{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:50:25Z","timestamp":1785851425577,"version":"3.56.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Maternal malnutrition affects the somatic growth of the fetus and subsequent adverse events during infancy and childhood period. Though trials have been conducted on multiple micronutrient (MMN) supplements initiated during the preconception period, there is no collated evidence on this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We performed a systematic review of published trials with the application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE). The searches were conducted until 30 September 2023. Meta-analysis was performed using Review Manager 5 software. The primary objective was to compare the effect of preconception MMN vs. iron\u2013folic acid (IFA) supplementation on newborn anthropometric parameters at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 11,832 total citations retrieved, 12 studies with data from 11,391 participants [Intervention\u2009=\u20095,767; Control\u2009=\u20095,624] were included. For the primary outcome, there was no significant difference in the birth weight [MD, 35.61 (95% CI, \u22127.83 to 79.06), <jats:italic>p<\/jats:italic>\u2009=\u20090.11], birth length [MD, 0.19 (95% CI, \u22120.03 to 0.42), <jats:italic>p<\/jats:italic>\u2009=\u20090.09], and head circumference [MD, \u22120.25 (95% CI, \u22120.64 to \u22120.14), <jats:italic>p<\/jats:italic>\u2009=\u20090.22] between the MMN and control groups. For all the secondary outcomes [except for small for gestational age (SGA) and low birth weight (LBW)], the difference between the MMN and control groups was not significant. The GRADE evidence generated for all the outcomes varied from \u201cvery low to moderate certainty.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A \u201cvery low certainty\u201d of evidence suggests that MMN supplementation may not be better than routine IFA supplementation in improving newborn anthropometric parameters (weight, length, and head circumference). The adverse events resulting from the supplementation were not significant. We need better quality uniformly designed RCTs before any firm recommendation can be made.<\/jats:p><jats:p><jats:bold>Systematic review registration<\/jats:bold>: identifier (CRD42019144878: <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/#searchadvanced<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1390661","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T04:39:37Z","timestamp":1718339977000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of preconception multiple micronutrients vs. iron\u2013folic acid supplementation on maternal and birth outcomes among women from developing countries: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Rashmi Ranjan","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhuma","family":"Sankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagirathi","family":"Dwibedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Satapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranita","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajyoti","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1186\/1742-4755-11-S3-S3","article-title":"Preconception care: nutritional risks and interventions","volume":"11","author":"Dean","year":"2014","journal-title":"Reprod Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1185696","DOI":"10.3389\/fnut.2023.1185696","article-title":"Opportunities and barriers for maternal nutrition behavior change: an in-depth qualitative analysis of pregnant women and their families in Uttar Pradesh, India","volume":"10","author":"Jhaveri","year":"2023","journal-title":"Front Nutr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"CD004905","DOI":"10.1002\/14651858.CD004905.pub6","article-title":"Multiple-micronutrient supplementation for women during pregnancy","volume":"3","author":"Keats","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12978-018-0545-0","article-title":"Effect of life skills building education and micronutrient supplements provided from preconception versus the standard of care on low birth weight births among adolescent and young Pakistani women (15-24 years): a prospective, population-based cluster-randomized trial","volume":"15","author":"Baxter","year":"2018","journal-title":"Reprod Health"},{"key":"ref5","volume-title":"Adolescent pregnancy: Unmet needs and undone deeds: A review of the literature and programmes","year":"2007"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/1471-0528.12630","article-title":"Pregnancy and childbirth outcomes among adolescent mothers: a World Health Organization multicountry study","volume":"121","author":"Ganchimeg","year":"2014","journal-title":"BJOG"},{"key":"ref7","volume-title":"WHO guidelines on preventing early pregnancy and poor reproductive health outcomes among adolescents in developing countries","year":"2011"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/nutrit\/nuab004","article-title":"Global Young Women\u2019s nutrition investigators\u2019 group. 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Version 5.3","year":"2014"},{"key":"ref25","volume-title":"GRADE working group. GRADE handbook for grading quality of evidence and strength of recommendations","author":"Sch\u00fcnemann","year":""},{"key":"ref26","year":""},{"key":"ref27","doi-asserted-by":"publisher","first-page":"CD012610","DOI":"10.1002\/14651858.CD012610.pub2","article-title":"Lipid-based nutrient supplements for maternal, birth, and infant developmental outcomes","volume":"2018","author":"Das","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.12669\/pjms.38.1.4396","article-title":"Effects of lipid based multiple micronutrients supplement on the birth outcome of underweight pre-eclamptic women: a randomized clinical trial","volume":"38","author":"Mohammad","year":"2022","journal-title":"Pak J Med Sci"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1390661\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T04:39:44Z","timestamp":1718339984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1390661\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":28,"alternative-id":["10.3389\/fnut.2024.1390661"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1390661","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"article-number":"1390661"}}