{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:20:59Z","timestamp":1781306459198,"version":"3.54.1"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Chronic liver disease is a global health issue. Patients with chronic liver disease require a fresh approach that focuses on the genetic and environmental factors that contribute to disease initiation and progression. Emerging knowledge in the fields of Genomic Medicine and Genomic Nutrition demonstrates differences between countries in terms of genetics and lifestyle risk factors such as diet, physical activity, and mental health in chronic liver disease, which serves as the foundation for the implementation of Personalized Medicine and Nutrition (PerMed-Nut) strategies. Most of the world\u2019s populations have descended from various ethnic groupings. Mexico\u2019s population has a tripartite ancestral background, consisting of Amerindian, European, and African lineages, which is common across Latin America\u2019s regional countries. The purpose of this review is to discuss the genetic and environmental components that could be incorporated into a PerMed-Nut model for metabolic-associated liver disease, viral hepatitis B and C, and hepatocellular carcinoma in Mexico. Additionally, the implementation of the PerMed-Nut approach will require updated medicine and nutrition education curricula. Training and equipping future health professionals and researchers with new clinical and investigative abilities focused on preventing liver illnesses in the field of genomic hepatology globally is a vision that clinicians and nutritionists should be concerned about.<\/jats:p>","DOI":"10.3389\/fnut.2024.1379364","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:02:36Z","timestamp":1715259756000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico"],"prefix":"10.3389","volume":"11","author":[{"given":"Arturo","family":"Panduro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Mariscal-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Jose-Abrego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Gonzalez-Aldaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ojeda-Granados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ramos-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Torres-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6055","DOI":"10.1038\/srep06055","article-title":"Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry","volume":"4","author":"Shriner","year":"2014","journal-title":"Sci Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"26565","DOI":"10.1038\/srep26565","article-title":"Ancient human migration after out-of-Africa","volume":"6","author":"Shriner","year":"2016","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1146\/annurev-genom-083115-022331","article-title":"The genetic diversity of the Americas","volume":"18","author":"Adhikari","year":"2017","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8072","DOI":"10.1073\/pnas.1601068113","article-title":"Human phylogeography and diversity","volume":"113","author":"Harcourt","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.aaf5098","article-title":"Going global by adapting local: a review of recent human adaptation","volume":"354","author":"Fan","year":"2016","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev-genom-091212-153509","article-title":"Selection and adaptation in the human genome","volume":"14","author":"Fu","year":"2013","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref7","year":"2024"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"dvv014","DOI":"10.1093\/eep\/dvv014","article-title":"The role of non-genetic inheritance in evolutionary rescue: epigenetic buffering, heritable bet hedging and epigenetic traps. 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