacol"},{"key":"ref246","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41371-020-0359-8","article-title":"The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats","volume":"35","author":"Thomaz","year":"2021","journal-title":"J Hum Hypertens"},{"key":"ref247","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00394-021-02669-y","article-title":"Inulin-type prebiotics reduce serum uric acid levels via gut microbiota modulation: a randomized, controlled crossover trial in peritoneal dialysis patients","volume":"61","author":"He","year":"2022","journal-title":"Eur J Nutr"},{"key":"ref248","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1039\/D2FO03332A","article-title":"Ferulic acid supplementation alleviates hyperuricemia in high-fructose\/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1291853\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T05:57:51Z","timestamp":1702619871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2023.1291853\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":248,"alternative-id":["10.3389\/fnut.2023.1291853"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2023.1291853","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"article-number":"1291853"}}