{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:59:12Z","timestamp":1773327552420,"version":"3.50.1"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This investigation aims to elucidate the correlations between dietary intakes of vitamin E, B6, and niacin and the incidence of cataracts, utilizing the comprehensive NHANES 2005\u20132008 dataset to affirm the prophylactic roles of these nutrients against cataract formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the NHANES 2005\u20132008 cycles, this analysis concentrated on 7,247 subjects after exclusion based on incomplete dietary or cataract data. The identification of cataracts was determined through participants\u2019 self-reported ophthalmic surgical history. Nutritional intake was gauged using the automated multiple pass method, and the data were analyzed using logistic and quantile regression analyses to investigate the relationship between vitamin consumption and cataract prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis identified significant inverse associations between the intake of vitamins E, B6, and niacin and the risk of cataract development. Specifically, higher intakes of vitamin B6 (OR = 0.85, 95% CI = 0.76\u20130.96, <jats:italic>p<\/jats:italic> = 0.0073) and niacin (OR = 0.98, 95% CI = 0.97\u20131.00, <jats:italic>p<\/jats:italic> = 0.0067) in the top quartile were significantly associated with a reduced likelihood of cataract occurrence. Vitamin E intake showed a consistent reduction in cataract risk across different intake levels (OR = 0.96, 95% CI = 0.94\u20130.99, <jats:italic>p<\/jats:italic> = 0.0087), demonstrating a nonlinear inverse correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcomes indicate that elevated consumption of vitamin B6 and niacin, in conjunction with regular vitamin E intake, may have the potential to delay or prevent cataract genesis. These results suggest a novel nutritional strategy for cataract prevention and management, advocating that focused nutrient supplementation could be instrumental in preserving eye health and reducing the risk of cataracts. Further research is recommended to validate these findings and establish optimal dosages for maximum benefit.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1406147","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T15:03:07Z","timestamp":1723215787000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of vitamin E, vitamin B6, and niacin intake on cataract incidence based on NHANES 2005-2008 data"],"prefix":"10.3389","volume":"11","author":[{"given":"Guo-Bin","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Nan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/s0140-6736(05)17911-2","article-title":"Age-related cataract.","volume":"365","author":"Asbell","year":"2005","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-2019-rcs-04","article-title":"The history of cataract surgery: From couching to phacoemulsification.","volume":"8","author":"Leffler","year":"2020","journal-title":"Ann Transl Med."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00466","article-title":"Medicinal plants and natural products used in cataract management.","volume":"10","author":"Tewari","year":"2019","journal-title":"Front Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.2147\/opth.S258783","article-title":"Visual impairment and mental health: Unmet needs and treatment options.","volume":"14","author":"Demmin","year":"2020","journal-title":"Clin Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1076\/opep.6.2.95.1562","article-title":"Prevalence and incidence of age-related cataract in a population sample from Priverno, Italy.","volume":"6","author":"Cedrone","year":"1999","journal-title":"Ophthalm Epidemiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/09286580902863031","article-title":"The prevalence of lens opacities in Tehran: The Tehran eye study.","volume":"16","author":"Hashemi","year":"2009","journal-title":"Ophthalm Epidemiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/s0140-6736(17)30544-5","article-title":"Cataracts.","volume":"390","author":"Liu","year":"2017","journal-title":"Lancet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/ceo.13430","article-title":"Longitudinal changes in global cataract surgery rate inequality and associations with socioeconomic indices.","volume":"47","author":"Yan","year":"2019","journal-title":"Clin Exp Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.1167\/iovs.07-1202","article-title":"Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population.","volume":"49","author":"Dherani","year":"2008","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3109\/10715762.2013.777155","article-title":"Antioxidants and cataract.","volume":"47","author":"Thiagarajan","year":"2013","journal-title":"Free Radic Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.nut.2014.02.025","article-title":"Association of vitamin A and \u03b2-carotene with risk for age-related cataract: A meta-analysis.","volume":"30","author":"Wang","year":"2014","journal-title":"Nutrition."},{"key":"B12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev.nu.10.070190.001313","article-title":"Nutritional factors in cataract.","volume":"10","author":"Bunce","year":"1990","journal-title":"Annu Rev Nutr."},{"key":"B13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1749-6632.1992.tb17085.x","article-title":"Antioxidant functions of vitamins. 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