{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:42:36Z","timestamp":1791510156891,"version":"4.3.4"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. <jats:italic>Portulaca oleracea<\/jats:italic> exhibits anti-oxidant, anti-inflammatory, and hepatoprotective effects. This clinical trial aimed to investigate the potential benefits of <jats:italic>Portulaca oleracea<\/jats:italic> in improving NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double-blind, randomized clinical trial enrolled 70 patients with NAFLD assigned to either the intervention group (<jats:italic>n<\/jats:italic>\u2009=\u200935) or placebo group (<jats:italic>n<\/jats:italic>\u2009=\u200935) using stratified block randomization. The intervention group received 700\u2009mg <jats:italic>Portulaca oleracea<\/jats:italic> supplement for eight weeks, while the control group received placebo capsules. In addition, all participants received a calorie-restricted diet. Liver steatosis and fibrosis were assessed using elastography along with liver function and metabolic tests, blood pressure measurements, body composition analysis and dietary records pre-and post-intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age of the participants was 44.01\u2009\u00b1\u20098.6\u2009years, of which 34 (48.6%) were women. The group receiving <jats:italic>Portulaca oleracea<\/jats:italic> showed significant weight changes, body mass index, fat mass index, and waist circumference compared to the placebo (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). In addition, blood sugar, lipid profile, liver enzymes aspartate and alanine transaminase, gamma-glutamyl transferase, and systolic blood pressure were significantly improved in the intervention group compared to those in the placebo (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). During the study, inflammatory and oxidative stress indicators, improved significantly (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Based on the elastography results, the hepatorenal ultrasound index and liver stiffness decreased significantly in the <jats:italic>Portulaca oleracea<\/jats:italic> group compared to the placebo (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present clinical trial showed that receiving <jats:italic>Portulaca oleracea<\/jats:italic> supplement for eight weeks can improve the condition of liver steatosis and fibrosis in patients with NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1371137","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T04:51:11Z","timestamp":1722228671000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Portulaca oleracea (purslane) on liver function tests, metabolic profile, oxidative stress and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: a randomized, double-blind clinical trial"],"prefix":"10.3389","volume":"11","author":[{"given":"Narges","family":"Milkarizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Barghchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Belyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Bahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnood","family":"Rajabzade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andisheh 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