{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:15Z","timestamp":1791492615074,"version":"4.3.4"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Collagen peptide supplementation in conjunction with exercise has been shown to improve structural and functional adaptations of both muscles and the extracellular matrix. This study aimed to explore whether specific collagen peptide (SCP) supplementation combined with a concurrent training intervention can improve muscular stress after exercise-induced muscle damage, verified by reliable blood markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>55 sedentary to moderately active males participating in a concurrent training (CT) intervention (3x\/week) for 12\u2009weeks were administered either 15\u2009g of SCP or placebo (PLA) daily. Before (T1) and after the intervention (T2), 150 muscle-damaging drop jumps were performed. Blood samples were collected to measure creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin (MYO) and high-sensitivity C-reactive protein (hsCRP) before, after, and at 2\u2009h, 24\u2009h and 48\u2009h post exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A combination of concurrent training and SCP administration showed statistically significant interaction effects, implying a lower increase in the area under the curve (AUC) of MYO (<jats:italic>p<\/jats:italic>\u2009=\u20090.004, \u03b7p<jats:sup>2<\/jats:sup>\u2009=\u20090.184), CK (<jats:italic>p<\/jats:italic>\u2009=\u20090.01, \u03b7p<jats:sup>2<\/jats:sup>\u2009=\u20090.145) and LDH (<jats:italic>p<\/jats:italic>\u2009=\u20090.016, \u03b7p<jats:sup>2<\/jats:sup>\u2009=\u20090.133) in the SCP group. On closer examination, the absolute mean differences (\u0394AUCs) showed statistical significance in MYO (<jats:italic>p<\/jats:italic>\u2009=\u20090.017, <jats:italic>d<\/jats:italic>\u2009=\u20090.771), CK (<jats:italic>p<\/jats:italic>\u2009=\u20090.039, <jats:italic>d<\/jats:italic>\u2009=\u20090.633) and LDH (<jats:italic>p<\/jats:italic>\u2009=\u20090.016, <jats:italic>d<\/jats:italic>\u2009=\u20090.764) by SCP supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, 12\u2009weeks of 15\u2009g SCP supplementation combined with CT intervention reduced acute markers of exercise-induced muscle damage and improved post-exercise regenerative capacity, as evidenced by the altered post-exercise time course. The current findings indicate that SCP supplementation had a positive effect on the early phase of muscular recovery by either improving the structural integrity of the muscle and extracellular matrix during the training period or by accelerating membrane and cytoskeletal protein repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.clinicaltrials.gov\/study\/NCT05220371?cond=NCT05220371&amp;amp;rank=1<\/jats:ext-link>, NCT05220371.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1384112","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T04:42:14Z","timestamp":1711341734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides \u2013 a randomized controlled trial"],"prefix":"10.3389","volume":"11","author":[{"given":"Kevin","family":"Bischof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savvas","family":"Stafilidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Bundschuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Oesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Baca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3389\/fphys.2019.00536","article-title":"Eccentric muscle contractions: risks and benefits","volume":"10","author":"Hody","year":"2019","journal-title":"Front Physiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00421-020-04432-3","article-title":"Nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage and accelerate recovery in athletes: current knowledge, practical application and future perspectives","volume":"120","author":"Bongiovanni","year":"2020","journal-title":"Eur J Appl Physiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.3390\/nu13113997","article-title":"Potential relevance of bioactive peptides in sports nutrition","volume":"13","author":"K\u00f6nig","year":"2021","journal-title":"Nutrients"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s00421-020-04566-4","article-title":"Exercise-induced muscle damage: mechanism, assessment and nutritional factors to accelerate recovery","volume":"121","author":"Markus","year":"2021","journal-title":"Eur J Appl Physiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1123\/ijsnem.2018-0020","article-title":"IOC consensus statement: dietary supplements and the high-performance athlete","volume":"28","author":"Maughan","year":"2018","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1249\/MSS.0000000000000852","article-title":"American College of Sports Medicine joint position statement. Nutrition and athletic performance","volume":"48","author":"Thomas","year":"2016","journal-title":"Med Sci Sports Exerc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/nu14010070","article-title":"Dietary supplementation for attenuating exercise-induced muscle damage and delayed-onset muscle soreness in humans","volume":"14","author":"Tanabe","year":"2021","journal-title":"Nutrients"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/17461391.2018.1505957","article-title":"Exercise-induced muscle damage: what is it, what causes it and what are the nutritional solutions?","volume":"19","author":"Owens","year":"2019","journal-title":"Eur J Sport Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s00726-021-03072-x","article-title":"The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review","volume":"53","author":"Khatri","year":"2021","journal-title":"Amino Acids"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00726-019-02706-5","article-title":"The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial","volume":"51","author":"Clifford","year":"2019","journal-title":"Amino Acids"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1550-2783-11-S1-P48","article-title":"Evaluation of the effects of bio cell collagen, a novel cartilage extract, on connective tissue support and functional recovery from exercise","volume":"14","author":"Lopez","year":"2015","journal-title":"Integr Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1123\/ijsnem.2020-0149","article-title":"Effects of collagen peptides on recovery following eccentric exercise in resistance-trained males-a pilot study","volume":"31","author":"Prowting","year":"2021","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2206392","DOI":"10.1080\/15502783.2023.2206392","article-title":"Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-blinded crossover clinical trial","volume":"20","author":"Kuwaba","year":"2023","journal-title":"J Int Soc Sports Nutr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3390\/nu11051072","article-title":"Effects of 12 weeks of hypertrophy resistance exercise training combined with collagen peptide supplementation on the skeletal muscle proteome in recreationally active men","volume":"11","author":"Oertzen-Hagemann","year":"2019","journal-title":"Nutrients"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"838004","DOI":"10.3389\/fphys.2022.838004","article-title":"Supplementation of specific collagen peptides following high-load resistance exercise upregulates gene expression in pathways involved in skeletal muscle signal transduction","volume":"13","author":"Centner","year":"2022","journal-title":"Front Physiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00417-011-1766-x","article-title":"The PI3K\/Akt pathway mediates the expression of type I collagen induced by TGF-\u03b22 in human retinal pigment epithelial cells","volume":"250","author":"Yokoyama","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1093\/nutrit\/nuab083","article-title":"The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: a narrative review","volume":"80","author":"Holwerda","year":"2022","journal-title":"Nutr Rev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3945\/ajcn.116.138594","article-title":"Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis","volume":"105","author":"Shaw","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1167449","DOI":"10.3389\/fphys.2023.1167449","article-title":"Biomarkers of post-match recovery in semi-professional and professional football (soccer)","volume":"14","author":"P\u00e9rez-Castillo","year":"2023","journal-title":"Front Physiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e13903","DOI":"10.1111\/apha.13903","article-title":"The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training","volume":"237","author":"Balshaw","year":"2023","journal-title":"Acta Physiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1266056","DOI":"10.3389\/fnut.2023.1266056","article-title":"Influence of specific collagen peptides and 12-week concurrent training on recovery-related biomechanical characteristics following exercise-induced muscle damage-a randomized controlled trial","volume":"10","author":"Bischof","year":"2023","journal-title":"Front Nutr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1249\/MSS.0000000000000664","article-title":"Updating ACSM's recommendations for exercise preparticipation health screening","volume":"47","author":"Riebe","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.clinbiochem.2015.06.010","article-title":"Multi-center evaluation of analytical performance of the Beckman coulter AU5822 chemistry analyzer","volume":"48","author":"Zimmerman","year":"2015","journal-title":"Clin Biochem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fphys.2019.00086","article-title":"C-reactive protein is elevated only in high Creatine kinase responders to muscle damaging exercise","volume":"10","author":"Isaacs","year":"2019","journal-title":"Front Physiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00421-008-0961-x","article-title":"Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race","volume":"105","author":"Kim","year":"2009","journal-title":"Eur J Appl Physiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00421-015-3290-x","article-title":"The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise","volume":"116","author":"Clifford","year":"2016","journal-title":"Eur J Appl Physiol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"130869","DOI":"10.1016\/j.foodchem.2021.130869","article-title":"Comparison of gelatin and low-molecular weight gelatin hydrolysate ingestion on hydroxyproline (Hyp), pro-Hyp and Hyp-Gly concentrations in human blood","volume":"369","author":"Iwasaki","year":"2022","journal-title":"Food Chem"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fnut.2019.00163","article-title":"Plasma amino acid concentrations after the ingestion of dairy and collagen proteins, in healthy active males","volume":"6","author":"Alcock","year":"2019","journal-title":"Front Nutr"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/nu11051064","article-title":"Enzymatic hydrolysis of a collagen hydrolysate enhances postprandial absorption rate-a randomized controlled trial","volume":"11","author":"Skov","year":"2019","journal-title":"Nutrients"},{"key":"ref30","first-page":"307","article-title":"The effects of training on heart rate; a longitudinal study","volume":"35","author":"Karvonen","year":"1957","journal-title":"Ann Med Exp Biol Fenn"},{"key":"ref31","first-page":"1","article-title":"Using trapezoidal rule for the area under a curve calculation","author":"Yeh","year":"2002"},{"key":"ref32","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"ref33","author":"Lenhard","year":"2017"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1249\/JES.0000000000000095","article-title":"Mechanisms and mediators of the skeletal muscle repeated bout effect","volume":"45","author":"Hyldahl","year":"2017","journal-title":"Exerc Sport Sci Rev"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s40279-023-01836-x","article-title":"Blood-based biomarkers for managing workload in athletes: considerations and recommendations for evidence-based use of established biomarkers","volume":"53","author":"Haller","year":"2023","journal-title":"Sports Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.4049\/jimmunol.1103779","article-title":"Myeloid hypoxia-inducible factor-1\u03b1 is essential for skeletal muscle regeneration in mice","volume":"191","author":"Scheerer","year":"2013","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"3810","DOI":"10.1172\/JCI30487","article-title":"Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition","volume":"117","author":"Higgins","year":"2007","journal-title":"J Clin Invest"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"10819","DOI":"10.1074\/jbc.M112.442939","article-title":"Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts","volume":"288","author":"Gilkes","year":"2013","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s12192-012-0343-5","article-title":"Acute heat stress prior to downhill running may enhance skeletal muscle remodeling","volume":"17","author":"Touchberry","year":"2012","journal-title":"Cell Stress Chaperones"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"11451","DOI":"10.3390\/ijms231911451","article-title":"Hsp 90 as a Myokine: its association with systemic inflammation after exercise interventions in patients with myositis and healthy subjects","volume":"23","author":"\u0160vec","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/6678457","article-title":"Heat shock proteins in oxidative stress and ischemia\/reperfusion injury and benefits from physical exercises: a review to the current knowledge","volume":"2021","author":"Szyller","year":"2021","journal-title":"Oxidative Med Cell Longev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s40279-018-0876-6","article-title":"Turning up the heat: an evaluation of the evidence for heating to promote exercise recovery, muscle rehabilitation and adaptation","volume":"48","author":"McGorm","year":"2018","journal-title":"Sports medicine"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1152\/japplphysiol.01052.2018","article-title":"Role of heat shock proteins 70\/90 in exercise physiology and exercise immunology and their diagnostic potential in sports","volume":"126","author":"Kr\u00fcger","year":"2019","journal-title":"J Appl Physiol (1985)"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1167\/iovs.03-1276","article-title":"p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19","volume":"45","author":"Kimoto","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e0120774","DOI":"10.1371\/journal.pone.0120774","article-title":"p38 MAP kinase inhibitor suppresses transforming growth factor-\u03b22-induced type 1 collagen production in trabecular meshwork cells","volume":"10","author":"Inoue-Mochita","year":"2015","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"10055","DOI":"10.1074\/jbc.M409381200","article-title":"SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells","volume":"280","author":"Tsukada","year":"2005","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"17058","DOI":"10.1074\/jbc.M100754200","article-title":"Identification of novel TGF-beta\/Smad gene targets in dermal fibroblasts using a combined cDNA microarray\/promoter transactivation approach","volume":"276","author":"Verrecchia","year":"2001","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"10542","DOI":"10.1038\/s41598-019-46896-0","article-title":"Extracellular matrix composition of connective tissues: a systematic review and meta-analysis","volume":"9","author":"McKee","year":"2019","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"495","DOI":"10.3389\/fphys.2020.00495","article-title":"The structure and role of intramuscular connective tissue in muscle function","volume":"11","author":"Purslow","year":"2020","journal-title":"Front Physiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1096\/fj.14-266668","article-title":"Extracellular matrix remodeling and its contribution to protective adaptation following lengthening contractions in human muscle","volume":"29","author":"Hyldahl","year":"2015","journal-title":"FASEB J"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1152\/japplphysiol.00577.2016","article-title":"Connective tissue regeneration in skeletal muscle after eccentric contraction-induced injury","volume":"122","author":"Mackey","year":"2017","journal-title":"J Appl Physiol (1985)"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"11924","DOI":"10.1038\/s41598-020-69280-9","article-title":"Reliability and suitability of physiological exercise response and recovery markers","volume":"10","author":"Reichel","year":"2020","journal-title":"Sci Rep"},{"key":"ref53","first-page":"72","article-title":"Eccentric exercise-induced delayed-onset muscle soreness and changes in markers of muscle damage and inflammation","volume":"19","author":"Kanda","year":"2013","journal-title":"Exerc Immunol Rev"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/jappl.1996.80.1.47","article-title":"Adaptation to eccentric exercise: effect on CD64 and CD11b\/CD18 expression","volume":"80","author":"Pizza","year":"1996","journal-title":"J Appl Physiol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1152\/jappl.1993.74.6.2976","article-title":"Relations between muscle soreness and biochemical and functional outcomes of eccentric exercise","volume":"74","author":"Rodenburg","year":"1993","journal-title":"J Appl Physiol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1515\/hukin-2017-0071","article-title":"Creatine kinase and lactate dehydrogenase responses after different resistance and aerobic exercise protocols","volume":"58","author":"Callegari","year":"2017","journal-title":"J Hum Kinet"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/sms.13388","article-title":"Damage and the repeated bout effect of arm, leg, and trunk muscles induced by eccentric resistance exercises","volume":"29","author":"Chen","year":"2019","journal-title":"Scand J Med Sci Sports"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1515\/CCLM.2010.179","article-title":"Biochemical markers of muscular damage","volume":"48","author":"Brancaccio","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1600-0838.2009.01005.x","article-title":"Influence of tart cherry juice on indices of recovery following marathon running","volume":"20","author":"Howatson","year":"2010","journal-title":"Scand J Med Sci Sports"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.3390\/nu12082382","article-title":"Effects of whey and pea protein supplementation on post-eccentric exercise muscle damage: a randomized trial","volume":"12","author":"Nieman","year":"2020","journal-title":"Nutrients"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1080\/02640414.2020.1820184","article-title":"Whey protein supplementation does not accelerate recovery from a single bout of eccentric exercise","volume":"39","author":"Hilkens","year":"2021","journal-title":"J Sports Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s40279-021-01587-7","article-title":"Compatibility of concurrent aerobic and strength training for skeletal muscle size and function: an updated systematic review and Meta-analysis","volume":"52","author":"Schumann","year":"2022","journal-title":"Sports Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1080\/02640414.2017.1364405","article-title":"The physiological effects of concurrent strength and endurance training sequence: a systematic review and meta-analysis","volume":"36","author":"Murlasits","year":"2018","journal-title":"J Sports Sci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s40279-022-01764-2","article-title":"Effects of concurrent strength and endurance training on measures of physical fitness in healthy middle-aged and older adults: a systematic review with Meta-analysis","volume":"53","author":"Markov","year":"2023","journal-title":"Sports Med"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s40279-021-01620-9","article-title":"The effects of dietary protein supplementation on acute changes in muscle protein synthesis and longer-term changes in muscle mass, strength, and aerobic capacity in response to concurrent resistance and endurance exercise in healthy adults: a systematic review","volume":"52","author":"Hartono","year":"2022","journal-title":"Sports Med"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1249\/MSS.0000000000000390","article-title":"Protein ingestion increases myofibrillar protein synthesis after concurrent exercise","volume":"47","author":"Camera","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fphys.2016.00087","article-title":"Selective modulation of MicroRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle","volume":"7","author":"Camera","year":"2016","journal-title":"Front Physiol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00421-010-1648-7","article-title":"Comparison in eccentric exercise-induced muscle damage among four limb muscles","volume":"111","author":"Chen","year":"2011","journal-title":"Eur J Appl Physiol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/ajcn\/nqaa073","article-title":"Dose-response effects of dietary protein on muscle protein synthesis during recovery from endurance exercise in young men: a double-blind randomized trial","volume":"112","author":"Churchward-Venne","year":"2020","journal-title":"Am J Clin Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1384112\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T04:42:19Z","timestamp":1711341739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1384112\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":69,"alternative-id":["10.3389\/fnut.2024.1384112"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1384112","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"article-number":"1384112"}}